The emotional well-being of young people: a review of the literature.

Suicide is increasingly described by governments and policy-makers as a global public health problem. Between 1950 and 1995 global suicide rates have increased by 60%. In recent years concerns have been expressed in Scotland and the UK about rising suicide rates amongst children and young people and the accumulation of increasing evidence that the adoption of negative coping strategies is contributing to rising levels of deliberate self harm (DSH).This literature review was in part used and incorporated into chapter two of the final report, The emotional wellbeing of young people: final report of phase one of a 'Choose Life' research project in Aberdeenshire (March 2004-March 2007), which can be found at http://hdl.handle.net/10059/439

Health & homelessness in Aberdeen City: a report for the Scottish Health Council.

1. Background According to the latest official figures, 1900 households presented themselves as homeless in Aberdeen City in the year 2005/2006 (Scottish Executive 2006). The problems faced by homeless people in Aberdeen and elsewhere have already been documented in terms of inadequate housing, family and relationship breakdown, unemployment, multiple debt, reliance on benefits and low income. (Love, 1993, 1997, 2002; Spicker, Love, Strangward, McLaverty & Strachan, 2002). Such multiple and linked problems serve to marginalise homeless people relegating them to ways of life outside of mainstream society. A corollary of such exclusion is the relatively high levels of poor health (both physical and mental) found among the homeless population. Hence, physical hardship, accidents, inadequate resources to practice personal hygiene, poor diet, stress, difficulty registering with a GP, a lack of preventative care, a lack of (suitable) health information and stigma combine to increase the rates of morbidity and mortality among homeless people. 2. Research The study examined the health status and health behaviours of homeless people in Aberdeen. It sought to find out how well NHS services engage with homeless people in the city. The intention was to explore how patient and public involvement could be developed meaningfully to ensure that the views of homeless people are actively sought, listened to and acted upon. The definition of homelessness used corresponded to that used by the Homelessness Task Force (see Appendix A) and covered the statutory homeless and non statutory homeless (e.g. roofless, houseless, temporarily housed, those living in insecure accommodation etc.)

Health & ethnicity in Aberdeenshire: a study of Polish in-migrants; a report for the Scottish Health Council.

In Scotland as a whole, around 2% of the population are from minority ethnic backgrounds, although the distribution of people from such backgrounds is uneven across the country. In Aberdeenshire, out of a total population of 232,850, 1,165 people come from ethnic minority backgrounds, around 0.5% of the total population. According to the 2001 Census, there are nine main ethnic minority groups in Aberdeenshire, the largest of which is Chinese, comprising around a quarter of the total ethnic minority population of the area (n=277, 24%). The remaining groups are made up of Indians, Pakistanis, other South Asians, Africans, Black Scottish and people from the Caribbean. However, around 29% come from other minority ethnic groups. With respect to the latter, there has been a noticeable influx of people from Eastern Europe, particularly Poland, Lithuania and Latvia following the accession of ten new member states to the European Union on the 1st April 2004. It has been estimated that around 800 migrant workers and their families are now coming to Grampian each month (400 of whom are Polish), if levels of applications for National Insurance numbers are indicative in this respect (NHS Grampian, 2005). The health needs of migrants is becoming increasingly recognised. As such, the International Organization for Migrations most recent World Migration Report (2005) argued that, the social and economic costs of neglecting migration health, also as a public health issue, can be immeasurable. The experience of migration can lead to increased vulnerability to ill health as well as ill health, which arises after arrival. Poorer migrants are often lowly paid, living in damp conditions, badly nourished and exposed to higher risks in working environments yet under-utilise health services. In addition, the stigma generated from wider perceptions of poor migrant health can contribute to an undermining of the benefits of migration. In short, migration is a public health issue, which seems likely to endure in an emerging age of migration (Castles and Miller 2003). Finally communication is considered fundamentally important to the health of migrants due to language barriers having adverse effects on the accessibility of care, the quality of care received, patient satisfaction and patient health outcomes (Bischoff 2003). To help in-migrants settle into Scotland generally and Aberdeenshire in particular the Scottish Executive and a range of national and regional bodies have introduced a range of policies. Within healthcare, NHS Grampian (2005) aims to make genuine and lasting improvements in the quality of services provided to the local ethnic communities and to make NHS Grampian the leader, for other Health Boards to follow. To this end a range of policies are being implemented. These include, interpretation and translation services, training for NHS Grampian staff to better understand the needs of the local ethnic communities, access and service delivery, racial equality within NHS Grampian, appointments procedures, training procedures, actively promoting health within the ethnic communities and meeting the healthcare needs of recently arrived migrant workers and their families and asylum seekers

A bayesian meta-analysis of multiple treatment comparisons of systemic regimens for advanced pancreatic cancer

© 2014 Chan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Background: For advanced pancreatic cancer, many regimens have been compared with gemcitabine (G) as the standard arm in randomized controlled trials. Few regimens have been directly compared with each other in randomized controlled trials and the relative efficacy and safety among them remains unclear

Alginate Oligosaccharide-Induced Modification of the lasI-lasR and rhlI-rhlR Quorum Sensing Systems in Pseudomonas aeruginosa

Pseudomonas aeruginosa plays a major role in many chronic infections. Its ability to readily form biofilms contributes to its success as an opportunistic pathogen and its resistance/tolerance to antimicrobial/antibiotic therapy. A low-molecular-weight alginate oligomer (OligoG CF-5/20) derived from marine algae has previously been shown to impair motility in P. aeruginosa biofilms and disrupt pseudomonal biofilm assembly. As these bacterial phenotypes are regulated by quorum sensing (QS), we hypothesized that OligoG CF-5/20 may induce alterations in QS signaling in P. aeruginosa. QS regulation was studied by using Chromobacterium violaceum CV026 biosensor assays that showed a significant reduction in acyl homoserine lactone (AHL) production following OligoG CF-5/20 treatment (≥2%; P < 0.05). This effect was confirmed by liquid chromatography-mass spectrometry analysis of C4-AHL and 3-oxo-C12-AHL production (≥2%; P < 0.05). Moreover, quantitative PCR showed that reduced expression of both the las and rhl systems was induced following 24 h of treatment with OligoG CF-5/20 (≥0.2%; P < 0.05). Circular dichroism spectroscopy indicated that these alterations were not due to steric interaction between the AHL and OligoG CF-5/20. Confocal laser scanning microscopy (CLSM) and COMSTAT image analysis demonstrated that OligoG CF-5/20-treated biofilms had a dose-dependent decrease in biomass that was associated with inhibition of extracellular DNA synthesis (≥0.5%; P < 0.05). These changes correlated with alterations in the extracellular production of the pseudomonal virulence factors pyocyanin, rhamnolipids, elastase, and total protease (P < 0.05). The ability of OligoG CF-5/20 to modify QS signaling in P. aeruginosa PAO1 may influence critical downstream functions such as virulence factor production and biofilm formation

The hospital microbiome project: meeting report for the UK science and innovation network UK-USA workshop ‘beating the superbugs: hospital microbiome studies for tackling antimicrobial resistance’, October 14th 2013

The UK Science and Innovation Network UK-USA workshop ‘Beating the Superbugs: Hospital Microbiome Studies for tackling Antimicrobial Resistance’ was held on October 14th 2013 at the UK Department of Health, London. The workshop was designed to promote US-UK collaboration on hospital microbiome studies to add a new facet to our collective understanding of antimicrobial resistance. The assembled researchers debated the importance of the hospital microbial community in transmission of disease and as a reservoir for antimicrobial resistance genes, and discussed methodologies, hypotheses, and priorities. A number of complementary approaches were explored, although the importance of the built environment microbiome in disease transmission was not universally accepted. Current whole genome epidemiological methods are being pioneered in the UK and the benefits of moving to community analysis are not necessarily obvious to the pioneers; however, rapid progress in other areas of microbiology suggest to some researchers that hospital microbiome studies will be exceptionally fruitful even in the short term. Collaborative studies will recombine different strengths to tackle the international problems of antimicrobial resistance and hospital and healthcare associated infections

Lottery judgments:A philosophical and experimental study

In this paper, we present the results of two surveys that investigate subjects&rsquo; judgments about what can be known or justifiably believed about lottery out- comes on the basis of statistical evidence, testimonial evidence, and &lsquo;mixed&rsquo; evidence, while considering possible anchoring and priming effects. We dis- cuss these results in light of seven distinct hypotheses that capture various claims made by philosophers about lay people&rsquo;s lottery judgments. We con- clude by summarizing the main findings, pointing to future research, and comparing our findings to recent studies by Turri and Friedman (2014) and Friedman and Turri (2015)

Inclusive jet cross sections and dijet correlations in D∗±D^{*\pm} photoproduction at HERA

Inclusive jet cross sections in photoproduction for events containing a $D^*$ meson have been measured with the ZEUS detector at HERA using an integrated luminosity of $78.6 {\rm pb}^{-1}$. The events were required to have a virtuality of the incoming photon, $Q^2$, of less than 1 GeV$^2$, and a photon-proton centre-of-mass energy in the range $130<W_{\gamma p}<280 {\rm GeV}$. The measurements are compared with next-to-leading-order (NLO) QCD calculations. Good agreement is found with the NLO calculations over most of the measured kinematic region. Requiring a second jet in the event allowed a more detailed comparison with QCD calculations. The measured dijet cross sections are also compared to Monte Carlo (MC) models which incorporate leading-order matrix elements followed by parton showers and hadronisation. The NLO QCD predictions are in general agreement with the data although differences have been isolated to regions where contributions from higher orders are expected to be significant. The MC models give a better description than the NLO predictions of the shape of the measured cross sections.Comment: 43 pages, 12 figures, charm jets ZEU

Dissociation of virtual photons in events with a leading proton at HERA

The ZEUS detector has been used to study dissociation of virtual photons in events with a leading proton, gamma^* p -> X p, in e^+p collisions at HERA. The data cover photon virtualities in two ranges, 0.03<Q^2<0.60 GeV^2 and 2<Q^2<100 GeV^2, with M_X>1.5 GeV, where M_X is the mass of the hadronic final state, X. Events were required to have a leading proton, detected in the ZEUS leading proton spectrometer, carrying at least 90% of the incoming proton energy. The cross section is presented as a function of t, the squared four-momentum transfer at the proton vertex, Phi, the azimuthal angle between the positron scattering plane and the proton scattering plane, and Q^2. The data are presented in terms of the diffractive structure function, F_2^D(3). A next-to-leading-order QCD fit to the higher-Q^2 data set and to previously published diffractive charm production data is presented

Australian Aboriginal Ethnometeorology and Seasonal Calendars

This paper uses a cultural anthropological approach to investigate an indigenous Australian perspective on atmospheric phenomena and seasons, using data gained from historical records and ethnographic fieldwork. Aboriginal people believe that the forces driving the weather are derived from Creation Ancestors and spirits, asserting that short term changes are produced through ritual. By recognizing signals such as wind direction, rainfall, temperature change, celestial movements, animal behaviour and the flowering of plants, Aboriginal people are able to divide the year into seasons. Indigenous calendars vary widely across Australia and reflect annual changes within Aboriginal lifestyles