52 research outputs found
Quantum chemistry calculation aided design of chiral ionic liquid-based extraction system for amlodipine separation
Amlodipine is a widely used medication in treating hypertension, which is also
known as a chiral compound. So far efforts have been made to obtain optically pure
(S)-amlodipine because (R)-amlodipine has poor efficacy and is related to undesirable side
effects. However, the available separation methods for amlodipine are still unsatisfactory.
Recently, chiral separation has become a promising application of chiral ionic liquids (CILs),
because the structural designability enables them adjustable separation efficiency for specific
tasks. In this work, a high-efficient CIL-based liquid-liquid extraction system was developed
for racemic amlodipine separation with the assistance of quantum chemistry calculations.
Enantioselectivity up to 1.35 achieved by the novel system at 298.15 K is significantly higher
than other available extraction systems. Moreover, the recycling of CIL can be easily realized
by backward extraction of amlodipine, which is important for the industrial application of
CILs
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