Identifying a protocol to assess literacy-related skills in Maltese children and adolescents with Down syndrome

Acquiring the ability to read is a complex process that involves a number of skills. Recent literature confirms that many individuals with Down syndrome (DS) can acquire useful levels of reading ability which can open new opportunities. In contrast with the typically-developing (TD) population, students with DS portray an uneven pattern of development of pre-reading and reading skills. This commentary explores the aspects that need to be considered when assessing the pre-literacy and literacy abilities of students with DS in the Maltese bilingual context. Its aim is to identify the components of an assessment protocol that could be used to evaluate the literacy-related abilities of students with DS.peer-reviewe

PISA in brief : highlights from the full Australian report : PISA 2012 : how Australia measures up

PISA is a survey that measures the knowledge and skills of 15-year-olds, who are near the end of compulsory schooling in most participating education systems. PISA in Brief summarises the results from the PISA 2012 assessment of students’ mathematical, scientific and reading literacy skills. It tells us about how students performed in the assessment and describes some wider findings about what lies behind their results

Longitudinal predictors of early language in infants with Down syndrome: a preliminary study

Purpose: Children with Down syndrome (DS) typically have marked delays in language development relative to their general cognitive development, with particular difficulties in expressive compared to receptive language. Although early social communication skills, including gestures and joint attention, have been shown to be related to later language outcomes in DS, knowledge is limited as to whether these factors exclusively predict outcomes, or whether other factors (e.g. perceptual and non-verbal skills) are involved. This study addressed this question. Method: Longitudinal data for a group of infants with DS (n=14) and a group of typically-developing (TD) infants (n=35) were collected on measures that have been shown to predict language in TD infants and/or those with developmental delays. These included: non-verbal mental ability, speech segmentation skills, and early social communication skills (initiating and responding to joint attention, initiating behavioural requests). Results: Linear regression analyses showed that speech segmentation and initiating joint attention were the strongest predictors of later language in the TD group, whereas non-verbal mental ability and responding to joint attention were the strongest predictors of later language for infants with DS. Conclusions: Speech segmentation ability may not determine language outcomes in DS, and language acquisition may be more constrained by social communication and general cognitive skills

Gait Asymmetry Post-Stroke: Determining Valid and Reliable Methods Using a Single Accelerometer Located on the Trunk

Asymmetry is a cardinal symptom of gait post-stroke that is targeted during rehabilitation. Technological developments have allowed accelerometers to be a feasible tool to provide digital gait variables. Many acceleration-derived variables are proposed to measure gait asymmetry. Despite a need for accurate calculation, no consensus exists for what is the most valid and reliable variable. Using an instrumented walkway (GaitRite) as the reference standard, this study compared the validity and reliability of multiple acceleration-derived asymmetry variables. Twenty-five post-stroke participants performed repeated walks over GaitRite whilst wearing a tri-axial accelerometer (Axivity AX3) on their lower back, on two occasions, one week apart. Harmonic ratio, autocorrelation, gait symmetry index, phase plots, acceleration, and jerk root mean square were calculated from the acceleration signals. Test–retest reliability was calculated, and concurrent validity was estimated by comparison with GaitRite. The strongest concurrent validity was obtained from step regularity from the vertical signal, which also recorded excellent test–retest reliability (Spearman’s rank correlation coefficients (rho) = 0.87 and Intraclass correlation coefficient (ICC21) = 0.98, respectively). Future research should test the responsiveness of this and other step asymmetry variables to quantify change during recovery and the effect of rehabilitative interventions for consideration as digital biomarkers to quantify gait asymmetry

The 'questionableness' of things: opening up the conversation

The authors show, through its structure and form, what it means to open up a collaborative conversation. This chapter developed from a number of conversations that took place at the Fourth International Conference on Value and Virtue in Practice-Based Research, the twin themes of which were 'openness' and 'criticality'. These chance and often fleeting conversations focused on ideas explored in the keynote address that Jon delivered at the conference, but spanned out into a wider discussion of the relevance of those ideas within different areas of professional practice

Quantifying Reliable Walking Activity with a Wearable Device in Aged Residential Care: How Many Days Are Enough?

Strong associations exist between quality of life and physical activity for those living in aged residential care (ARC). Suitable and reliable tools are required to quantify physical activity for descriptive and evaluative purposes. We calculated the number of days required for reliable walking outcomes indicative of physical activity in an ARC population using a trunk-worn device. ARC participants (n = 257) wore the device for up to 7 days. Reasons for data loss were also recorded. The volume, pattern, and variability of walking was calculated. For 197 participants who wore the device for at least 3 days, linear mixed models determined the impact of week structure and number of days required to achieve reliable outcomes, collectively and then stratified by care level. The average days recorded by the wearable device was 5.2 days. Day of the week did not impact walking activity. Depending on the outcome and level of care, 2–5 days was sufficient for reliable estimates. This study provides informative evidence for future studies aiming to use a wearable device located on the trunk to quantify physical activity walking out in the ARC population

How professionals work and learn in digitalised work contexts: Insights from an Australian survey of Education Professionals

How professionals work and learn in digitalised work contexts The Australian Research Council Discovery project titled: “Investigating Professional Learning Lives in the digital evolution of work” (DP210100164) investigated how Education and Health professionals in Australia learn as they work in increasingly digitalised work contexts through a survey. The survey was sent to members of 11 Education and 10 Health Australian professional associations. The survey ran from August to November 2022. This report presents the findings of Education professionals’ responses to this survey (299 responses)

Gene expression profiling and expanded immunohistochemistry tests to guide selection of chemotherapy regimens in breast cancer management: a systematic review

OBJECTIVES: The aim of this report was to assess the clinical effectiveness of two Gene expression profiling (GEP) and two expanded immunohistochemistry (IHC) tests compared with current prognostic tools in guiding the use of adjuvant chemotherapy in patients with early breast cancer. METHODS: A systematic review of the evidence on clinical effectiveness of OncotypeDX, IHC4, MammaPrint and Mammostrat, compared with current clinical practice using clinicopathological parameters, in women with early breast cancer was conducted. Ten databases were searched to include citations to May 2016. RESULTS: Searches identified 7064 citations, of which 41 citations satisfied the criteria for the review. A narrative synthesis was performed. Evidence for OncotypeDX demonstrated the impact of the test on decision-making and there was some support for OncotypeDX predicting chemotherapy benefit. There were relatively lower levels of evidence for the other three tests included in the analysis. MammaPrint, Mammostrat and IHC4 tests were limited to a small number of studies. Limitations in relation to study design were identified for all tests. CONCLUSIONS: The evidence base for OncotypeDX is considered to be the most robust. Methodological weaknesses relating to heterogeneity of patient cohorts and issues arising from the retrospective nature of the evidence were identified. Further evidence is required for all of the tests using prospective randomised controlled trial data

Do infants with Down syndrome show an early receptive language advantage?

Purpose The study explored longitudinally the course of vocabulary and general language development in a group of infants with Down syndrome (DS) compared to a group of typically-developing (TD) infants matched on non-verbal mental ability (NVMA). Method We compared the vocabulary and general language trajectories of the two groups in two ways: a) at three time points during a 12 month period, and b) at 2 time points when the groups had made equal progress in non-verbal mental ability (a period of 6 months for the TD infants, versus 12 months for the infants with DS). Results The TD group had overtaken the DS group on all general language and vocabulary measures by the end of the 12-month period. However, expressive communication and expressive vocabulary were developing at the same rate and level in the two groups when examined over a period in which the two groups were matched in gains in non-verbal mental ability. Furthermore, the infants with DS showed a receptive language advantage over the TD group; this group’s auditory comprehension and receptive vocabulary scores were superior to those of the TD group at both time points when non-verbal mental ability was accounted for. Conclusion The results shed light on the widely reported discrepancy between expressive and receptive language in individuals with DS. Although infants with DS appear to be developing language skills more slowly than chronological age TD peers, when NVMA is taken into account, infants with DS do not have expressive language delays and they seem to show a receptive language advantage