Linking regional unconformities in the Barents Sea to compression-induced forebulge uplift at the Triassic-Jurassic transition

The Triassic-Jurassic transition marks an important change in the basin configuration of the Greater Barents Sea. A contiguous basin with km-thick sedimentary successions changed into a partitioned basin with uplift in the west and foreland basins in the east with significant implication for the basin infill history. Our study employs a range of different high-resolution datasets from a distal part of the basin which unravels the complex pattern of differential uplift and erosion in the basin during this period. We record for the first time distinct angular unconformities between Upper Triassic strata and overlying Lower Jurassic strata within the basin, showing that large parts of it formed topographic highs. Our study links these angular unconformities to compression induced by the Novaya Zemlya Fold and Thrust Belt. A heterolithic basement below a thick sedimentary succession where the fold belt developed created a complex uplift pattern in the basin, at the same time similar to but different from typical forebulge areas. Compression caused inversion of older basement rooted faults defining platforms and graben systems throughout western parts of the Barents Sea basin, in addition to salt remobilization that resulted in differential uplift and erosion. These local zones of uplift controlled the sediment distribution pattern to the basin at a time when the most important reservoir units in the basin were deposited. This new understanding of the basin development explains hitherto enigmatic sequence boundaries that has inspired complex paleogeographic models in the past.publishedVersio

Platelet hemostasis in patients with metabolic syndrome and type 2 diabetes mellitus: cGMP- and NO-dependent mechanisms in the insulin-mediated platelet aggregation

Patients with metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) have high risk of microcirculation complications and microangiopathies. An increase in thrombogenic risk is associated with platelet hyperaggregation, hypercoagulation, and hyperfibrinolysis. Factors leading to platelet activation in MetS and T2DM comprise insulin resistance, hyperglycemia, non-enzymatic glycosylation, oxidative stress, and inflammation. This review discusses the role of nitric oxide (NO) in the regulation of platelet adhesion and aggregation processes. Nitric oxide is synthesized both in endotheliocytes, smooth muscle cells, macrophages, and platelets. Modification of platelet NO-synthase (NOS) activity in MetS patients can play a central role in the manifestation of platelet hyperactivation. Metabolic changes, accompanying T2DM, can lead to an abnormal NOS expression and activity in platelets. Hyperhomocysteinemia, often accompanying T2DM, is a risk factor for cardiovascular accidents. Homocysteine can reduce NO production by platelets. This review provides data on the insulin effects in platelets. Decrease in a number and sensitivity of the insulin receptors on platelets in T2DM can cause platelet hyperactivation. Various intracellular mechanisms of anti-aggregating insulin effects are discussed. Anti-aggregating effects of insulin are mediated by a NO-induced elevation of cGMP and upregulation of cAMP- and cGMP-dependent pathways. The review presents data suggesting an ability of platelets to synthesize humoral factors stimulating thrombogenesis and inflammation. Proinflammatory cytokines are considered as markers of T2DM and cardiovascular complications and are involved in the development of dyslipidemia and insulin resistance. The article provides an evaluation of NO-mediated signaling pathway in the effects of cytokines on platelet aggregation. The effects of the proinflammatory cytokines on functional activity of platelets are demonstrated

Linking regional unconformities in the Barents Sea to compression-induced forebulge uplift at the Triassic-Jurassic transition

The Triassic-Jurassic transition marks an important change in the basin configuration of the Greater Barents Sea. A contiguous basin with km-thick sedimentary successions changed into a partitioned basin with uplift in the west and foreland basins in the east with significant implication for the basin infill history. Our study employs a range of different high-resolution datasets from a distal part of the basin which unravels the complex pattern of differential uplift and erosion in the basin during this period. We record for the first time distinct angular unconformities between Upper Triassic strata and overlying Lower Jurassic strata within the basin, showing that large parts of it formed topographic highs. Our study links these angular unconformities to compression induced by the Novaya Zemlya Fold and Thrust Belt. A heterolithic basement below a thick sedimentary succession where the fold belt developed created a complex uplift pattern in the basin, at the same time similar to but different from typical forebulge areas. Compression caused inversion of older basement rooted faults defining platforms and graben systems throughout western parts of the Barents Sea basin, in addition to salt remobilization that resulted in differential uplift and erosion. These local zones of uplift controlled the sediment distribution pattern to the basin at a time when the most important reservoir units in the basin were deposited. This new understanding of the basin development explains hitherto enigmatic sequence boundaries that has inspired complex paleogeographic models in the past