Aplicação da Análise SWOT nas empresas cabo-verdianas

Este trabalho, que tem como tema a Analise Swot nas empresas cabo-verdianas, inicia-se com a revisão dos conceitos do modelo e da matriz Swot. Seguidamente, foram abordadas questões relacionadas com a importância do modelo Swot no planeamento das empresas, como instrumento que possibilita a obtenção de uma visão clara e objectiva sobre a posição da empresa no mercado e facilita a elaboração de estratégias com vista a alcançar vantagens competitivas e melhoria do desempenho organizacional. Posteriormente, como resposta a pergunta de partida e utilizando a metodologia do questionário por inquérito, foram analisadas por sector de actividade e no seu conjunto a aplicação do modelo Swot nas empresas cabo-verdianas e as suas vantagens, e optou-se também por mostrar a matriz Swot por cada sector de actividade. Finalmente, e a partir dos resultados da análise obtidos, procurou-se responder o quanto é usado o modelo Swot nas empresas em Cabo Verde, suas vantagens e o papel que tem no aumento da competitividade no mercado

Instagram, estilo de vida saludable y modelo de negocios: el caso Sascha Fitness

Sascha Barboza es una influencer mejor conocida en los medios digitales de Instagram, Facebook y Twitter con el pseudónimo ‘Sasha Fitness’. Nacida en Venezuela, a sus 33 años es un caso de estudio por su modelo de negocio y la rigurosidad con la que ha construido su nicho de mercado; así como, por las nuevas formas de crear comunidad que ha implementado. Sus seguidores se convierten en clientes potenciales a partir de la creación de un contenido en específico, en su caso está asociado a un fitness lifestyle, que en español se asocia con el significado de ‘vida saludable’

Comunicación en salud, lengua de señas y mediación tecnológica: relación médico-paciente en Barranquilla

“Health Communication, Sign Language and technological mediation: doctor-patient relationship in Barranquilla” is a research project that evidences the communicational gap existing between deaf and hearing individuals outside of their family circle, which generates several difficulties in their daily lives, behavior and social interactions. The project tries to legitimize sign language as a means of communication by employing the deaf individual’s mobile devices and technological competences as a tool of this communication process. This process is envisioned as a solution of hearing-impaired interactions. The former is achieved by collecting data through snowball interviews, which exposed the difficulties in communication between the hearing and hearing-impaired, affecting their integrity.“Comunicación en salud, lengua de señas y mediación tecnológica: relación médico-paciente en Barranquilla” es un proyecto de investigación en el que se demuestra, con evidencias, la brecha comunicacional que existe entre los sordos y las personas oyentes ajenas a su círculo familiar, generando varias dificultades en situaciones de la vida cotidiana que complejizan su comportamiento en las interacciones sociales. Se busca legitimar este tipo de lenguaje como forma de comunicación utilizando los dispositivos móviles y las competencias tecnológicas de las personas sordas como una herramienta en el proceso, dando a conocer esta forma de comunicación como una solución de interacciones entre las dos poblaciones en estudio. Lo anterior se logró al recolectar datos a través de la técnica de entrevistas en bola de nieve que permitieron ver la dificultad de comunicación que existe en estas dos poblaciones, afectando de manera indirecta su integridad

Burden of Atopic Dermatitis in the United States: Analysis of Healthcare Claims Data in the Commercial, Medicare, and Medi-Cal Databases

Comparative data on the burden of atopic dermatitis (AD) in adults relative to the general population are limited. We performed a large-scale evaluation of the burden of disease among US adults with AD relative to matched non-AD controls, encompassing comorbidities, healthcare resource utilization (HCRU), and costs, using healthcare claims data. The impact of AD disease severity on these outcomes was also evaluated

Deambulação no trabalho de parto

A deambulação durante o trabalho de parto, tem vindo a ser uma prática cada vez mais adotada, pois existem evidências científicas do seu benefício para a mãe e bebé, tais como regularizar as contrações, encurtar o tempo do trabalho de parto e as mulheres que deambulam durante o trabalho de parto referem alívio da dor das contrações ou pelo menos melhor tolerância da vivência da dor. Uma vez que a deambulação durante o trabalho de parto acompanhada do uso de telemetria ainda não é uma prática recorrente no serviço de obstetrícia do hospital de Beja, mas existem recursos materiais para ser feito, desenha-se o atual projeto que tem como objetivo geral: Construir um programa de assistência à mulher no 1º Estádio do Trabalho de Parto com recurso a deambulação e telemetria. Este relatório descreve as intervenções necessárias para a aquisição de competências neste sentido, mostrando uma análise reflexiva sobre os resultados obtidos; ### ABSTRACT: Title: Walking during labor Walking during labor has been more and more used in maternities because there`s scientific evidence of its benefits for the mother and the baby. It helps to regularize the contractions, shortens the time of labor and women who walk during labor say that it helps to control their pain. Since walking during labor used with telemetry is not a common practice on the maternity ward of Beja´s Hospital, but since there´s material means to do so, I realized the following project. The main goal of this project is: Build an assistant program to women in the first stage of labor using telemetry while they walk. This paper describes the interventions needed to acquire competencies. It also shows a reflective analyze of the results obtained with the questionnaire of this present study

Hematocrit levels and thrombotic events in patients with polycythemia vera: an analysis of Veterans Health Administration data

Patients with polycythemia vera (PV) have a high incidence of thrombotic events (TEs), contributing to a greater mortality risk than the general population. The relationship between hematocrit (HCT) levels and TE occurrence among patients with PV from the Veterans Health Administration (VHA) was evaluated to replicate findings of the CYTO-PV trial with a real-world patient population. This retrospective study used VHA medical record and claims data from the first claim with a PV diagnosis (index) until death, disenrollment, or end of study, collected between October 1, 2005, and September 30, 2012. Patients were aged ? 18 years at index, had ? 2 claims for PV (ICD-9-CM code, 238.4) ? 30 days apart during the identification period, continuous health plan enrollment from 12 months pre-index until end of study, and ? 3 HCT measurements per year during follow-up. This analysis focused on patients with no pre-index TE, and with all HCT values either < 45% or ? 45% during the follow-up period. The difference in TE risk between HCT groups was assessed using unadjusted Cox regression models based on time to first TE. Patients (N = 213) were mean (SD) age 68.9 (11.5) years, 98.6% male, and 61.5% white. TE rates for patients with HCT values < 45% versus ? 45% were 40.3% and 54.2%, respectively. Among patients with ? 1 HCT before TE, TE risk hazard ratio was 1.61 (95% CI, 1.03–2.51; P = 0.036). This analysis of the VHA population further supports effective monitoring and control of HCT levels < 45% to reduce TE risk in patients with PV.WOS:000495797000006Scopus - Affiliation ID: 60105072PMID: 31552445Science Citation Index ExpandedQ2ArticleUluslararası işbirliği ile yapılan - EVETKasım2019YÖK - 2019-2

C–H insertion as a key step to spiro-oxetanes, scaffolds for drug discovery

A new route to spiro-oxetanes, potential scaffolds for drug discovery, is described. The route is based on the selective 1,4-C–H insertion reactions of metallocarbenes, generated from simple carbonyl precursors in flow or batch mode, to give spiro-β-lactones that are rapidly converted into spiro-oxetanes. The three-dimensional and lead like-properties of spiro-oxetanes is illustrated by the conversion of the 1-oxa-7-azaspiro[3,5]nonane scaffold into a range of functionalized derivatives

Elevated white blood cell levels and thrombotic events in patients with polycythemia vera: a real-world analysis of veterans health administration data

Background: Patients with polycythemia vera (PV) have a substantial risk of thrombotic events (TEs). The objective of the present analysis was to describe the association between white blood cell (WBC) levels and occurrence of TEs among patients with PV from a large real-world population. Patients and Methods: The present retrospective analysis using Veterans Health Administration claims data (October 1, 2005, to September 30, 2012) evaluated adult patients assigned to 4 WBC count categories (WBC count < 7.0, 7.0-8.4, 8.5 to < 11.0, and ≥ 11.0 × 109/L) to compare the risk of TEs (reference, WBC count, < 7.0 × 109/L group). Analysis was performed using a Cox proportional hazards model, considering WBC status as a time-dependent covariate. Results: Of the 1565 patients with PV included in the present analysis, the WBC count was < 7.0 × 109/L for 428 (27.3%), 7.0 to 8.4 × 109/L for 375 (24.0%), 8.5 to < 11.0 × 109/L for 284 (18.1%), and ≥ 11.0 × 109/L for 478 (30.5%). Of the 1565 patients, 390 (24.9%) had experienced a TE during the study period. The mean follow-up ranged from 3.6 to 4.5 years. Compared with the reference group (WBC count < 7.0 ×109/L), the hazard ratio for TEs was 1.10 (95% confidence interval [CI], 0.82-1.48; P = .5395), 1.47 (95% CI, 1.10-1.96; P = .0097), and 1.87 (95% CI, 1.44-2.43; P < .0001) for patients with a WBC count of 7.0 to 8.4, 8.5 to < 11.0, and ≥ 11.0 ×109/L, respectively. Conclusion: A positive, significant association between an increased WBC count of ≥ 8.5 ×109/L and the occurrence of TEs was observed in patients with PV. The potential thrombogenic role of WBCs in patients with PV supports the continued inclusion of WBC count control in disease management and evaluation of the response to therapy. © 2019 The AuthorsPatients with polycythemia vera (PV) have a substantial risk of thrombotic events (TEs). In the present retrospective analysis using Veterans Health Administration claims data, 25% of 1565 patients experienced a TE during follow-up. We observed a positive, significant association between white blood cell (WBC) counts ≥ 8.5 × 109/L and TE occurrence (reference, WBC count < 7.0 × 109/L), supporting continued inclusion of WBC count control in disease management. © 2019 The AuthorsIncyte Corporation (Wilmington, DE)WOS:000513918800013Scopus - Affiliation ID: 60105072PMID: 31865003Science Citation Index ExpandedQ3ArticleUluslararası işbirliği ile yapılan - EVETŞubat2020YÖK - 2019-2

Application of simple fed-batch technique to high-level secretory production of insulin precursor using Pichia pastoris with subsequent purification and conversion to human insulin

<p>Abstract</p> <p>Background</p> <p>The prevalence of diabetes is predicted to rise significantly in the coming decades. A recent analysis projects that by the year 2030 there will be ~366 million diabetics around the world, leading to an increased demand for inexpensive insulin to make this life-saving drug also affordable for resource poor countries.</p> <p>Results</p> <p>A synthetic insulin precursor (IP)-encoding gene, codon-optimized for expression in <it>P. pastoris</it>, was cloned in frame with the <it>Saccharomyces cerevisiae </it>α-factor secretory signal and integrated into the genome of <it>P. pastoris </it>strain X-33. The strain was grown to high-cell density in a batch procedure using a defined medium with low salt and high glycerol concentrations. Following batch growth, production of IP was carried out at methanol concentrations of 2 g L^-1, which were kept constant throughout the remaining production phase. This robust feeding strategy led to the secretion of ~3 gram IP per liter of culture broth (corresponding to almost 4 gram IP per liter of cell-free culture supernatant). Using immobilized metal ion affinity chromatography (IMAC) as a novel approach for IP purification, 95% of the secreted product was recovered with a purity of 96% from the clarified culture supernatant. Finally, the purified IP was trypsin digested, transpeptidated, deprotected and further purified leading to ~1.5 g of 99% pure recombinant human insulin per liter of culture broth.</p> <p>Conclusions</p> <p>A simple two-phase cultivation process composed of a glycerol batch and a constant methanol fed-batch phase recently developed for the intracellular production of the Hepatitis B surface antigen was adapted to secretory IP production. Compared to the highest previously reported value, this approach resulted in an ~2 fold enhancement of IP production using <it>Pichia </it>based expression systems, thus significantly increasing the efficiency of insulin manufacture.</p

3C.co Comunicación, Capitalismo y Crítica en la Colombia Digital

El presente libro comprende una producción Académica que integra los aportes derivados de diferentes reflexiones, estudios e investigaciones sobre el rol que tiene el campo de la Comunicación Social y Medios Digitales, como escenario de formación especializada, investigación, innovación y apropiación social del conocimiento aplicado al análisis de la “Economía Política de la Información”. En este tópico de estudio, se indaga acerca de las relaciones económicas presentes en los medios digitales: Apps, nuevos medios y más media, redes sociales, y emprendimientos tecnológicos, a partir de investigaciones que se han enfocado en el análisis del impacto socio económico que ejercen estos medios dentro del entorno naciona