Geologic factors in the evaluation of water pollution potential at mountain dwelling sites

December, 1973.Bibliography: pages [133]-135.In order to establish the relationship between the geologic setting and the occurrence of water pollution in mountain home developments containing individual sewage disposal systems, three areas in Colorado's Front Range were studied. Two of the areas were known to have biological contamination as confirmed by microbiological tests. Also, each area had adequate rock exposures to allow for detailed geologic study, the absence of thick soil profiles above bedrock and current development for mountain home location. In addition, each of the selected study areas differed in geologic setting, age of development and home density in the development. The extent of water pollution was established by a program of well and surface water testing for total coliform. Fecal coliform and inorganic contaminants were tested in selected wells. Detailed geologic maps were made of each area to locate features such as dikes or shear zones which might act as either barriers or conduits to ground water movement. Slope maps were prepared for the area by computer plots of digitized data of elevations taken from U.S. Geological Survey topographic maps. Determination of the water table profile and extent of alluvial fill in valley bottoms was accomplished using driller's well logs for each well in the area. In addition, soils were tested to determine their effective grain size, a joint and foliation study was conducted to determine the direction of pollutant travel should effluent enter these openings, driller's well logs were used to establish depth of soils and depth of weathering in bedrock and data from county health records were used to establish soil percolation rates. Data were compiled in the form of overlays on base maps of the areas involved. A topographic map with the geologic overlay was used in conjunction with various combinations of the field derivative overlays to indicate the pollution potential for specific areas. The overlays used in this procedure were compiled from. the following parameters: 1) slope, 2) depth of soil, 3) depth of intensely weathered bedrock, 4) local water table profile, and 5) soil percolation rates. These overlays indicated that the Glen Haven area is unsuitable for soil absorption sewage systems because of steep slopes, soil depth and depth of the water table. Most of the Tall Timbers area was indicated as unsuitable for soil absorption systems because of slope, soil depth and local geology. The Crescent Park area was categorized as safe (in part) for soil absorption systems, however, local areas within the subdivision were categorized as hazardous. From the results it was suggested that a procedure such as the one used in this study could be used for each subdivision proposed in the mountainous regions of Colorado. Thus more effective use of mountainous areas might be passable while maintaining a low probability of ground water contamination. Areas within each proposed subdivision would be classified as safe, hazardous, or unsuitable for soil absorption sewage systems. Unsuitable areas could be used as parks or greenbelts, hazardous areas would have low population densities and safe areas would be allowed to have higher population densities as long as other factors were favorable. In addition, procedures such as the one used in this investigation could be used to indicate mountain areas which should require a municipal sewage disposal system before development to ensure that the ground water system was not polluted.Supported by the Colorado Water Quality Control Commission and the United States Department of Interior, Office of Water Resources Research, no.87-194-2. (s) 14-01-001-1882

Targeting Neuroplasticity to Improve Motor Recovery after Stroke

After neurological injury, people develop abnormal patterns of neural activity that limit motor recovery. Traditional rehabilitation, which concentrates on practicing impaired skills, is seldom fully effective. New targeted neuroplasticity (TNP) protocols interact with the CNS to induce beneficial plasticity in key sites and thereby enable wider beneficial plasticity. They can complement traditional therapy and enhance recovery. However, their development and validation is difficult because many different TNP protocols are conceivable, and evaluating even one of them is lengthy, laborious, and expensive. Computational models can address this problem by triaging numerous candidate protocols rapidly and effectively. Animal and human empirical testing can then concentrate on the most promising ones. Here we simulate a neural network of corticospinal neurons that control motoneurons eliciting unilateral finger extension. We use this network to (1) study the mechanisms and patterns of cortical reorganization after a stroke, and (2) identify and parameterize a TNP protocol that improves recovery of extension force. After a simulated stroke, standard training produced abnormal bilateral cortical activation and suboptimal force recovery. To enhance recovery, we interdigitated standard trials with trials in which the teaching signal came from a targeted population of sub-optimized neurons. Targeting neurons in secondary motor areas on 5-20% of the total trials restored lateralized cortical activation and improved recovery of extension force. The results illuminate mechanisms underlying suboptimal cortical activity post-stroke; they enable identification and parameterization of the most promising TNP protocols. By providing initial guidance, computational models could facilitate and accelerate realization of new therapies that improve motor recovery

Targeting Neuroplasticity to Improve Motor Recovery after Stroke

After neurological injury, people develop abnormal patterns of neural activity that limit motor recovery. Traditional rehabilitation, which concentrates on practicing impaired skills, is seldom fully effective. New targeted neuroplasticity (TNP) protocols interact with the CNS to induce beneficial plasticity in key sites and thereby enable wider beneficial plasticity. They can complement traditional therapy and enhance recovery. However, their development and validation is difficult because many different TNP protocols are conceivable, and evaluating even one of them is lengthy, laborious, and expensive. Computational models can address this problem by triaging numerous candidate protocols rapidly and effectively. Animal and human empirical testing can then concentrate on the most promising ones. Here we simulate a neural network of corticospinal neurons that control motoneurons eliciting unilateral finger extension. We use this network to (1) study the mechanisms and patterns of cortical reorganization after a stroke, and (2) identify and parameterize a TNP protocol that improves recovery of extension force. After a simulated stroke, standard training produced abnormal bilateral cortical activation and suboptimal force recovery. To enhance recovery, we interdigitated standard trials with trials in which the teaching signal came from a targeted population of sub-optimized neurons. Targeting neurons in secondary motor areas on 5-20% of the total trials restored lateralized cortical activation and improved recovery of extension force. The results illuminate mechanisms underlying suboptimal cortical activity post-stroke; they enable identification and parameterization of the most promising TNP protocols. By providing initial guidance, computational models could facilitate and accelerate realization of new therapies that improve motor recovery

Characterization of disturbance sources for LISA: torsion pendulum results

A torsion pendulum allows ground-based investigation of the purity of free-fall for the LISA test masses inside their capacitive position sensor. This paper presents recent improvements in our torsion pendulum facility that have both increased the pendulum sensitivity and allowed detailed characterization of several important sources of acceleration noise for the LISA test masses. We discuss here an improved upper limit on random force noise originating in the sensor. Additionally, we present new measurement techniques and preliminary results for characterizing the forces caused by the sensor's residual electrostatic fields, dielectric losses, residual spring-like coupling, and temperature gradients.Comment: 11 pages, 8 figures, accepted for publication Classical and Quantum Gravit

Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity

Virus infection of mammalian cells is sensed by pattern recognition receptors and leads to an innate immune response that restricts virus replication and induces adaptive immunity. In response, viruses have evolved many countermeasures that enable them to replicate and be transmitted to new hosts, despite the host innate immune response. Poxviruses, such as vaccinia virus (VACV), have large DNA genomes and encode many proteins that are dedicated to host immune evasion. Some of these proteins are secreted from the infected cell, where they bind and neutralize complement factors, interferons, cytokines and chemokines. Other VACV proteins function inside cells to inhibit apoptosis or signalling pathways that lead to the production of interferons and pro-inflammatory cytokines and chemokines. In this review, these VACV immunomodulatory proteins are described and the potential to create more immunogenic VACV strains by manipulation of the gene encoding these proteins is discussed

Ontogenetic changes in the body plan of the sauropodomorph dinosaur Mussaurus patagonicus reveal shifts of locomotor stance during growth

Ontogenetic information is crucial to understand life histories and represents a true challenge in dinosaurs due to the scarcity of growth series available. Mussaurus patagonicus was a sauropodomorph dinosaur close to the origin of Sauropoda known from hatchling, juvenile and mature specimens, providing a sufficiently complete ontogenetic series to reconstruct general patterns of ontogeny. Here, in order to quantify how body shape and its relationship with locomotor stance (quadruped/biped) changed in ontogeny, hatchling, juvenile (~1 year old) and adult (8+ years old) individuals were studied using digital models. Our results show that Mussaurus rapidly grew from about 60 g at hatching to ~7 kg at one year old, reaching >1000 kg at adulthood. During this time, the body’s centre of mass moved from a position in the mid-thorax to a more caudal position nearer to the pelvis. We infer that these changes of body shape and centre of mass reflect a shift from quadrupedalism to bipedalism occurred early in ontogeny in Mussaurus. Our study indicates that relative development of the tail and neck was more influential in determining the locomotor stance in Sauropodomorpha during ontogeny, challenging previous studies, which have emphasized the influence of hindlimb vs. forelimb lengths on sauropodomorph stance

The European Large Area ISO Survey II: mid-infrared extragalactic source counts

We present preliminary source counts at 6.7um and 15um from the Preliminary Analysis of the European Large Area ISO survey, with limiting flux densities of \~2mJy at 15um & ~1mJy at 6.7um. We separate the stellar contribution from the extragalactic using identifications with APM sources made with the likelihood ratio technique. We quantify the completeness & reliability of our source extraction using (a) repeated observations over small areas, (b) cross-IDs with stars of known spectral type, (c) detections of the PSF wings around bright sources, (d) comparison with independent algorithms. Flux calibration at 15um was performed using stellar IDs; the calibration does not agree with the pre-flight estimates, probably due to effects of detector hysteresis and photometric aperture correction. The 6.7um extragalactic counts are broadly reproduced in the Pearson & Rowan-Robinson model, but the Franceschini et al. (1997) model underpredicts the observed source density by ~0.5-1 dex, though the photometry at 6.7um is still preliminary. At 15um the extragalactic counts are in excellent agreement with the predictions of the Pearson & Rowan-Robinson (1996), Franceschini et al. (1994), Guiderdoni et al. (1997) and the evolving models of Xu et al. (1998), over 7 orders of magnitude in 15um flux density. The counts agree with other estimates from the ISOCAM instrument at overlapping flux densities (Elbaz et al. 1999), provided a consistent flux calibration is used. Luminosity evolution at a rate of (1+z)^3, incorporating mid-IR spectral features, provides a better fit to the 15um differential counts than (1+z)^4 density evolution. No-evolution models are excluded, and implying that below around 10mJy at 15um the source counts become dominated by an evolving cosmological population of dust-shrouded starbursts and/or active galaxies.Comment: MNRAS in press. 14 pages, uses BoxedEPS (included). For more information on the ELAIS project see http://athena.ph.ic.ac.uk

Collimation and asymmetry of the hot blast wave from the recurrent nova V745 Scorpii

The recurrent symbiotic nova V745 Sco exploded on 2014 February 6 and was observed on February 22 and 23 by the Chandra X-ray Observatory Transmission Grating Spectrometers. By that time the supersoft source phase had already ended and Chandra spectra are consistent with emission from a hot, shock-heated circumstellar medium with temperatures exceeding 10^7K. X-ray line profiles are more sharply peaked than expected for a spherically-symmetric blast wave, with a full width at zero intensity of approximately 2400 km/s, a full width at half maximum of 1200 +/- 30 km/s and an average net blueshift of 165 +/- 10 km/s. The red wings of lines are increasingly absorbed toward longer wavelengths by material within the remnant. We conclude that the blast wave was sculpted by an aspherical circumstellar medium in which an equatorial density enhancement plays a role, as in earlier symbiotic nova explosions. Expansion of the dominant X-ray emitting material is aligned close to the plane of the sky and most consistent with an orbit seen close to face-on. Comparison of an analytical blast wave model with the X-ray spectra, Swift observations and near-infrared line widths indicates the explosion energy was approximately 10^43 erg, and confirms an ejected mass of approximately 10^-7 Msun. The total mass lost is an order of magnitude lower than the accreted mass required to have initiated the explosion, indicating the white dwarf is gaining mass and is a supernova Type 1a progenitor candidate.Comment: To appear in the Astrophysical Journa

Subaqueous shrinkage cracks in the Sheepbed mudstone: Implications for early fluid diagenesis, Gale crater, Mars

The Sheepbed mudstone, Yellowknife Bay formation, Gale crater, represents an ancient lakebed now exhumed and exposed on the Martian surface. The mudstone has four diagenetic textures, including a suite of early diagenetic nodules, hollow nodules, and raised ridges and later diagenetic light-toned veins that crosscut those features. In this study, we describe the distribution and characteristics of the raised ridges, a network of short spindle-shaped cracks that crosscut bedding, do not form polygonal networks, and contain two to four layers of isopachous, erosion-resistant cement. The cracks have a clustered distribution within the Sheepbed member and transition laterally into concentrations of nodules and hollow nodules, suggesting that these features formed penecontemporaneously. Because of the erosion-resistant nature of the crack fills, their three-dimensional structure can be observed. Cracks that transition from subvertical to subhorizontal orientations suggest that the cracks formed within the sediment rather than at the surface. This observation and comparison to terrestrial analogs indicate that these are syneresis cracks—cracks that formed subaqueously. Syneresis cracks form by salinity changes that cause sediment contraction, mechanical shaking of sediment, or gas production within the sediment. Examination of diagenetic features within the Sheepbed mudstone favors a gas production mechanism, which has been shown to create a variety of diagenetic morphologies comparable to the raised ridges and hollow nodules. The crack morphology and the isopachous, layered cement fill show that the cracks were filled in the phreatic zone and that the Sheepbed mudstone remained fluid saturated after deposition and through early burial and lithification