Quality Assurance through Process Improvement - A Concise Review

The past two decades has seen the realization of the manufacturing firms towards quality consciousness. The various firms worldwide employed the statistical tools for minimizing the deviations and subsequently the number of rejects of the manufactured parts. In this process, more prominence is laid on prevention of defects rather than detecting and rejecting the defect in the usual traditional end inspection quality check. This review paper witnesses the procedures involved in the improvement of the manufacturing process capability and focuses on achieving quality assurance through sustained improvement in the manufacturing process. The different methodologies for sustained improvement in manufacturing process across varied industrial sectors, are identified, discussed and presented. The nuances of enhanced product quality levels through process capability improvement work performed in varied areas of industrial manufacturing are also captured

Synthesis, characterization and DNA cleavage activity of nickel(II) adducts with aromatic heterocyclic bases

Mixed ligand complexes of nickel(II) with 2,4-dihydroxyaceto-phenone oxime (DAPO) and 2,4-dihydroxybenzophenone oxime (DBPO) as primary ligands, and pyridine (Py) and imidazole (Im) as secondary ligands were synthesized and characterized by molar conductivity, magnetic moments measurements, as well as by electronic, IR, and 1H-NMR spectroscopy. Electrochemical studies were performed by cyclic voltammetry. The active signals are assignable to the NiIII/II and NiII/I redox couples. The binding interactions between the metal complexes and calf thymus DNA were investigated by absorption and thermal denaturation. The cleavage activity of the complexes was determined using double-stranded pBR322 circular plasmid DNA by gel electrophoresis. All complexes showed increased nuclease activity in the presence of the oxidant H2O2. The nuclease activities of mixed ligand complexes were compared with those of the parent copper(II) complexes

Functional outcome of proximal 1/3rd, distal 1/3rd and diaphysial tibial fractures in adults operated with expert tibial nailing

Background: Fractures of the tibial shaft are increasing due to high velocity trauma and industrialisation. Not only they are common but also difficult to treat. Until recently surgeons had to rely on non-operative treatment, V nailing, plates and screws and external fixator but they had their drawbacks like prolonged immobilisation infection, delayed union and non-union. Numerous modifications in nail and screw design have led to development of the expert tibial nail. Multidirectional interlocking screws ensure that alignment can be well maintained and stability preserved in short proximal or distal tibial segments.Methods: 30 patients were admitted and operated during September 2014 to September 2016 in Mamata general hospital Khammam. All patients were evaluated with Klemm Borner’s criteria and complications following surgery.Results: 87% of patients achieved good or excellent results, fair results were obtained in 3 (10%) patient and poor result in one (3%) patient. 2 (6%) patients had malunion, 2 (6%) patients had delayed union, 1 (3%) patient had deep infection led to implant failure.Conclusions: Intramedullary nailing is a safe and effective technique for the treatment of tibial metaphyseal fractures. It avoids the additional soft-tissue dissection associated with traditional open procedures as well as the complications associated with external fixators. Expert tibial nail can give excellent functional and clinical results. Complications such as failure of the bone-implant construct or post-operative malallignment are avoidable if careful pre-operative planning is allied with meticulous surgical technique

Assessment of Self-Care Practices among Type 2 Diabetes Mellitus Patients attending Health Care Centres of Urban Area of Hyderabad, India

Introduction: As per the International Diabetic Federation Atlas, 2021, 3 in 4 adults with type 2 diabetes mellitus live in low and middle income countries. This represents a tremendous burden on the healthcare system of these countries. Self-care practices can mitigate the disease burden. Objectives: To assess the self-care practices among the type 2 patients using Summary of Diabetes Self-Care Activities (SDSCA). Method: A facility based cross sectional study was undertaken among adults aged 25-60 years using a modified SDSCA, validated in Indian settings to study the self-care practices in diabetic patients. The modified domains included practices on dietary modifications, regular physical activity, foot care, regular blood glucose monitoring, drug adherence and addictions. Mean scores of these domains in SDSCA were compared with HbA1c measurements. Statistical tests performed included unpaired T test and chi-square. Results: Mean age of the patients was 49.60+ 11.13 Years. There were about 117(54.4%) patients with controlled HbA1c measurements. There was a statistically significant association of dietary modifications, regular physical activity, foot care, drug adherence and addictions with controlled HbA1c measurements. (p value=0.05) Conclusion: Self-care practices can significantly alter diabetes control and prevent complications. Regular glucose monitoring was lacking in several patients and led to poor glycemic controls. These results can inform clinical practice and patient care for better management of the type 2 diabetes mellitus

Effect of projectile on incomplete fusion reactions at low energies

Present work deals with the experimental studies of incomplete fusion reaction dynamics at energies as low as ≈ 4 - 7 MeV/A. Excitation functions populated via complete fusion and/or incomplete fusion processes in 12C+175Lu, and 13C+169Tm systems have been measured within the framework of PACE4 code. Data of excitation function measurements on comparison with different projectile-target combinations suggest the existence of ICF even at slightly above barrier energies where complete fusion (CF) is supposed to be the sole contributor, and further demonstrates strong projectile structure dependence of ICF. The incomplete fusion strength functions for 12C+175Lu, and 13C+169Tm systems are analyzed as a function of various physical parameters at a constant vrel ≈ 0.053c. It has been found that one neutron (1n) excess projectile 13C (as compared to 12C) results in less incomplete fusion contribution due to its relatively large negative α-Q-value, hence, α Q-value seems to be a reliable parameter to understand the ICF dynamics at low energies. In order to explore the reaction modes on the basis of their entry state spin population, the spin distribution of residues populated via CF and/or ICF in 16O+159Tb system has been done using particle-γ coincidence technique. CF-α and ICF-α channels have been identified from backward (B) and forward (F) α-gated γspectra, respectively. Reaction dependent decay patterns have been observed in different α emitting channels. The CF channels are found to be fed over a broad spin range, however, ICF-α channels was observed only for high-spin states. Further, the existence of incomplete fusion at low bombarding energies indicates the possibility to populate high spin state

Synthesis, characterization and nuclease activity of copper(II), nickel(II), cobalt(II) and iron(II) complexes with oxime-thiosemicarbazones

1233-1238A novel ligand viz. l-phenyl- 1,2-propanedione-2-oxime thiosemicarbazone (PPDOT) has been synthesized and characterized. Complexes of copper(II), nickel(II), cobalt(II) and iron(II) with PPDOT have been synthesized and characterized by molar conductance, magnetic moments, electronic, IR and ESR spectroscopy. Electrochemical behaviour of these complexes is investigated by cyclic voltammetric studies. The nuclease activity of these complexes has been carried out on double stranded pBR 322 plasmid DNA by using gel electrophoresis experiments in absence and in the presence of oxidant (H2O2) . Metal complexes of diacetylmonoxime thiosemicarbazone (DAMOT) are also investigated for better compariso