Memoria de restauración de la torre de Vallferosa (La Segarra, Lleida)

En este artículo se analizan los trabajos de restauración llevados a cabo en la torre de Vallferosa (La Segarra, Lleida) entre los años 2006 y 2009, siguiendo el proyecto redactado por los autores. Se expone en primer lugar el proceso de revalorización de este monumento en la historiografía reciente, en segundo lugar su marco legal, en tercer lugar los datos históricos básicos que se disponen de él, en cuarto lugar su descripción con anterioridad a la restauración, en quinto lugar las patologías que sufría en 2006, en sexto lugar los criterios seguidos en la intervención, y finalmente, en séptimo lugar, una relación sucinta de los trabajos llevados a cabo

Relacion entre factores meteorológicos y recuentos de pólenes de gramíneas causantes de alergias

Ponencia presentada en: IV Congreso de la Asociación Española de Climatología "El Clima entre el Mar y la Montaña", celebrado en Santander del 2 al 5 de noviembre de 2004.[ES]Los pólenes de gramíneas son la causa más importante de la fiebre del heno. Esta comunicación es desarrollo y ampliación de trabajos previos para hallar relaciones entre factores meteorológicos y cantidades totales de dichos pólenes en la ciudad de Madrid. Se establecen correlaciones entre diferentes combinaciones de totales de precipitación y temperaturas para los meses previos y durante la época de polinización en la zona centro de España: meses de mayo y junio. El periodo de datos utilizado abarca desde 1979 a 2001.Los resultados apuntan fundamentalmente a la importancia de las precipitaciones invernales previas a la temporada de floración por lo que puede ser utilizado como un predictor de la intensidad del fenómeno en la primavera siguiente.[EN]Grass pollens are the most important cause of hay fever in Spain. This communication is a development and improvement of previous works in order to find relationships between meteorological factors and total quantities of those pollens in the area of Madrid. Several correlations were found among different combinations of total of precipitation and temperatures for the previous months and during the pollination period in the central area of Spain: May and June. Data period ranges from 1979 to 2001. The importance of previous winter precipitations to the pollination season is highlighted. That factor could be used as a predictor for the intensity of the allergenic phenomenon in the following spring

A topical microemulsion for the prevention of allergic rhinitis symptoms: results of a randomized, controlled, double-blind, parallel group, multicentre, multinational clinical trial (Nares study)

Background: Since barrier protection measures to avoid contact with allergens are being increasingly developed, we assessed the clinical efficacy and tolerability of a topical nasal microemulsion made of glycerol esters in patients with allergic rhinitis. Methods: Randomized, controlled, double-blind, parallel group, multicentre, multinational clinical trial in which adult patients with allergic rhinitis or rhinoconjunctivitis due to sensitization to birch, grass or olive tree pollens received treatment with topical microemulsion or placebo during the pollen seasons. Efficacy variables included scores in the mini-RQLQ questionnaire, number and severity of nasal, ocular and lung signs and symptoms, need for symptomatic medications and patients" satisfaction with treatment. Adverse events were also recorded. Results: Demographic characteristics were homogeneous between groups and mini-RQLQ scores did not differ significantly at baseline (visit 1). From symptoms recorded in the diary cards, the ME group showed statistically significant better scores for nasal congestion (0.72 vs. 1.01; p = 0.017) and mean total nasal symptoms (0.7 vs. 0.9; p = 0.045). At visit 2 (pollen season), lower values were observed in the mini-RQLQ in the ME group, although there were no statistically significant differences between groups in both full analysis set (FAS) and patients completing treatment (PPS) populations. The results obtained in the nasal symptoms domain of the mini-RQLQ at visit 2 showed the highest difference (−0.43; 95% CI: -0.88 to 0.02) for the ME group in the FAS population. The topical microemulsion was safe and well tolerated and no major discomforts were observed. Satisfaction rating with the treatment was similar between the groups. Conclusions: The topical application of the microemulsion is a feasible and safe therapy in the prevention of allergic symptoms, particularly nasal congestion

Predicción de eventos extremos de polen alergénico en la Comunidad de Madrid. Inicio de la estación polínica del plátano de sombra

Ponencia presentada en: XXX Jornadas Científicas de la AME y el IX Encuentro Hispano Luso de Meteorología celebrado en Zaragoza, del 5 al 7 de mayo de 2008.Allergenic pollens originated health problems in a rising segment of population on developed countries. Adequate forecast of extreme health related events such peaks or start of pollination season could allow to take preventive measurement that reduce hospitalization cases and an improvement in life conditions for patients that are allergic to pollens. In central part of Spain, main species that originate such pollens are grasses, plane tree, olive tree and Cupressaceae. In Madrid autonomous region, PALINOCAM Network operates 11 pollen catchments stations and issues pollen forecasts daily. AEMET supports this structure providing observed and forecast meteorological data and also new prediction tools. In this paper, a description of plane tree start of pollination season forecast procedure is shown. Main basis is the fact that it is needed to reach a value threshold on previous heat accumulation that allow to plane tree buttons to grow and start spreading its pollen. Threshold adjustment procedure for accumulate heat and daily pollen accounts is described. Up to seven days of forecasted extreme temperatures are added to observed temperature series to give forecasted accumulated heat. An evaluation of an operational scheme for the start of pollination season in March 2008 for Madrid-City has been done

Predicción del inicio de la temporada de polinización del plátano de sombra en la Comunidad de Madrid y en la ciudad de Córdoba. Técnicas y resultados

Esta nota técnica es el resultado de un trabajo interdisciplinar en el que han intervenido meteorólogos, biólogos y médicos, con el objetivo final de mejorar la calidad de vida de las personas aquejadas por problemas de alergia. Con el fin de avanzar en el conocimiento de todos los aspectos ligados a la emisión de polen de plátano en primavera, poder así mejorar el actual sistema de vigilancia de dicho polen y optimizar los recursos del sistema sanitario, han colaborado AEMET, que ha aportado su banco de datos de variables meteorológicas para diferentes horas y distintos emplazamientos, y la Consejería de Salud de la Comunidad de Madrid, que ha proporcionado los recuentos de polen diarios de su red Palinocam. El objetivo de esta colaboración ha sido avanzar en el conocimiento de todos los aspectos ligados a la emisión del polen del plátano para poder predecir con antelación suficiente su aparición en la primavera

A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells

14 p.-8 fig.Functional Tregs play a key role in tumor development and progression, representing a major barrier to anticancer immunity. The mechanisms by which Tregs are generated in cancer and the influence of the tumor microenvironment on these processes remain incompletely understood. Herein, by using NMR, chemoenzymatic structural assays and a plethora of in vitro and in vivo functional analyses, we demonstrate that the tumoral carbohydrate A10 (Ca10), a cell-surface carbohydrate derived from Ehrlich’s tumor (ET) cells, is a heparan sulfate-related proteoglycan that enhances glycolysis and promotes the development of tolerogenic features in human DCs. Ca10-stimulated human DCs generate highly suppressive Tregs by mechanisms partially dependent on metabolic reprogramming, PD-L1, IL-10, and IDO. Ca10 also reprograms the differentiation of human monocytes into DCs with tolerogenic features. In solid ET-bearing mice, we found positive correlations between Ca10 serum levels, tumor size and splenic Treg numbers. Administration of isolated Ca10 also increases the proportion of splenic Tregs in tumor-free mice. Remarkably, we provide evidence supporting the presence of a circulating human Ca10 counterpart (Ca10H) and show, for the first time, that serum levels of Ca10H are increased in patients suffering from different cancer types compared to healthy individuals. Of note, these levels are higher in prostate cancer patients with bone metastases than in prostate cancer patients without metastases. Collectively, we reveal novel molecular mechanisms by which heparan sulfate-related structures associated with tumor cells promote the generation of functional Tregs in cancer. The discovery of this novel structural-functional relationship may open new avenues of research with important clinical implications in cancer treatment.The authors’ laboratories were supported by grants FEI 16_60 from Art.83 4154605 (138/2012)(24/2013), SAF-2017-84978-R from MINECO (Spain) and PID2020-114396RB-I00 from Ministerio de Ciencia e Innovación (Spain) to OP and PID2021-123781OB-C22 to FJC funded by MCIN/AEI/10.13039/501100011033 (Spain) and RTC-2015-3805-1 from MINECO to Inmunotek SL.Peer reviewe

Al-Bustān. Las fincas aristocráticas y la construcción de los paisajes periurbanos de al-Ándalus y Sicilia

Navarro Palazón, Julio, editorLa presente publicación se enmarca en el Proyecto I+D+i «Almunias medievales en el Mediterráneo: Historia y conservación de los paisajes culturales periurbanos» (PID2019-111508GB-I00, dirigido por Julio Navarro Palazón), del Ministerio de Ciencia e Innovación. Agencia Estatal de Investigación. Proyectos de I+D+i, de los Programas Estatales de Generación de Conocimiento y fortalecimiento Científico y Tecnológico del Sistema de I+D+i y de I+D+i Orientada a los Retos de la Sociedad, del Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020. Esta obra es también un fruto destacado del trabajo realizado en el marco de la Unidad Asociada de I+D+i Patrimonio Cultural Árabe e Islámico, Consejo Superior de Investigaciones Científicas-Universidad de Granada, a través de la Escuela de Estudios Árabes de Granad