Pollen Serum Specific IgE Sensitization in Respiratory Allergic Patients in Jakarta, Indonesia

Background: pollens from trees or grasses in Indonesia have a perennial distribution due to the tropical climate. However, pollen allergy has not been well studied. This study aimed to evaluate the profile of pollen IgE sensitization in respiratory allergic patients in Jakarta. Methods: this was a cross-sectional study in patients with a history of respiratory allergy in Jakarta, Indonesia between September and December 2016. Adult asthmatic patients aged 19-60 years were invited to undergo serum specific IgE testing at the Allergy and Immunology Clinic, Cipto Mangunkusumo Hospital, Jakarta. Patients were included if they showed at least one positive skin prick test with environmental allergens. Quantitative determination of specific IgE in serum was carried out by multiple allergosorbent (MAST) assays (Polycheck Allergy®, Biocheck GmbH, Munster, Germany).  Serum specific IgE levels of more than 0.35 kU/L or Class 1 was considered positive. Results: a total of 106 cases were eligible for analysis; 81 (76.4%) were women. Patients’ mean age was 38.8+12.1 (range 19-59) years old. 59.4% of patients have both asthma and allergic rhinitis. There are 9 (8.5%) patients positive for IgE-pollen sensitization; 8 among them showed sensitization to at least 2 pollens. Sensitivity to goosefoot pollen is the highest (5.7%), followed by rye pollen (4.7%), plantain pollen (4.7%), wall pellitory pollen (4.7%), and Bermuda grass pollen (3.8%). Conclusion: although most pollens tested are not originated from native plants to Indonesia, a small number of patients showed specific IgE-sensitizations. Allergic persons planning to travel to the endemic areas of the relevant pollen should be advised. A panel of pollen allergens from local plants is highly desired

PENGARUH PERILAKU, KEPRIBADIAN, DAN NILAI- NILAI BUDAYA KARYAWAN TERHADAP KINERJA GREEN HOSPITAL DI RUMAH SAKIT KETERGANTUNGAN OBAT (RSKO) CIBUBUR, JAKARTA TIMUR

Abstrak Tujuan penelitian ini adalah untuk mendapatkan informasi dan mengetahui pengaruh perilaku, kepribadian, dan nilai-nilai budaya terhadap kinerja green hospital. Data dikumpulkan dengan menggunakan kuesioner yang didistribusikan ke 101 sampel. Sampel dipilih melalui teknik probability sampling dari populasi sebanyak 136 karyawan di Rumah Sakit Ketergantungan Obat (RSKO) Cibubur Jakarta Timur. Metode penelitian yang digunakan adalah asosiatif kausal dengan pendekatan kuantitatif. Analisis data menggunakan analisis jalur (path analysis). Hasil penelitian menunjukkan bahwa, terdapat pengaruh langsung perilaku karyawan terhadap kinerja green hospital (β = 0,285); terdapat pengaruh langsung kepribadian karyawan terhadap kinerja green hospital (β = 0,291); terdapat pengaruh langsung dari nilai-nilai budaya pada kinerja green hospital (β = 0,412); terdapat pengaruh langsung perilaku karyawan terhadap nilai-nilai budaya (β = 0,209); terdapat pengaruh langsung kepribadian karyawan terhadap nilai-nilai budaya (β = 0,210); terdapat pengaruh tidak langsung dari perilaku karyawan melalui nilai-nilai budaya terhadap kinerja green hospital (β = 0,421); terdapat pengaruh tidak langsung kepribadian karyawan melalui nilai-nilai budaya terhadap kinerja green hospital (β = 0,512). Kesimpulan dari penelitian ini menunjukkan bahwa, apabila ingin meningkatkan kinerja green hospital, maka faktor-faktor seperti perilaku karyawan, kepribadian karyawan, dan nilai-nilai budaya, perlu ditingkatkan juga. Nilai-nilai budaya bukan satu-satunya yang mempengaruhi kinerja green hospital, tetapi perlu mempertimbangkan juga variabel perilaku karyawan dan kepribadian karyawan. Kata kunci: Green hospital, kinerja, perilaku, kepribadian, nilai-nilai budaya. ************ Abstract The purpose of the study was to obtain information and find out the direct influence of behavior, personality, and cultural values on green hospital performance. The data were collected by using quesionnaires distributed to 101 samples. The samples were chosen through probability sampling technique from the population - all 136 employees in Rumah Sakit Ketergantungan Obat (RSKO) Cibubur Jakarta Timur. The research method was associative causal using a quantitative approach. Applying a path analysis, the results showed that there was a direct influence of employees behavior on green hospital performance (β = 0.285); there is a direct effect of employees personality on green hospital performance (β = 0.291); there is a direct effect of cultural values on green hospital performance model (β = 0.412); there is a direct influence of employees behavior on cultural values (β = 0.209); there is a direct effect of employees personality on cultural values (β = 0.210); there is an indirect effect of employees behavior through cultural values on green hospital performance (β = 0.421); there is an indirect effect of employees personality through cultural values on green hospital performance (β = 0.512). The conclusion of this study shows that, if you want to improve the performance of green hospitals, then factors such as employee behavior, employee personality, and cultural values, need to be improved as well. Cultural values are not the only ones that affect the performance of green hospitals, but it also needs to consider employee behavior and employee personality. Keywords: Green hospital, performance, behavior, personality, cultural values

MENINGKATKAN AKTIFITAS MAHASISWA MELALUI PEMBELAJARAN BERBASIS MASALAH MATA KULIAH STRUKTUR ALJABAR

Tujuan penelitian ini adalah meningkatkan aktifitas mahasiswa melalui pembelajaran berbasis masalah pada mata kuliah struktur aljabar. Design penelitian dilakukan adalah penelitian tindakan kelas.Aktifitas mahasiswa dilihat dari kegiatan bertanya, menjawab pertanyaan dosen, memberikan tanggapan kepada teman dan menyelesaikan masalah di depan kelas. Dari pertemuan sebanyak tiga kali, dapat diperoleh hasil adanya peningkatan aktifitas bertanya, memberikan tanggapan dan menyelesaikan permasalahan didepan kelas. Dari hasil penelitian ini, disimpulkan bahwa melalui pembelajaran berbasis masalah, dapat meningkatkan aktifitas mahasiswa. Kata kunci : aktifitas, pembelajaran berbasis masala

Effect of Vitamin D3 2000 IU Tablets on Serum Vitamin D 25-OH Levels, Hemoglobin Levels, Body Mass Index and CD4/CD8 Ratio in Patients Infected with Human Immunodeficiency Virus / Acquired Immunodeficiency Syndrome Who Have Been Treated with Antiretrovira

Background: Human Immunodeficiency Virus (HIV) is a retrovirus subgroup of lentivirus family that has RNA genetic characteristics that attack the body's immune system, especially infecting Cluster Differential Four (CD4) lymphocytes and replicating according to the host's DNA. Vitamin D is important in stimulating innate immunity. Availability of vitamin D has an important role to improve the nutritional status of HIV/AIDS patients, improve the immune system, and improve prognosis. Research Objectives: To assess the effect of administration of vitamin D3 tablet therapy on serum vitamin D 25-OH levels, hemoglobin levels, body mass index (BMI), and CD4/CD8 ratio in HIV/AIDS infected patients who have been treated with antiretrovirals (ARV). Methods: This study was a cross-sectional study using 40 samples of HIV patients who were routinely controlled at the VCT polyclinic at Dr. Moewardi who received regular antiretrovirals. The inclusion and exclusion criteria are intended to obtain samples that are currently in HIV stages I and II so that it is expected to reduce other factors that cause bias levels of vitamin D apart from the chronic inflammatory process that occurs in HIV-infected patients. Patients who have come informed their consent to take blood samples during one of their visits to the VCT poly to check BMI, serum vitamin D (25-(OH)), and routine blood to determine the value of hemoglobin and the CD4/CD8 ratio. The statistical test uses an analysis of the difference in the average of the two groups. Results: The results of testing the mean difference between the two groups of serum levels of vitamin D 25-OH in the Vitamin D3 treatment and control groups showed a value of Z = -2.277 (p = 0.023). The results of the different test mean that the two groups of hemoglobin in the Vitamin D3 treatment group and the control showed a value of Z = -3.484 (p = 0.001). The results of different tests mean that the two BMI groups in the Vitamin D3 treatment group and the control group show a value of t = -5.098 (p = 0.001). The results of the mean difference test of the two CD4/CD8 ratio groups in the Vitamin D3 treatment group and the control group showed a value of t = -6.203 (p = 0.001). Conclusion: Administration of 2000 IU vitamin D3 tablets can increase serum vitamin D 25-OH levels, hemoglobin, BMI, and CD4/CD8 ratio in HIV/AIDS-infected patients treated with antiretroviral (ARV)

Hubungan Kualitas Pelayanan Informasi Obat dengan Kepuasan Pelayanan Obat di Kecamatan Kluwut, Kabupaten Brebes

Pelayanan kesehatan yang berkualitas dan menyatu dengan masyarakat sangat penting dalam dunia kesehatan, dengan tujuan menciptakan pola hidup masyarakat yang peduli, mengerti, dan tanggap akan permasalahan kesehatan. Penelitian ini bertujuan untuk mengetahui hubungan antara kualitas pelayanan informasi obat (PIO) dengan kepuasan pelayanan obat di Puskesmas Kluwut. Metode penelitian yang digunakan adalah analitik kuantitatif dengan desain cross sectional. Populasi penelitian ini adalah pasien yang mendapatkan pelayanan informasi obat di Puskesmas Kluwut, Kabupaten Brebes. Besar sampel penelitian ini  adalah 106 orang yang telah memenuhi kriteria penelitian. Pengambilan sampel dilakukan dengan metode accidental sampling. Kuesioner digunakan sebagai alat pengumpulan data dengan skala Ordinal. Analisis data dengan menggunakan metode Chi-Square 0,05. Hasil penelitian bahwa kualitas PIO adalah pada kategori sangat baik (52,8%)  dan kepuasan pelayan obat pada kategori sangat puas (77%). Hasil uji Chi-Square didapatkan p-value sebesar 0,000 (pV<0,05).  Hasil ini menunjukkan bahwa terdapat hubungan yang signifikan antara kualitas PIO dengan kepuasaan pelayanan obat

MODEL PERAN ANTAR KELEMBAGAAN DESA DALAM PENYEDIAAN AIR BAKU MELALUI PARADIGMA KEPEDULIAN AIR (Studi Kasus Desa Bendungan, Kecamatan Ciawi, Kabupaten Bogor)

Based on water balance and temporal water sufficiency analysis in Ciliwung Hulu watershed, it shows that Ciseuseupan sub watershed belongs toinsufficient water category. Of the 8 villages in the Ciseuseupan sub watershed, there is a Bendungan village that is not enough water category in the provision of raw water, because in the provision of raw water is still dependent on natural reliability such as rivers, springs, wells, and others. This research discusses insufficient water solutions at the village level with one of them is institutional analysis through concern of water paradigm. The method used is ISM (Interpretative Structural Model), with emphasis on 4 (four) elements structured in relation to the provision of raw water ie: (1) needs of the program, (2) the main obstacle, (3) purpose program, and (4) institutions involved in program implementation. Therefore, it is required an independent water provision expert, involving various parties. The purpose of this research is to build an institutional role model in the provision of concern of water paradigm. The results show that: to realize a new paradigm in the provision of raw water, the main constraint is quality of human resources (village officials, communities, and NGOs), which must be resolved first, so that they can participate together to build the infrastructure by adequate socialization.   Berdasarkan analisis neraca air dan ketercukupan air temporal DAS Ciliwung Hulu menunjukkan bahwa Sub DAS Ciseuseupan termasuk ke dalam kategori kurang cukup air dalam penyediaan air baku. Dari delapan desa yang ada di Sub DAS tersebut, Desa Bendungan merupakan salah satu desa yang ketercukupan airnya termasuk dalam kategori tidak cukup, sebab dalam penyediaan airnya masih mengandalkan alam, seperti sungai, air tanah melalui sumur, mata air, dan lain-lain. Penelitian ini menjelaskan solusi ketidak cukupan di tingkat desa, dimana salah satunya adalah dengan analisis peran antar kelembagaan melalui paradigma kepedulian air. Metode yang digunakan adalah ISM (Interpretative Structural Model), yang menekankan pada empat elemen yang berhubungan dengan penyediaan air baku, yaitu: (1) kebutuhan program, (2) kendala utama, (3) tujuan program, dan (4) lembaga yang terkait dengan program. Oleh karena itu, diperlukan ahli penyediaan air mandiri, yang melibatkan berbagai pihak. Tujuan dari penelitian ini adalah membangun struktur model kelembagaan penyediaan air baku melalui paradigma kepedulian air. Hasil analisis menunjukkan bahwa: untuk merealisasikan paradigma baru di dalam penyediaan air baku,kendala utamanya adalah kualitas sumber daya manusia (aparat desa, masyarakat, dan LSM) yang harus diatasi terlebih dahulu agar mereka dapat berpartisipasi bersama-sama untuk membangun infrastruktur air melalui sosialisasi yang memadai

The Differences in Serum Quantitative Specific IgE Levels Induced by Dermatophagoides pteronyssinus, Dermatophagoides farinae and Blomia tropicalis Sensitization in Intermittent and Persistent Allergic Asthma

Background: house dust mites (HDM) are an important inhalant allergen in allergic asthma. However, molecular diagnostic study of specific IgE to HDM allergens has not been done in Indonesia. In addition, the association of quantitative specific IgE measurement with asthma severity has not been investigatedd. This study aimed to investigate the difference of serum quantitative specific IgE levels induced by Dermatophagoides (D.) pteronyssinus, D. farinae and Blomia tropicalis sensitization in intermittent and persistent allergic asthma.Methods: this was a cross-sectional study on adult allergic asthma patients who were invited for serum specific IgE testing. This study was a part of a larger study within the Division of Allergy and Immunology, Cipto Mangunkusumo Hospital. Asthma severity was defined based on Global Initiative on Asthma (GINA) 2015 criteria and were grouped as intermittent or persistent. Quantitative specific IgE testing was done on blood serum using a multiple allergosorbent test (Polycheck Allergy, Biocheck GmbH, Munster, Germany). The HDM allergens tested were D. pteronyssinus, D. farinae, and Blomia tropicalis. Difference between two groups were analyze using Mann-Whitney test.Results: a total of 87 subjects were enrolled in this study; 69 (79.3%) were women. Mean patients’ age was 40, 2 years. Sixty-three (72.4%) subjects had asthma and allergic rhinitis. Fifty-eight (66.7%) subjects were classified as persistent asthma. The prevalence of sensitization was 62.1% for D. farinae, 51.7% for D. pteronyssinus, and 48.3% for Blomia tropicalis. The median of specific IgE levels were significantly higher in persistent asthma compares to intermittent asthma induced by D. farinae (median 1.30 vs. 0.0 kU/L; p=0.024) and B. tropicalis (median 0.57 vs. 0.0 kU/L; p=0.015) sensitization. Level of Specific IgE  D. pteronyssinus was also to be higher in persistent asthma than the level measured in intermittent asthma (0.67 vs. 0.00 kU/L; p=0.066).Conclusion: Sensitization of HDM allergens was shown to be highest for D. farinae 62.1%, followed by D. pteronyssinus 51.7% and Blomia tropicalis 48.3%. Specific IgE level induced by D. farinae and Blomia tropicalis sensitization were significantly higher in patients with persistent asthma compared to intermittent asthma, whereas specific IgE level induced by D. pteronyssinus sensitization was higher in persistent asthma although not statistically significant

Peran Jinten Hitam (Nigella Sativa) sebagai Imunomodulator Menurunkan Sitokin Il-6 pada Penderita Covid 19: Review Artikel

Coronavirus-19 (Covid-19) adalah penyakit yang disesbabkan oleh Severe Acute Respiratory Syndrom (SARS CoV-2) yang ditemukan pada akhir 2019 di kota Wuhan. Jinten hitam (Nigella Sativa ) merupakan tumbuhan yang memiliki kandungan Thymoquinone yang mempunyai efek imunomodulator, analgesik, anti okisdan ,anti inflamasi, anti kanker, anti virus dan profilaksis anti alergi serta berfungsi sebagai inhibitor kuat untuk SARS-CoV-2. Penelitian ini merupakan tinjauan kepustakaan dari artikel terkait efek yang dimiliki Jinten Hitam (Nigella Sativa) pada pasien yang terinfeksi Covid-19. Kami menggunakan PubMed, Google Scholar, Science Direct sebagai sumber pencarian artikel. Penelitian ini dilakukan dengan periode waktu antara bulan Januari-Maret 2022. Sebanyak 30 artikel dipelajari yang meliputi artikel terbaru tentang  manfaat Jinten Hitam (Nigella Sativa ) dan Covid-19 yang sesuai dengan kriteria inklusi dan eksklusi. Secara in vitro, kandungan Thymoquinone pada Jinten Hitam (Nigella Sativa) menunjukkan efek imunomodulator, anti inflamasi dan efek proteksi terhadap saluran napas yang dapat dikembangkan sebagai terapi adjuvant covid-19. Manfaat Thymoquinone pada Jinten Hitam(Nigella Sativa ) memiliki banyak sekali manfaat dalam membantu pengobatan infeksi Covid-19. Pada pemberian ekstrak jinten hitam (Nigella Sativa ) terjadi penurunan kadar IL-6 pada pasien Covid -19 sehingga dapat mengurangi terjadinya badai sitokin

Relative Expression of mRNA BARF1 Epstein-Barr Virus from Tumor Tissue Biopsy in Formalin-Fixed Paraffin-Embedded in Nasopharyngeal Carcinoma

Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from nasopharyngeal epithelial cells. NPC is endemic in some regions, especially in Southeast Asia countries. NPC is also a multifactorial disease involving environmental factors, genetic factors, and infection from Epstein-Barr virus (EBV). According to WHO classification, Undifferentiated NPC is histopathologically associated with EBV infection and categorized into WHO subtype 3. EBV has two phases in its infection cycle: the lytic and latent phases. The BARF1 gene is a mediator of the transition from the latent phase to the lytic phase. Previous studies suggest measurement of EBV mRNA activity at the primary tumor site in the nasopharyngeal reflects the pathogenesis of NPC rather than measuring circulating EBV DNA or serological diagnosis. This study aimed to determine the relative expression potential of BARF1 mRNA at different tumor stages in NPC patients as a predictor of NPC pathogenesis. This research design was a descriptive research method in the form of a cross-sectional study. The samples used were 22 patients diagnosed as NPC WHO class III at the Anatomical Pathology Section of Prof. Dr. Margono Soekarjo, Purwokerto, who met the inclusion criteria. The relative expression of BARF1 mRNA was carried out using the one-step real-time RT-PCR technique and then calculated using a formula of 2-ΔCt. The T-test was used to compare the relative expression of early and late-stage BARF1 mRNA. The relative expression of BARF1 mRNA in the late-stage advanced stage (n = 6; 0.708292-0.840177; med = 0.7164655) was increased compared to the early stage (n = 2; 0.708841-0.712423; med = 0. 710632)

Konsep Urban Naturalisme pada Desain Bangunan Karya Toyo Ito

Aliran Naturalisme dalam arsitektur adalah sebuah konsep arsitektural yang mengambil dari bentukan maupun sifat yang terdapat di alam. Arsitektur Urban Naturalisme dapat dikatakan sebagai penggabungan antara konsep perancangan secara naturalis dengan penerapannya dalam kebutuhan bangunan pada kawasan perkotaan. Bangunan karya Arsitek Toyo Ito selalu menunjukkan karakter visual memperlihatkan keindahan yang mengalir serta keseimbangan antara dunia nyata dan virtual dalam penerapan konsep urban naturalismenya. Tujuan penelitian ini adalah untuk mempelajari implementasi konsep urban naturalism Karya Toyo Ito dan membaca ‘tanda’ elemen fisik terhadap perwujudan konsep tersebut pada fungsi bangunan, bentuk bangunan dan sistem struktur dari desain bangunan karya Toyo Ito, yaitu Sendai Mediatheque, TOD’s Omotesando Building dan Kaohsiung National Stadium. Metode penelitian yang digunakan adalah pendekatan semiotik untuk mencari penggunaan ‘tanda’ dari elemen-elemen yang mempermudah proses visual pengamat terhadap suatu karya arsitektur melalui substance of content (signified), form of content (signified), Form of expression (signifier) dan Substance of expression.  Penggunaan konsep urban naturalisme ini menghasilkan adanya interaksi dengan alam yang tidak dibatasi oleh dinding fasade, keindahan struktur bangunan yang bisa diciptakan dari alam sekitar dengan pola organik serta kenyamanan dalam bangunan dengan memanfaatkan aliran energi positif dan memaksimalkan efek pendingin alami dari angin di lingkungan perkotaan yang tropis