Overcoming the Systemic Challenges of Wealth Inequality in the U.S.

The galvanizing public murder of George Floyd and the disproportionate impact of COVID-19 on Black and Hispanic people have put structural racism and its influence on wealth inequality in the U.S. into stark relief. As multiracial groups express outrage at these visible disparities, we risk missing the other side of the coin: that wealth inequality in turn fans structural racism. Moreover, as they reinforce each other, these two factors erode the social, economic, and political viability of our democracy. Understanding and then breaking this vicious cycle are essential to realizing our renewed commitment to a country that works everyone. This article seeks to draw renewed attention to the damaging impacts of wealth inequality, its root causes, and strategies for overcoming it. More broadly, it presents proposals for what leaders in the nonprofit, public, and private sectors can do to assert our country’s underlying moral values of self-reliance and community, rebuild our devastated economy in a way that works for all citizens, and reestablish reason and fairness in the political sphere. This article specifically applies systems thinking to identify the root causes of wealth inequality, including structural racism, and then proposes four primary strategies for both fairly distributing and generating new wealth

When is open-endedness desirable in restoration projects?

A low-intervention approach to restoration that also allows restoration outcomes to be framed as trajectories of ecosystem change can be described as ‘open-ended’ restoration. It is an approach that recognizes that long-term ecosystem behavior involves continual change at small and large spatial and temporal scales. There are a number of situations in which it is appropriate to adopt an open-ended approach to restoration including: in remote and large areas; where ecological limiting factors will be changed by future climates; where antecedent conditions cannot be replicated; where there are novel starting points for restoration; where restoration relies strongly on processes outside the restoration area; in inherently dynamic systems; where costs are high and where the public demands ‘wildness’. Where this approach is adopted managers need to explain the project and deal with public expectations and public risk. Monitoring biotic and abiotic components of the project are very important as an open-ended approach does not equate to ‘abandon and ignore it’

Traffic-related air pollution associated with prevalence of asthma and COPD/chronic bronchitis. A cross-sectional study in Southern Sweden

<p>Abstract</p> <p>Background</p> <p>There is growing evidence that air pollution from traffic has adverse long-term effects on chronic respiratory disease in children, but there are few studies and more inconclusive results in adults. We examined associations between residential traffic and asthma and COPD in adults in southern Sweden. A postal questionnaire in 2000 (n = 9319, 18–77 years) provided disease status, and self-reported exposure to traffic. A Geographical Information System (GIS) was used to link geocoded residential addresses to a Swedish road database and an emission database for NOx.</p> <p>Results</p> <p>Living within 100 m of a road with >10 cars/minute (compared with having no heavy road within this distance) was associated with prevalence of asthma diagnosis (OR = 1.40, 95% CI = 1.04–1.89), and COPD diagnosis (OR = 1.64, 95%CI = 1.11–2.4), as well as asthma and chronic bronchitis symptoms. Self-reported traffic exposure was associated with asthma diagnosis and COPD diagnosis, and with asthma symptoms. Annual average NOx was associated with COPD diagnosis and symptoms of asthma and chronic bronchitis.</p> <p>Conclusion</p> <p>Living close to traffic was associated with prevalence of asthma diagnosis, COPD diagnosis, and symptoms of asthma and bronchitis. This indicates that traffic-related air pollution has both long-term and short-term effects on chronic respiratory disease in adults, even in a region with overall low levels of air pollution.</p

Imaging morphological details and pathological differences of red blood cells using tapping-mode AFM

The surface topography of red blood cells (RBCs) was investigated under nearphysiological conditions using atomic force microscopy (AFM). An immobilization protocol was established where RBCs are coupled via molecular bonds of the membrane glycoproteins to wheat germ agglutinin (WGA), which is covalently and flexibly tethered to the support. This results in a tight but noninvasive attachment of the cells. Using tappingmode AFM, which is known as gentle imaging mode and therefore most appropriate for soft biological samples like erythrocytes, it was possible to resolve membrane skeleton structures without major distortions or deformations of the cell surface. Significant differences in the morphology of RBCs from healthy humans and patients with systemic lupus erythematosus (SLE) were observed on topographical images. The surface of RBCs from SLE patients showed characteristic circularshaped holes with approx. 200 nm in diameter under physiological conditions, a possible morphological correlate to previously published changes in the SLE erythrocyte membrane

Traffic exposure associated with allergic asthma and allergic rhinitis in adults. A cross-sectional study in southern Sweden

BACKGROUND: There is conflicting evidence that traffic-related air pollution is a risk factor for allergic conditions. Few studies have investigated this in adults. In adults, a high proportion of asthma, rhinitis and eczema is triggered by non-allergic factors. We investigated traffic as a risk factor for allergic versus non-allergic asthma and rhinitis, and eczema, in adults. A questionnaire from 2000 (n = 9319, 18-77 years) provided individual data about disease outcome and self-reported traffic exposure. Additional exposure assessments were obtained using Geographical Informations Systems (GIS). Residential addresses were linked to the national Swedish Road Database and to a pollutant database with modelled annual means of NOx (Nitrogen Oxids). RESULTS: Living within 100 m from a road with a traffic intensity of >10 cars/min (24 hour mean) was associated with prevalence of current asthma reported to be triggered by allergic factors (OR = 1.83, 95% CI = 1.23-2.72) and with allergic rhinitis (OR = 1.30, 95%CI = (1.05-1.61). No relation was seen with asthma or rhinitis triggered by other factors. Living within 100 m of a road with >10 cars/min was also associated with hand-eczema during the last 12 months (OR = 1.63, 95% CI = 1.19-2.23), but not with allergic eczema or diagnosed hand-eczema. Consistent results were seen using self-reported traffic, but the associations with NOx were less consistent. CONCLUSION: Exposure to traffic was associated with a higher prevalence of allergic asthma and allergic rhinitis, but not with asthma or rhinitis triggered by non-allergic factors. This difference was suggested by the overall pattern, but only clear using GIS-measured traffic intensity as a proxy for traffic exposure. An association was also found with hand-eczema during the last 12 months. We suggest that asthma and rhinitis should not be treated as homogenous groups when estimating effects from traffic in adults

Understanding Inconsistencies in Thermohydraulic Characteristics Between Experimental and Numerical Data for Di Water Flow Through a Rectangular Microchannel

Facing discrepancies between numerical simulation, experimental measurement and theory is common in studies of fluid flow and heat transfer in microchannels. The cause of these discrepancies is often linked to the transition from the macro-scale to the micro-scale, where the flow dynamics might be expected to deviate due to possible change in dominant forces. In this work, an attempt is made to achieve agreement between experiment, numerical simulation and theoretical description within the usual framework of laminar flow theory. For this purpose, the pressure drop, friction factor, and Poiseuille number under isothermal conditions and the temperature profile, heat transfer coefficient, Nusselt number, and thermal performance index under diabatic conditions (heating power of 10 W) in a heat sink with a stainless steel microchannel with a hydraulic diameter of 850 µm were investigated numerically and experimentally for mass flow rates between 1 and 68 g/min. The source of inconsistencies in pressure drop characteristics is found to be linked to the geometrical details of the utilized microchannel, e.g. the design of inlet/outlet manifolds, the artefacts of manufacturing technique and other features of the experimental test rig. For the heat transfer characteristics, it is identified, that an appropriate estimation of the outer boundary condition for the numerical simulation remains the crucial challenge to obtain a reasonable agreement. The manuscript presents a detailed overview on how to consider these details to mitigate the discrepancies and to establish a handshake between experiments, numerical simulations and theory

Viral factors in influenza pandemic risk assessment

The threat of an influenza A virus pandemic stems from continual virus spillovers from reservoir species, a tiny fraction of which spark sustained transmission in humans. To date, no pandemic emergence of a new influenza strain has been preceded by detection of a closely related precursor in an animal or human. Nonetheless, influenza surveillance efforts are expanding, prompting a need for tools to assess the pandemic risk posed by a detected virus. The goal would be to use genetic sequence and/or biological assays of viral traits to identify those non-human influenza viruses with the greatest risk of evolving into pandemic threats, and/or to understand drivers of such evolution, to prioritize pandemic prevention or response measures. We describe such efforts, identify progress and ongoing challenges, and discuss three specific traits of influenza viruses (hemagglutinin receptor binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency) that contribute to pandemic risk

Temporal changes in distributions and the species atlas: how can British and Irish plant data shoulder the inferential burden?

Species distribution atlases often rely on volunteer effort to achieve their desired coverage, an activity now typically discussed, at least in academia, under the general theme of “citizen science”. Such data, however, are rarely without complex biases, particularly with respect to the estimation of trends in species’ distributions over many decades. The data of the Botanical Society of Britain and Ireland (BSBI) are no exception to this, and both careful thought in data aggregation (spatial, temporal, and taxonomic) and appropriate modelling procedures are required to overcome these challenges. We discuss these issues, with a primary focus on the statistical models that have been put forward to adjust for such biases. Such models include the Telfer method, various “reporting rate” approaches based on generalised linear models, the frequency scaling using local occupancy (“Frescalo”) model, occupancy models, and spatial smoothing methods. In each case the strengths and limitations in relation to estimating trends from distribution data with important time-varying biases are assessed. Various properties of BSBI data, in particular the increasing numbers of records at fine spatial and temporal scales over the past century, coupled with a general lack of re-visits to sites at such finer scales and the time-varying biases previously mentioned, imply that methods that can be sensibly applied at coarser levels are likely to be most appropriate for estimating accurate long-term trends in distributions. We conclude that Frescalo, which can be seen as a type of occupancy model where an adjustment for overlooked species is made in relation to spatial rather than temporal replication, whilst simultaneously adjusting for variable regional effort, is currently the most sophisticated tool for achieving this. Although recording community-accepted adjustments to data collection practices may allow for a greater application of occupancy modelling or other approaches in the future, methods that seek accurate trends over the long-term are necessarily limited either to scales at which various properties of the data in hand are most likely to be unbiased, or at which the biases are well enough understood to be modelled accurately