The influence of relative age effects on the cardiorespiratory fitness levels of children age 9 to 10 and 11 to 12 years of age

The aims of this study were firstly to examine whether there was an observed relative age effect in the cardiorespiratory fitness scores of 9-10 and 11-12 year old children, and secondly whether any observed effect was maintained after controlling for somatic maturity. Cardiorespiratory fitness data from 11,404 children aged 9-10 years and 3,911 children aged 11-12 years were obtained from a large cross-sectional field-based fitness testing program. A one-way ANOVA revealed a statistically significant relative age effect (p &lt; .01) existed in the 20mSRT scores across all the age groups. Furthermore, ANCOVA analyses identified a statistically significant relative age effect was maintained after controlling for somatic maturation (p &lt; .05). From a public health perspective these results confirm the existence of relative age effects for the first time and consequently may hold implications for relatively younger children in the accurate assessment of their cardiorespiratory fitness scores.</jats:p

The IASLC/ITMIG thymic epithelial tumors staging project: Proposals for the T component for the forthcoming (8th) edition of the TNM classification of malignant tumors

Despite longstanding recognition of thymic epithelial neoplasms, there is no official American Joint Committee on Cancer/ Union for International Cancer Control stage classification. This article summarizes proposals for classification of the T component of stage classification for use in the 8th edition of the tumor, node, metastasis classification for malignant tumors. This represents the output of the International Association for the Study of Lung Cancer and the International Thymic Malignancies Interest Group Staging and Prognostics Factor Committee, which assembled and analyzed a worldwide database of 10,808 patients with thymic malignancies from 105 sites. The committee proposes division of the T component into four categories, representing levels of invasion. T1 includes tumors localized to the thymus and anterior mediastinal fat, regardless of capsular invasion, up to and including infiltration through the mediastinal pleura. Invasion of the pericardium is designated as T2. T3 includes tumors with direct involvement of a group of mediastinal structures either singly or in combination: lung, brachiocephalic vein, superior vena cava, chest wall, and phrenic nerve. Invasion of more central structures constitutes T4: aorta and arch vessels, intrapericardial pulmonary artery, myocardium, trachea, and esophagus. Size did not emerge as a useful descriptor for stage classification. This classification of T categories, combined with a classification of N and M categories, provides a basis for a robust tumor, node, metastasis classification system for the 8th edition of American Joint Committee on Cancer/Union for International Cancer Control stage classification