Limitations Of Artificial Intelligence

Artificial Intelligence is a groundbreaking technology that is now an established field. It is being used to mimic human capabilities such as speaking, listening, learning, and planning by using different algorithms to process data and produce results depending on the information provided by the user. Artificial Intelligence has been used in several industries when it comes to data processing and decision making. Artificial Intelligence has been invented to help decision and solutionmaking processes using a problem-solving approach. The development of Artificial Intelligence software provides efficiency and acceleration on different kinds of workflows, which will help organizations increase their profit and reduce wastage and costs due to poor productivity. There are already many applications that Artificial Intelligence powers; some of these are Web Search, Cybersecurity, and Machine Translations. All people are now having the benefit of using Artificial Intelligence, and it is beneficial for humanity. Artificial Intelligence has many positive aspects as it produces substantial results in people\u27s daily lives and businesses today; some of the most common Artificial Intelligence technologies used by the industry are robots and Virtual Assistants. Artificial Intelligence are powered by Natural Language Processing (NLP) and Speech Recognition Platform (SRP), but it is not limited to these two (2); many factors need to be considered, but these branches help in interpretation and manipulation of the commands stipulated. Indeed, Artificial Intelligence is rapidly advancing, and many organizations are willing to try and test out what is available in the market. However, others are not convinced with the Artificial Intelligence as there are alleged ethical issues that might cause accountability in a particular manner. This thesis will explain how Artificial Intelligence is used in different fields like Law, Medicine, the Military, and others while discussing the limitations present

A study on the cell mediated immunity of human cytomegalovirus infection in kidney transplant recipients

Cytomegalovirus (CMV) infection is a major complication after kidney transplantation. Despite antiviral therapy it contributes significantly to high morbidity. This study was aimed at (a) detecting· a CMV specific antigen pp65 in CMV -infected fibroblast cells and in leukocytes of kidney transplant recipients by flow cytometric assay (FCA) (b) determining the stimulation index (S.I.) of phytohaemagglutinin (PHA) and CMV-stimulated peripheral blood mononuclear cells (PBMC), (c) determining the levels of Th1- and Th-2 related cytokines in the supernatant of stimulated PBMC from kidney transplant recipients with and without active CMV infection (d) determining immunophenotyping of cells found in the peripheral blood of CMV -infected and CMV -uninfected kidney transplant recipients by flow cytometry using antibodies specific to CD2+ (pan T), CD3+ (mature T), CD4+ (T helper), CD8+ (T suppressor), CD26+(T activated), CDI6+/CDS6+ (NK cell), CDI9+(pan B), CDIS+ (granulocytes). Thirty-five patients with, and 44 without active CMV infections, as diagnosed by a CMV antigenemia assay (AA), were inducted into this study. FCA distinguished clearly between the infected and uninfected fibroblast cells. Regarding kidney transplant recipients, the FCA was positive when the number of AA positive cells was five or more per 5x10(4). Moreover, the percentage of antigenemia-positive cells by FCA correlated well with symptomatic CMV infections. After PHA and CMV stimulation of PBMC from patients, S.I. was determined by radioactive thymidine uptake while the production of Th1-type cytokines [interleukin-2 (iL-2), interferon-y (IFN-y) and tumor necrosis factor-a (TNFex)] and Th2-type cytokines (IL-4, IL-1O) were measured by ELISA. PBMC of patients with active CMV infection showed significantly lower S.I. values than patients without an ongoing CMV infection (p<O.OOO1). Levels of Th2- type cytokines in CMV -infected and uninfected kidney recipients were similar;however, the levels of the Th1-type cytokines were significantly lower in CMV -infected patients (p<O.O5). Low levels of Th1-type cytokines seem to correlate well with active CMV infection in kidney recipients. The percentage of CD3+ immunocompetent T lymphocytes and CD4+ T lymphocytes were consistently higher in kidney transplant recipients without an active CMV infection than in the group of recipients with an active CMV infection. These differences were statistically significant in the case of CD3+ (p<O.O5) and CD4+ (p<O.OO5). On the other hand the difference in percentage CD2+, CD8+, CD16++CD56+, CD19+, CD15+ cells were statistically insignificant. Therefore, these data suggest that active CMV infection in kidney transplant recipients is associated with a significant alteration in the lymphocyte proliferative responses, the levels of Th1-type cytokines (IFN-y, TNF-ex, IL-2), and the percentage of CD3+, CD4+ when compared to kidney transplant recipients without active CMV infection

Data protection based neural cryptography and deoxyribonucleic acid

The need to a robust and effective methods for secure data transferring makes the more credible. Two disciplines for data encryption presented in this paper: machine learning and deoxyribonucleic acid (DNA) to achieve the above goal and following common goals: prevent unauthorized access and eavesdropper. They used as powerful tool in cryptography. This paper grounded first on a two modified Hebbian neural network (MHNN) as a machine learning tool for message encryption in an unsupervised method. These two modified Hebbian neural nets classified as a: learning neural net (LNN) for generating optimal key ciphering and ciphering neural net CNN) for coding the plaintext using the LNN keys. The second granulation using DNA nucleated to increase data confusion and compression. Exploiting the DNA computing operations to upgrade data transmission security over the open nets. The results approved that the method is effective in protect the transferring data in a secure manner in less tim

Survey of Features Extraction and Classification Techniques for Speaker Identification

تكسب تقنيات معالجة الكلام شيوعًا اكثر يومًا بعد يوم لتوفير قدر هائل من الأمان.كما يشيع استخدام الكلام لغرض التوثيق. التعرف على المتكلم هو الطريقة التي يمكن من خلالها فحص المتكلم والتعرف عليه. يختلف نظام التعرف على الكلام عن طريقة التعرف على المتكلم. يشيع استخدام التعرف على المتكلمين في القطاعات والمستشفيات والمختبرات وما إلى ذلك. فوائده أكثر أمانًا وأسهل في التنفيذ وأكثر سهولة في الاستخدام. تعد طريقة تحديد المتكلم واحدة من أكثر التقنيات شيوعًا في المنطقة حيث تعتبر السلامة أمرًا بالغ الأهمية. تقدم هذه المقالة نظرة عامة على الطرق المختلفة التي يمكن استخدامها للتعرف على المتكلمين مثل الترميز الخطي التنبؤي (LPC) ، معاملات الطيف التنبؤية الخطية (LPCC) ، التحويل الحقيقي الفريد المعين (UMRT) ، معاملات Cepstral الحقيقية (RCC) ، "تردد ميل Cepstrum" (MFCC).&nbsp; &nbsp;بالإضافة إلى مجموعة من المصنفات المختلفة مثل "نموذج الخليط الغاوسي (GMM)"، "تزييف الوقت الديناميكي (DTW)" ، آلة المتجهات الداعمة (SVM) ، الشبكة العصبية (NN) ، "تكميم المتجهات" (VQ). الغرض الأساسي من شرح طرق التعرف على السماعات الشائعة. النتائج التي تم الحصول عليها هي أنه تم اختيار MFCC لكفاءة عالية ومنخفضة التعقيد. و GMM مفيد في تصنيف ذاكرة أقل ونتائج تخطيط واختبار أقل.Speech processing is more common day by day to provide enormous safety. The speech for the purpose of authentication is commonly used. Recognition of the speaker is the method that can check and recognize the speaker. The scheme of speech recognition is distinct from the scheme of speaker recognition. Recognition of speakers is commonly used in sectors, hospitals, laboratories, etc. Its benefits are safer, easier to implement, more user-friendly. Speaker identification method is one of the most commonly used techniques for the region where safety is very crucial. This article presents an overview of various methods that can be used to recognize speakers’ systems, the feature extraction techniques such as Linear Predictive Coding (LPC), Linear Predictive Cepstral Coefficients (LPCC), Unique Mapped Real Transform (UMRT), Real Cepstral Coefficients (RCC), “Mel-frequency Cepstrum” (MFCC), in addition to &nbsp;various classification techniques such as “Gaussian mixture model (GMM)”, “Dynamic Time Warping (DTW)”, Support Vector Machine (SVM), Neural Network (NN), “Vector Quantization” (VQ). The primary purpose of is to explain the common speaker recognition methods. The obtained results are that, MFCC is chosen for high efficiency and low complexity. and GMM is helpful in classifying less memory and less planning and efficient test results

Docetaxel Induced Toxic Erythema of Chemotherapy: A Case Report

Toxic erythema of chemotherapy (TEC) refers to a group of chemotherapy-induced cutaneous toxicities. It is important to raise awareness of TEC clinical presentation to prevent misdiagnosis and treat them promptly. We present a patient diagnosed with invasive ductal carcinoma of the left breast who had undergone mastectomy with axillary dissection who developed TEC after docetaxel chemotherapy infusion

Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients.

BACKGROUND: Middle East respiratory syndrome coronavirus infection is associated with high mortality rates but limited clinical data have been reported. We describe the clinical features and outcomes of patients admitted to an intensive care unit (ICU) with Middle East respiratory syndrome coronavirus (MERS-CoV) infection. METHODS: Retrospective analysis of data from all adult (>18 years old) patients admitted to our 20-bed mixed ICU with Middle East respiratory syndrome coronavirus infection between October 1, 2012 and May 31, 2014. Diagnosis was confirmed in all patients using real-time reverse transcription polymerase chain reaction on respiratory samples. RESULTS: During the observation period, 31 patients were admitted with MERS-CoV infection (mean age 59 ± 20 years, 22 [71 %] males). Cough and tachypnea were reported in all patients; 22 (77.4 %) patients had bilateral pulmonary infiltrates. Invasive mechanical ventilation was applied in 27 (87.1 %) and vasopressor therapy in 25 (80.6 %) patients during the intensive care unit stay. Twenty-three (74.2 %) patients died in the ICU. Nonsurvivors were older, had greater APACHE II and SOFA scores on admission, and were more likely to have received invasive mechanical ventilation and vasopressor therapy. After adjustment for the severity of illness and the degree of organ dysfunction, the need for vasopressors was an independent risk factor for death in the ICU (odds ratio = 18.33, 95 % confidence interval: 1.11-302.1, P = 0.04). CONCLUSIONS: MERS-CoV infection requiring admission to the ICU is associated with high morbidity and mortality. The need for vasopressor therapy is the main risk factor for death in these patients

Invasive hemodynamic parameters in patients with hepatorenal syndrome.

Background: Hepatorenal syndrome (HRS), a form of kidney dysfunction frequent in cirrhotic patients, is characterized by low filling pressures and impaired kidney perfusion due to peripheral vasodilation and reduced effective circulatory volume. Cardiorenal syndrome (CRS), driven by renal venous hypertension and elevated filling pressures, is a separate cause of kidney dysfunction in cirrhotic patients. The two entities, however, have similar clinical phenotypes. To date, limited invasive hemodynamic data are available to help distinguish the primary forces behind worsened kidney function in cirrhotic patients. Objective: Our aim was to analyze invasive hemodynamic profiles and kidney outcomes in patients with cirrhosis who met criteria for HRS. Methods: We conducted a single center retrospective study among cirrhotic patients with worsening kidney function admitted for liver transplant evaluation between 2010 and 2020. All met accepted criteria for HRS and underwent concurrent right heart catheterization (RHC). Results: 127 subjects were included. 79 had right atrial pressure \u3e10 mmHg, 79 had wedge pressure \u3e15 mmHg, and 68 had both. All patients with elevated wedge pressure were switched from volume loading to diuretics resulting in significant reductions between admission and post diuresis creatinine values (2.0 [IQR 1.5-2.8] vs 1.5 [IQR 1.2-2.2]; p = 0.003). Conclusion: 62% of patients diagnosed with HRS by clinical criteria have elevated filling pressures. Improvement of renal function after diuresis suggests the presence of CRS physiology in these patients. Invasive hemodynamic data profiling can lead to meaningful change in management of cirrhotic patients with worsened kidney function, guiding appropriate therapies based on filling pressures

Parental knowledge of RVS infection and attitude to infant immunization with monoclonal antibodies in western region, Saudi Arabia

Background: Human Respiratory Syncytial Virus (RSV) is a single-stranded (RNA) virus belongs to genus orthopneumovirus. It accounted as one of the main causes of lower respiratory tract infection in the pediatric age group and associated with their hospitalization and morbidity. Prophylactic monoclonal antibodies help in improvement and reduction of the serious complications resulting from the virus. Objective : The aim of this paper is to assess parental knowledge of RSV infection and attitudes to infant immunization with monoclonal antibodies. Method: A cross-sectional study conducted using online questionnaire from February 2023 to June 2023 in western region in the Kingdom of Saudi Arabia. A total of 606 of participants, which include any parents or caregiver who believe in childhood vaccination in western region of Saudi Arabia with exclusion of any parents who hesitate towards or refuse childhood vaccinations and outside western region. The statistical analysis done using IBM SPSS. Results: The study included 606 participants from the western province of Saudi Arabia, 218 (36%) were in the age group of 20-30 years, 383 (63.2%) had bachelor degrees And 77(12.7) works in healthcare, RSV was the least known childhood infectious agent (48.7%) of the participants never heard of it. 542 (89.4%) had a positive attitude toward childhood vaccinations in general and (51.2%) toward RSV vaccination with (75.2%) concerned about its safety.Conclusion: Despite the fact that practically all children were exposed to RSV, a sizable percentage of parents never heard of it. We propose that dependable healthcare professionals provide evidence-based information regarding RSV and its safety, effectiveness, and duration of protection against RSV for parents

The clinical and genetic spectrum of autosomal-recessive TOR1A-related disorders.

In the field of rare diseases, progress in molecular diagnostics led to the recognition that variants linked to autosomal-dominant neurodegenerative diseases of later onset can, in the context of biallelic inheritance, cause devastating neurodevelopmental disorders and infantile or childhood-onset neurodegeneration. TOR1A-associated arthrogryposis multiplex congenita 5 (AMC5) is a rare neurodevelopmental disorder arising from biallelic variants in TOR1A, a gene that in the heterozygous state is associated to torsion dystonia-1 (DYT1 or DYT-TOR1A), an early-onset dystonia with reduced penetrance. While 15 individuals with TOR1A-AMC5 have been reported (less than 10 in detail), a systematic investigation of the full disease-associated spectrum has not been conducted. Here, we assess the clinical, radiological and molecular characteristics of 57 individuals from 40 families with biallelic variants in TOR1A. Median age at last follow-up was 3 years (0-24 years). Most individuals presented with severe congenital flexion contractures (95%) and variable developmental delay (79%). Motor symptoms were reported in 79% and included lower limb spasticity and pyramidal signs, as well as gait disturbances. Facial dysmorphism was an integral part of the phenotype, with key features being a broad/full nasal tip, narrowing of the forehead and full cheeks. Analysis of disease-associated manifestations delineated a phenotypic spectrum ranging from normal cognition and mild gait disturbance to congenital arthrogryposis, global developmental delay, intellectual disability, absent speech and inability to walk. In a subset, the presentation was consistent with fetal akinesia deformation sequence with severe intrauterine abnormalities. Survival was 71% with higher mortality in males. Death occurred at a median age of 1.2 months (1 week - 9 years) due to respiratory failure, cardiac arrest, or sepsis. Analysis of brain MRI studies identified non-specific neuroimaging features, including a hypoplastic corpus callosum (72%), foci of signal abnormality in the subcortical and periventricular white matter (55%), diffuse white matter volume loss (45%), mega cisterna magna (36%) and arachnoid cysts (27%). The molecular spectrum included 22 distinct variants, defining a mutational hotspot in the C-terminal domain of the Torsin-1A protein. Genotype-phenotype analysis revealed an association of missense variants in the 3-helix bundle domain to an attenuated phenotype, while missense variants near the Walker A/B motif as well as biallelic truncating variants were linked to early death. In summary, this systematic cross-sectional analysis of a large cohort of individuals with biallelic TOR1A variants across a wide age-range delineates the clinical and genetic spectrum of TOR1A-related autosomal-recessive disease and highlights potential predictors for disease severity and survival