“ALLA SCOPERTA dei TESORI del MARE” - Scienza e Tecnologia, Memoria Popolare e Identità Culturale di una città della costa ligure

“Il dovere degli scienziati non è quello di educare il pubblico, ma piuttosto di interagire con esso. Il pubblico è la vera forza trainante dietro decisioni con conseguenze sociali, e deve essere coinvolto su base paritaria nei dibattiti inerenti queste decisioni” . La comunicazione scientifica e tecnologica fra scienza e società, da anni, non è più un mero scambio di informazioni e risultati (spesso fra determinate élite), ma è diventata il veicolo privilegiato per insegnare, formare ed ispirare un pubblico sempre più ampio. Ma non si parla solo di trasmissione uni-direzionale: il dibattito fra scienza, tecnologia e società (amministratori locali, politici, imprenditori, giornalisti, studenti e semplici cittadini) sta guadagnando una partecipazione di interlocutori sempre più numerosi e preparati su temi dalle complesse caratteristiche ed implicazioni (etiche, sociali, economiche, politiche). Questo è in parte dovuto ai cambiamenti avvenuti negli ultimi anni nella scienza (e all’impatto che essa sta avendo in molti ambiti della vita sociale. Tali cambiamenti stanno determinando nuove forme di comunicazione scientifica e cooperazione con la società e l’aumento, nell’ultimo decennio, di iniziative e percorsi di formazione, spesso organizzati dalle stesse istituzioni scientifiche. Uno dei risultati più tangibili della cambiata interazione fra scienza e società è la nuova generazione di ricercatori-comunicatori, dotati di una maggiore abilità nel comunicare la scienza in modo efficace e ad un pubblico più ampio e diversificato. In questo contesto diventa importante capire l’efficacia di ogni azione di comunicazione scientifica, impostando uno studio che analizzi, volta per volta, i punti di successo e le criticità emerse nei due comparti causa-effetto. Causa – gli elementi di base della comunicazione scientifica e tecnologica:  i valori sociali e culturali di riferimento (ad es. protezione ambientale, sicurezza, salute); - i contenuti (formato di presentazione, tematiche scelte); - i canali usati (web, social networks, stampa cartacea etc.); - i modelli di relazione con il pubblico (scienza vs pubblico, peer education). Effetto - la risposta della società:  diretta (affluenza; questionari di gradimento)  indiretta (visualizzazioni web; like se tweet dei social network). Questo lavoro presenta una relazione illustrativa (per la prima volta sul territorio della Spezia) dell’efficacia di un evento specifico inserito all’interno di una manifestazione di portata locale, la “Festa della Marineria 2013 ”, destinato al grande pubblico e caratterizzato da diverse attività (tra le quali quelle di tipo ludico-educativo) concepite con l’obiettivo di puntare l’attenzione sui ‘tesori’ scientifici e culturali di una ‘Città di Mare’qual'è La Spezia

An Analysis of Resting-State Functional Transcranial Doppler Recordings from Middle Cerebral Arteries

Functional transcrannial Doppler (fTCD) is used for monitoring the hemodynamics characteristics of major cerebral arteries. Its resting-state characteristics are known only when considering the maximal velocity corresponding to the highest Doppler shift (so called the envelope signals). Significantly more information about the resting-state fTCD can be gained when considering the raw cerebral blood flow velocity (CBFV) recordings. In this paper, we considered simultaneously acquired envelope and raw CBFV signals. Specifically, we collected bilateral CBFV recordings from left and right middle cerebral arteries using 20 healthy subjects (10 females). The data collection lasted for 15 minutes. The subjects were asked to remain awake, stay silent, and try to remain thought-free during the data collection. Time, frequency and time-frequency features were extracted from both the raw and the envelope CBFV signals. The effects of age, sex and body-mass index were examined on the extracted features. The results showed that the raw CBFV signals had a higher frequency content, and its temporal structures were almost uncorrelated. The information-theoretic features showed that the raw recordings from left and right middle cerebral arteries had higher content of mutual information than the envelope signals. Age and body-mass index did not have statistically significant effects on the extracted features. Sex-based differences were observed in all three domains and for both, the envelope signals and the raw CBFV signals. These findings indicate that the raw CBFV signals provide valuable information about the cerebral blood flow which can be utilized in further validation of fTCD as a clinical tool. © 2013 Sejdić et al

Sailing for Science: on board experiences for transferring knowledge on Historical Oceanography for Future Innovation

Smart, sustainable and inclusive Blue Growth means also knowing past technology and the paths followed by ancients in order to understand and monitor marine environments. In general, history of Science is a matter that is not enough explored and explained or promoted in high schools or university official programmes, and, usually, scientist do not consider it as an important part of their curricula. However, bad or good ideas, abandoned or forgotten beliefs, concepts, opinions, do still have a great potential for inspiring present and future scientists, no matter in which historical period they may have been formulated: they should be always be taken into consideration, critically examined and observed by a very close point of view, not just as part of the intellectual framework of some obsolete ‘Cabinet of Curiosities’ with limited access except for the chosen few. Moreover, history of Science should be transmitted in a more practical way, with hands-on labs showing the limits and challenges that prior generations of ocean explorers, investigators and seafarers had to face in order to answer to crucial questions as self-orientation in open sea, understanding main currents and waves, predicting meteorological conditions for a safe navigation. Oceanography is a relatively young branch of science, and still needs further approvals and knowledge (National Science Foundation, 2000). The Scientific Dissemination Group (SDG) “La Spezia Gulf of Science” – made up by Research Centres, Schools and Cultural associations located in La Spezia (Liguria, Italy) - has a decadal experience in initiatives aimed at people and groups of people of all ages, who are keen on science or who can be guided in any case to take an interest in scientific matters (Locritani et al., 2015). Amongst the SDG activities, the tight relationship with the Historical Oceanography Society, the Italian Navy and the Naval Technical Museum (that collects a rich heritage of civilization, technology and culture witnesses, related to the naval history of seamanship from the origins up to nowadays), allowed the creation of a special educational format based on Historical Oceanography, for university and high school students as an integration for their curriculum. The Historical Oceanography Society has provided the major knowledges included in the ancient volumes of its archive, thanks to the availability of its members that also held theoretical and practical lessons during the course. The present paper will describe the one-week special course (about 60 hours of theory and practice with technical visits to Research centres and Museums) that has been planned to be carried out on board of the Italian Training Navy Ship (A. Vespucci) and has been organized in order to give the hints about on board life, as well as theoretical lessons on modern and historical oceanography, hands-on labs on oceanographic instruments from public and private collections, physiology of diving techniques and astronomy. The general aim of this course has been, hence, to give to excellent students all those technological but also creative and imaginative features of our past.PublishedVienna1TM. Formazion

PBP-A, a cyanobacterial dd-peptidase with high specificity for amidated muropeptides, exhibits pH-dependent promiscuous activity harmful to <em>Escherichia coli</em>

\ua9 The Author(s) 2024. Penicillin binding proteins (PBPs) are involved in biosynthesis, remodeling and recycling of peptidoglycan (PG) in bacteria. PBP-A from Thermosynechococcus elongatus belongs to a cyanobacterial family of enzymes sharing close structural and phylogenetic proximity to class A β-lactamases. With the long-term aim of converting PBP-A into a β-lactamase by directed evolution, we simulated what may happen when an organism like Escherichia coli acquires such a new PBP and observed growth defect associated with the enzyme activity. To further explore the molecular origins of this harmful effect, we decided to characterize deeper the activity of PBP-A both in vitro and in vivo. We found that PBP-A is an enzyme endowed with dd-carboxypeptidase and dd-endopeptidase activities, featuring high specificity towards muropeptides amidated on the d-iso-glutamyl residue. We also show that a low promiscuous activity on non-amidated peptidoglycan deteriorates E. coli’s envelope, which is much higher under acidic conditions where substrate discrimination is mitigated. Besides expanding our knowledge of the biochemical activity of PBP-A, this work also highlights that promiscuity may depend on environmental conditions and how it may hinder rather than promote enzyme evolution in nature or in the laboratory

The development and application of a new tool to assess the adequacy of the content and timing of antenatal care

Abstract Background: Current measures of antenatal care use are limited to initiation of care and number of visits. This study aimed to describe the development and application of a tool to assess the adequacy of the content and timing of antenatal care. Methods: The Content and Timing of care in Pregnancy (CTP) tool was developed based on clinical relevance for ongoing antenatal care and recommendations in national and international guidelines. The tool reflects minimal care recommended in every pregnancy, regardless of parity or risk status. CTP measures timing of initiation of care, content of care (number of blood pressure readings, blood tests and ultrasound scans) and whether the interventions were received at an appropriate time. Antenatal care trajectories for 333 pregnant women were then described using a standard tool (the APNCU index), that measures the quantity of care only, and the new CTP tool. Both tools categorise care into 4 categories, from ‘Inadequate’ (both tools) to ‘Adequate plus’ (APNCU) or ‘Appropriate’ (CTP). Participants recorded the timing and content of their antenatal care prospectively using diaries. Analysis included an examination of similarities and differences in categorisation of care episodes between the tools. Results: According to the CTP tool, the care trajectory of 10,2% of the women was classified as inadequate, 8,4% as intermediate, 36% as sufficient and 45,3% as appropriate. The assessment of quality of care differed significantly between the two tools. Seventeen care trajectories classified as ‘Adequate’ or ‘Adequate plus’ by the APNCU were deemed ‘Inadequate’ by the CTP. This suggests that, despite a high number of visits, these women did not receive the minimal recommended content and timing of care. Conclusions: The CTP tool provides a more detailed assessment of the adequacy of antenatal care than the current standard index. However, guidelines for the content of antenatal care vary, and the tool does not at the moment grade over-use of interventions as ‘Inappropriate’. Further work needs to be done to refine the content items prior to larger scale testing of the impact of the new measure

Beliefs and traditions related to a child´s first year of life : a study of the Northwest of Portugal

In this paper we propose an approach to investigate, in the North-west of Portugal, the parents’ behaviour at birth and during the first year of life of their children. We compare the heritage, specifically the beliefs and traditions, with the changes that resulted from the recent and deep cultural transformations that have taken place in Portugal in the last few decades. In parallel, we tried to determine if the parents’ behaviours, based on beliefs and traditions, can affect the children’s health. We based our investigation on standardized interviews with 76 mothers of one-year-old children (born between January and December 2001) who lived in two parishes of Vizela city. This is a territory where a more traditional way of life prevails than in other territories of the centre and south of the country, where there is a strong attachment for religious and social values and where the influence of the ancestral traditions is still alive. The paper concludes that cultural heritage can have important impact on individual health. Health professionals, who work in primary care and in hospitals, must be aware of the responsibility they have to change this scenario.(undefined

Physical conditioning and mental stress reduction - a randomised trial in patients undergoing cardiac surgery

<p>Abstract</p> <p>Background</p> <p>Preoperative anxiety and physical unfitness have been shown to have adverse effects on recovery from cardiac surgery. This study involving cardiac surgery patients was primarily aimed at assessing the feasibility of delivering physical conditioning and stress reduction programs within the public hospital setting. Secondary aims were to evaluate the effect of these programs on quality of life (QOL), rates of postoperative atrial fibrillation (AF) and length of stay (LOS) in hospital.</p> <p>Methods</p> <p>Elective patients scheduled for coronary artery bypass graft and/or valve surgery at a public hospital in Melbourne, Australia were enrolled. Patients were randomized to receive either holistic therapy (HT) or usual care (UC). HT consisted of a series of light physical exercise sessions together with a mental stress reduction program administered in an outpatient setting for the first two weeks after placement on the waiting list for surgery. A self-administered SF-36 questionnaire was used to measure QOL and hospital records to collect data on LOS and rate of postoperative AF.</p> <p>Results</p> <p>The study population comprised 117 patients of whom 60 received HT and 57 received UC. Both programs were able to be delivered within the hospital setting but ongoing therapy beyond the two week duration of the program was not carried out due to long waiting periods and insufficient resources. HT, as delivered in this study, compared to UC did not result in significant changes in QOL, LOS or AF incidence.</p> <p>Conclusions</p> <p>Preoperative holistic therapy can be delivered in the hospital setting, although two weeks is insufficient to provide benefits beyond usual care on QOL, LOS or postoperative AF. Further research is now required to determine whether a similar program of longer duration, or targeted to high risk patients can provide measurable benefits.</p> <p>Trial registration</p> <p>This trial was conducted as part of a larger study and according to the principles contained in the CONSORT statement 2001.</p