The Hope Venture: Strategic Audit

The Hope Venture is an international nonprofit headquartered in Lincoln, Nebraska. Their work is comprised of education and health projects targeted at individuals living in extreme poverty. Currently, most of their projects are located in India and Sub-Saharan Africa. A PESTEL analysis was performed to assess the external environment in which they operate, while a Porter’s 5 Forces analysis explained industry dynamics. Their competitive advantages, such as their unique 100% model, are explored, while key challenges regarding scalability are discussed. In the end, recommendations are given to overcome potential threats and to continue to sustain a competitive advantage in the crowded industry they exist in

Role of Coagulation in Xenobiotic-Induced Liver Injury

The liver is a common target for xenobiotic-induced toxicity. Of importance, synthesis of soluble coagulation factors by the liver plays an essential role in hemostasis. Blood coagulation cascade activation is evident in both human patients and in animal models of liver injury. Several studies have shown that coagulation is not merely a process reactive to toxicity, but rather a critical determinant of liver disease pathogenesis. Previous studies have utilized global anticoagulation as a strategy to investigate the role of coagulation in liver injury. Currently, our understanding of the mechanisms whereby individual coagulation proteases contribute to hepatotoxicity is inadequate. Blood coagulation is initiated by tissue factor (TF), a transmembrane cellular receptor for the coagulation factor VII/VIIa. The TF:VIIa complex initiates a serine protease cascade, which culminates in the generation of the serine protease thrombin. Thrombin cleaves circulating fibrinogen to initiate fibrin clot formation. Additionally, thrombin signals to multiple cell types through activation of protease activated receptors (PARs), which can promote inflammation and platelet aggregation. The procoagulant response is balanced by several anticoagulant proteins and fibrin clot degradation is catalyzed by plasmin, the main endogenous fibrin degradation enzyme. The aim of this dissertation was to determine the role of several blood coagulation cascade components in the responses elicited by two model hepatotoxicants; &alpha-naphthylisothiocyanate (ANIT) a toxicant that damages bile duct epithelial cells (BDECs), and acetaminophen (APAP), a common analgesic that causes centrilobular hepatocellular necrosis at high doses. We found that TF-dependent generation of thrombin contributed to the progression of chronic ANIT-induced hepatic inflammation and fibrosis by a mechanism requiring PAR-1. PAR-1 activation amplified TGF-&beta1-induced &alphaV&beta6 integrin expression by BDECs, and activation of TGF-&beta signaling in vivo. This suggests a novel feed-forward mechanism whereby coagulation can promote fibrogenesis. In contrast, PAR-1 was not required for the acute hepatotoxic effects of ANIT. Rather, ANIT-induced liver injury occurred by a mechanism involving activation of PAR-4 on platelets and fibrin(ogen). The results highlight a differential contribution of thrombin signaling in acute and chronic cholestatic liver injury. Previous studies identified the primary inhibitor of fibrinolysis, plasminogen activator inhibitor-1 (PAI-1), as a key hepatoprotective factor in APAP-induced liver injury. Indeed, hepatic fibrin deposition is a prominent feature of APAP-induced hepatocellular necrosis. To our surprise, fibrin(ogen) did not contribute to acute APAP-induced liver injury. Of importance, plasminogen deficiency reduced APAP hepatotoxicity. Taken together, the results suggest that plasmin(ogen) promotes APAP-induced liver injury in a fibrin independent manner. Overall, these studies revealed novel pathways whereby elements of the coagulation cascade promote liver injury induced by two classical hepatotoxicants. The results suggest that individual coagulation cascade components may play divergent roles in different models of liver injury and potentially at different time points during injury development. Further studies systematically evaluating individual coagulation factors in animal models and human disease are required to fully understand the dynamic contribution that coagulation cascade proteins play in liver injury

Thermal Expansion of Polyurethane Foam

Closed cell foams are often used for thermal insulation. In the case of the Space Shuttle, the External Tank uses several thermal protection systems to maintain the temperature of the cryogenic fuels. A few of these systems are polyurethane, closed cell foams. In an attempt to better understand the foam behavior on the tank, we are in the process of developing and improving thermal-mechanical models for the foams. These models will start at the microstructural level and progress to the overall structural behavior of the foams on the tank. One of the key properties for model characterization and verification is thermal expansion. Since the foam is not a material, but a structure, the modeling of the expansion is complex. It is also exacerbated by the anisoptropy of the material. During the spraying and foaming process, the cells become elongated in the rise direction and this imparts different properties in the rise direction than in the transverse directions. Our approach is to treat the foam as a two part structure consisting of the polymeric cell structure and the gas inside the cells. The polymeric skeleton has a thermal expansion of its own which is derived from the basic polymer chemistry. However, a major contributor to the thermal expansion is the volume change associated with the gas inside of the closed cells. As this gas expands it exerts pressure on the cell walls and changes the shape and size of the cells. The amount that this occurs depends on the elastic and viscoplastic properties of the polymer skeleton. The more compliant the polymeric skeleton, the more influence the gas pressure has on the expansion. An additional influence on the expansion process is that the polymeric skeleton begins to breakdown at elevated temperatures and releases additional gas species into the cell interiors, adding to the gas pressure. The fact that this is such a complex process makes thermal expansion ideal for testing the models. This report focuses on the thermal expansion tests and the response of the microstructure. A novel optical method is described which is appropriate for measuring thermal expansion at high temperatures without influencing the thermal expansion measurement. Detailed microstructural investigations will also be described which show cell expansion as a function of temperature. Finally, a phenomenological model on thermal expansion will be described

Experimental Investigations of Space Shuttle BX-265 Foam

This report presents a variety of experimental studies on the polyurethane foam, BX-265. This foam is used as a close-out foam insulation on the space shuttle external tank. The purpose of this work is to provide a better understanding of the foam s behavior and to support advanced modeling efforts. The following experiments were performed: Thermal expansion was measured for various heating rates. The in situ expansion of foam cells was documented by heating the foam in a scanning electron microscope. Expansion mechanisms are described. Thermogravimetric analysis was performed at various heating rates and for various environments. The glass transition temperature was also measured. The effects of moisture on the foam were studied. Time-dependent effects were measured to give preliminary data on viscoelastoplastic properties

An Elongated Tetrakaidecahedron Model for Open-Celled Foams

A micro-mechanics model for non-isotropic, open-celled foams is developed using an elongated tetrakaidecahedron (Kelvin model) as the repeating unit cell. The micro-mechanics model employs an elongated Kelvin model geometry which is more general than that employed by previous authors. Assuming the cell edges possess axial and bending rigidity, the mechanics of deformation of the elongated tetrakaidecahedron lead to a set of equations for the Young's modulus, Poisson's ratio and strength of the foam in the principal material directions. These equations are written as a function of the cell edge lengths and cross-section properties, the inclination angle and the strength and stiffness of the solid material. The model is applied to predict the strength and stiffness of several polymeric foams. Good agreement is observed between the model results and the experimental measurements

Constraining the Progenitor Companion of the Nearby Type Ia SN 2011fe with a Nebular Spectrum at +981 Days

We present an optical nebular spectrum of the nearby Type Ia supernova 2011fe, obtained 981 days after explosion. SN 2011fe exhibits little evolution since the +593 day optical spectrum, but there are several curious aspects in this new extremely late-time regime. We suggest that the persistence of the $\sim5800$~\AA\ feature is due to Na I D, and that a new emission feature at $\sim7300$~\AA\ may be [Ca II]. Also, we discuss whether the new emission feature at $\sim6400$~\AA\ might be [Fe I] or the high-velocity hydrogen predicted by Mazzali et al. The nebular feature at 5200~\AA\ exhibits a linear velocity evolution of $\sim350$ $\rm km\ s^{-1}$ per 100 days from at least +220 to +980 days, but the line's shape also changes in this time, suggesting that line blending contributes to the evolution. At $\sim 1000$ days after explosion, flux from the SN has declined to a point where contribution from a luminous secondary could be detected. In this work we make the first observational tests for a post-impact remnant star and constrain its temperature and luminosity to $T \gtrsim 10^4$ $\rm K$ and $L \lesssim 10^4$ $\rm L_{\odot}$. Additionally, we do not see any evidence for narrow H$\alpha$ emission in our spectrum. We conclude that observations continue to strongly exclude many single-degenerate scenarios for SN 2011fe.Comment: 11 pages, 10 figures, published by MNRA

A Micromechanics Finite Element Model for Studying the Mechanical Behavior of Spray-On Foam Insulation (SOFI)

A micromechanics model has been constructed to study the mechanical behavior of spray-on foam insulation (SOFI) for the external tank. The model was constructed using finite elements representing the fundamental repeating unit of the SOFI microstructure. The details of the micromechanics model were based on cell observations and measured average cell dimensions discerned from photomicrographs. The unit cell model is an elongated Kelvin model (fourteen-sided polyhedron with 8 hexagonal and six quadrilateral faces), which will pack to a 100% density. The cell faces and cell edges are modeled using three-dimensional 20-node brick elements. Only one-eighth of the cell is modeled due to symmetry. By exercising the model and correlating the results with the macro-mechanical foam behavior obtained through material characterization testing, the intrinsic stiffness and Poisson s Ratio of the polymeric cell walls and edges are determined as a function of temperature. The model is then exercised to study the unique and complex temperature-dependent mechanical behavior as well as the fracture initiation and propagation at the microscopic unit cell level

Application of an Elongated Kelvin Model to Space Shuttle Foams

The space shuttle foams are rigid closed-cell polyurethane foams. The two foams used most-extensively oil space shuttle external tank are BX-265 and NCFL4-124. Because of the foaming and rising process, the foam microstructures are elongated in the rise direction. As a result, these two foams exhibit a nonisotropic mechanical behavior. A detailed microstructural characterization of the two foams is presented. Key features of the foam cells are described and the average cell dimensions in the two foams are summarized. Experimental studies are also conducted to measure the room temperature mechanical response of the two foams in the two principal material directions (parallel to the rise and perpendicular to the rise). The measured elastic modulus, proportional limit stress, ultimate tensile strength, and Poisson's ratios are reported. The generalized elongated Kelvin foam model previously developed by the authors is reviewed and the equations which result from this model are summarized. Using the measured microstructural dimensions and the measured stiffness ratio, the foam tensile strength ratio and Poisson's ratios are predicted for both foams and are compared with the experimental data. The predicted tensile strength ratio is in close agreement with the measured strength ratio for both BX-265 and NCFI24-124. The comparison between the predicted Poisson's ratios and the measured values is not as favorable

Late-Time Spectral Observations of the Strongly Interacting Type Ia Supernova PTF11kx

PTF11kx was a Type Ia supernova (SN Ia) that showed time-variable absorption features, including saturated Ca II H&K lines that weakened and eventually went into emission. The strength of the emission component of H{\alpha} increased, implying that the SN was undergoing significant interaction with its circumstellar medium (CSM). These features were blueshifted slightly and showed a P-Cygni profile, likely indicating that the CSM was directly related to, and probably previously ejected by, the progenitor system itself. These and other observations led Dilday et al. (2012) to conclude that PTF11kx came from a symbiotic nova progenitor like RS Oph. In this work we extend the spectral coverage of PTF11kx to 124-680 rest-frame days past maximum brightness. These spectra of PTF11kx are dominated by H{\alpha} emission (with widths of ~2000 km/s), strong Ca II emission features (~10,000 km/s wide), and a blue "quasi-continuum" due to many overlapping narrow lines of Fe II. Emission from oxygen, He I, and Balmer lines higher than H{\alpha} is weak or completely absent at all epochs, leading to large observed H{\alpha}/H{\beta} intensity ratios. The broader (~2000 km/s) H{\alpha} emission appears to increase in strength with time for ~1 yr, but it subsequently decreases significantly along with the Ca II emission. Our latest spectrum also indicates the possibility of newly formed dust in the system as evidenced by a slight decrease in the red wing of H{\alpha}. During the same epochs, multiple narrow emission features from the CSM temporally vary in strength. The weakening of the H{\alpha} and Ca II emission at late times is possible evidence that the SN ejecta have overtaken the majority of the CSM and agrees with models of other strongly interacting SNe Ia. The varying narrow emission features, on the other hand, may indicate that the CSM is clumpy or consists of multiple thin shells.Comment: 12 pages, 7 figures, 1 table, re-submitted to Ap

Elongated Tetrakaidecahedron Micromechanics Model for Space Shuttle External Tank Foams

The results of microstructural characterization studies and physical and mechanical testing of BX-265 and NCFI24-124 foams are reported. A micromechanics model developed previously by the authors is reviewed, and the resulting equations for the elastic constants, the relative density, and the strength of the foam in the principal material directions are presented. The micromechanics model is also used to derive equations to predict the effect of vacuum on the tensile strength and the strains induced by exposure to vacuum. Using a combination of microstructural dimensions and physical and mechanical measurements as input, the equations for the elastic constants and the relative density are applied and the remaining microstructural dimensions are predicted. The predicted microstructural dimensions are in close agreement with the average measured values for both BX-265 and NCFI24-124. With the microstructural dimensions, the model predicts the ratio of the strengths in the principal material directions for both foams. The model is also used to predict the Poisson s ratios, the vacuum-induced strains, and the effect of vacuum on the tensile strengths. However, the comparison of these predicted values with the measured values is not as favorable