Intra-uterine fetal demise caused by amniotic band syndrome after standard amniocentesis

The amniotic band syndrome represents a prime example of exogenous disruption of an otherwise normal feta I development. It may be a sequel of invasive diagnostic procedures such as amniocentesis or fetal blood sampling. A 38-year-old gravida II, para II delivered a morphologically normal male stillborn at term. The pregnancy history had been unremarkable but for an early 2nd-trimester amniocentesis. Cause of the intra-uterine fetal demise was noted to be an amniotic band constricting the umbilical cord, An amniotic band is a rare but potentially fatal condition which may be induced by, e.g., invasive prenatal procedures. Such bands are not usually diagnosed prenatally; however, selected patients with augmented risk may profit from intensive ultrasound evaluation including Doppler studies. Copyright (C) 2000 S. Karger AG, Basel

Molecular Basis for poly(A) RNP Architecture and Recognition by the Pan2-Pan3 Deadenylase

The stability of eukaryotic mRNAs is dependent on a ribonucleoprotein (RNP) complex of poly(A)-binding proteins (PABPC1/Pab1) organized on the poly(A) tail. This poly(A) RNP not only protects mRNAs from premature degradation but also stimulates the Pan2-Pan3 deadenylase complex to catalyze the first step of poly(A) tail shortening. We reconstituted this process in vitro using recombinant proteins and show that Pan2-Pan3 associates with and degrades poly(A) RNPs containing two or more Pab1 molecules. The cryo-EM structure of Pan2-Pan3 in complex with a poly(A) RNP composed of 90 adenosines and three Pab1 protomers shows how the oligomerization interfaces of Pab1 are recognized by conserved features of the deadenylase and thread the poly(A) RNA substrate into the nuclease active site. The structure reveals the basis for the periodic repeating architecture at the 3' end of cytoplasmic mRNAs. This illustrates mechanistically how RNA-bound Pab1 oligomers act as rulers for poly(A) tail length over the mRNAs' lifetime.We would like to thank ... the MPIB cryo-EM, and core facilities ..

A discrete time relativistic Toda lattice

Four integrable symplectic maps approximating two Hamiltonian flows from the relativistic Toda hierarchy are introduced. They are demostrated to belong to the same hierarchy and to examplify the general scheme for symplectic maps on groups equiped with quadratic Poisson brackets. The initial value problem for the difference equations is solved in terms of a factorization problem in a group. Interpolating Hamiltonian flows are found for all the maps.Comment: 32 pages, LaTe

Pairwise sums in colourings of the reals

Suppose that we have a finite colouring of R. What sumset-type structures can we hope to find in some colour class? One of our aims is to show that there is such a colouring for which no uncountable set has all of its pairwise sums monochromatic. We also show that there is such a colouring such that there is no infinite set X with X + X (the pairwise sums from X, allowing repetition) monochromatic. These results assume CH. In the other direction, we show that if each colour class is measurable, or each colour class is Baire, then there is an infinite set X (and even an uncountable X, of size the reals) with X + X monochromatic. We also give versions for all of these results for k-wise sums in place of pairwise sums

Integrating The E In E-Marketing

The domain of e-marketing is much greater than pure play and enterprise level dot-coms. E-marketing concerns the deployment of information technology to render marketing strategy and process more effective and efficient. Technology and the Internet also changed the way marketing is conducted. For example, the fundamental idea of digitizing data has transformed media and software delivery methods as well as created a new transaction channel. Also, the Internet as information equalizer has shifted the balance of power from marketer to consumer. As developed nations enter what Gartner Group calls the slope of enlightenment on the way to dropping the “e” from e-business, successful marketers will grasp the risks and rewards of various levels of information technology commitment. Fortunately, marketers do not have to personally develop the technologies, but they need to know enough to understand technology, select appropriate suppliers, and direct technology professionals in order to harness its power. In this article we define e-marketing, then present a framework for a menu of business models along with best practices. The framework is designed to ease the navigation and integration of technology in marketing strategy to fully capitalize on Internet properties and reap advantages of its role in marketing and business strategy

High resolution Ge/Li/ spectrometer reduces rate-dependent distortions at high counting rates

Modified spectrometer system with a low-noise preamplifier reduces rate-dependent distortions at high counting rates, 25,000 counts per second. Pole-zero cancellation minimizes pulse undershoots due to multiple time constants, baseline restoration improves resolution and prevents spectral shifts

A steerable UV laser system for the calibration of liquid argon time projection chambers

A number of liquid argon time projection chambers (LAr TPC's) are being build or are proposed for neutrino experiments on long- and short baseline beams. For these detectors a distortion in the drift field due to geometrical or physics reasons can affect the reconstruction of the events. Depending on the TPC geometry and electric drift field intensity this distortion could be of the same magnitude as the drift field itself. Recently, we presented a method to calibrate the drift field and correct for these possible distortions. While straight cosmic ray muon tracks could be used for calibration, multiple coulomb scattering and momentum uncertainties allow only a limited resolution. A UV laser instead can create straight ionization tracks in liquid argon, and allows one to map the drift field along different paths in the TPC inner volume. Here we present a UV laser feed-through design with a steerable UV mirror immersed in liquid argon that can point the laser beam at many locations through the TPC. The straight ionization paths are sensitive to drift field distortions, a fit of these distortion to the linear optical path allows to extract the drift field, by using these laser tracks along the whole TPC volume one can obtain a 3D drift field map. The UV laser feed-through assembly is a prototype of the system that will be used for the MicroBooNE experiment at the Fermi National Accelerator Laboratory (FNAL)

Neurodynamic evaluation of hearing aid features using EEG correlates of listening effort

In this study, we propose a novel estimate of listening effort using electroencephalographic data. This method is a translation of our past findings, gained from the evoked electroencephalographic activity, to the oscillatory EEG activity. To test this technique, electroencephalographic data from experienced hearing aid users with moderate hearing loss were recorded, wearing hearing aids. The investigated hearing aid settings were: a directional microphone combined with a noise reduction algorithm in a medium and a strong setting, the noise reduction setting turned off, and a setting using omnidirectional microphones without any noise reduction. The results suggest that the electroencephalographic estimate of listening effort seems to be a useful tool to map the exerted effort of the participants. In addition, the results indicate that a directional processing mode can reduce the listening effort in multitalker listening situations