250 research outputs found
Liver Resection after Downstaging Hepatocellular Carcinoma with Sorafenib
Background. Sorafenib is a molecular-targeted therapy used in palliative treatment of advanced hepatocellular carcinoma in Child A patients. Aims. To address the question of sorafenib as neoadjuvant treatment. Methods. We describe the cases of 2 patients who had surgery after sorafenib.
Results. The patients had a large hepatocellular carcinoma in the right liver with venous neoplastic thrombi (1 in the right portal branch, 1 in the right hepatic vein). After 9 months of sorafenib, reassessment showed that tumours had decreased in size with a necrotic component. A right hepatectomy with thrombectomy was performed, and histopathology showed 35% to 60% necrosis. One patient had a recurrence after 6 months and had another liver resection; they are both recurrence-free since then. Conclusion. Sorafenib can downstage hepatocellular carcinoma and thus could represent a bridge to surgery. It may be possible to select patients in good general condition with partial regression of the tumour with sorafenib for a treatment in a curative intent
Precision stellar radial velocity measurements with FIDEOS at the ESO 1-m telescope of La Silla
We present results from the commissioning and early science programs of
FIDEOS, the new high-resolution echelle spectrograph developed at the Centre of
Astro Engineering of Pontificia Universidad Catolica de Chile, and recently
installed at the ESO 1m telescope of La Silla. The instrument provides spectral
resolution R = 43,000 in the visible spectral range 420-800 nm, reaching a
limiting magnitude of 11 in V band. Precision in the measurement of radial
velocity is guaranteed by light feeding with an octagonal optical fibre,
suitable mechanical isolation, thermal stabilisation, and simultaneous
wavelength calibration. Currently the instrument reaches radial velocity
stability of = 8 m/s over several consecutive nights of observation
The Mass-Radius Relationship for Very Low Mass Stars: Four New Discoveries from the HATSouth Survey
We report the discovery of four transiting F-M binary systems with companions
between 0.1-0.2 Msun in mass by the HATSouth survey. These systems have been
characterised via a global analysis of the HATSouth discovery data, combined
with high-resolution radial velocities and accurate transit photometry
observations. We determined the masses and radii of the component stars using a
combination of two methods: isochrone fitting of spectroscopic primary star
parameters, and equating spectroscopic primary star rotation velocity with
spin-orbit synchronisation. These new very low mass companions are HATS550-016B
(0.110 -0.006/+0.005 Msun, 0.147 -0.004/+0.003 Rsun), HATS551-019B (0.17
-0.01/+0.01 Msun, 0.18 -0.01/+0.01 Rsun), HATS551-021B (0.132 -0.005/+0.014
Msun, 0.154 -0.008/+0.006 Rsun), HATS553-001B (0.20 -0.02/+0.01 Msun, 0.22
-0.01/+0.01 Rsun). We examine our sample in the context of the radius anomaly
for fully-convective low mass stars. Combining our sample with the 13 other
well-studied very low mass stars, we find a tentative 5% systematic deviation
between the measured radii and theoretical isochrone models.Comment: 17 pages, 8 figures, accepted for publication in MNRA
HATS-9b and HATS-10b: Two Compact Hot Jupiters in Field 7 of the K2 Mission
We report the discovery of two transiting extrasolar planets by the HATSouth
survey. HATS-9b orbits an old (10.8 1.5 Gyr) V=13.3 G dwarf star, with a
period P = 1.9153 d. The host star has a mass of 1.03 M, radius of
1.503 R and effective temperature 5366 70 K. The planetary
companion has a mass of 0.837 M, and radius of 1.065 R yielding a mean
density of 0.85 g cm . HATS-10b orbits a V=13.1 G dwarf star, with a
period P = 3.3128 d. The host star has a mass of 1.1 M, radius of 1.11
R and effective temperature 5880 120 K. The planetary companion
has a mass of 0.53 M, and radius of 0.97 R yielding a mean density of
0.7 g cm . Both planets are compact in comparison with planets receiving
similar irradiation from their host stars, and lie in the nominal coordinates
of Field 7 of K2 but only HATS-9b falls on working silicon. Future
characterisation of HATS-9b with the exquisite photometric precision of the
Kepler telescope may provide measurements of its reflected light signature.Comment: 15 pages, 10 figures, accepted for publication in A
HATS-17b: A Transiting Compact Warm Jupiter in a 16.3 Days Circular Orbit
We report the discovery of HATS-17b, the first transiting warm Jupiter of the
HATSouth network. HATS-17b transits its bright (V=12.4) G-type
(M=1.131 0.030 M,
R=1.091 R) metal-rich ([Fe/H]=+0.3 dex)
host star in a circular orbit with a period of P=16.2546 days. HATS-17b has a
very compact radius of 0.777 0.056 R given its Jupiter-like mass of
1.338 0.065 M. Up to 50% of the mass of HATS-17b may be composed of
heavy elements in order to explain its high density with current models of
planetary structure. HATS-17b is the longest period transiting planet
discovered to date by a ground-based photometric survey, and is one of the
brightest transiting warm Jupiter systems known. The brightness of HATS-17b
will allow detailed follow-up observations to characterize the orbital geometry
of the system and the atmosphere of the planet.Comment: 12 page, 8 figures, submitted to A
HATS-3b: An inflated hot Jupiter transiting an F-type star
We report the discovery by the HATSouth survey of HATS-3b, a transiting
extrasolar planet orbiting a V=12.4 F-dwarf star. HATS-3b has a period of P =
3.5479d, mass of Mp = 1.07MJ, and radius of Rp = 1.38RJ. Given the radius of
the planet, the brightness of the host star, and the stellar rotational
velocity (vsini = 9.0km/s), this system will make an interesting target for
future observations to measure the Rossiter-McLaughlin effect and determine its
spin-orbit alignment. We detail the low/medium-resolution reconnaissance
spectroscopy that we are now using to deal with large numbers of transiting
planet candidates produced by the HATSouth survey. We show that this important
step in discovering planets produces logg and Teff parameters at a precision
suitable for efficient candidate vetting, as well as efficiently identifying
stellar mass eclipsing binaries with radial velocity semi-amplitudes as low as
1 km/s.Comment: 11 pages, 10 figures, submitted to A
HATS-5b: A Transiting hot-Saturn from the HATSouth Survey
We report the discovery of HATS-5b, a transiting hot-Saturn orbiting a G type
star, by the HAT-South survey. HATS-5b has a mass of Mp=0.24 Mj, radius of
Rp=0.91 Rj, and transits its host star with a period of P=4.7634d. The radius
of HATS-5b is consistent with both theoretical and empirical models. The host
star has a V band magnitude of 12.6, mass of 0.94 Msun, and radius of 0.87
Rsun. The relatively high scale height of HATS-5b, and the bright,
photometrically quiet host star, make this planet a favourable target for
future transmission spectroscopy follow-up observations. We reexamine the
correlations in radius, equilibrium temperature, and metallicity of the
close-in gas-giants, and find hot Jupiter-mass planets to exhibit the strongest
dependence between radius and equilibrium temperature. We find no significant
dependence in radius and metallicity for the close-in gas-giant population.Comment: 10 pages, submitted to A
Increase of CXCR3+ T cells impairs Th17 cells recruitment in the small intestine mucosa through IFN-g and IL-18 during treated HIV-1 infection
The restoration of CD4+ T cells, especially T-helper type 17 (Th17) cells, remains incomplete in the gut mucosa of most human immunodeficiency virus type 1 (HIV-1)âinfected individuals despite sustained antiretroviral therapy (ART). Herein, we report an increase in the absolute number of CXCR3+ T cells in the duodenal mucosa during ART. The frequencies of Th1 and CXCR3+ CD8+ T cells were increased and negatively correlated with CCL20 and CCL25 expression in the mucosa. In ex vivo analyses, we showed that interferon Îł, the main cytokine produced by Th1 and effector CD8+ T cells, downregulates the expression of CCL20 and CCL25 by small intestine enterocytes, while it increases the expression of CXCL9/10/11, the ligands of CXCR3. Interleukin 18, a pro-Th1 cytokine produced by enterocytes, also contributes to the downregulation of CCL20 expression and increases interferon Îł production by Th1 cells. This could perpetuate an amplification loop for CXCR3-driven Th1 and effector CD8+ T cells recruitment to the gut, while impairing Th17 cells homing through the CCR6-CCL20 axis in treated HIV-1âinfected individuals
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