Serum acid phosphatase level - is it a marker for diagnosis of malaria

Background: Malaria is endemic throughout most of the tropics. Technically, detection of malaria parasite may be missed due to low parasite density at sampling time and poor blood film preparation. The study was aimed to evaluate the serum acid phosphatase levels as a possible diagnostic marker for malarial infections.Methods: This study was conducted on a total of 100 subjects (40 malaria cases, 30 non-malarial cases and 30 sex and age matched healthy controls attending the department of medicine, PESIMSR, Kuppam. Venous blood sample was collected and serum acid phosphatase (ACP) level estimation was be done by enzymatic method using commercial kit (Raichem diagnostics kit).Results: Serum ACP level was highly significantly elevated in malarial group (Mean±SD) (3.14±1.22) when compared with control (1.33±0.72) and non-malarial (1.81±0.30) groups (P value <0.001.).Conclusions: In this study, there was a significant increase in the serum ACP levels in malarial patients as compared to other groups. This suggests that serum ACP levels can be used as a marker for malaria.

ΛΛ Correlation Function in Au+Au Collisions at √\u3cem\u3e\u3csup\u3eS\u3c/sup\u3e\u3csub\u3eNN\u3c/sub\u3e\u3c/em\u3e=200 GeV

We present ΛΛ correlation measurements in heavy-ion collisions for Au+Au collisions at √SNN=200  GeV using the STAR experiment at the Relativistic Heavy-Ion Collider. The Lednický-Lyuboshitz analytical model has been used to fit the data to obtain a source size, a scattering length and an effective range. Implications of the measurement of the ΛΛ correlation function and interaction parameters for dihyperon searches are discussed

Charged-to-Neutral Correlation at Forward Rapidity in Au + Au collisions at √\u3cem\u3e\u3csup\u3eS\u3c/sup\u3e\u3csub\u3eNN\u3c/sub\u3e\u3c/em\u3e=200 GeV

Event-by-event fluctuations of the multiplicities of inclusive charged particles and photons at forward rapidity in Au+Au collisions at √SNN=200 GeV have been studied. The dominant contribution to such fluctuations is expected to come from correlated production of charged and neutral pions. We search for evidence of dynamical fluctuations of different physical origins. Observables constructed out of moments of multiplicities are used as measures of fluctuations. Mixed events and model calculations are used as base lines. Results are compared to the dynamical net-charge fluctuations measured in the same acceptance. A nonzero statistically significant signal of dynamical fluctuations is observed in excess to the model prediction when charged particles and photons are measured in the same acceptance. We find that, unlike dynamical net-charge fluctuation, charge-neutral fluctuation is not dominated by correlation owing to particle decay. Results are compared to the expectations based on the generic production mechanism of pions owing to isospin symmetry, for which no significant (\u3c1%) deviation is observed

Beam-Energy-Dependent Two-Pion Interferometry and the Freeze-Out Eccentricity of Pions Measured in Heavy Ion Collisions at the STAR Detector

We present results of analyses of two-pion interferometry in Au+Au collisions at √SNN=7.7, 11.5, 19.6, 27, 39, 62.4, and 200 GeV measured in the STAR detector as part of the BNL Relativistic Heavy Ion Collider Beam Energy Scan program. The extracted correlation lengths (Hanbury-Brown–Twiss radii) are studied as a function of beam energy, azimuthal angle relative to the reaction plane, centrality, and transverse mass (mT) of the particles. The azimuthal analysis allows extraction of the eccentricity of the entire fireball at kinetic freeze-out. The energy dependence of this observable is expected to be sensitive to changes in the equation of state. A new global fit method is studied as an alternate method to directly measure the parameters in the azimuthal analysis. The eccentricity shows a monotonic decrease with beam energy that is qualitatively consistent with the trend from all model predictions and quantitatively consistent with a hadronic transport model

\u3cem\u3eJ\u3c/em\u3e/\u3cem\u3eψ\u3c/em\u3e Production at Low \u3cem\u3ep\u3csub\u3eT\u3c/sub\u3e\u3c/em\u3e in Au + Au and Cu + Cu Collisions at √\u3cem\u3e\u3csup\u3eS\u3c/sup\u3eNN\u3c/em\u3e = 200 GeV with the STAR Detector

The J/ψ pT spectrum and nuclear modification factor (RAA) are reported for pT \u3c 5 GeV/c and |y| \u3c 1 from 0% to 60% central Au + Au and Cu + Cu collisions at √SNN = 200 GeV at STAR. A significant suppression of pT-integrated J/ψ production is observed in central Au + Au events. The Cu + Cu data are consistent with no suppression, although the precision is limited by the available statistics. RAA in Au + Au collisions exhibits a strong suppression at low transverse momentum and gradually increases with pT. The data are compared to high-pT STAR results and previously published BNL Relativistic Heavy Ion Collider results. Comparing with model calculations, it is found that the invariant yields at low pT are significantly above hydrodynamic flow predictions but are consistent with models that include color screening and regeneration

Beam-Energy Dependence of Charge Separation Along the Magnetic Field in Au+Au Collisions at RHIC

Local parity-odd domains are theorized to form inside a quark-gluon plasma which has been produced in high-energy heavy-ion collisions. The local parity-odd domains manifest themselves as charge separation along the magnetic field axis via the chiral magnetic effect. The experimental observation of charge separation has previously been reported for heavy-ion collisions at the top RHIC energies. In this Letter, we present the results of the beam-energy dependence of the charge correlations in Au+Au collisions at midrapidity for center-of-mass energies of 7.7, 11.5, 19.6, 27, 39, and 62.4 GeV from the STAR experiment. After background subtraction, the signal gradually reduces with decreased beam energy and tends to vanish by 7.7 GeV. This implies the dominance of hadronic interactions over partonic ones at lower collision energies

Intramuscular vaccination of Atlantic lumpfish (Cyclopterus lumpus L.) induces inflammatory reactions and local immunoglobulin M production at the vaccine administration site

Atlantic lumpfish were vaccinated by intramuscular (im) or intraperitoneal (ip) injection with a multivalent oil‐based vaccine, while control fish were injected with phosphate‐buffered saline. Four lumpfish per group were sampled for skin/muscle and head kidney tissue at 0, 2, 7, 21 and 42 days post‐immunization (dpi) for histopathology and immunohistochemistry (IHC). Gene expressions of secretory IgM, membrane‐bound IgM, IgD, TCRα, CD3ε and MHC class IIβ were studied in tissues by using qPCR. Im. vaccinated fish showed vaccine‐induced inflammation with formation of granulomas and increasing number of eosinophilic granulocyte‐like cells over time. On IHC sections, we observed diffuse intercellular staining of secretory IgM at the injection site at 2 dpi, while IgM + cells appeared in small numbers at 21 and 42 dpi. Skin/muscle samples from im. vaccinated fish demonstrated an increase in gene expression of IgM mRNA (secretory and membrane‐bound) at 21 and 42 dpi and small changes for other genes. Our results indicated that im. vaccination of lumpfish induced local IgM production at the vaccine injection site, with no apparent proliferation of IgM + cells. Eosinophilic granulocyte‐like cells appeared shortly after im. injection and increased in numbers as the inflammation progressed.publishedVersio

Application of postmortem imaging modalities in cases of sudden death due to cardiovascular diseases-current achievements and limitations from a pathology perspective : Endorsed by the Association for European Cardiovascular Pathology and by the International Society of Forensic Radiology and Imaging.

Postmortem imaging (PMI) is increasingly used in postmortem practice and is considered a potential alternative to a conventional autopsy, particularly in case of sudden cardiac deaths (SCD). In 2017, the Association for European Cardiovascular Pathology (AECVP) published guidelines on how to perform an autopsy in such cases, which is still considered the gold standard, but the diagnostic value of PMI herein was not analyzed in detail. At present, significant progress has been made in the PMI diagnosis of acute ischemic heart disease, the most important cause of SCD, while the introduction of postmortem CT angiography (PMCTA) has improved the visualization of several parameters of coronary artery pathology that can support a diagnosis of SCD. Postmortem magnetic resonance (PMMR) allows the detection of acute myocardial injury-related edema. However, PMI has limitations when compared to clinical imaging, which severely impacts the postmortem diagnosis of myocardial injuries (ischemic versus non-ischemic), the age-dating of coronary occlusion (acute versus old), other potentially SCD-related cardiac lesions (e.g., the distinctive morphologies of cardiomyopathies), aortic diseases underlying dissection or rupture, or pulmonary embolism. In these instances, PMI cannot replace a histopathological examination for a final diagnosis. Emerging minimally invasive techniques at PMI such as image-guided biopsies of the myocardium or the aorta, provide promising results that warrant further investigations. The rapid developments in the field of postmortem imaging imply that the diagnosis of sudden death due to cardiovascular diseases will soon require detailed knowledge of both postmortem radiology and of pathology

Measurement of Longitudinal Spin Asymmetries for Weak Boson Production in Polarized Proton-Proton Collisions at RHIC

We report measurements of single- and double-spin asymmetries for W± and Z/γ∗ boson production in longitudinally polarized p+p collisions at √S=510  GeV by the STAR experiment at RHIC. The asymmetries for W± were measured as a function of the decay lepton pseudorapidity, which provides a theoretically clean probe of the proton’s polarized quark distributions at the scale of the W mass. The results are compared to theoretical predictions, constrained by polarized deep inelastic scattering measurements, and show a preference for a sizable, positive up antiquark polarization in the range 0.05\u3cx\u3c0.2