Tripodal oxazolidine-N-oxyl diradical complexes of Dy3+ and Eu3+

Two diradical complexes of the formula [LnRad2(CF3SO3)3] c (Ln(III) = Dy, Eu, Rad = 4,4-dimethyl-2,2-bis(pyridin-2-yl)-1,3-oxazolidine-3-oxyl) were obtained in air conditions. These are the first examples of diradical compounds of lanthanides and oxazolidine nitroxide. The complexes were characterized crystallographically and magnetically. Single crystal XRD analysis revealed that their coordination sphere is composed of three monodentate triflates and two tripodal Rad, which coordinate the central atom in a tridentate manner via two N atoms of the pyridine groups and the O atom of a nitroxide group. The LnO5N4 polyhedron represents a spherical capped square antiprism with point symmetry close to C4v. The data of static magnetic measurements are compatible with the presence of two paramagnetic ligands in the coordination sphere of the metal

Modern requirements for the lesson of physical culture at school

This article discusses the features of physical education lesson in contemporary realities and on the basis of modern educational standards, problems and features of the control of students' activities in physical education lessons. It also discusses the issue of intensity and load control for students in physical education classes of secondary schools.В данной статье рассматриваются особенности урока физической культуры в современных реалиях и на основании современных образовательных стандартов, проблемы и особенности контроля деятельности учащихся на уроках физической культуры. Также обсуждается вопрос интенсивности и контроля нагрузок для учащихся на уроках физической культуры общеобразовательной школы

Observation of soft X-ray Cherenkov radiation in Al

The soft X-ray radiation generated by 5.7 MeV electrons from both an Al foil and a Mylar film in forward direction was experimentally studied. A narrow specific directivity, an ultra-narrow spectral bandwidth and a good consistency between the experiment and theory prove that the Cherenkov radiation (CR) with photon energy near the L-edge of absorption in Al was observed. The results demonstrate that the CR spectral-angular properties and the absolute photon yield can be described well enough using Pafomov's theoretical model and Henke's refractive index database, which is essential for all practical applications

Two novel mutations associated with ataxia-telangiectasia identified using an ion ampliSeq inherited disease panel

© 2017 Kuznetsova, Trofimov, Shubina, Kochetkova, Karetnikova, Barkov, Bakharev, Gusev and Sukhikh. Ataxia-telangiectasia (A-T), or Louis-Bar syndrome, is a rare neurodegenerative disorder associated with immunodeficiency. For families with at least one affected child, timely A-T genotyping during any subsequent pregnancy allows the parents to make an informed decision about whether to continue to term when the fetus is affected. Mutations in the ATM gene, which is 150 kb long, give rise to A-T; more than 600 pathogenic variants in ATM have been characterized since 1990 and new mutations continue to be discovered annually. Therefore, limiting genetic screening to previously known SNPs by PCR or hybridization with microarrays may not identify the specific pathog enic genotype in ATM for a given A-T family. However, recent developments in next-generation sequencing technology offer prompt high-throughput full-length sequencing of genomic fragments of interest. This allows the identification of the whole spectrum of mutations in a gene, including any novel ones. We report two A-T families with affected children and current pregnancies. Both families are consanguineous and originate from Caucasian regions of Russia and Azerbaijan. Before our study, no ATM mutations had been identified in the older children of these families. We used ion semiconductor sequencing and an Ion AmpliSeq ™ Inherited Disease Panel to perform complete ATM gene sequencing in a single member of each family. Then we compared the experimentally determined genotype with the affected/normal phenotype distribution in the whole family to provide unambiguous evidence of pathogenic mutations responsible for A-T. A single novel SNP was allocated to each family. In the first case, we found a mononucleotide deletion, and in the second, a mononucleotide insertion. Both mutations lead to truncation of the ATM protein product. Identification of the pathogenic mutation in each family was performed in a timely fashion, allowing the fetuses to be tested and diagnosed. The parents chose to continue with both pregnancies as both fetuses had a healthy genotype and thus were not at risk of A-T

Modern Techniques for Cervical Cancer Radiotherapy

Cervical cancer is a socially significant illness often impacting women of reproductive and working age. The patients’ young age and social activity warrant the development of effective and safe therapies.The past decades have witnessed the novel radiation techniques to contain cervical cancer: 3DCRT-3D, IMRT, and VMAT, adaptive radiotherapy, CT/MRI-guided intracavitary radiation, combined interstitial and intracavitary radiation, abandoning intracavitary intervention for external beam delivery with sequential or concurrent cervical dose escalation, under brachytherapy unfeasible.Modern equipment and treatment planning systems allow a high dose delivery to the tumour and intracavitary treatment with visual control of the target and organs at risk. Combining of intracavitary and interstitial radiotherapy enables a better dose coverage of the target at a minimal radiation impact on organs at risk.Phasing-out of intracavitary for external radiotherapy may enable a cancericide dose delivery to the tumour under intractable intracavitary treatment.The major goal of technic novelties is the establishment of personalised radiotherapy for improving treatment outcomes and reducing the incidence and/or severity of radiation side effects. The article overviews the radiotherapy techniques for cervical cancer treatment and routes of their development

Silver(I) coordination compounds with polydentate pyrimidine ligands: thermochromism of luminescence

The main goal of this work is to study how the substituent in position 2 of the pyrimidine ring affects both luminescent properties and structures of silver(I) complexes. A series of coordination compounds, [AgL1NO3], [AgL1X]n, [Ag2(L2)2X2] (X = I, Br, Cl–), [AgL1(PPh3)Y] (Y = CF3SO3, BF4, NO3), [AgL3NO3·CH3CN]n, have been synthesized and structurally characterized. According to the X-ray single data, the complexes [AgL1NO3], [AgL1(PPh3)Y] adopt mononuclear structures; the complexes [Ag2(L2)2X2] are binuclear; [AgL1X]n and [AgL3NO3·CH3CN]n are polymeric compounds.The research was supported by the President of the Russian Federation Grant for young scientists МК-1219.2020.3; by Russian Foundation for Basic Research and the government of the Novosibirsk region of the Russian Federation, grant № 18–43–540016 r_a