HLA-G: expression in human keratinocytes in vitro and in human skin in vivo

Classical, polymorphic major histocompatibility complex class I molecules are expressed on most nucleated cells.They present peptides at the cell surface and, thus, enable the immune system to scan peptides for their antigenicity. The function of the other, nonclassical class I molecules in man is controversial. HLA-G which has been shown by transfection experiments to be expressed at the cell surface, is only transcribed in placental tissue and in the fetal eye.Therefore, a role of HLA-G in the control of rejection of the allogeneic fetus has been discussed. We found that HLA-G expression is induced in keratinocytes by culture in vitro. Three different alternative splicing products of HLA-G can be detected: a full length transcript, an mRNA lacking exon 3 and a transcript devoid of exon 3 and 4. Reverse transcription followed by polymerase chain reaction also revealed the presence of HLA-G mRNA in vivo in biopsies of either diseased or healthy skin

Magnetic properties of HO2 thin films

We report on the magnetic and transport studies of hafnium oxide thin films grown by pulsed-laser deposition on sapphire substrates under different oxygen pressures, ranging from 10-7 to 10-1 mbar. Some physical properties of these thin films appear to depend on the oxygen pressure during growth: the film grown at low oxygen pressure (P ~= 10-7 mbar) has a metallic aspect and is conducting, with a positive Hall signal, while those grown under higher oxygen pressures (7 x 10-5 <= P <= 0.4 mbar) are insulating. However, no intrinsic ferromagnetic signal could be attributed to the HfO2 films, irrespective of the oxygen pressure during the deposition.Comment: 1

On the appearance of hyperons in neutron stars

By employing a recently constructed hyperon-nucleon potential the equation of state of \beta-equilibrated and charge neutral nucleonic matter is calculated. The hyperon-nucleon potential is a low-momentum potential which is obtained within a renormalization group framework. Based on the Hartree-Fock approximation at zero temperature the densities at which hyperons appear in neutron stars are estimated. For several different bare hyperon-nucleon potentials and a wide range of nuclear matter parameters it is found that hyperons in neutron stars are always present. These findings have profound consequences for the mass and radius of neutron stars.Comment: 12 pages, 12 figures, RevTeX4; summary and conclusions are strengthened, to appear in PR

High resolution spectroscopy of Pluto's atmosphere: detection of the 2.3 μ\mum CH4_4 bands and evidence for carbon monoxide

The goal is to determine the composition of Pluto's atmosphere and to constrain the nature of surface-atmosphere interactions. We perform high--resolution spectroscopic observations in the 2.33--2.36 $\mu$m range, using CRIRES at the VLT. We obtain (i) the first detection of gaseous methane in this spectral range, through lines of the $\nu_3$ + $\nu_4$ and $\nu_1$ + $\nu_4$ bands (ii) strong evidence (6-$\sigma$ confidence) for gaseous CO in Pluto. For an isothermal atmosphere at 90 K, the CH$_4$ and CO column densities are 0.75 and 0.07 cm-am, within factors of 2 and 3, respectively. Using a physically--based thermal structure model of Pluto's atmosphere also satisfying constraints from stellar occultations, we infer CH$_4$ and CO mixing ratios q$_{CH_4}$= 0.6$^{+0.6}_{-0.3}$% (consistent with results from the 1.66 $\mu$m range) and q$_{CO}$ = 0.5$^{+1}_{-0.25}$$\times10^{-3}$. The CO atmospheric abundance is consistent with its surface abundance. As for Triton, it is probably controlled by a thin, CO-rich, detailed balancing layer resulting from seasonal transport and/or atmospheric escape.Comment: Astronomy and Astrophysics Letters, in pres