Discussion on the Effect of Emergency Tracheal Intubation on Cardiopulmonary Resuscitation by Emergency Medical Staff

Objective: To study the positive effect of emergency tracheal intubation on cardiopulmonary resuscitation. Methods: 90 patients with cardiopulmonary arrest were randomly selected from the emergency department of our hospital from November 2017 to November 2019, and were randomly divided into the control group and the experimental group (n=45). The control group was given routine anesthesia combined with cardiopulmonary resuscitation, while the experimental group was given emergency tracheal intubation combined with cardiopulmonary resuscitation. The effect of cardiopulmonary resuscitation and operation time of the two groups were observed and discussed, and the results were recorded. Results: Under different intervention measures, the time from visiting a doctor to tracheal intubation in the experimental group was obviously shorter than that in the control group (P < 0.05). There is no significant difference in the time of intubation between the two groups (P > 0.05). In addition, the success probability of cardiopulmonary resuscitation and the discharge survival rate in the experimental group were higher than those in the control group (P < 0.05). The above-mentioned results with p < 0.05 indicated the statistically significant differences. Conclusion: In clinical practice, emergency tracheal intubation for patients with cardiopulmonary arrest by emergency medical staff can bring a higher success probability of cardiopulmonary resuscitation, buy valuable time for rescue operation, and obviously improve the prognosis of patients. Therefore, it is worthy of wider promotion and application

COVID-19 Cases Detection: Suspect Case Strategy

Background and objective: as COVID-19 has triggered enormous human casualties and disastrous economic loss, the strategies to contain its spread are urgently needed. We aim to assess the value of our suspect case strategy on COVID-19 cases detection and ensure it to be a complement to the RT-PCR test. Materials and methods: from January 23 to April 30, 2020, patients admitted to our emergence isolation ward (EIW) were analyzed in this study. With RT-PCR as a reference standard, all participants were assigned to COVID-19 positive and negative groups. We compared the performance of the suspect case strategy, WBC, LYM, and chest radiography on COVID-19 detection. Results: one hundred twenty-five cases were analyzed in the study period. The receiver operating characteristic (ROC) curve revealed the sensitivity of WBC and LYM on COVID-19 detection was 92.11% and 76.31%, respectively. The sensitivity of the suspect case was 94.73%, and the sensitivity of chest CT was 53.33%. Statistically significant differences were observed for the suspect case, WBCs, LYM, and chest CT on COVID-19 detection. Discussion: suspect case strategy can help identify false negative RT-PCR tests and be a useful complement to RT-PCR in some countries with a tremendous shortage of RT-PCR agents and specialized laboratory during the COVID-19 outbreak

Application Effect of “3P†Nursing Management Mode in Emergency Patients with Acute Ischemic Stroke

Objective:To explore the application effects of the 3P(perfecting equipment,perfecting nursing ability, perfecting emergency pathway and application) nursing management mode of acute ischemic stroke nursing care. Methods: Clinical data of 80 cases of patients were selected as research group,and 80 acute ischemic stroke patients were selected as reference group. Results: Vein opening time, CT completion time and thrombolysis DNT in the research group were significantly lower than that of the reference group（P < 0.05. Conclusion: The "3P" management mode can significantly shorten the patients' vein opening time, CT completion time and DNT time of thrombolysis, improve the first aid effect,improve the treatment effect of AIS, which can be widely used

A Survey of Recent Advances in Particle Filters and Remaining Challenges for Multitarget Tracking

[EN]We review some advances of the particle filtering (PF) algorithm that have been achieved in the last decade in the context of target tracking, with regard to either a single target or multiple targets in the presence of false or missing data. The first part of our review is on remarkable achievements that have been made for the single-target PF from several aspects including importance proposal, computing efficiency, particle degeneracy/impoverishment and constrained/multi-modal systems. The second part of our review is on analyzing the intractable challenges raised within the general multitarget (multi-sensor) tracking due to random target birth and termination, false alarm, misdetection, measurement-to-track (M2T) uncertainty and track uncertainty. The mainstream multitarget PF approaches consist of two main classes, one based on M2T association approaches and the other not such as the finite set statistics-based PF. In either case, significant challenges remain due to unknown tracking scenarios and integrated tracking management

Neurotoxicological effects induced by up-regulation of miR-137 following triclosan exposure to zebrafish (Danio rerio).

Triclosan (TCS) is a prevalent anthropogenic contaminant in aquatic environments and its chronic exposure can lead to a series of neurotoxic effects in zebrafish. Both qRT-PCR and W-ISH identified that TCS exposure resulted in significant up-regulation of miR-137, but downregulation of its regulatory genes (bcl11aa, MAPK6 and Runx1). These target genes are mainly associated with neurodevelopment and the MAPK signaling pathway, and showed especially high expression in the brain. After overexpression or knockdown treatments by manual intervention of miR-137, a series of abnormalities were induced, such as ventricular abnormality, bent spine, yolk cyst, closure of swim sac and venous sinus hemorrhage. The most sensitive larval toxicological endpoint from intervened miR-137 expression was impairment of the central nervous system (CNS), ventricular abnormalities and notochord curvature. Microinjection of microRNA mimics or inhibitors of miR-137 both caused zebrafish malformations. The posterior lateral line neuromasts became obscured and decreased in number in intervened miR-137 groups and TCS-exposure groups. Up-regulation of miR-137 led to more severe neurotoxic effects than its down-regulation. Behavioral observations demonstrated that both TCS exposure and miR-137 over-expression led to inhibited hearing or vision sensitivity. HE staining indicated that hearing and vision abnormalities induced by long-term TCS exposure originated from CNS injury, such as reduced glial cells and loose and hollow fiber structures. The findings of this study enhance our mechanistic understanding of neurotoxicity in aquatic animals in response to TCS exposure. These observations provide theoretical guidance for development of early intervention treatments for nervous system diseases

Interference in Autophagosome Fusion by Rare Earth Nanoparticles Disrupts Autophagic Flux and Regulation of an Interleukin-1β Producing Inflammasome

Engineered nanomaterials (ENMs) including multiwall carbon nanotubes (MWCNTs) and rare earth oxide (REO) nanoparticles, which are capable of activating the NLRP3 inflammasome and inducing IL-1β production, have the potential to cause chronic lung toxicity. Although it is known that lysosome damage is an upstream trigger in initiating this pro-inflammatory response, the same organelle is also an important homeostatic regulator of activated NLRP3 inflammasome complexes, which are engulfed by autophagosomes and then destroyed in lysosomes after fusion. Although a number of ENMs have been shown to induce autophagy, no definitive research has been done on the homeostatic regulation of the NLRP3 inflammasome during autophagic flux. We used a myeloid cell line (THP-1) and bone marrow derived macrophages (BMDM) to compare the role of autophagy in regulating inflammasome activation and IL-1β production by MWCNTs and REO nanoparticles. THP-1 cells express a constitutively active autophagy pathway and are also known to mimic NLRP3 activation in pulmonary macrophages. We demonstrate that, while activated NLRP3 complexes could be effectively removed by autophagosome fusion in cells exposed to MWCNTs, REO nanoparticles interfered in autophagosome fusion with lysosomes. This leads to the accumulation of the REO-activated inflammasomes, resulting in robust and sustained IL-1β production. The mechanism of REO nanoparticle interference in autophagic flux was clarified by showing that they disrupt lysosomal phosphoprotein function and interfere in the acidification that is necessary for lysosome fusion with autophagosomes. Binding of LaPO4 to the REO nanoparticle surfaces leads to urchin-shaped nanoparticles collecting in the lysosomes. All considered, these data demonstrate that in contradistinction to autophagy induction by some ENMs, specific materials such as REOs interfere in autophagic flux, thereby disrupting homeostatic regulation of activated NLRP3 complexes