3,119 research outputs found

    Benign Bilateral Adenomyoepithelioma of the Mammary Gland in a Ring-tailed Lemur (Lemur catta)

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    Naturally occurring mammary tumours are uncommon in prosimians. A 20-year-old female ring-tailed lemur (Lemur catta) developed bilateral enlargement of the mammary glands. Surgical removal revealed that both masses were comprised of multiple nodules and cystic areas that entirely replaced the normal glands. Histologically, a benign neoplastic biphasic cellular proliferation, composed of luminal–epithelial and basal–myoepithelial components, was identified. Immunohistochemical analysis for expression of cytokeratin (CK) AE1/AE3, CK7, CK5 + 8, CK14, vimentin, p63 and 14-3-3σ highlighted the biphasic nature of the neoplasm. A low mitotic count, low Ki67 labelling index, expression of oestrogen receptor-α, lack of expression of human epidermal growth factor receptor and a 3-year disease-free period without recurrence supported the benign nature of the tumour. Macroscopically, histologically and immunohistochemically this neoplasm resembled benign adenomyoepithelioma of the breast in women. This is the first complete report of a naturally occurring mammary tumour in a ring-tailed lemur

    Diagnosis of anaplastic large-cell lymphoma in a dog using CD30 immunohistochemistry

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    Anaplastic large-cell lymphoma or null-cell lymphoma is a clinical entity reported in people, classified according to the unique appearance of large pleomorphic cells that express CD30. Null-cell lymphoma has also been described in dogs when neither CD3 nor CD79α is expressed by the tumor. We describe a case of lymphoma in the dog in which neoplastic cells did not express routine B- or T-lymphocyte markers on flow cytometry or immunohistochemistry; however, cells immunohistochemically labeled for CD30. The dog in our case died 5 mo after initial presentation, confirming a poor prognosis. Identification of further similar cases in dogs would provide additional prognostic information for this subset of lymphomas. CD30 may also serve as a potential therapeutic target in anaplastic large-cell lymphomas

    VISIR-VLT high resolution study of the extended emission of four obscured post-AGB candidates

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    The onset of the asymmetry of planetary nebulae (PNe) is expected to occur during the late Asymptotic Giant Branch (AGB) and early post-AGB phases of low- and intermediate-mass stars. Among all post-AGB objects, the most heavily obscured ones might have escaped the selection criteria of previous studies detecting extreme axysimmetric structures in young PNe. Since the most heavily obscured post-AGB sources can be expected to descend from the most massive PN progenitors, these should exhibit clear asymmetric morphologies. We have obtained VISIR-VLT mid-IR images of four heavily obscured post-AGB objects barely resolved in previous Spitzer IRAC observations to analyze their morphology and physical conditions across the mid-IR. The VISIR-VLT images have been deconvolved, flux calibrated, and used to construct RGB composite pictures as well as color and optical depth maps that allow us to study the morphology and physical properties of the extended emission of these sources. We have detected extended emission from the four objects in our sample and resolved it into several structural components that are greatly enhanced in the temperature and optical depth maps. They reveal the presence of asymmetry in three young PNe (IRAS 15534-5422, IRAS 17009-4154, and IRAS 18454+0001), where the asymmetries can be associated with dusty torii and slightly bipolar outflows. The fourth source (IRAS 18229-1127), a possible post-AGB star, is better described as a rhomboidal detached shell. The heavily obscured sources in our sample do not show extreme axisymmetric morphologies. This is at odds with the expectation of highly asymmetrical morphologies in post-AGB sources descending from massive PN progenitors. The sources presented in this paper may be sampling critical early phases in the evolution of massive PN progenitors, before extreme asymmetries develop.Comment: 9 pages, 4 figure

    gOntt, a Tool for Scheduling and Executing Ontology Development Projects

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    Nowadays the ontology engineering field does not have any method that guides ontology practitioners when planning and scheduling their ontology development projects. The field also lacks the tools that help ontology practitioners to plan, schedule, and execute such projects. This paper tries to contribute to the solution of these problems by proposing the identification of two ontology life cycle models, the definition of the methodological basis for scheduling ontology projects, and a tool called gOntt that (1) supports the scheduling of ontology developments and (2) helps to execute such development projects

    Cerámica campaniforme de Galicia (NW de España): Caracterización arqueométrica y estudio de procedencia de algunos yacimientos representativos

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    Se describen los resultados del estudio arqueométrico (composición mineral y elemental) de 55 muestras de recipientes campaniformes recuperadas en 8 yacimientos arqueológicos del NW de la Península Ibérica. Las muestras son representativas de la variación formal de la cerámica (tanto lisa como decorada) y del tipo de contextos (ceremonial, doméstico y funerario) donde las cerámicas campaniformes fueron encontradas en la región. Las composiciones mineral y elemental mostraron un alto grado de coherencia. La mayor parte de los recipientes tenía composiciones con proporciones variables de feldespato potásico y plagioclasa, o de plagioclasa y anfíbol, coherentes con la litología local. También se encontraron composiciones mezcla de feldespato potásico y anfíbol, que no se encuentran de forma natural en los materiales geológicos del entorno, lo que apunta a una mezcla intencional de materias primas. La cerámica campaniforme, comparada con la de otros períodos previos, muestra fuertes cambios en relación con el estilo, pero mantiene una continuidad en cuanto al uso de los recursos de materia prima. No se encontró relación entre aspectos formales y la composición de la cerámica. La mayor parte de la cerámica estudiada procede probablemente del entorno de los yacimientos. Un análisis de distancias a las áreas potenciales para los materiales, empleando un sistema de información geográfica, sugiere que prácticamente todas pueden encontrarse en un radio de 16 km (la mayoría entre 2 y 5 km), lo que implica una a dos horas. Parece que el esfuerzo asociado a las cerámicas de contextos ceremoniales fue mayor que el de la cerámica de contextos funerarios y de asentamientoWe describe the results of an archaeometric study (mineral and elemental composition) of 55 samples from Bell Beaker vessels recovered from 8 archaeological sites in the northwest of the Iberian Peninsula. The samples are representative of the formal variation of the pottery (both decorated and undecorated) and type of contexts (ceremonial, domestic and funerary) in which Bell Beaker pottery is found in the region. Both, mineral and elemental composition were found to be highly consistent. Most of the vessels had compositions resulting from mixtures of potassium feldspar and plagioclase or plagioclase and amphibole, which are coherent with the local lithology. A few pottery samples showed a mixed composition of potassium feldspar and amphibole, which is not found naturally in the surrounding geological materials, indicating an intentional mixing of different raw materials. Compared to previous periods, Bell Beaker pottery represented a significant change in terms of style but continuity in terms of the use of raw materials. No relationship was found between the formal aspects and the composition of the pottery. Most of the samples we studied were probably manufactured with materials obtained from the area around the sites. An analysis of distances to potential source areas for the materials, using a geographical information system, indicates that almost all can be found within a radius of 16 km (most between 2-5 km), implying between one and two hours walk. A greater effort seems to have been associated to pottery of ceremonial sites compared to funerary and settlement sites

    Growth of InP on GaAs (001) by hydrogen-assisted low-temperature solid-source molecular beam epitaxy

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    Direct heteroepitaxial growth of InP layers on GaAs (001) wafers has been performed by solid-source molecular beam epitaxy assisted by monoatomic hydrogen (H∗). The epitaxial growth has been carried out using a two-step method: for the initial stage of growth the temperature was as low as 200 °C and different doses of H∗ were used; after this, the growth proceeded without H∗ while the temperature was increased slowly with time. The incorporation of H∗ drastically increased the critical layer thickness observed by reflection high-energy electron diffraction; it also caused a slight increase in the luminescence at room temperature, while it also drastically changed the low-temperature luminescence related to the presence of stoichiometric defects. The samples were processed by rapid thermal annealing. The annealing improved the crystalline quality of the InP layers measured by high-resolution x-ray diffraction, but did not affect their luminescent behavior significantly
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