A new genus and species of sabretooth, Oriensmilus liupanensis (Barbourofelinae, Nimravidae, Carnivora), from the middle Miocene of China suggests barbourofelines are nimravids, not felids

Since the early 2000s, a revival of a felid relationship for barbourofeline sabretooths has become popular due to recent discoveries of fragmentary fossils from Africa. According to this view, barbourofelines trace their common ancestor with felids through shared similarities in dental morphology going back to the early Miocene of Africa and Europe. However, whether or not such an idea is represented in the basicranial morphology, a conservative area of high importance in family-level relationships, is yet to be tested. A nearly complete skull of Oriensmilus liupanensis gen. and sp. nov. from the middle Miocene Tongxin Basin of northern China represents the most primitive known barbourofeline with an intact basicranial region, affording an opportunity to re-examine the relationship of felids and nimravines. We also present an update on East Asian records of barbourofelines. The new skull of Oriensmilus possesses a suite of characters shared with nimravines, such as the lack of an ossified (entotympanic) bullar floor, absence of an intrabullar septum, lack of a ventral promontorial process of the petrosal, presence of a small rostral entotympanic on the dorsal side of the caudal entotympanic, and a distinct caudal entry of the internal carotid artery and nerve that pierces the caudal entotympanic at the junction of the ossified and unossified caudal entotympanics. The absence of an ossified bullar floor in O. liupanensis and its presence in those from the middle Miocene of Sansan, France thus help to bracket the transition of this character, which must have happened in the early part of the middle Miocene. Spatial relationships between bullar construction and the middle ear configuration of the carotid artery in Oriensmilus strongly resemble those in nimravines but are distinctly different from felids and other basal feliforms. Despite the attractive notion that early barbourofelines arose from a Miocene ancestor that also gave rise to felids, the basicranial evidence argues against this view. http://zoobank.org/urn:http://lsid:zoobank.org:pub:2DE98DBC-4D02-4E18-9788-0B0D8587E73F

Theories of developmental dyslexia: Insights from a multiple case study of dyslexic adults

A multiple case study was conducted in order to assess three leading theories of developmental dyslexia: the phonological, the magnocellular (auditory and visual) and the cerebellar theories. Sixteen dyslexic and 16 control university students were administered a full battery of psychometric, phonological, auditory, visual and cerebellar tests. Individual data reveal that all 16 dyslexics suffer from a phonological deficit, 10 from an auditory deficit, 4 from a motor deficit, and 2 from a visual magnocellular deficit. Results suggest that a phonological deficit can appear in the absence of any other sensory or motor disorder, and is sufficient to cause a literacy impairment, as demonstrated by 5 of the dyslexics. Auditory disorders, when present, aggravate the phonological deficit, hence the literacy impairment. However, auditory deficits cannot be characterised simply as rapid auditory processing problems, as would be predicted by the magnocellular theory. Nor are they restricted to speech. Contrary to the cerebellar theory, we find little support for the notion that motor impairments, when found, have a cerebellar origin, or reflect an automaticity deficit. Overall, the present data support the phonological theory of dyslexia, while acknowledging the presence of additional sensory and motor disorders in certain individuals

E.B. White Correspondence

Entries include a brief biography, a typed and a hand written letter on personal stationery, and a copy of a review articl

Performance of downscaled regional climate simulations using a variable-resolution regional climate model : Tasmania as a test case

In this study we develop methods for dynamically downscaling output from six general circulation models (GCMs) for two emissions scenarios using a variable-resolution atmospheric climate model. The use of multiple GCMs and emissions scenarios gives an estimate of model range in projected changes to the mean climate across the region. By modeling the atmosphere at a very fine scale, the simulations capture processes that are important to regional weather and climate at length scales that are subgrid scale for the host GCM. We find that with a multistaged process of increased resolution and the application of bias adjustment methods, the ability of the simulation to reproduce observed conditions improves, with greater than 95% of the spatial variance explained for temperature and about 90% for rainfall. Furthermore, downscaling leads to a significant improvement for the temporal distribution of variables commonly used in applied analyses, reproducing seasonal variability in line with observations. This seasonal signal is not evident in the GCMs. This multistaged approach allows progressive improvement in the skill of the simulations in order to resolve key processes over the region with quantifiable improvements in the correlations with observations

Assessment of the Water Quality in the Salt River Prior to Its Impoundment in Anderson and Spencer Counties, Kentucky

Monthly water samples were taken and analyzed to determine the water quality of the Salt River in Anderson and Spencer counties Kentucky prior to the river\u27s impoundment. Sediments from the area watershed were analyzed to total acid digestion, barium chloride extraction, and aqueous extraction methods. Rainwater and runoff water were collected and analyzed for major cations and anions from two sites in the watershed. The Salt River at Taylorsville is characterized by hard water with high levels of calcium (33.5-74.8 mg/1), bicarbonate (136-236 mg/l), specific conductance (200-535 μmhos/cm), and sulfate (16.5-71.5 mg/l). Nitrates (0.6-5.7 mg/l), phosphates (0.2-2.4 mg/l), sodium (3.2-20.3 mg/l), and potassium (1.3-5.6 mg/l), are moderate. Iron, manganese, copper, and nitrites are less than 0.5 mg/1. Suspended solids in the river (4.0-l ,684.0 mg/l) are highly variable and directly related to fluctuations in discharge. Sediments from the Salt River Basin are high in potassium (12.4-213.3 mg/g) and iron (23.4-135.1 mg/g), with moderate levels of calcium (0.8-45.7 mg/g), sodium (4.5-10.5 mg/g), magnesium (3.2-6.3 mg/g), and phosphate (1.3-15.3 mg/g). Approximately 10% of the total ionic composition of these sediments is exchangeable and may be extracted with barium chloride. Calcium (309-3,292 μg/g), was the most readily adsorbed cation, with lower levels of potassium (17.6-490.5 μg/g), sodium (12.9-458.1 μg/g), and magnesium (89.4-266.2 μg/g). In the aqueous extractions, calcium (18-486 μg/g), potassium (16.6-69.5 μg/g), sodium (11.1-30.8 μg/g), and magnesium (6.6-68.7 μg/g) comprised about 10% of the exchangeable fraction. Ranges of rainwater ions from the Salt River Basin were: sulfate (8.3-27.8 mg/l), calcium (0.3-10.7 mg/l), potassium (0.4-15.4 mg/l), sodium (0.0-0.7 mg/l), and magnesium (0.1-2.8 mg/l). Ionic composition and sediment yield of runoff water was variable and was related to magnitude of rainfall and runoff sampler placement. Ranges for selected constituents at the two samplers near Taylorsville were: suspended solids (44.0-8,808.0 mg/l), potassium (1.1-84.0 mg/l), magnesium (l.5-7.1 mg/l), calcium (9.5-33.0 mg/l), and sodium (0.6-3.0 mg/l). Calcium and bicarbonate in the Salt River originate from weathering of calcite, although mole ratios of these two ions greater than 1:2 suggest that weathering of magnesium carbonates also contributes bicarbonate to the water. Carbonate equilibrium calculations using field pH and ionic strength suggest calcium is at saturation in the Salt River. High levels of sulfate in rainwater indicate some of this anion may be introduced into the area watershed by atmospheric precipitation

Quantifying Asthenospheric and Lithospheric Controls on Mafic Magmatism Across North Africa

African basin‐and‐swell morphology is often attributed to the planform of sub‐plate mantle convection. Across North Africa, the coincidence of Neogene and Quaternary (i.e. <23 Ma) magmatism, topographic swells, long wavelength gravity anomalies, and slow shear wave velocity anomalies within the asthenosphere provides observational constraints for this hypothesis. Admittance analysis of topographic and gravity fields corroborates the existence of sub‐plate support. To investigate quantitative relationships between intraplate magmatism, shear wave velocity, and asthenospheric temperature, we collected and analyzed a suite of 224 lava samples from Tibesti, Jabal Eghei, Haruj, Sawda/Hasawinah and Gharyan volcanic centers of Libya and Chad. Forward and inverse modeling of major, trace, and Rare Earth elements were used for thermobarometric studies and to determine melt fraction as a function of depth. At each center, mafic magmatism is modeled by assuming adiabatic decompression of dry peridotite with asthenospheric potential temperatures of 1300–1360°C. Surprisingly, the highest temperatures are associated with the low‐lying Haruj volcanic center rather than with the more prominent Tibesti swell. Our results are consistent with earthquake tomographic models which show that the slowest shear wave anomalies within the upper mantle occur directly beneath the Haruj center. This inference is corroborated by converting observed velocities into potential temperatures, which are in good agreement with those determined by geochemical inverse modeling. Our results suggest that North African volcanic swells are primarily generated by thermal anomalies located beneath thinned lithosphere.Shell Research National Aeronautics and space administration National environmental research council ForschungsGermeinsChaf

Rare recessive loss-of-function methionyl-tRNA synthetase mutations presenting as a multi-organ phenotype

BACKGROUND: Methionyl-tRNA synthetase (MARS) catalyzes the ligation of methionine to its cognate transfer RNA and therefore plays an essential role in protein biosynthesis. METHODS: We used exome sequencing, aminoacylation assays, homology modeling, and immuno-isolation of transfected MARS to identify and characterize mutations in the methionyl-tRNA synthetase gene (MARS) in an infant with an unexplained multi-organ phenotype. RESULTS: We identified compound heterozygous mutations (F370L and I523T) in highly conserved regions of MARS. The parents were each heterozygous for one of the mutations. Aminoacylation assays documented that the F370L and I523T MARS mutants had 18 ± 6% and 16 ± 6%, respectively, of wild-type activity. Homology modeling of the human MARS sequence with the structure of E. coli MARS showed that the F370L and I523T mutations are in close proximity to each other, with residue I523 located in the methionine binding pocket. We found that the F370L and I523T mutations did not affect the association of MARS with the multisynthetase complex. CONCLUSION: This infant expands the catalogue of inherited human diseases caused by mutations in aminoacyl-tRNA synthetase genes

Ariel - Volume 10 Number 3

Executive Editors Madalyn Schaefgen David Reich Business Manager David Reich News Editors Medical College Edward Zurad CAHS John Guardiani World Mark Zwanger Features Editors Meg Trexler Jim O\u27Brien Editorials Editor Jeffrey Banyas Photography and Sports Editor Stuart Singer Commons Editor Brenda Peterso

The Density Matrix Renormalization Group for finite Fermi systems

The Density Matrix Renormalization Group (DMRG) was introduced by Steven White in 1992 as a method for accurately describing the properties of one-dimensional quantum lattices. The method, as originally introduced, was based on the iterative inclusion of sites on a real-space lattice. Based on its enormous success in that domain, it was subsequently proposed that the DMRG could be modified for use on finite Fermi systems, through the replacement of real-space lattice sites by an appropriately ordered set of single-particle levels. Since then, there has been an enormous amount of work on the subject, ranging from efforts to clarify the optimal means of implementing the algorithm to extensive applications in a variety of fields. In this article, we review these recent developments. Following a description of the real-space DMRG method, we discuss the key steps that were undertaken to modify it for use on finite Fermi systems and then describe its applications to Quantum Chemistry, ultrasmall superconducting grains, finite nuclei and two-dimensional electron systems. We also describe a recent development which permits symmetries to be taken into account consistently throughout the DMRG algorithm. We close with an outlook for future applications of the method.Comment: 48 pages, 17 figures Corrections made to equation 19 and table

Early Cenozoic denudation of central west Britain in response to transient and permanent uplift above a mantle plume

Upwelling mantle plumes beneath continental crust are predicted to produce difficult to quantify, modest uplift and denudation. The contribution of permanent and transient components to the uplift is also difficult to distinguish. A pulse of denudation in Britain in the Early Paleogene has been linked, although with some controversy, with the arrival of the proto-Iceland mantle plume. In this contribution we show that combining apatite and zircon (U-Th-Sm)/He and apatite fission track analyses from central west Britain with numerical modeling clearly identifies a pulse of early Cenozoic denudation. The data indicate that rock uplift and denudation were centered on the northern East Irish Sea Basin and 1.0–2.4 km of rocks were removed during the latest Cretaceous-early Paleogene. Uplift and erosion appears to have started a few million years before the earliest magmatism in the region. The regional denudation pattern mirrors the distribution of low-density magmatic rocks that has been imaged in the deep crust. However, the injection of the underplating melt is not enough to account for the total denudation. An additional regional uplift of at least 300 m is required, which is consistent with a transient thermal effect from the hot mantle plume. The rapid exhumation event ceased by ~40 Ma and the data do not require significant Neogene exhumation