A phenomenographic study of English faculty's conceptions of information literacy

The purpose of this research is to identify UK English academics' conceptions of information literacy and compare those conceptions with current information literacy standards and frameworks

The governance of European security

This article seeks to develop a concept of ‘security governance’ in the context of post-Cold War Europe. The validity of a governance approach lies in its ability to locate some of the distinctive ways in which European security has been coordinated, managed and regulated. Based on an examination of the way governance is utilised in other political fields of political analysis, the article identifies the concept of security governance as involving the coordinated management and regulation of issues by multiple and separate authorities, the interventions of both public and private actors (depending upon the issue), formal and informal arrangements, in turn structured by discourse and norms, and purposefully directed toward particular policy outcomes. Three issues are examined to demonstrate the utility of the concept of security governance for understanding security in post-Cold War Europe: the transformation of NATO, the Europeanisation of security accomplished through EU-led initiatives and, finally, the resultant dynamic relationship between forms of exclusion and inclusion in governance

Comparaison des conceptions pédagogiques de la maîtrise de l\u27information chez des universitaires britanniques de différentes disciplines

Intervention aux 5èmes Rencontres FORMIST (Lyon, 9 juin 2005). Cette communication décrit et compare les résultats d\u27une enquête sur les conceptions que des universitaires britanniques de deux disciplines (le marketing et l\u27anglais) ont de la pédagogie de la maîtrise de l\u27information

Dynamic operation of amine scrubbing in response to electricity demand and pricing

AbstractThis paper examines dynamic operation of CO2 capture with absorption/stripping using 7 m MEA, where the absorber is operated at full capacity with the stripper at reduced load. Depending on the cost of CO2 emissions, doing so in response to variations in electricity demand could improve annual profits by $10–$100 million or more at facilities with CO2 capture. Dynamic scenarios were simulated with a controlled, constant ratio of heat rate and solvent rate. With an 80% load reduction, scenarios that turn CO2 capture off and on affect stripper performance only slightly and reach the steady state in about 90 and 18 minutes respectively

Développer des conditions pédagogiques pour la culture informationnelle : l’impact des contextes disciplinaires

L’objectif de cette recherche était d’étudier les conceptions de la culture informationnelle des enseignants-chercheurs du Royaume-Uni et la pédagogie qu’ils utilisent pour l’enseigner, en lien avec leur discipline. Ce projet sur trois ans (novembre 2002 – octobre 2005) a reçu un financement de 130 000 livres de l’Arts and humanities research council (AHRC). La méthode de recherche suivie est la phénoménographie, suivant le modèle utilisé par C. Bruce (1997). 20 interviews ont été menées dans..

Pediatric Transplantation in the United States, 1995–2004

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72899/1/j.1600-6143.2006.01271.x.pd

Kidney after nonrenal transplantation-the impact of alemtuzumab induction

BACKGROUND.: Calcineurin inhibitor nephrotoxicity in nonrenal allograft recipients can lead to end-stage renal disease and the need for kidney transplantation. We sought to evaluate the role of alemtuzumab induction in this population. PATIENTS AND METHODS.: We evaluated 144 patients undergoing kidney transplantation after nonrenal transplantation between May 18, 1998, and October 8, 2007. Seventy-two patients transplanted between January 15, 2003, and October 8, 2007, received alemtuzumab induction and continued their pretransplant immunosuppression. Seventy-two patients transplanted between May 18, 1998, and July 21, 2007, did not receive alemtuzumab induction, but received additional steroids and maintenance immunosuppression. Donor and recipient demographics were comparable. RESULTS.: Overall, 1-and 3-year patient survival and renal function were comparable between the two groups. One-and 3-year graft survival was 93.0% and 75.3% in the alemtuzumab group and 83.3% and 68.7% in the no alemtuzumab group, respectively (P=0.051). The incidence of acute rejection was lower in the alemtuzumab group, 15.3%, than in the no alemtuzumab group, 41.7% (P=0.0001). The incidence of delayed graft function was lower in the alemtuzumab group, 9.7%, than in the no alemtuzumab group, 25.0% (P=0.003). The incidence of viral complications was comparable. CONCLUSION.: Alemtuzumab induction with simple resumption of baseline immunosuppression in patients undergoing kidney transplantation after nonrenal transplantation represents a reasonable immunosuppressive strategy. Copyright © 2009 by Lippincott Williams & Wilkins

5es Rencontres FORMIST - 2005

Actes des 5èmes Rencontres FORMIST qui se sont déroulées à Lyon le 9 juin 2005. Compétences informationnelles pour une meilleure insertion universitaire ; Le développement des compétences informationnelles à l\u27université de Laval ; Comparaison des conceptions pédagogiques de la maîtrise de l\u27information chez des universitaires britanniques de différentes disciplines ; Quelle recherche d\u27information pour une discipline donnée ? ; La relation de la discipline à la documentation en philosophie ; Mise en place d\u27un programme de formation documentaire en théologie et science des religions ; La relation entre discipline et documentation et ses répercussions dans les formations à l\u27information en sciences de la vie ; A l\u27ouest, du nouveau ? Regards sur quelques pratiques américaines

Neurokinin B Receptor Antagonism in Women with Polycystic Ovary Syndrome: A Randomized, Placebo-Controlled Trial

Context: Polycystic ovary syndrome (PCOS), the most common endocrinopathy in women, is characterized by high secretion levels of LH and T. Currently, there is no treatment licensed specifically for PCOS. Objective: The objective of this study was to investigate whether a targeted therapy would decrease LH pulse frequency in women with PCOS, subsequently reducing serum LH and T concentrations and thereby presenting a novel therapeutic approach to the management of PCOS. Design: This study is a double-blind, double-dummy, placebo-controlled, phase 2 trial. Settings: University hospitals and private clinical research centers were included. Participants: Women with PCOS aged 18–45 years participated. Intervention: Intervention included AZD4901 (a specific neurokinin-3 [NK3] receptor antagonist) at a dose of 20, 40, or 80 mg/day or matching placebo for 28 days. Main Outcome Measure: Change from baseline in the area under the LH serum concentration–time curve over 8 hours (area under the curve) on day 7 relative to placebo was measured. Results: Of a total 67 randomized patients, 65 were evaluable. On day 7, the following baseline-adjusted changes relative to placebo were observed in patients receiving AZD4901 80 mg/day: 1) a reduction of 52.0% (95% confidence interval [CI], 29.6–67.3%) in LH area under the curve; 2) a reduction of 28.7% (95% CI, 13.9–40.9%) in total T concentration; and 3) a reduction of 3.55 LH pulses/8 hours (95% CI, 2.0–5.1) (all nominal P &amp;lt; .05). Conclusions: The NK3 receptor antagonist AZD4901 specifically reduced LH pulse frequency and subsequently serum LH and T concentrations, thus presenting NK3 receptor antagonism as a potential approach to treating the central neuroendocrine pathophysiology of PCOS. </jats:sec

Neuroblastoma arginase activity creates an immunosuppressive microenvironment that impairs autologous and engineered immunity

Neuroblastoma is the most common extra cranial solid tumour of childhood, and survival remains poor for patients with advanced disease. Novel immune therapies are currently in development, but clinical outcomes have not matched preclinical results. Here, we describe key mechanisms in which neuroblastoma inhibits the immune response. We show that murine and human neuroblastoma tumour cells suppress T cell proliferation, through increased arginase activity. Arginase II is the predominant isoform expressed and creates an arginine deplete local and systemic microenvironment. Neuroblastoma arginase activity results in inhibition of myeloid cell activation and suppression of bone marrow CD34+ progenitor proliferation. Finally we demonstrate that the arginase activity of neuroblastoma impairs NY-ESO-1 specific TCR and GD2-specific CAR engineered T cell proliferation and cytotoxicity. High arginase II expression correlates with poor survival for neuroblastoma patients. The results support the hypothesis that neuroblastoma creates an arginase-dependent immunosuppressive microenvironment in both the tumour and blood that leads to impaired immune surveillance and sub-optimal efficacy of immunotherapeutic approaches