EVALUATION OF STREAM MEIOFAUNA AS A MONITOR OF TRACE METAL CONTAMINATION

Members of the meiobenthos have been used extensively to determine the effects of anthropogenic perturbation in marine systems (Coull & Chandler, 1992). Despite this, the meiofauna has been virtually excluded from freshwater pollution monitoring. This thesis aimed to address this research caveat, by evaluating the potential of stream meiofauna for monitoring metal-contamination. Meiofaunal communities were sampled from streams in SW England representing a gradient in metal contamination. Environmental variables in these streams were also measured to identify the important forcing agents structuring the stream benthos. Multivariate techniques demonstrated Cu, either alone or in combination with other environmental variables was of most importance in correlations with the composition of meiofaunal communities. Comparison with the macrofaunal data demonstrated that both components of the benthos responded in a similar way to metal contamination, although the meiofauna also highlighted other differences in water chemistry. The combination of meiofauna, macrofauna and temporary meiofauna in a combined metazoan community analysis gave the best discrimination of sites. Detection of metal-contamination was retained in meiofaunal data aggregated to the family level. The abundances of the harpacticoid copepod Bryocamptus zschokkei were consistently important in contributing to between-site differences in community structure. The harpacticoid, therefore was selected as an ecologically-relevant freshwater toxicity test for Cu. Laboratory experiments demonstrated that Cu had toxic effects on the survival and reproduction of Bryocamptus zschokkei. Although acute toxicity tests gave more rapid results, these effects on survival occurred at a higher Cu concentration than those in the chronic tests. Sub-lethal concentrations of Cu led to a reduction in the numbers of offspring per brood Animals with pre-exposure to chronic concentrations of Cu exhibited greater tolerance to this metal. In conclusion, more information may be gained by including the meiofauna, alongside the macrofauna, when monitoring the impact of contaminants on freshwater systems. To reduce the effort of processing samples it appears family level data could be used to detect metal-contamination. The novel use of B. zschokkei in laboratory tests, where it showed lethal and sub-lethal responses to Cu, demonstrated that this species may have much potential as an ecologically-relevant freshwater bioassay organism for this metal. The advantages of using meiofaunal species such as B. zschokkei as toxicity test organisms are discussed

Intravenous Fluids for Children with Gastroenteritis

Most children with gastroenteritis do not require intravenous fluids and will respond favorably to ORT. Intravenous fluids do not shorten the duration of gastroenteritis and are more likely to cause adverse effects than ORT. [Strength of recommendation: B

Master Gardener Satisfaction and Intent to Remain After Training via Remote Delivery

One year after using remote delivery via video web conferencing (VWC) in training, we surveyed Delaware master gardeners to assess the remote delivery trainees\u27 satisfaction and intent to remain as compared to those characteristics in volunteers who had had face-to-face training. Although the remote delivery trainees were satisfied overall, they were significantly less satisfied than those who had participated in face-to-face trainings. A more positive perception of the VWC experience was associated with master gardeners\u27 increased satisfaction, suggesting the importance of VWC quality. However, volunteers trained via VWC did not report more or less of an intention to remain with the organization

COKAMO: A Model for Fast, Inexpensive Interstate Delivery

Shipping materials via a library courier service is much cheaper than shipping via the U.S. Postal Service. Most library delivery services are regional or state-based. This article illustrates how two separate services combined to develop the multi-state courier system COKAMO. COKAMO is moving tens of thousands of items between three states at a fraction of U.S. Postal Service rates. Within one year of implementing the system, over 57,000 items have been shipped, creating savings of over $215,000 for participating libraries. Significant changes in the behavior of interlibrary loan staff throughout the region are evidenced in statistics which show an increase in borrowing between participating states and a decline in interlibrary loan to adjacent states not in COKAMO

Self-perceived professional identity of pharmacy educators

The philosophy of pharmaceutical care, which defines a patient-centred approach to practice, has been embraced and upheld by national and international pharmaceutical organisations for two decades. However, pharmacists have been slow to change their practice and implement a pharmaceutical care approach. It has been suggested that amongst other factors, short-comings in pharmaceutical education have contributed to this reluctance of the profession to transform practice. Efforts to address these short-comings in pharmaceutical education have focused on the curriculum and pedagogic practices, and not on the pharmacy educators themselves. Palmer (1998) asserts that “good teaching cannot be reduced to technique; good teaching comes from the identity and integrity of the teacher”. In essence, "we teach who we are" and good teachers have one common trait: “a strong sense of personal identity that infuses their work”. This study identified, described and analysed the self-perceived professional identities of pharmacy educators within the South African context. This included ascertaining factors and contexts which contributed to participants’ self-perception of their professional identity. In an effort to understand the influence the educators have on practice and on changing practice and vice-versa, the attitudes, beliefs and behaviours of participants regarding the philosophy and practice of pharmaceutical care, and pharmaceutical education were also explored. Situated within a constructivist-interpretive, qualitative paradigm and making use of methodological triangulation, this study was conducted in three phases, each employing a different qualitative method to collect data. The first phase made use of narrative analysis to gain an in-depth understanding of pharmacy educators’ perceived professional identities and to explore how their experiences, across various contexts, have formed their professional identities. In-depth individual narrative interviews were used to provide a forum in which the participants could reflect upon and tell their professional life-story. This phase of the study also made use of the exploration of metaphors to further investigate the participants’ professional identity and, more particularly, their images of themselves as “teacher” and role model for students. A maximum variation, purposeful sampling approach was used to recruit eight pharmacy academics - one from each school or faculty of pharmacy in South Africa, as participants in this phase of the study. The second and third phases explored more widely, the insights gained from the first phase and the formation of professional identity, attitudes, beliefs and practices of pharmacy educators in South Africa. Two focus groups were employed during the second phase and the study sample was broadened to include a further ten pharmacy educators. In the third phase, a purpose-designed, qualitative questionnaire was used to extend the study sample to all pharmacy educators in South Africa. A convenience sampling approach was used in both the second and third phases of the study. Thematic analysis and interpretation of the narrative interview and focus group transcripts and the questionnaire responses were conducted using qualitative data analysis software – Atlas.ti®. A multiplicity of self-perceived professional identities was described. However, all of these were multi-faceted and could be situated on a continuum between pharmacist identity on one end and academic identity on the other. In addition, six key determinants were recognised as underpinning the participants’ self-perception of their professional identity. These included three structural determinants: expected role; knowledge base; and practice, and three determinants relating to the emotional dimensions and agency of professional identity: professional status; passions; and satisfiers. The professional identity of the participants had been formed through membership of multiple pharmacy-related communities of practice and continued to be sustained through a nexus of multi-membership. There was extensive support by the participants for the concept of pharmaceutical care; however, it did not impact extensively on their role as pharmacy educators. Furthermore, many expressed concern around the use of the term ‘pharmaceutical care’: its definition; its lack of penetration into, and implementation within the practice environment; and even its relevance to the South African healthcare context. Many of the participants perceived the professional development of future pharmacists to be integral to their role as educators, and was often their source of greatest professional satisfaction. However, concern was also expressed at the dissonance that students were perceived to experience, sometimes, because of the incongruities that they are taught and what they experience in practice. This study has afforded pharmacy educators in South Africa an opportunity to understand better “who” they are as professionals, and to reflect on their role as educators and as role models for future pharmacist. Moreover, the findings contribute to a collective understanding of the professional identity of pharmacy educators and socialisation of pharmacy students into the profession. The insights and recommendations emerging from the study have the potential to make academic pharmacy a more attractive career choice which may have positive implications for the future attraction and retention of pharmacists to academic posts within universities

The C/C Genotype of the C957T Polymorphism of the Dopamine D2 Receptor is Associated with Schizophrenia

The T allele of the human dopamine D2 receptor (DRD2) gene C957T polymorphism is associated with reduced mRNA translation and stability. This results in decreased dopamine induced DRD2 upregulation and decreased in-vivo D2 dopamine binding. Conversely, the C allele of the C957T polymorphism is not associated with such changes in mRNA leading to increased DRD2 expression. PET and post-mortem binding studies show that schizophrenia is often associated with increased DRD2 availability. We report that on the basis of comparing the frequencies of the C/C and T/T genotypes of 153 patients with schizophrenia and 148 controls that schizophrenia is associated with the C/C genotype. The C957T shows a population attributable risk for schizophrenia of 24% and an attributable risk in those with schizophrenia of 42%. Increased expression of D2 receptors associated with the C allele is likely to be important in the underlying pathophysiology of at least some forms of schizophrenia. Enhanced understanding of schizophrenia afforded by this finding may lead to advances in treatment and prevention

Ground-level climate at a peatland wind farm in Scotland is affected by wind turbine operation

The global drive to produce low-carbon energy has resulted in an unprecedented deployment of onshore wind turbines, representing a significant land use change for wind energy generation with uncertain consequences for local climatic conditions and the regulation of ecosystem processes. Here, we present high-resolution data from a wind farm collected during operational and idle periods that shows the wind farm affected several measures of ground-level climate. Specifically, we discovered that operational wind turbines raised air temperature by 0.18 °C and absolute humidity (AH) by 0.03 g m−3 during the night, and increased the variability in air, surface and soil temperature throughout the diurnal cycle. Further, the microclimatic influence of turbines on air temperature and AH decreased logarithmically with distance from the nearest turbine. These effects on ground-level microclimate, including soil temperature, have uncertain implications for biogeochemical processes and ecosystem carbon cycling, including soil carbon stocks. Consequently, understanding needs to be improved to determine the overall carbon balance of wind energy