Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence

Prohibitin 1 (PHB1) is a highly conserved protein that is mainly localized to the inner mitochondrial membrane and has been implicated in regulating mitochondrial function in yeast. Because mitochondria are emerging as an important regulator of vascular homeostasis, we examined PHB1 function in endothelial cells. PHB1 is highly expressed in the vascular system and knockdown of PHB1 in endothelial cells increases mitochondrial production of reactive oxygen species via inhibition of complex I, which results in cellular senescence. As a direct consequence, both Akt and Rac1 are hyperactivated, leading to cytoskeletal rearrangements and decreased endothelial cell motility, e.g., migration and tube formation. This is also reflected in an in vivo angiogenesis assay, where silencing of PHB1 blocks the formation of functional blood vessels. Collectively, our results provide evidence that PHB1 is important for mitochondrial function and prevents reactive oxygen species–induced senescence and thereby maintains the angiogenic capacity of endothelial cells

Abordaje de enfermería en el cuidado de niños con trastorno del espectro autista, desde la teoría del cuidado humanizado y la teoría: interacción para la evaluación de la salud infantil

Introduction: Autism spectrum disorders (ASD) are neuropsychiatric problems whose first manifestations appear before three years of age and persist throughout life. Objective: To recognize the nursing approach in the care of children with autism spectrum disorder, from the theory of humanized care and the theory: interaction for the evaluation of child health. Materials and method: This study is a systematic review, through the search equation in DeCS with the keywords: Autism, nursing, humanized care, in different databases. Results: Through Watson's theory, the nursing approach documented through the concepts: nurse/patient interaction, phenomenological field, transpersonal care relationship, moment of care, humanization can be fulfilled in the care of autistic children and their families. Also from Barnard's theory with the integration of theoretical elements: clarity of the child's messages, child's response to the caregiver, parental sensitivity to the child's signals, allowing work on the child's health of the child with ASD. Conclusion: Behavioral approaches produce positive results in children with ASD.Introducción: Los trastornos del espectro autista (TEA), son problemas neuropsiquiátricos cuyas primeras manifestaciones aparecen antes de los tres años de edad y persisten durante toda la vida. Objetivo: Reconocer el abordaje de enfermería en el cuidado de niños con trastorno del espectro autista, desde la teoría del cuidado humanizado y la teoría: interacción para la evaluación de la salud infantil. Materiales y método: El presente estudio es una revisión sistemática, por medio de la ecuación de búsqueda en DeCS con las palabras clave: Autismo, enfermería, cuidado humanizado, en diferentes bases de datos. Resultados: A través de la teoría de Watson el abordaje enfermero documentado a traves de los conceptos: interacción enfermera/paciente, campo fenomenológico, relación cuidado transpersonal, momento de cuidado, se puede dar cumplimiento a la humanización en la atención de niños autistas y sus familias. Asimismo desde la teoría de Barnard con la integración de los elementos teóricos: claridad de los mensajes del niño, respuesta del niño al cuidador, sensibilidad de los padres a las señales del hijo, permitiendo trabajar en la salud infantil del niño con TEA. Conclusión: Los acercamientos conductuales producen resultados positivos en niños con TEA

Abordaje de contextos desde los enfoques narrativos.

El presente documento se ha elaborado con el objetivo de realizar el análisis de los relatos de los casos de violencia y esperanza contenidos en el diplomado de profundización acompañamiento psicosocial en escenarios de violencia de la Universidad Nacional Abierta y a Distancia UNAD, mediante la lectura crítica y reflexiva que permitió comprender y dar inicio al abordaje de los relatos, los cuales brindaron herramientas de apoyo para lograr identificar la temática a realizar, su abordaje contribuyo significativamente para el desarrollo y aprendizaje de conocimientos previos, igualmente se seleccionó uno de los relatos de vida tomados del libro Voces: historias de violencia y esperanza en Colombia. Denominado: Relato 1. Jennifer Pinzón, para luego responder a dichas preguntas las cuales llevaban al estudiante al análisis reflexivo frente a las vivencias obtenidas tanto físicas, psicológicas y emocionales por la violencia de la época por parte de Jennifer pinzón. En ese mismo sentido, se resuelven preguntas orientadoras presentes en la guía de actividades, con el fin de brindar estrategias que contribuyeran a proponer y elaborar grupalmente interrogantes que se clasifican de la siguiente manera: circulares, reflexivas y estratégicas, cuya finalidad es generar una mayor comprensión del caso elegido. Por otra parte, también se realizó el análisis del caso Pandurí y se inició la propuesta de abordaje psicosocial, donde se permite proponer estrategias que nos ha brinda el presente diplomado, posteriormente se resolvieron interrogantes con el ánimo de generar parámetros fundamentales para fijar bases de la propuesta psicosocial del caso antes mencionado y esta a su vez ayudaron a generar resultados positivos. No obstante, teniendo claro el reflejo de una violencia vivida bajo el flagelo del horror, se expone el informe de la experiencia de ejercicio de la foto voz, donde queda plasmado las vivencias obtenidas de manera individual y grupal, su aporte logro suscitar la reflexión y desarrollar aspectos fundamentales que llevaron no solo al análisis visual sino ir más allá de la memoria histórica donde se guardan el pasado sin importar el daño que ha causado en nuestro país. Por último se encuentra el link colaborativo del blog y las referencias bibliográficas.The present document has been elaborated with the objective of carrying out the analysis of the stories of the cases of violence and hope contained in the diploma of deepening psychosocial accompaniment in scenarios of violence of the National Open University and Distance UNAD, through critical and reflexive reading that allowed us to understand and initiate the approach of the stories, which provided support tools to identify the theme to be carried out, its approach contributed significantly to the development and learning of previous knowledge, and one of the life stories taken from the Voices book: stories of violence and hope in Colombia. Denominated: Story 1. Jennifer Pinzón, to then respond to these questions which led the student to reflective analysis of the experiences obtained both physical, psychological and emotional violence of the time by Jennifer Chaffinch. In this same sense, orienting questions present in the activity guide are solved, in order to provide strategies that contribute to propose and elaborate group questions that are classified as follows: circular, reflexive and strategic, whose purpose is to generate a greater understanding of the chosen case. On the other hand, the analysis of the Pandurí case was also carried out and the psychosocial approach proposal was initiated, where it is possible to propose strategies that the present diploma has given us, later questions were resolved in order to generate fundamental parameters to establish bases of the psychosocial proposal of the aforementioned case and this in turn helped to generate positive results. However, having a clear reflection of a violence lived under the scourge of horror, the report of the experience of photo voice exercise is exposed, where the experiences obtained in an individual and group manner are captured, their contribution is able to provoke reflection and develop fundamental aspects that led not only to visual analysis but to go beyond the historical memory where the past is kept regardless of the damage it has caused in our country. Finally, there is the collaborative link of the blog and the bibliographical references

Genetic deficiency or pharmacological inhibition of miR-33 protects from kidney fibrosis

Previous work has reported the important links between cellular bioenergetics and the development of chronic kidney disease, highlighting the potential for targeting metabolic functions to regulate disease progression. More recently, it has been shown that alterations in fatty acid oxidation (FAO) can have an important impact on the progression of kidney disease. In this work, we demonstrate that loss of miR-33, an important regulator of lipid metabolism, can partially prevent the repression of FAO in fibrotic kidneys and reduce lipid accumulation. These changes were associated with a dramatic reduction in the extent of fibrosis induced in 2 mouse models of kidney disease. These effects were not related to changes in circulating leukocytes because bone marrow transplants from miR-33–deficient animals did not have a similar impact on disease progression. Most important, targeted delivery of miR-33 peptide nucleic acid inhibitors to the kidney and other acidic microenvironments was accomplished using pH low insertion peptides as a carrier. This was effective at both increasing the expression of factors involved in FAO and reducing the development of fibrosis. Together, these findings suggest that miR-33 may be an attractive therapeutic target for the treatment of chronic kidney disease

Adaptando estrategias pedagógicas a los estilos de aprendizaje en educación primaria y secundaria: un enfoque integrador

This study addresses the influence of learning styles on the effectiveness of pedagogical strategies in primary and secondary education. Utilizing a mixed approach that combines literature review, surveys, interviews with educators, and case study analysis, the diversity of learning styles in young students is highlighted, with an emphasis on the importance of adapting teaching methodologies. A varied preference for visual, auditory, kinesthetic, and reading/writing styles is observed. Despite the recognition of the need for adaptation by educators, significant challenges related to resource availability and teacher training are identified. The findings indicate that the implementation of adaptive strategies improves both academic performance and student satisfaction, underscoring the need for flexible pedagogical practices and ongoing training for teachers at early educational levels.Este estudio abordó la influencia de los estilos de aprendizaje en la eficacia de las estrategias pedagógicas en la educación primaria y secundaria. Utilizando un enfoque mixto que combina revisión de literatura, encuestas, entrevistas con educadores y análisis de estudios de caso, se destaca la diversidad de estilos de aprendizaje en estudiantes jóvenes, con énfasis en la importancia de adaptar las metodologías de enseñanza. Se observa una variada preferencia por estilos visuales, auditivos, kinestésicos y de lectura/escritura. A pesar del reconocimiento de la necesidad de adaptación por parte de los educadores, se identifican desafíos significativos relacionados con la disponibilidad de recursos y la formación docente. Los hallazgos indican que, la implementación de estrategias adaptativas, mejora tanto el rendimiento académico como la satisfacción estudiantil, subrayando la necesidad de prácticas pedagógicas flexibles y formación continua para docentes en niveles educativos tempranos

Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening, had elevated FPG, HbA1c or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardized proportion of diabetes that was previously undiagnosed and detected in survey screening ranged from 30% in the high-income western region to 66% in south Asia. Among those with screen-detected diabetes with either test, the age-standardized proportion who had elevated levels of both FPG and HbA1c was 29-39% across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c was more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global shortfall in diabetes diagnosis and surveillance

Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI <18·5 kg/m2) and obesity (BMI ≥30 kg/m2). For schoolaged children and adolescents, we report thinness (BMI <2 SD below the median of the WHO growth reference) and obesity (BMI >2 SD above the median). Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining underweight or thinness. Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesit

Global variations in diabetes mellitus based on fasting glucose and haemogloblin A1c

Fasting plasma glucose (FPG) and haemoglobin A1c (HbA1c) are both used to diagnose diabetes, but may identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening had elevated FPG, HbA1c, or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardised proportion of diabetes that was previously undiagnosed, and detected in survey screening, ranged from 30% in the high-income western region to 66% in south Asia. Among those with screen-detected diabetes with either test, the agestandardised proportion who had elevated levels of both FPG and HbA1c was 29-39% across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global gap in diabetes diagnosis and surveillance.peer-reviewe

Intervención del trabajador social para el fortalecimiento de las estrategias metodológicas con grupo juveniles beneficiarios de los proyectos de desarrollados en el secretariado de pastoral social de la ciudad de Cartagena de indias. Año 2006

Reflexión teórica, metodológico y epistemológica sobre el proceso de intervención frente a la articulación teórica práctica, así como el de los aprendizajes adquiridos en cuanto al desarrollo de destrezas, habilidades, competencias y capacidades en la formación integral del estudiante.PregradoTrabajador(a) Socia

Intervención del trabajador social para el fortalecimiento de las estrategias metodológicas con grupo juveniles beneficiarios de los proyectos de desarrollados en el secretariado de pastoral social de la ciudad de Cartagena de indias. Año 2006

Tesis (Trabajadora Social) -- Universidad de Cartagena. Facultad de Ciencias Sociales y Educación. Programa de Trabajo Social, 2006Reflexión teórica, metodológica y epistemológica sobre el proceso de intervención frente a la articulación teoría práctica, como aprendizajes adquiridos, destrezas, habilidades, competencias y capacidades en la formación del estudiante