Care and the self: biotechnology, reproduction, and the good life

This paper explores a novel philosophy of ethical care in the face of burgeoning biomedical technologies. I respond to a serious challenge facing traditional bioethics with its roots in analytic philosophy. The hallmarks of these traditional approaches are reason and autonomy, founded on a belief in the liberal humanist subject. In recent years, however, there have been mounting challenges to this view of human subjectivity, emerging from poststructuralist critiques, such as Michel Foucault's, but increasingly also as a result of advances in biotechnology itself. In the face of these developments, I argue that the theoretical relevance and practical application of mainstream bioethics is increasingly under strain. Traditionalists will undoubtedly resist. Together, professional philosopher-bioethicists, public health policymakers, and the global commercial healthcare industry tend to respond conservatively by shoring up the liberal humanist subject as the foundation for medical ethics and consumer decision-making, appealing to the familiar tropes of reason, autonomy, and freedom

The Living from the Dead

In a society that aims above all to safeguard life, how might we reckon with ethical responsibility when we are complicit in sacrificial economies that produce and tolerate death as a necessity of life?Arguing that biopower can be fully exposed only through an analysis of those whom society has “let die,” Stuart J. Murray employs a series of transdisciplinary case studies to uncover the structural and rhetorical conditions through which biopower works. These case studies include the concept of “sacrifice” in the “war” against COVID-19, where emergent cultures of pandemic “resistance” are explored alongside suicide bombings and military suicides; the California mass hunger strikes of 2013; legal cases involving “preventable” and “untimely” childhood deaths, exposing the irreconcilable claims of anti-vaxxers and Indigenous peoples; and the videorecording of the death of a disabled Black man. Murray demonstrates that active resistance to biopower inevitably reproduces tropes of “making live” and “letting die.” His counter to this fact is a critical stance of disaffirmation, one in which death disrupts the politics of life itself.A philosophically nuanced critique of biopower, The Living from the Dead is a meditation on life, death, power, language, and control in the twenty-first century. It will appeal to students and scholars of rhetoric, philosophy, and critical theory

Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML

Pharmacological targeting of BTK using ibrutinib has recently shown encouraging clinical activity in a range of lymphoid malignancies. Recently we reported that ibrutinib inhibits human acute myeloid leukemia (AML) blast proliferation and leukemic cell adhesion to the surrounding bone marrow stroma cells. Here we report that in human AML ibrutinib, in addition, functions to inhibit SDF1/CXCR4-mediated AML migration at concentrations achievable in vivo. It has previously been shown that SDF1/CXCR4-induced migration is dependent on activation of downstream BTK in chronic lymphocytic leukaemia (CLL) and multiple myeloma. Here we show that SDF-1 induces BTK phosphorylation and downstream MAPK signalling in primary AML blast. Furthermore, we show that ibrutinib can inhibit SDF1-induced AKT and MAPK activation. These results reported here provide a molecular mechanistic rationale for clinically evaluating BTK inhibition in AML patients and suggests that in some AML patients the blasts count may initially rise in response to ibrutinib therapy, analgous to similar clinical observations in CLL

Governing through community-based research: Lessons from the Canadian HIV research sector

AbstractThe “general public” and specific “communities” are increasingly being integrated into scientific decision-making. This shift emphasizes “scientific citizenship” and collaboration between interdisciplinary scientists, lay people, and multi-sector stakeholders (universities, healthcare, and government). The objective of this paper is to problematize these developments through a theoretically informed reading of empirical data that describes the consequences of bringing together actors in the Canadian HIV community-based research (CBR) movement. Drawing on Foucauldian “governmentality” the complex inner workings of the impetus to conduct collaborative research are explored. The analysis offered surfaces the ways in which a formalized approach to CBR, as promoted through state funding mechanisms, determines the structure and limits of engagement while simultaneously reinforcing the need for finer grained knowledge about marginalized communities. Here, discourses about risk merge with notions of “scientific citizenship” to implicate both researchers and communities in a process of governance

Larval behaviour, dispersal and population connectivity in the deep sea

Ecosystem connectivity is an essential consideration for marine spatial planning of competing interests in the deep sea. Immobile, adult communities are connected through freely floating larvae, depending on new recruits for their health and to adapt to external pressures. We hypothesize that the vertical swimming ability of deep-sea larvae, before they permanently settle at the bottom, is one way larvae can control dispersal. We test this hypothesis with more than 3x108 simulated particles with a range of active swimming behaviours embedded within the currents of a high-resolution ocean model. Despite much stronger horizontal ocean currents, vertical swimming of simulated larvae can have an order of magnitude impact on dispersal. These strong relationships between larval dispersal, pathways, and active swimming demonstrate that lack of data on larval behaviour traits is a serious impediment to modelling deep-sea ecosystem connectivity; this uncertainty greatly limits our ability to develop ecologically coherent marine protected area networks

Thepolitics of evidence on “domestic terrorists”: obesity discourses and their effects,”

Abstract The recent construction of an 'obesity epidemic' has been fueled by epidemiologically-based studies recuperated by the media and suggesting the rapid acceleration of obesity rates in the Western world. Studies linking obesity to ill-health have also exploded with more recipes on how to wage 'a war' on obesity and dispose of 'domestic terrorists.' In this paper, we assert that the fabrication of 'evidence' in obesity research constitutes a good example of micro-fascism at play in the contemporary scientific arena. Favoring a particular ideology and excluding alternative forms of knowledge, obesity scientists have established a dominant 'obesity discourse' within which obese and 'at-risk' bodies are constructed as lazy and expensive bodies that should be submitted to disciplinary technologies (for example, surveillance), expert investigation and regulation. Using a poststructuralist approach, we examine the politics of evidence in obesity science and explore the connections between obesity discourses and the ways in which health and the body are discursively constructed by Canadian youth. Social Theory & Health (2010) 8, 259-279. doi:10.1057/sth.2009 Keywords: body; obesity; health; youth; discourse analysis; poststructuralist theory Obesity and 'Evidence' Few North Americans will have escaped the avalanche of scientific and public comments about obesity in recent years. Escalating concerns over an 'obesity epidemic' have been fueled by the epidemiological, physiological and medical

Tracking the rapid loss of tidal wetlands in the Yellow Sea

In the Yellow Sea region of East Asia, tidal wetlands are the frontline ecosystem protecting a coastal population of more than 60 million people from storms and sea-level rise. However, unprecedented coastal development has led to growing concern about the status of these ecosystems. We developed a remote-sensing method to assess change over ∼4000 km of the Yellow Sea coastline and discovered extensive losses of the region's principal coastal ecosystem - tidal flats - associated with urban, industrial, and agricultural land reclamations. Our analysis revealed that 28% of tidal flats existing in the 1980s had disappeared by the late 2000s (1.2% annually). Moreover, reference to historical maps suggests that up to 65% of tidal flats were lost over the past five decades. With the region forecast to be a global hotspot of urban expansion, development of the Yellow Sea coastline should pursue a course that minimizes the loss of remaining coastal ecosystems

High-resolution global maps of tidal flat ecosystems from 1984 to 2019

Assessments of the status of tidal flats, one of the most extensive coastal ecosystems, have been hampered by a lack of data on their global distribution and change. Here we present globally consistent, spatially-explicit data of the occurrence of tidal flats, defined as sand, rock or mud flats that undergo regular tidal inundation. More than 1.3 million Landsat images were processed to 54 composite metrics for twelve 3-year periods, spanning four decades (1984–1986 to 2017–2019). The composite metrics were used as predictor variables in a machine-learning classification trained with more than 10,000 globally distributed training samples. We assessed accuracy of the classification with 1,348 stratified random samples across the mapped area, which indicated overall map accuracies of 82.2% (80.0–84.3%, 95% confidence interval) and 86.1% (84.2–86.8%, 95% CI) for version 1.1 and 1.2 of the data, respectively. We expect these maps will provide a means to measure and monitor a range of processes that are affecting coastal ecosystems, including the impacts of human population growth and sea level rise