Understanding Scholarly Communication – Tools to Help Graduate Students Publish

Although graduate students are increasingly expected to publish before graduation, they are rarely offered formal education in the full range of the scholarly communication process in their discipline. They quickly learn how to do the research and to present their findings in a format suitable for submission to an academic peer-reviewed journal, but seldom do they (or their faculty advisors) understand the business of publishing and how that may affect their ability to get published. At Utah State University, the Department of Environment and Society (College of Natural Resources) started in 2010 requiring first-term graduate students to take a 2-credit class that will prepare them to publish in their field. Called Graduate Student Publishing Seminar (GSPS) it covers a broad range of topics related to scholarly communication and publishing. Actual publications are required to pass the class. The GSPS final grade is given the semester of their graduation. A senior professor in the department teaches GSPS with guest lectures provided by other faculty in the university. The subject librarian and a university press editor teach approximately 25% of the class. Based on the librarian’s lectures, this presentation will focus on why and how the GSPS curriculum includes information on the following topics: understanding the business of publishing, identifying and navigating the plethora of various publication types in a discipline, understanding impact and what it really means, reading publishing contracts and the copyright implications for the author (not only as a researcher but also as a future teacher), and familiarizing them to alternatives to traditional publishing – including open access models of publishing. The presentation will also provide a brief overview of GSPS’s overall course requirements as well as an assessment of student learning to the above curriculum

What Is Keeping You Up At Night? A Discussion of Current Hot Topics in Collection Development

In this interactive lunch discussion, participants discussed the top issues in collection development that kept them up at night. Unlike the collection development issues included in the ARL “Issue Brief: 21st-Century Collections,” released in May 2012, these participants talked about very local and immediate issues as compared to the strategic issues listed in the ARL document. The collection development issues that were discussed can be grouped into several broad categories: budget, discovery tools, collection management, and media collections

Campus Copyright Education: Creating a culture of compliance and empowerment

Copyright is a complex issue that many raises questions for many people on university campuses. This presentation describes the approach Utah State University took to forming a committee comprised of people from across campus and efforts to educate members of the faculty about copyright issues

Collecting for Digital Repositories: New Ways to Disseminate and Share Information

No abstract

Comparing Approval and Librarian-selected Monographs: An Analysis of Use

This chapter will demonstrate that monographic material acquired at the University of Kansas (KU) through the approval plan and firm orders are, in some cases, being used for research more extensively than originally believed. A circulation analysis of approval plan and librarian-selected monographs, and a review of use by different user groups, reveal a surprising mixture of monographic usage patterns among the disciplines under consideration. Additionally, departmental dissertation output provides further indication that some of these disciplines still make substantive use of monographs. In this chapter Business, Psychology, Religious Studies, and Sociology collections are compared and discussed. Further, this chapter describes our analysis methodology, presents potential implications for approval and firm ordering, and makes suggestions for using and collecting similar data in the future

Study design of a randomised, placebo-controlled trial of nintedanib in children and adolescents with fibrosing interstitial lung disease

Childhood interstitial lung disease (chILD) comprises >200 rare respiratory disorders, with no currently approved therapies and variable prognosis. Nintedanib reduces the rate of forced vital capacity (FVC) decline in adults with progressive fibrosing interstitial lung diseases (ILDs). We present the design of a multicentre, prospective, double-blind, randomised, placebo-controlled clinical trial of nintedanib in patients with fibrosing chILD (1199-0337 or InPedILD; ClinicalTrials.gov: NCT04093024). Male or female children and adolescents aged 6–17 years (≥30; including ≥20 adolescents aged 12–17 years) with clinically significant fibrosing ILD will be randomised 2:1 to receive oral nintedanib or placebo on top of standard of care for 24 weeks (double-blind), followed by variable-duration nintedanib (open-label). Nintedanib dosing will be based on body weight-dependent allometric scaling, with single-step dose reductions permitted to manage adverse events. Eligible patients will have evidence of fibrosis on high-resolution computed tomography (within 12 months of their first screening visit), FVC ≥25% predicted, and clinically significant disease (Fan score of ≥3 or evidence of clinical progression over time). Patients with underlying chronic liver disease, significant pulmonary arterial hypertension, cardiovascular disease, or increased bleeding risk are ineligible. The primary endpoints are pharmacokinetics and the proportion of patients with treatment-emergent adverse events at week 24. Secondary endpoints include change in FVC% predicted from baseline, Pediatric Quality of Life Questionnaire, oxygen saturation, and 6-min walk distance at weeks 24 and 52. Additional efficacy and safety endpoints will be collected to explore long-term effects

A distributed national stored collection: Testing the possibilities

This paper reports on a study of the holdings of a single discipline (Design) by a single institution (RMIT University Library) in order to test for the possibility of a form of distributed national storage in Australia. The study was undertaken using OCLC Collection Analysis software and the WorldCat database. The collection of RMIT University Library is compared with two ‘groups’ of libraries, the first consisting of seven Victorian academic library collections, and the second of three Melbourne-based non-academic libraries considered to have strong Design collections. Conclusions indicate that for this discipline a form of distributed storage is already in place, with the RMIT University Library collection making a considerable and complementary contribution to the state wide holdings

Remodeling of secretory lysosomes during education tunes functional potential in NK cells

Inhibitory signaling during natural killer (NK) cell education translates into increased responsiveness to activation;however, the intracellular mechanism for functional tuning by inhibitory receptors remains unclear. Secretory lysosomes are part of the acidic lysosomal compartment that mediates intracellular signalling in several cell types. Here we show that educated NK cells expressing self-MHC specific inhibitory killer cell immunoglobulin-like receptors (KIR) accumulate granzyme B in dense-core secretory lysosomes that converge close to the centrosome. This discrete morphological phenotype is independent of transcriptional programs that regulate effector function, metabolism and lysosomal biogenesis. Meanwhile, interference of signaling from acidic Ca2+ stores in primary NK cells reduces target-specific Ca2+-flux, degranulation and cytokine production. Furthermore, inhibition of PI (3,5) P-2 synthesis, or genetic silencing of the PI(3,5) P-2-regulated lysosomal Ca2+-channel TRPML1, leads to increased granzyme B and enhanced functional potential, thereby mimicking the educated state. These results indicate an intrinsic role for lysosomal remodeling in NK cell education

Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB–mediated pathogenic pathways

TDP-43 interacts with and coactivates NF-κB p65 in the spinal cord of amyotrophic lateral sclerosis (ALS) patients, and an NF-κB inhibitor suppresses ALS disease symptoms and neuromuscular junction denervation in an ALS mouse model