Synthesis, characterization and thrombolytic activity of n-benzyl piperidin 4-one phenyl hydrazone

The aim of this study was to synthesize, characterization and thrombolytic activity of    N-Benzyl piperidin 4-one phenyl hydrazone derivative. Check the purity of all the synthesized compounds using thin layer chromatography. The synthesized compound was characterized by IR, 13C and 1H NMR spectral studies. The synthesized compound was subjected to thrombolytic activity. The thrombolytic activity was observed in 2 different concentrations of N-Benzyl piperidin 4-one phenyl hydrazone. Our findings support the reported therapeutic use of this compound as a thrombolytic agent in the Indian system of medicine. Keywords: N-Benzyl piperidin 4-one phenyl hydrazone, thrombolytic activity, streptokinase

Coupled Phonons, Magnetic Excitations and Ferroelectricity in AlFeO3: Raman and First-principles Studies

We determine the nature of coupled phonons and magnetic excitations in AlFeO3 using inelastic light scattering from 5 K to 315 K covering a spectral range from 100-2200 cm-1 and complementary first-principles density functional theory-based calculations. A strong spin-phonon coupling and magnetic ordering induced phonon renormalization are evident in (a) anomalous temperature dependence of many modes with frequencies below 850 cm-1, particularly near the magnetic transition temperature Tc ~ 250 K, (b) distinct changes in band positions of high frequency Raman bands between 1100-1800 cm-1, in particular a broad mode near 1250 cm-1 appears only below Tc attributed to the two-magnon Raman scattering. We also observe weak anomalies in the mode frequencies at ~ 100 K, due to a magnetically driven ferroelectric phase transition. Understanding of these experimental observations has been possible on the basis of first-principles calculations of phonons spectrum and their coupling with spins

Hadronic Vacuum Polarization and the Lamb Shift

Recent improvements in the determination of the running of the fine-structure constant also allow an update of the hadronic vacuum-polarization contribution to the Lamb shift. We find a shift of -3.40(7) kHz to the 1S level of hydrogen. We also comment on the contribution of this effect to the determination by elastic electron scattering of the r.m.s. radii of nuclei.Comment: 7 pages, latex, 1 figure -- Submitted to Phys. Rev. A -- epsfig.sty require

Optical, Magnetic and Magneto-Transport Properties of Nd 1-xAxMn0.5Fe0.5O3-δ (A=Ca, Sr, Ba; x=0, 0.25)

The effect of A-site doping by alkaline earth metals (A = Ca, Sr and Ba) on optical, magnetic, and electrical properties of Nd1-xAxMn0.5Fe0·5O3-δ (x = 0, 0.25) has been investigated. The UV–vis absorption spectra show that the A-site doping decreases the absorption. Two values of optical band-gap energy (Eg) can be estimated for each studied sample: the higher Eg value is associated with the charge transfer involving iron cations and the lower Eg value – with the charge transfer via manganese cations. Partial substitution of neodymium by alkaline earth metals decreases the Néel temperature (TN) and induces significant irreversibility between the zero-field cooled (ZFC) and field-cooled (FC) data below TN. The field-dependent magnetization at 3 K indicates antiferromagnetic ordering with a spin canting. Temperature dependencies of resistivity demonstrate the change from metallic to semiconductor-type conduction (with increasing temperature) at T = Tp < TN. The Tp temperature significantly decreases with doping. The introduction of alkaline earth metals in Nd1-xAxMn0.5Fe0·5O3-δ noticeably reduces the resistivity in the semiconducting region. The small polaron hopping (SPH) mechanism of conduction is suggested at T > TN. Within the range of Tp < T < TN, the resistivity data are interpreted by the variable range hopping (VRH) mechanism. A significant value of magnetoresistance (∼44%) is observed only for Nd0.75Sr0·25Mn0·5Fe0·5O3-δ at 120 K. © 2020 Elsevier B.V.A. S. acknowledges, the financial support provided by the Department of Science and Technology (DST), Government of India (Indo-Russian project (INT/RUS/RFBR/P-239); A.R.G and V.A.C. acknowledge the financial support from Indo-Russian project (RFBR grant No 16-53-45010); and A.H. acknowledges financial support obtained from the Government of the Russian Federation by Act 211 agreement 02.A03.21.0006

A decentralized spectrum allocation and partitioning scheme for a two-tier macro-femtocell network with downlink beamforming

This article examines spectrum allocation and partitioning schemes to mitigate cross-tier interference under downlink beamforming environments. The enhanced SIR owing to beamforming allows more femtocells to share their spectrum with the macrocell and accordingly improves overall spectrum efficiency. We first design a simplified centralized scheme as the optimum and then propose a practical decentralized algorithm that determines which femtocells to use the full or partitioned spectrum with acceptable control overhead. To exploit limited information of the received signal strength efficiently, we consider two types of probabilistic femtocell base station (HeNB) selection policies. They are equal selection and interference weighted selection policies, and we drive their outage probabilities for a macrocell user. Through performance evaluation, we demonstrate that the outage probability and the cell capacity in our decentralized scheme are significantly better than those in a conventional cochannel deployment scheme. Furthermore, we show that the cell utility in our proposed scheme is close to that in the centralized scheme and better than that in the spectrum partitioning scheme with a fixed ratio.open0

Automated Detection of Candidate Subjects With Cerebral Microbleeds Using Machine Learning

Cerebral microbleeds (CMBs) appear as small, circular, well defined hypointense lesions of a few mm in size on T2*-weighted gradient recalled echo (T2*-GRE) images and appear enhanced on susceptibility weighted images (SWI). Due to their small size, contrast variations and other mimics (e.g., blood vessels), CMBs are highly challenging to detect automatically. In large datasets (e.g., the UK Biobank dataset), exhaustively labelling CMBs manually is difficult and time consuming. Hence it would be useful to preselect candidate CMB subjects in order to focus on those for manual labelling, which is essential for training and testing automated CMB detection tools on these datasets. In this work, we aim to detect CMB candidate subjects from a larger dataset, UK Biobank, using a machine learning-based, computationally light pipeline. For our evaluation, we used 3 different datasets, with different intensity characteristics, acquired with different scanners. They include the UK Biobank dataset and two clinical datasets with different pathological conditions. We developed and evaluated our pipelines on different types of images, consisting of SWI or GRE images. We also used the UK Biobank dataset to compare our approach with alternative CMB preselection methods using non-imaging factors and/or imaging data. Finally, we evaluated the pipeline's generalisability across datasets. Our method provided subject-level detection accuracy > 80% on all the datasets (within-dataset results), and showed good generalisability across datasets, providing a consistent accuracy of over 80%, even when evaluated across different modalities

Decreased endothelin receptor B expression in large primary uveal melanomas is associated with early clinical metastasis and short survival

The most devastating aspect of cancer is the metastasis of tumour cells to organs distant from the original tumour site. The major problem facing oncologists treating uveal melanoma, the most common cancer of the eye, is metastatic disease. To lower mortality, it is necessary to increase our understanding of the molecular genetic alterations involved in this process. Using suppression subtractive hybridisation, we have analysed differential gene expression between four primary tumours from patients who have developed clinical metastasis and four primary tumours from patients with no evidence of metastasis to date. We have identified endothelin receptor type B as differentially expressed between these tumours and confirmed this observation using comparative multiplex RT–PCR. In a further 33 tumours, reduced endothelin receptor type B expression correlated with death from metastatic disease. Reduced expression also correlated with other known prognostic indicators, including the presence of epithelioid cells, chromosome 3 allelic imbalance and chromosome 8q allelic imbalance. Endothelin receptor type B expression was also reduced in four out of four primary small cell lung carcinomas compared to normal bronchial epithelium. We also show that the observed down-regulation of endothelin receptor type B in uveal melanoma was not due to gene deletion. Our findings suggest a role for endothelin receptor type B in the metastasis of uveal melanoma and, potentially, in the metastasis of other neural crest tumours

Infrared studies of the phase transition in the organic charge transfer salt N-propylquinolinium(TCNQ)2

Polarized infrared and optical reflectance spectroscopies were used to study the structural phase transition in the organic charge-transfer salt N-propylquinolinium ditetracyanoquinodimethane. Above the 220-K phase-transition temperature, the spectra are characteristic of other 1:2 semiconducting charge-transfer salts. Three significant changes occur below T(c). First, the midinfrared charge-transfer band can be resolved into two distinct excitations. Second, there is enhanced oscillator strength, indicative of a larger intratetramer transfer integral in the low-temperature phase. Finally, the vibrational lines split into doublets, providing evidence for an uneven charge distribution within the tetramer. The weakly metallic transport properties above T(c) are attributed to the uniform charge distribution within the tetramer and the high degree of overlap between the intratetramer and intertetramer charge-transfer bands. The transport properties in the low-temperature phase are dominated by charge localization, which may act to reduce the overlap between these low-energy charge-transfer features