66 research outputs found
Community action on alcoholism: a case study of Gallup, New Mexico
- Author
- Publication venue
- EliScholar â A Digital Platform for Scholarly Publishing at Yale
- Publication date
- 01/01/1972
- Field of study
Beverly Matthews
- Publication venue
- eRepository @ Seton Hall
- Publication date
- 02/10/2015
- Field of study
This case describes the difficult challenges facing Beverly Matthews as she returned to the workforce after taking time from paid employment in order to spend time with her two children. She desired a workplace that would give her the flexibility to excel in both the work and family domains. Beverly specifically chose the organization because of its award-winning family-friendly reputation and the positive word of mouth from a friend who worked there. Unfortunately, she has encountered a supervisor whose values conflict with the values of Beverly and the organization. Beverly is contemplating her options as the status quo has become intolerable. Readers are also presented with a teaching note as an accompaniment to the case. Numerous options guide instructors on how to enhance student learning using this case study for theory application in organizational behavior and human resource management courses
BHPR research: qualitative1.âComplex reasoning determines patients' perception of outcome following foot surgery in rheumatoid arhtritis
- Author
- Abernethy Veronica
- Abignano Giuseppina
- Abraham David
- Abraham David
- Abraham David J.
- Abraham Sonya
- Adams Jo
- Adams Jo
- Adshead Rebecca
- Ahmad Yasmeen A.
- Ahmed Tazeen J.
- Ainley Louise
- Al-Allaf Wahab
- Alber Catherine Fouad
- Alhusain Awal Z.
- Ali Fizzah
- Allen Roger
- Alston Claire
- Alton Peter
- Anderson Marina
- Appleton Louise H.
- Ariyo Mercy
- Aronson Diane
- Arthanari S.
- Atteno Mariangela
- Backhouse Michael R.
- Backhouse Michael R.
- Bacon Paul A.
- Bacon Pauline
- Baker Sarah
- Baker Sharon
- Baker Sharon
- Balarajah Sharmili
- Ball Elisabeth
- Baqai Charlotte
- Bari Farhan
- Barton Anne
- Benson Claire
- Berry Jacqueline
- Bertolino Arthur
- Betteridge Zoe
- Beutler Anna
- Beutler Anna
- Beynon Huw
- Bhaduri Mahua
- Birt Linda
- Black Carol M.
- Bombardieri Michele
- Boton-Maggs Ben
- Bourke Brian E.
- Bouças Sofia Barbosa
- Braun JĂŒrgen
- Breslin Anne
- Briggs N.
- Brophy Richard
- Brophy Sinead
- Brown Diane
- Browne Hannah K.
- Bruce Ian
- Bruce Ian
- Brunner Hermine
- Buch Maya H.
- Buckley Christopher
- Bunn Chris
- Bunn Diane
- Burns James
- Cadman Susan
- Campbell Sophie
- Carroll Douglas
- Carroll Douglas
- Castiglione Fabiana
- Cavet Guy
- Chaitow Jeffrey
- Chamberlain Victoria A.
- Chan Marian
- Chard Michael
- Charles Peter
- Charleton Rebecca C.
- Charlton-Menys Valentine
- Chattopadhyay Chandrabhusan
- Chattopadhyay Chandrabhusan
- Chevance Aurelie
- Chighizola Cecilia
- Chowdhary Bhavani
- Choy Ernest
- Choy Ernest H.
- Ciurtin Coziana
- Ciurtin Coziana
- Clayton Ann M.
- Clemence Mark
- Clewes Adrian
- Coghlan Gerry
- Coghlan Gerry
- Cohen Carla J.
- Collins David
- Conaghan Philip
- Conaghan Philip
- Conaghan Philip
- Connor John
- Cook Haley
- Cooksey Roxanne
- Cooney Jennifer K.
- Coop Hazel
- Cope Andrew
- Cornell Patricia
- Cornell Tricia
- Costa Luisa
- Crooks Daniel
- Cuomo Giovanna
- Dabu Bogdan
- Dabu Mihaela
- Dahmen Georg
- Dale Rebecca M.
- Dario Di Minno M. N.
- Davies Helen
- Davies Rebecca
- Davies Ursula
- Dawson Julie
- De Benedetti Fabrizio
- De Lord Denise
- Del Galdo Francesco
- Dennis Michael S.
- Dennis Sean
- Denton Chris
- Denton Christopher P.
- Denton Christopher P.
- Denton Christopher P.
- Denton Christopher P.
- Denton Christopher P.
- Denton Christopher P.
- Derrett-Smith Emma
- Devlin Clare
- Dey Dzifa
- Di Cicco Maria
- Dimofte Ionela
- Dixon William
- Dobarro David
- Dobarro David
- Done John
- Donnelly Simon P.
- Dougados Maxime
- Douiri Abdel
- Drew Sarah
- Duddy Martin
- Dunkley Lisa
- Dunphy Juliet
- Dures Emma
- Durrington Paul
- Dyke Claire
- Dziedzic Krysia
- Edwards Elizabeth A.
- Ehrenstein Michael
- Ellegard Karen
- Emery Paul
- Emery Paul
- Emery Paul
- Emery Paul
- Emery Paul
- Ennis Holly
- Epis Oscar
- Espada Graciela
- Evans Rob
- Eyes Brian
- Farewell Daniel
- Farrar Claire
- Ferguson Anna M.
- Filer Andrew
- Fisher Ben
- Flato Berit
- Fleischmann Roy
- Flurey Caroline A.
- Foglia Francesca
- Fonseca Carmen
- Foo Joanne
- France Brisa
- France Brisa
- Freeman Tanya
- Freeston Jane
- Freeston Jane
- Furlong Anita
- Furlong Anita
- Galloway James
- Gathany Tim
- Gaywood Ian C.
- Genovese Mark C.
- George Malal Joby J.
- Giancola Giorgio
- Giles Ian
- Gill Rachel
- Gladman Dafna
- Gladman Dafna
- Gooberman-Hill Rachael
- Goodacre Lynne
- Goodfellow Rhian
- Gordhan Chandrika
- Gorodkin Rachel
- Grainger Andrew
- Greenhalgh Ann
- Greenwood James
- Greenwood Mandy
- Griffith Sian
- Griffiths Ann E.
- Griffiths Bridget
- Grover Bob
- Gsteiger Sandro
- Gullick Nicola J.
- Gullick Nicola J.
- Hadjinicolaou Andreas V.
- Hadjinicolaou Andreas V.
- Hale Elizabeth
- Hale Elizabeth D.
- Hall Frances C.
- Hall Frances C.
- Hall John
- Halls Serena
- Hamilton Jennifer
- Hamilton Jennifer
- Hammond Alison
- Han Chenglong
- Han Chenglong
- Han Chenglong
- Handler Clive
- Handler Clive
- Hands Rebecca
- Haney Doug
- Hanson Mark
- Haq Inam
- Haq Inam
- Hayes Janita
- Haywood Kirstie L.
- Heckaman Michele
- Heckaman Michele
- Helliwell Philip
- Helliwell Philip
- Hensor Elizabeth
- Hensor Elizabeth
- Herrick Ariane L.
- Herrick Ariane L.
- Hewlett Sarah
- Hewlett Sarah
- Heycock Carol
- Hill Ingrid
- Hill Ingrid
- Hislop Kelly
- Ho Pauline
- Hodgson Richard
- Holmes A.
- Horneff Gerd
- Howell Kevin
- Hoyles Rachel
- Hsia Elizabeth
- Hueber Wolfgang
- Hughes Gwenan
- Hughes Lyndsay
- Hughes Rod
- Humby Fran
- Hurley Mike
- Hyrich Kimme
- Hyrich Kimme
- Ibrahim Fowzia
- Iervolino Salvatore
- Ioannou John
- Irvine Elizabeth
- Isaacs Anthony
- Isaacs David
- Isaacs John
- Ishorari Jasmine
- Jack James
- Jenkins Jessica
- Jenkins Suzanne
- Jinks Clare
- Jinks Clare
- Jobanputra Paresh
- John Holly
- Jones Jeremy
- Jones Jeremy G.
- Jones Tadeusz
- Jordan Kelsey
- Jordan Kelvin P.
- Juneja Parmjit
- Kamath Sanjeet
- Karaderi Tugce
- Karaderi Tugce
- Kavanaugh Arthur
- Kavanaugh Arthur
- Keenan Anne-Maree
- Keenan Anne-Maree
- Keidel Sarah
- Keller Majella
- Kelly Clive
- Kelly Clive
- Kelly Stephen
- Kenwright Andrew
- Keystone Edward
- Khan Korsa
- Khan Korsa
- Khan Korsa
- Kiely Patrick D.
- Kiely Patrick D.
- Kingsley Gabrielle H.
- Kingsley Gabrielle H.
- Kirkham Bruce
- Kirkham Bruce W.
- Kirwan John
- Kitas George
- Kitas George D.
- Kitas George D.
- Kitas George D.
- Kraus Alexandra
- Krueger Gerald
- Landewé Robert
- Law Rebecca-Jane
- Law Rebecca-Jane
- Lawson Tom
- Lazarus Mark
- Leandro Maria
- Leask Andrew
- Lemmey Andrew
- Lempp Heidi
- Leone Francesca
- Leung Alexander
- Lille Kate
- Liu Shangxi
- Lloyd Mark
- Lloyd Mark
- Lofrano Mariana
- Lottay Neena
- Lovell Daniel
- Low Audrey
- Lunt Mark
- Lunt Mark
- Lynch Michael
- Ma Margaret H.
- Mack Michael
- Mackay Kirsten
- Maddison Peter
- Maddison Peter
- Maddison Peter J.
- Makadsi Raad
- Malaviya Anshuman P.
- Malaviya Anshuman P.
- Malik Saadia
- Malik Saadia
- Manning Joanne
- Markland David
- Martin James C.
- Martin Keith
- Martini Alberto
- McArthur Margaret
- McHugh Neil
- McHugh Neil
- McInnes Iain
- McInnes Iain
- McInnes Iain
- McKeeman Helen
- McKenna Frank
- McLaughlin Maeve
- McLoughlin YokeMei
- McNeilly Natasha E.
- Mease Philip
- Mease Philip
- Mease Philip
- Mercer Louise
- Mewar Devesh
- Mirjafari Hoda
- Moffat Claire
- Moinzadeh Pia
- Moinzadeh Pia
- Moore Jonathan P.
- Moore Owen
- Moore Tonia
- Morris Marianne
- Morris Vanessa
- Mudivarthy Surekha
- Muir Lindsay
- Munns Catherine
- Nandagudi Anupama
- Neville Cai
- Neville Cai
- Ng Nora
- Ngcozana Tanaka
- Nguyen Dianne
- Nightingale Peter
- Nihtyanova Svetlana
- Nisar M.
- Nisar Muhammad K.
- Nisar Muhammad K.
- Nordenskiold Ulla
- O'Connor Philip J.
- Ong Bie Nio
- Ong Voon
- Ong Voon
- Ong Voon
- Owen Pat
- Packham Jon
- Pande Ira
- Panthakalam Sathianathan
- Pardeo Manuela
- Parker Louise
- Parker S.
- Partlett Rosamund
- Patel Dipti
- Patterson Chris
- Pauling John
- Pauling John D.
- Pavey Chee
- Pease Colin T.
- Pease Emily E.
- Pellegrini Vincent
- Peluso Rosario
- Penn Henry
- Petford Sharon
- Pitzalis Costantino
- Pointon Jennifer J.
- Pointon Jennifer J.
- Pollard Louise C.
- Pollock Jon
- PradĂšre Marie-JosĂšphe
- Price Elizabeth
- Price Shyra
- Puntis Daniel
- Quest Enid
- Quinlan Tim M.
- Rahmeh Fouz
- Rajak Rizwan
- Rajak Rizwan
- Ramanujan Saroja
- Rankin Elizabeth
- Raut-Roy Dominique
- Redmond Anthony
- Redmond Anthony
- Reynolds John A.
- Rhodes Carol
- Rhys-Dillon Ceril
- Rhys-Dillon Ceril
- Richards Pam
- Richards Selwyn
- Richardson Ann
- Robinson Sandra M.
- Rodziewicz Mia
- Rose Katy
- Rosenberg William M.
- Rubbert-Roth Andrea
- Ruddlesden Michael
- Ruddlesden Michael
- Ruperto Nicola
- Russell Bridget
- Ryan Sarah
- Ryan Sarah
- Ryan Sarah
- Rynne Martin
- Sandhu Amrita
- Sandhu Virinderjit
- Sandoo Aamer
- Sandoo Aamer
- Sanyal Kaushik
- Saravanan Vadivelu
- Scali Juan
- Scarpa Raffaele
- Schneider Rayfel
- Schreiber Benjamin E.
- Schreiber Benjamin E.
- Schulze-Koops Hendrik
- Scott David
- Scott David L.
- Scott David L.
- Scott David L.
- Scott David L.
- Sebba Anthony
- Sen Debajit
- Sengupta Raj
- Sengupta Raj
- Shah Preeti
- Shattles Warren
- Shipley Mike
- Shiwen Xu
- Shiwen Xu
- Siebert Stefan
- Sieper Joachim
- Silman Alan
- Singh Animesh
- Smith Angela
- Smith H.
- Smith Jacqueline
- Smith Jacqueline
- Smith Jacqueline P.
- Soh Vicky
- Soscia Ernesto
- Spencer Simon
- Stratton Richard
- Stratton Richard
- Strickland Gemma
- Sykes Rebecca
- Symmons Deborah
- Symmons Deborah
- Taggart Allister
- Tahir Hasan
- Tak Paul P.
- Tandon Neeta
- Tanner Lorraine
- Tarzi Mike
- Taylor Peter
- Taylor Peter
- Tennant Alan
- Terslev Lene
- Thalayasingam Nishanthi
- Thom Jeanette
- Thom Jeanette M.
- Thom Jeanette M.
- Thomas Amanda
- Thomas Amanda
- Thomas Eleri
- Thomas Tasmin
- Thompson Katherine
- Thompson Liz
- Thompson Nicola
- Thwaites Catharine
- Tibble Jeremy
- Toberty Elizabeth
- Toms Tracey
- Toms Tracey E.
- Trehane Anne
- Treharne Gareth J.
- Turner Michael
- Turner-Cobb Julie
- Tyson Sarah
- Vail Andy
- Valentini Gabriele
- van der Heijde Desiree
- van der Heijde Désirée
- Van Vollenhoven Ronald
- van Zanten Jet J. Veldhuijzen
- Verstappen Suzanne M.
- Vinall Karen A.
- Wajed Julekha
- Wakefield Richard J.
- Walker David
- Wallis Dinny
- Wardle Phil
- Warrell Clare
- Warrell Clare E.
- Waterfield Jackie
- Watson Kath
- Watson Liam
- Westlake Sarah L.
- Westlake Sarah L.
- White Catherine
- White Derrick
- Wig Surabhi
- Wilby M. J.
- Wilkinson Kate
- Williams Ann
- Williamson Lyn
- Wilson Jo
- Wilson Oonagh
- Wincup Chris
- Winfield Rachel A.
- Wing Charlotte
- Winter Richard
- Wollenhaupt JĂŒrgen
- Wong Henna
- Woo Patricia
- Wordsworth Bryan P.
- Wordsworth Bryan P.
- Wren Damian
- Wright Gary
- Xu Weichun
- Yau Wing Hoi
- Youll Matthew J.
- Young Adam
- Young Adam
- Zayat Ahmed S.
- Zilberstein Moshe
- Zouita Louisa
- Publication venue
- Publication date
- 02/08/2017
- Field of study
Background: Foot surgery is common in patients with RA but research into surgical outcomes is limited and conceptually flawed as current outcome measures lack face validity: to date no one has asked patients what is important to them. This study aimed to determine which factors are important to patients when evaluating the success of foot surgery in RA Methods: Semi structured interviews of RA patients who had undergone foot surgery were conducted and transcribed verbatim. Thematic analysis of interviews was conducted to explore issues that were important to patients. Results: 11 RA patients (9 â, mean age 59, dis dur = 22yrs, mean of 3 yrs post op) with mixed experiences of foot surgery were interviewed. Patients interpreted outcome in respect to a multitude of factors, frequently positive change in one aspect contrasted with negative opinions about another. Overall, four major themes emerged. Function: Functional ability & participation in valued activities were very important to patients. Walking ability was a key concern but patients interpreted levels of activity in light of other aspects of their disease, reflecting on change in functional ability more than overall level. Positive feelings of improved mobility were often moderated by negative self perception ("I mean, I still walk like a waddling duckâ). Appearance: Appearance was important to almost all patients but perhaps the most complex theme of all. Physical appearance, foot shape, and footwear were closely interlinked, yet patients saw these as distinct separate concepts. Patients need to legitimize these feelings was clear and they frequently entered into a defensive repertoire ("it's not cosmetic surgery; it's something that's more important than that, you know?â). Clinician opinion: Surgeons' post operative evaluation of the procedure was very influential. The impact of this appraisal continued to affect patients' lasting impression irrespective of how the outcome compared to their initial goals ("when he'd done it ... he said that hasn't worked as good as he'd wanted to ... but the pain has goneâ). Pain: Whilst pain was important to almost all patients, it appeared to be less important than the other themes. Pain was predominately raised when it influenced other themes, such as function; many still felt the need to legitimize their foot pain in order for health professionals to take it seriously ("in the end I went to my GP because it had happened a few times and I went to an orthopaedic surgeon who was quite dismissive of it, it was like what are you complaining aboutâ). Conclusions: Patients interpret the outcome of foot surgery using a multitude of interrelated factors, particularly functional ability, appearance and surgeons' appraisal of the procedure. While pain was often noted, this appeared less important than other factors in the overall outcome of the surgery. Future research into foot surgery should incorporate the complexity of how patients determine their outcome Disclosure statement: All authors have declared no conflicts of interes
Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
- Author
- Abbas Rezaianzadeh
- Abdonas Tamosiunas
- Abdul Basit
- Abdul Hamid Zargar
- Abdullah Alkandari
- Abdullatif Husseini
- Abhijit Sen
- Abla M Sibai
- Abu Am Hanif
- Adela Chirita-Emandi
- Adelheid Weber
- Adetoyeje Y Oyeyemi
- Adewale L Oyeyemi
- Adolfo Rubinstein
- Adoubi Kassi Anicet
- Adroaldo Cesar Araujo Gaya
- Afshin Ostovar
- Agnes L Kadvan
- Agneta SjoÌberg
- Agneta Yngve
- AgneÌs Le Port
- Agustinus Soemantri
- AgustiÌn Perez-LondonÌo
- Ahmad A Zainuddin
- Ahmad Faudzi Yusoff
- Ahmad Reza Dorosty
- Ahmed A Madar
- Aida Pilav
- AiÌcha SoumareÌ
- Akaninyene Otu
- Akihiro Yoshihara
- Akkumis Salhanova
- Akram Pourshams
- Ala'a Alkerwi
- Alain Morejon
- Alanna G da Silva
- Albertino Damasceno
- Alberto BarceloÌ
- Alberto Palloni
- Albina A Fakhretdinova
- Alejandro Diaz
- Aleksander Giwercman
- Aleksandra Gomula
- Aleksandra Piwonska
- Alessandro Gialluisi
- Aletta E Schutte
- Alexander D Deev
- Alexandra M Cucu
- Alexandre C Pereira
- Alfonso Siani
- Alfonso Sousa-Poza
- Ali Ahmadi
- Ali Akbar Shayesteh
- Ali Esmaeili
- Ali Ghanbari
- Ali Reza Safarpour
- Alice Bonilla-Vargas
- Alicia Matijasevich
- Alina G Platonova
- Alina Kerimkulova
- Aline Meirhaeghe
- Aline P Batista
- Alireza Ansari-Moghaddam
- Alireza Khosravi
- Alireza Moslem
- Alireza Sadjadi
- Alisha N Wade
- Alison J Hayes
- Alison J Price
- Allan G Hill
- Allan Linneberg
- Almaz Sharman
- Altan Onat
- Aluisio Jd Barros
- Alun Evans
- Amalia De Curtis
- Amanda G Thrift
- Amanda J Cross
- Amaneh Shayanrad
- Ambady Ramachandran
- Amelia C Crampin
- Amina Barkat
- Amir Houshang Mehrparvar
- Amirabbas Momenan
- Ana Azevedo
- Ana B Crujeiras
- Ana Barradas-Pires
- Ana Carolina Mgn de SaÌ
- Ana D GonzaÌlez-Alvarez
- Ana Henriques
- Ana I Rito
- Ana JelakovicÌ
- Ana Maria B Menezes
- Ana P Ortiz
- Ana Paula C CaÌndido
- Anabela Mota-Pinto
- Anar Dushpanova
- Anastasia Markaki
- Anders GrĂžntved
- Andre L Guimaraes
- Andre P Kengne
- Andrea Gazzinelli
- Andrea Gualtieri
- Andrea Rodriguez-Martinez
- Andrea Rvr Horimoto
- Andrea Schneider
- Andrea Y RodriÌguez
- Andrea Zentai
- Andreas Stang
- Andreia N Pizarro
- Andrew Kingston
- Andrew Reynolds
- Andrew Wong
- Andrzej Galbarczyk
- Andrzej PajaÌšk
- Andrzej WieÌšcek
- Anelise Reis Gaya
- Aneta Grajda
- Aneta Weres
- Anette Varbo
- Angel R Gonzalez
- Angela Chetrit
- Angela DoÌring
- Angela Spinelli
- Angelika Schaffrath Rosario
- Angelique Chan
- AngeÌlica M Ochoa-AvileÌs
- Anie Marcil
- Anil Poudyal
- Anja L Madsen
- Anja Schienkiewitz
- Anna Bartosiewicz
- Anna Bugge
- Anna Fijalkowska
- Anna Jansson
- Anna V Alieva
- Annamari Lundqvist
- Anne A Bjerregaard
- Anne Chinnock
- Anne Juolevi
- Anne Taylor
- Anne Tjonneland
- Anneke Blokstra
- Annette J Dobson
- Annette Peters
- Annika Rosengren
- Anthony Kafatos
- Antonia Trichopoulou
- Antonio Bernabe-Ortiz
- Antonio Cabrera de LeoÌn
- Antonio M Silva
- Antonio Mistretta
- Antonio Pedro Graça
- Antonio Prista
- Antonis Zampelas
- Antonisamy Belavendra
- Anu Mishra
- Anwar M Batieha
- Archie W Rayner
- Areti Triantafyllou
- Argyro Karakosta
- Ari Voutilainen
- Aristides M Machado-Rodrigues
- Arnaud Chiolero
- Aroor Bhagyalaxmi
- Arsalan Khaledifar
- Artur Mazur
- Arvind Pandey
- Arwa M Alshangiti
- Aryeh D Stein
- Asher Fawwad
- Attilio Rigotti
- Atul Trivedi
- Augustin F Beybey
- Augustine N Odili
- Augusto Di Castelnuovo
- Aung Soe Htet
- Ausra Petrauskiene
- Avula Laxmaiah
- Axel C Carlsson
- Aya Mostafa
- Ayman A Zayed
- Azaliia M Tuliakova
- Azhar Dyussupova
- Azim Nejatizadeh
- Azli Baharudin
- AÌsa AÌgren
- Badreya Al-Lahou
- Bagher Larijani
- Bahareh Kheiri
- Bahman Cheraghian
- Bakary Jallow
- Baltazar Nunes
- Barbara Heude
- Barbara Thorand
- Barry M Popkin
- Batyrbek Assembekov
- Beatriz D Schaan
- Bee Koon Poh
- Behrooz Hamzeh
- Bekbolat Zholdin
- Belgin Unal
- Belong Cho
- Ben SchoÌttker
- Benjamin Acosta-Cazares
- Benoit Salanave
- Benson M Kazembe
- Bente Sparboe-Nilsen
- Bernard Maire
- Bernardo L Horta
- Bernhard O Boehm
- Bert-Jan van den Born
- Bettina Bringolf-Isler
- Bharathi Viswanathan
- Bhawesh Koirala
- Bihungum Bista
- Bill Stavreski
- Bin Zhou
- Bing Zhang
- Birgit Linkohr
- Biruta Velika
- Blanca Sandra Ruiz-Betancourt
- Bo Werner
- Boban MugosÌa
- Bogdan Wojtyniak
- Bojan JelakovicÌ
- Bontha V Babu
- Boyd A Swinburn
- BoÌrge Schmidt
- Branimir LeskosÌek
- Breige A McNulty
- Brian Oldenburg
- Brooklyn Fraser
- Bruna Gonçalves Cordeiro da Silva
- Buthaina M Alkhatib
- BĂžrge G Nordestgaard
- Caleb Ochimana
- Calogero Saieva
- Calvin Ke
- Camilla T Damsgaard
- Carl Lachat
- Carla MeneÌses Hardman
- Carlo Maria Barbagallo
- Carlos A Aguilar-Salinas
- Carlos O Mendivil
- Carlos P Boissonnet
- Carmen InÌiguez
- Carolina B Tarqui-Mamani
- Caroline H Fall
- Caroline Ramos de Moura Silva
- Carsten O Schmidt
- Cassiano Ricardo Rech
- Catherine Kyobutungi
- Catterina Ferreccio
- Cecilia BjoÌrkelund
- Cecily Kelleher
- Cesar G Victora
- CeÌzane P Reuter
- Chandini Nekkantti
- Chao Qiang Jiang
- Charalambos A Hadjigeorgiou
- Charles Agyemang
- Charles K Mondo
- Charles Lunogelo
- Charles Sossa JeÌrome
- Charlie Lim
- Charlotte B Ottendahl
- Charmaine A Duante
- Charumathi Sabanayagam
- Chiara Donfrancesco
- Chien-An Sun
- Chien-Jen Chen
- Ching-Yu Cheng
- Chinh Nguyen Huu
- Chinwuba Ijoma
- Chongjian Wang
- Chris Cowell
- Christa L Lilly
- Christa Meisinger
- Christian Gieger
- Christina C Dahm
- Christina Howitt
- Christina Mavrogianni
- Christine Cameron
- Christophe Tzourio
- Christopher J Paciorek
- Chung T Nguyen
- Cihangir Erem
- Claes Ohlsson
- Clara Homs
- Claudia M Hormiga
- ClaÌudia S Minderico
- Clicerio GonzaÌlez-Villalpando
- Clive Osmond
- Coimbatore Subramaniam Shanthirani
- Con Burns
- Constance Schultsz
- Constanta Huidumac Petrescu
- Cora L Craig
- Correia JuÌnior Marco AureÌlio de Valois
- Cosmin R Cojocaru
- Cristina P Padez
- Crizian G Saar
- Cynthia M PeÌrez
- Cyrus Cooper
- Daan Kromhout
- Dalia Luksiene
- Damaskini Valvi
- Damian K Francis
- Dan Zhu
- Daniel Bia
- Daniel FernaÌndez-BergeÌs
- Daniel Ferrante
- Daniel G Vasques
- Daniel Lemogoum
- Daniel Weghuber
- Daniela Galeone
- Daniela KaÌllayovaÌ
- Daniela Pierannunzio
- Daniela Rodrigues
- Daphne Lai
- Daphne Mirkopoulou
- David A Gonzalez-Chica
- David De Ridder
- David Faeh
- David Goltzman
- Davide Noto
- Davood Khalili
- Deborah C Malta
- Debra S Judge
- Deena Al Asfoor
- Deepak N Amarapurkar
- Delphine De Smedt
- Demetre Labadarios
- Denise Eldemire-Shearer
- Dermot O'Reilly
- DeÌnes MolnaÌr
- Diana A Santos
- Diane T Meto
- Dianna J Magliano
- Dickman Gareta
- Diego Augusto Santos Silva
- Diego G Christofaro
- Diego SalmeroÌn
- Diego Vanuzzo
- Dimitrios Papandreou
- Dimitrios Poulimeneas
- Dimitrios Trichopoulos
- Dirk De Bacquer
- Dirk Vanderschueren
- Dominique Cottel
- Dominique Hange
- Dong Zhao
- Dongfeng Gu
- Dora Romaguera
- Doris StoÌckl
- Dorja Vocanec
- Doroteia A HoÌfelmann
- Dusko J Bjelica
- DusÌan Grafnetter
- Duygu Islek
- Dwi Hapsari Tjandrarini
- E Shyong Tai
- Ebrahim Eftekhar
- Ebrahim Ghaderi
- Eduardo Capuano
- Eduardo Salazar Martinez
- Edward F Fottrell
- Edward Janus
- Edward W Gregg
- Edwige Landais
- Edyta Ćuszczki
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- Muhammad Fadhli Mohd Yusoff
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- Muhammed S Qadir
- Mukharram M Bikbov
- Mukhtar Kulimbet
- Murat Topbas
- Myriam Galfo
- N Charlotte Onland-Moret
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- Paula Duarte de Oliveira
- Paula Margozzini
- Paulo A Lotufo
- Pavel Piler
- Pawel Kurjata
- PaÌivi MaÌki
- Pedro DiÌaz FernaÌndez
- Pedro J Ortiz
- Pedro J Quiroga-Padilla
- Pedro Marques-Vidal
- Pedro Ordunez
- Pedro Plans-RubioÌ
- Pei Gao
- Peng Nie
- Per Tynelius
- Peter Bjerregaard
- Peter H Whincup
- Peter Lund Kristensen
- Peter Rohloff
- Peter Schnohr
- Peter Stehle
- Peter T Katzmarzyk
- Peter Ueda
- Peter Vollenweider
- Peter Willeit
- Petra Rust
- Phalakorn Suebsamran
- Philip Clare
- Philipp S Wild
- Philippe Amouyel
- Philippe B Katchunga
- Phoebe R Spencer
- Pierre Traissac
- Pietro A Modesti
- Pilar Amiano Etxezarreta
- Pilar De Miguel-Etayo
- Pilar Guallar-CastilloÌn
- Piotr MatĆosz
- Prabhdeep Kaur
- Pradeep Joshi
- Prakash C Gupta
- Prashant Mathur
- Preux Pierre-Marie
- Priscilla Duboz
- PrzemysĆaw Slusarczyk
- Qi Sheng You
- Qian Wang
- Qing Qiao
- Quang Ngoc La
- Quang Ngoc Nguyen
- Queenie Chan
- R Krishna Kumar
- Rachael M McLean
- Rachakulla Hari Kumar
- Rachel A Heap
- Rachel Dankner
- Radka TaxovaÌ BraunerovaÌ
- Radu Vatasescu
- Radwan F Qasrawi
- Rafael Dos Santos Henrique
- Rafael N Pichardo
- Rafaela V Rosario
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- Raija Korpelainen
- Raimund Pechlaner
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- Rajaa Al-Raddadi
- Rajeev Gupta
- Rajendra Pradeepa
- Rajiv T Erasmus
- Raluca M Pop
- Ramesh Godara
- Ramfis E Nieto-MartiÌnez
- Ramin Heshmat
- Ramiro Guerrero
- Ramon A Rascon-Pacheco
- Ramon O Jimenez
- RamoÌn SuaÌrez-Medina
- Ranjit Mohan Anjana
- Ranko StevanovicÌ
- Raphael E Arku
- Raphael M Ritti-Dias
- Reecha Sofat
- Regina Heidinger-FelsoÌ
- Reina Engle-Stone
- Reina G Roa
- Renata Cifkova
- Renata Kuciene
- ReneÌ Charles Sylva
- Reynaldo Martorell
- Reza Homayounfar
- Reza Malekzadeh
- Reza Mohammadpourhodki
- Ricardas Radisauskas
- Ricky Eddie
- Rildo de Souza Wanderley JuÌnior
- Rob M van Dam
- Robert Beaglehole
- Robert Eggertsen
- Robert J Adams
- Roberta B Caixeta
- Robespierre Ribeiro
- Rocco Capuano
- Rod T Jackson
- Rodica Nicolescu
- Rodrigo M Carrillo-Larco
- Rody G Sy
- Roger A Montenegro Mendoza
- Roger G Evans
- Rohina Joshi
- Roman TopoÌr-MaÌšdry
- Romana Roccaldo
- Romulo A Fernandes
- Ronald D Gregor
- Ronel Sewpaul
- Ronit Endevelt
- Ronnie George
- Rosa Haghshenas
- Rosalba Rojas-Martinez
- Rosalynn Siantar
- Rosangela L Batista
- Rosemarie Martin
- Rosie K Singleton
- Rossina G Pareja
- Rosu Maria-Magdalena
- Roy A Wong-McClure
- Roya Kelishadi
- Ruan Kruger
- Rudolf Kaaks
- Rui Ornelas
- Rui Providencia
- Rupert Ra Bourne
- Rusidah Selamat
- Ruslan D Devrishov
- Rute Santos
- Ruzena Kubinova
- Ryutaro Ohtsuka
- S Goya Wannamethee
- Sabina Zambon
- Sabine Schipf
- Sadaf G Sepanlou
- Saeed Dastgiri
- Saeed M Omar
- Saeid Eslami
- Saeid Safiri
- Safiah Md Yusof
- Sahar Saeedi Moghaddam
- Sai Yin Ho
- Sajid Soofi
- Salar Rahimikazerooni
- Salim Berkinbayev
- Salim Mohanna
- Salvador Villalpando
- Sameer Narake
- Samuel C Dumith
- San-Lin You
- Sanda M Kolo
- Sandjaja
- Sandra C Fuchs
- Sandra Colorado-Yohar
- Sania Nishtar
- Sanja MusicÌ MilanovicÌ
- Sanja SÌalaj
- Sanjay Rampal
- Sanjib K Sharma
- Santiago F GoÌmez
- Santosh K Bhargava
- Sara Magnacca
- Sara Schramm
- Sarah Cuschieri
- Sarah P Garnett
- Sare Safi
- Sareh Eghtesad
- Sari Hantunen
- Saskia Te Velde
- Satoko Sakata
- Sauli Herrala
- Savvas Savva
- Scott B McLean
- SemaÌnovaÌ Csilla
- Senthil K Vasan
- Seongjun Ha
- Seppo Koskinen
- Sergej M Ostojic
- Sergio Viana Peixoto
- Seth Adu-Afarwuah
- Seyed Mohammad Hashemi-Shahri
- Seyed Morteza Shamshirgaran
- Seyed Rasoul Zakavi
- Seyed-Ali Mostafavi
- Seyyed-Hadi Ghamari
- Shahla AlDhukair
- Shaker A Alomary
- Shariq R Masoodi
- Sheena E Ramsay
- Sheikh Mohammed Shariful Islam
- Shelly R McFarlane
- Sherali Rakhmatulloev
- Sherilynn Madraisau
- Shina Avi
- Shiqi Zhen
- Shirin Djalalinia
- Shoaib Afzal
- Shoichiro Tsugane
- Shouling Wu
- Shu-Ti Chiou
- Shubash Ganapathy
- Shufa Du
- Shukri F Mohamed
- Shuohua Chen
- Shynar Abdrakhmanova
- Sibel Gogen
- Sigmund A Anderssen
- Silje Steinsbekk
- Silvana P Donoso
- Silvia Bel-Serrat
- Silvije VuleticÌ
- Simo Pone Larissa
- Simona Bo
- Simona Costanzo
- Simona Giampaoli
- Sinead Brophy
- Sirkka KeinaÌnen-Kiukaanniemi
- Slavica Sovic
- Slawomir Koziel
- Snehalatha Chamukuttan
- Sofia K Malyutina
- Soheir H Ahmed
- Sok King Ong
- Solie Puhakka
- Son Thai Pham
- Songhomitra Panda-Jonas
- Sonya V Galcheva
- Soon-Woo Park
- Sophia J Kiechl
- Sophie Visvikis-Siest
- Sounnia Mediene Benchekor
- Sousana K Papadopoulou
- Srinivasan Kannan
- Stefaan De Henauw
- Stefaan Demarest
- Stefan Adela Gabriela
- Stefan Kiechl
- Stefan Rach
- Stefan Savin
- Stefan SoÌderberg
- Stefania Maggi
- Stefania Toselli
- Stefano Marventano
- Steinar Krokstad
- Stephen T McGarvey
- Steve Botomba
- Stevo R Popovic
- Stig E Bojesen
- Stine Schramm
- Sudha Ramachandra Rao
- Sudhir Kowlessur
- Suhad Bahijri
- Suhaila Abdul Ghaffar
- Sumit Bharadwaj
- Suntara Klanarong
- Susana C Confortin
- Susana Sans
- Susana Vale
- Susanne Kobel
- Susanne R de Rooij
- Susi Kriemler
- Suyeon Park
- Suzanne C Ho
- Suzanne N Morin
- Svetlana Shalnova
- Sylvain Sebert
- Sylvia Alexius
- Tabara Yasuharu
- Tahir Aris
- Tai Hing Lam
- Tajana Zeljkovic Vrkic
- Takafumi Ishida
- Take Naseri
- Takuro Furusawa
- Tal Shimony
- Tamara R Santos
- TamaÌs CsaÌnyi
- Tamerlan Rajabov
- Tandi E Matsha
- Tania Lopez
- Tania Tello
- Tanja Gm Vrijkotte
- Tara C Coppinger
- Taru Manyanga
- Tasanee Braithwaite
- Tatjana Hejgaard
- Tatyana Slazhnyova
- Tazeen Jafar
- Terence Dwyer
- Terence W O'Neill
- Teresa Haugsgjerd
- Teresa Shamah-Levy
- Terho LehtimaÌki
- Thamara Hubler FigueiroÌ
- Thein Thein Htay
- Themistoklis Tzotzas
- Theodora Benedek
- Thet Thet Mu
- Thi Tuyet-Hanh Tran
- Thirunavukkarasu Sathish
- Thomas Ferrao
- Thomas M Dantoft
- Thomas MuÌnzel
- Thomas WaldhoÌr
- Thor Aspelund
- Thorkild Ia SĂžrensen
- Tien Yin Wong
- Tiffany K Gill
- Tiina Laatikainen
- Tiina Lankila
- Tiina Vlasoff
- Tilema Cama
- Till Ittermann
- Timothy Key
- Tina Harmer Lassen
- Tint Swe Latt
- Tobias F Rinke de Wit
- Tom Wilsgaard
- Tomas Vega
- Tomasz Zdrojewski
- Tomi-Pekka Tuomainen
- Toomas Veidebaum
- Torben JĂžrgensen
- Toshiharu Ninomiya
- Tran Quoc Bao
- Trevor S Ferguson
- Tuija JaÌaÌskelaÌinen
- Tuyen D Le
- Tze Pin Ng
- Ulf Ekelund
- Ulf RiseÌrus
- Ulla Roggenbuck
- Ulrich Keil
- Ulrike Gehring
- Unjali P Gujral
- Urho M Kujala
- Ursula Kiechl-Kohlendorfer
- Uruwan Yamborisut
- Vaitheeswaran Kulothungan
- Valentina Peterkova
- ValeÌria RegecovaÌ
- ValeÌrie Deschamps
- Valirie N Agbor
- Valter Barbosa Filho
- Vanessa Rouzier
- Vanina Bongard
- Vasiliki Efthymiou
- Vassilis Zafiropulos
- Vayia Rarra
- Vedrana Sember
- Veikko Salomaa
- Vera Lanska
- Vera Musil
- Veronica Mocanu
- Vesna Juresa
- Vesselka L Duleva
- Victor M Herrera
- Victor Matsudo
- Victor Pf Lhoste
- Victoria E Soto-Rojas
- Victoria Farrugia Sant'Angelo
- Vijaya Lingam
- Viktoria Anna Kovacs
- Viktoriya Furdela
- Vilma E Irazola
- Vilma Kriaucioniene
- Vilmundur Gudnason
- Vilnis Dzerve
- Vinay B Nangia
- Vincent Jr DeGennaro
- Vincenzo Capuano
- Vincenzo Solfrizzi
- Violeta Iotova
- Virginija Dulskiene
- VirgiÌlio V Ramires
- Visnja Djordjic
- Viswanathan Mohan
- Viviana Guajardo
- Viviane C Cardoso
- Vladimir Kutsenko
- Wafaie W Fawzi
- Wan Mohamad Wan Bebakar
- Wan Nazaimoon Wan Mohamud
- Wei Zheng
- Wei-Cheng Lo
- Wei-Yen Lim
- Weili Yan
- Wen-Harn Pan
- Wenbin Wei
- Wendy Van Lippevelde
- Wenhua Zhao
- Wichai Aekplakorn
- Willem A Hanekom
- William A Neal
- William R Tebar
- Wilma M Hopman
- Winsome R Parnell
- Wm Monique Verschuren
- Wojciech Drygas
- Wojciech Rusek
- Wolfgang Ahrens
- Wolfgang Kratzer
- Xenophon Theodoridis
- Xiangjun Wang
- Xiaoguang Yang
- Xiaotian Liu
- Ximena Berrios Carrasola
- Xinyi Gwee
- Xiu-Hua Guo
- Xu Lin
- Xu Ma
- Xueling Sim
- Xun Tang
- Ya Xing Wang
- Yadlapalli S Kusuma
- Yajaira BricenÌo
- Yang Yang
- Yanhui Dong
- Yanina Zocalo
- Yanitsa V Zhecheva
- Yannis Manios
- Yanping Li
- Yemane Berhane
- Yeunsook Rho
- Yeva Movsesyan
- Yi Song
- Yi Zeng
- Yih Chung Tham
- Yiling J Cheng
- Yin Guo
- Ying-Wei Wang
- Yingfeng Zheng
- Yn-Tz Sung
- Yong Tao
- Yonghua Hu
- Yosef Farzi
- Yoto Yotov
- Youcef Laid
- Young-Ho Khang
- Yousef Saleh Khader
- Yu-Ling Yu
- Yuan He
- Yufang Bi
- Yuki Fujita
- Yulia Balanova
- Yuliya V Solovieva
- Yuna He
- Yunjiang Yu
- Yury P Nikitin
- Yves Kameli
- Yves Martin-Prevel
- Yvonne T van der Schouw
- Zahra Mohammadi
- Zbigniew Gaciong
- Zbigniew Kulaga
- Zengchang Pang
- Zhamilya Battakova
- Zhamyila Usupova
- Zhanna Kalmatayeva
- Zhen-Yu Zhang
- Zhengming Chen
- Ziad A Abdeen
- Zivka Dika
- Zlatko Fras
- Zulfiqar A Bhutta
- Zulfiya Abdurrahmonova
- Zumin Shi
- Ćukasz Kryst
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We
estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from
1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories.
Methods We used data from 3663 population-based studies with 222 million participants that measured height and
weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate
trends in the prevalence of different BMI categories, separately for adults (age â„20 years) and school-aged children
and adolescents (age 5â19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the
individual and combined prevalence of underweight (BMI <18·5 kg/m2) and obesity (BMI â„30 kg/m2). For schoolaged children and adolescents, we report thinness (BMI <2 SD below the median of the WHO growth reference)
and obesity (BMI >2 SD above the median).
Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in
11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed
changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and
140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of
underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and
countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior
probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse
was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of
thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a
posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%)
with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and
obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for
both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such
as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged
children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls
in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and
42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents,
the increases in double burden were driven by increases in obesity, and decreases in double burden by declining
underweight or thinness.
Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an
increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy
nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of
underweight while curbing and reversing the increase in obesit
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
- Author
- A Gordon Robertson
- Abdullah Kahraman
- Abel Gonzalez-Perez
- Adam A Margolin
- Adam Abeshouse
- Adam Grundhoff
- Adam J Struck
- Adam J Struck
- Adam J Wright
- Adam Lambert
- Adam P Butler
- Adam P Butler
- Adel El-Naggar
- Adnan M Nagrial
- Adrian Ally
- Adrian Baez-Ortega
- Adrian Thorogood
- Adriana Salcedo
- Adrienne M Flanagan
- Ake Borg
- Akihiro Fujimoto
- Akihiro Suzuki
- Akinyemi I Ojesina
- Alain Viari
- Alan J Robertson
- Alan P Hoyle
- Alan Thompson
- Alasdair Stenhouse
- Alastair M Thompson
- Aldo Scarpa
- Alessandro Pastore
- Alex Buchanan
- Alex Buchanan
- Alexander Claviez
- Alexander J Lazar
- Alexander Martinez-Fundichely
- Alfonso Muñoz
- Alfonso Valencia
- Aliaksei Z Holik
- Alice Meng
- Alicia L Bruzos
- Allison Creason
- Allison P Heath
- Alvin Wei Tian Ng
- Alvis Brazma
- Amaro Taylor-Weiner
- Amber L Johns
- Amie Radenbaugh
- Amit G Deshwar
- Ana Dueso-Barroso
- Ana Mijalkovic Mijalkovic-Lazic
- Ana Milovanovic
- Ana Milovanovic
- Andre Kahles
- Andrea Haake
- Andrea Holbrook
- Andrea L Richardson
- Andrea Mafficini
- Andrea Ruzzenente
- Andreas Behren
- Andreas Rosenwald
- Andreia V Pinho
- Andrew Berchuck
- Andrew D Cherniack
- Andrew J Dunford
- Andrew J Mungall
- Andrew J Spillane
- Andrew Menzies
- Andrew Menzies
- Andrew P Barbour
- Andrew Tutt
- Andrew V Biankin
- Andrey Korshunov
- Andrés Lanzós
- Andy Cafferkey
- Andy G Lynch
- Angela Chou
- Angela N Brooks
- Angela Tam
- Angelica Ochoa
- Angelika N Christ
- Angelo P Dei Tos
- Anieta M Sieuwerts
- Anil K Sood
- Anita LangerĂžd
- Anja FĂŒllgrabe
- Anke K Bergmann
- Ann-Marie Patch
- Anna deFazio
- Anna Ehinger
- Anna Fitzgerald
- Anne Hamilton
- Anne Vincent-Salomon
- Anne Y Warren
- Anne-Lise BĂžrresen-Dale
- Annegien Broeks
- Anthony DiBiase
- Anthony J Gill
- Anthony Ng
- Anthony R Green
- Antonia L Pritchard
- Antonio Pea
- Antonios Koures
- Aparna Prasad
- Apurva M Hegde
- Aquila Fatima
- Arcadi Navarro
- Arie B Brinkman
- Arif O Harmanci
- Arindam Maitra
- Armando Lopez-Guillermo
- Arndt Borkhardt
- Arnoud Boot
- Asger Hobolth
- Ashley Williams
- Ashton A Connor
- Atul J Butte
- Aurélien Chateigner
- Austin J Hepperla
- Axel Aretz
- Aya Sasaki-Oku
- Ayellet V Segre
- B F Francis Ouellette
- Bailey Matthew H
- Barbara Hutter
- Barbara Hutter
- Barbara Kremeyer
- Bartha M Knoppers
- Beifang Niu
- Beifang Niu
- Beifang Niu
- Benedikt Brors
- Benita Kiat Tee Tan
- Benjamin J Raphael
- Benjamin P Berman
- Benjamin Raeder
- Bernardo Rodriguez-Martin
- Bernhard Radlwimmer
- Bernice H Wong
- Beth Karlan
- Bin Tean Teh
- Bin Zhu
- Birgit Burkhardt
- Bishoy M Faltas
- Bodil Bjerkehagen
- Bogdan Czerniak
- Boris Winterhoff
- Borislav C Rusev
- Bradly G Wouters
- Brandi N Davis-Dusenbery
- Brian Craft
- Brian D O'Connor
- Brian Patrick O'Neill
- Brice Aminou
- Calvin Wing Yiu Chan
- Cameron M Soulette
- Carl Herrmann
- Carl Morrison
- Carlo Gambacorti-Passerini
- Carlos Caldas
- Carlos D Bustamante
- Carlos LĂłpez-OtĂn
- Carlota Rubio-Perez
- Carmen Gomez
- Carolien H M van Deurzen
- Carolyn M Hutter
- Carolyn M Hutter
- Carrie Cibulskis
- Caterina Vicentini
- Catherine A Shang
- Catherine D Moser
- Catherine J Kennedy
- Catrina C Fronick
- Chad J Creighton
- Chandra Sekhar Pedamallu
- Chang Li
- Charles David Imbusch
- Charles M Perou
- Charles Saller
- Charles Short
- Charlie E Massie
- Chawalit Pairojkul
- Chen Hong
- Chen Ye
- Cheng-Zhong Zhang
- Chin-Lee Wu
- Chip Stewart
- Chip Stewart
- Chip Stewart
- Choon Kiat Ong
- Chris Lawerenz
- Chris Mitchell
- Chris Sander
- Christian von Mering
- Christiane Buchholz
- Christina K Yung
- Christina K Yung
- Christina Yau
- Christine A Iacobuzio-Donahue
- Christine Chomienne
- Christine Desmedt
- Christine P'ng
- Christof von Kalle
- Christoph Borst
- Christoph Plass
- Christopher A Miller
- Christopher Benz
- Christopher J Scarlett
- Christopher J Yoon
- Christopher K Wong
- Christopher M Lalansingh
- Christopher M Lalansingh
- Christopher Ogden
- Christopher S Foster
- Christopher Umbricht
- Christopher W Toon
- Christos Sotiriou
- Cindy Bell
- Cinzia CantĂč
- Ciyue Shen
- Claes Wadelius
- Clare Verrill
- Clarissa Gerhauser
- Claudia Calabrese
- Claudio Bassi
- Claudio Luchini
- Claudiu Farcas
- Clemency Jolly
- Colin A Purdie
- Colin A Semple
- Colin C Collins
- Colin S Cooper
- Conrad R Leonard
- Constance H Li
- Corbin D Jones
- Craig Shriver
- Cristina LĂłpez
- Cyriac Kandoth
- Cyril Fisher
- D Neil Hayes
- Dai-Ying Wu
- Daiming Fan
- Daisuke Komura
- Dale W Garsed
- Daniel A Leongamornlert
- Daniel Baumhoer
- Daniel HĂŒbschmann
- Daniel J Turner
- Daniel J Weisenberger
- Daniel M Berney
- Daniel Rosebrock
- Daniel S Brewer
- Daniela S Gerhard
- Danielle Pasternack
- Darell Bigner
- Dariush Etemadmoghadam
- Darlene Lee
- Darrin F Taylor
- Dave Larson
- David A Wheeler
- David A Wheeler
- David C Wedge
- David Craft
- David D L Bowtell
- David E Neal
- David Haan
- David Haussler
- David Haussler
- David Hedley
- David Huntsman
- David I Heiman
- David J Adams
- David J Van Den Berg
- David K Chang
- David K Miller
- David Khoo
- David Mutch
- David N Louis
- David Nicol
- David Ocana
- David R Jones
- David R Jones
- David Scott
- David T Bowen
- David T W Jones
- David Tamborero
- David Torrents
- David Torrents
- David Townend
- David Vicente
- Davide Antonello
- Declan Cahill
- Denis Larsimont
- Denis Yuen
- Denise Brooks
- Deniz DemircioÄlu
- Dennis C Sgroi
- Dennis Karsch
- Dennis T Maglinte
- Dennis Wigle
- Derek W Wright
- Dianne E Chadwick
- Dido Lenze
- Dieter Kube
- Dieter Weichenhan
- Dilip D Giri
- Dimitri Livitz
- Dimitri Livitz
- Dimple Chakravarty
- Ding
- Dirk Schadendorf
- Dmitry A Gordenin
- Dominik Glodzik
- Don Chalmers
- Dong Guanlan
- Dongbing Liu
- Donghoon Lee
- Donghui Tan
- Donna M Muzny
- Dorthe Grabau
- Douglas A Levine
- Douglas F Easton
- Douglas Voet
- Duncan Beardsmore
- Dursi Lewis Jonathan
- Edward W Rowe
- Eigo Shimizu
- Ekta Khurana
- Elaine R Mardis
- Electron Kebebew
- Elena Piñeiro-Yåñez
- Elena Provenzano
- Elias Campo
- Elisabet Barrera
- Elisabetta Sereni
- Elizabeth A Musgrove
- Elizabeth L Appelbaum
- Elizabeth L Christie
- Elli Papaemmanuil
- Ellrott Kyle
- Emilie Lalonde
- Eoghan Harrington
- Eric Chuah
- Eric Green
- Eric Lander
- Eric Minwei Liu
- Eric Z Ma
- Eric Z Ma
- Erik Garrison
- Erik Larsson
- Erik Mayer
- Erik N Bergstrom
- Erin Curley
- Ermin Hodzic
- Erwin G Van Meir
- Esa PitkÀnen
- Esther Rheinbay
- Esther Rheinbay
- Eun Pyo Hong
- Eunjung Alice Lee
- Eva G Alvarez
- Eva Hellstrom-Lindberg
- Ewan Birney
- F GermĂĄn RodrĂguez-GonzĂĄlez
- Fabien C Lamaze
- Fabien Calvo
- Fabio C P Navarro
- Faiyaz Notta
- Fan Yang
- Fan Zhang
- Faraz Hach
- Faraz Hach
- Faridah Mbabaali
- Fatima Al-Shahrour
- Federico Abascal
- Fei-Fei Liu
- Felicity Newell
- Fenglin Liu
- Fernanda Amary
- Ferran Muiños
- Florian Markowetz
- Fouad Yousif
- Francesc Muyas
- Francesco Favero
- Francisco M De La Vega
- Francisco Sanchez-Vega
- Fraser R Duthie
- Fred Sweep
- Freddie C Hamdy
- Fruzsina MolnĂĄr-GĂĄbor
- Fumie Hosoda
- G Petur Nielsen
- G Steven Bova
- Gad Getz
- Gad Getz
- Gad Getz
- Gaetan MacGrogan
- Gaetano Finocchiaro
- Gary D Bader
- Gavin Ha
- Gavin W Wilson
- Genta Nagae
- Geoff Macintyre
- George B Hanna
- George L Mihaiescu
- Georgia Escaramis
- Georgina V Long
- Gerd Nettekoven
- German M Demidov
- German Ott
- Gerrit K Hooijer
- Gerstein Mark B
- Gert G Van den Eynden
- Getz Gad
- Ghislaine Scelo
- Giada Bonizzato
- Giampaolo Tortora
- Gilles Romieu
- Gilles Thomas
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- Niedzica Camacho
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- Nikolaus Schultz
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- Nischalan Pillay
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- Ofer Shapira
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- Olga Tucker
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- Subhajit Sengupta
- Sue Merson
- Suet-Feung Chin
- Sultan T Al-Sedairy
- Sung-Min Ahn
- Sung-Soo Yoon
- Sunghoon Cho
- Sunil R Lakhani
- Suresh Ramalingam
- Susan Bullman
- Susanna L Cooke
- Sushant Kumar
- Sushant Kumar
- Suyash S Shringarpure
- Syed Haider
- Sylvia Asa
- SĂžren Brunak
- Takafumi N Yamaguchi
- Takafumi N Yamaguchi
- Takanori Hasegawa
- Takashi Yugawa
- Takashi Yugawa
- Takuji Okusaka
- Tal Shmaya
- Tannistha Nandi
- Taobo Hu
- Taobo Hu
- Tapio Visakorpi
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- Tari A King
- Tatsuhiko Tsunoda
- Tatsuhiro Shibata
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- Tetsuo Ushiku
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- Thorsten Zenz
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- Tina Wong
- Tirso Pons
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- Todd A Johnson
- Todd D Pihl
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- Tom Mikkelsen
- Tom Roques
- Tomas J Tanskanen
- Tomas Marques-Bonet
- Tomoko Urushidate
- Torill Sauer
- Toru Nakamura
- Treasa A McPherson
- Troy Shelton
- Tsun-Po Yang
- Ultan McDermott
- Umadevi Veluvolu
- Umut H Toprak
- Valerie Jakrot
- Varsha Tembe
- Vasilisa A Rudneva
- Venkata D Yellapantula
- Venkata D Yellapantula
- Vera B Kaiser
- Veronica Y Sabelnykova
- Victor Reuter
- Vikram Deshpande
- Viktoriya Korchina
- Ville Mustonen
- Vinayak Bhandari
- Vincent Ferretti
- Vincent Huang
- Vincent Huang
- Vincent J Gnanapragasam
- Vincent Khoo
- Vincenzo Corbo
- Vishal S Chandan
- Volker Hovestadt
- W Kimryn Rathmell
- W M Linehan
- Walker Hale
- Wan Choi
- Wanding Zhou
- Wang Liang-Bo
- Weerasinghe Amila
- Wei Jiao
- Wendl Michael C
- Wenyi Wang
- Wenyi Wang
- Wenyi Wang
- Wheeler David A
- William B Isaacs
- William C Faquin
- William Friedman
- William Howat
- William U Meyerson
- Willie Yu
- Winghing Wong
- Wojciech Bazant
- Wolfgang Huber
- Wolfram Klapper
- Xavier Estivill
- Xavier Pivot
- Xiao Xiao
- Xiaobo Li
- Xiaoping Su
- Xiaotong Li
- Xiaotong Yao
- Xing Hua
- Xingmin Liu
- Xinyue Li
- Xiuqing Zhang
- Xiuqing Zheng
- Xose S Puente
- Xuan Le
- Xuanping Zhang
- Xuemei Luo
- Xueqing Zou
- Yan Shi
- Yan Zhang
- Yang Wu
- Yang Yang
- Yann Joly
- Yanxun Xu
- Yao He
- Yasin Senbabaoglu
- Yassen Assenov
- Yasser Riazalhosseini
- Yasuhito Arai
- Yasushi Rino
- Yasushi Totoki
- Yeng Ang
- Yi Huang
- Yi Huang
- Yifei Men
- Yiling Lu
- Yilong Li
- Yingyan Yu
- Yiwen Chen
- Yogesh Kumar
- Yogesh Kumar
- Yoke-Eng Chiew
- Yong Hou
- Yong Zhou
- Yong-Jie Lu
- Yongzhan Nie
- Yosef E Maruvka
- Yosef E Maruvka
- Yoshiiku Kawakami
- Young Seok Ju
- Youngchoon Woo
- Youngil Koh
- Youngwook Kim
- Youyong Lu
- Yu Fan
- Yu Fan
- Yu Fan
- Yu-Jia Shiah
- Yuan Ji
- Yuan Yuan
- Yuichi Shiraishi
- Yulia Newton
- Yulia Rubanova
- Yumeng Wang
- Yupeng Cun
- Yussanne Ma
- Zachary Heins
- Zechen Chong
- Zechen Chong
- Zemin Zhang
- Zhaohong Chen
- Zhenggang Wu
- Zhenggang Wu
- Zhining Wang
- Zhongming Zhao
- Ziao Lin
- Zsofia Kote-Jarai
- Ălafur Andri StefĂĄnsson
- Ăystein Garred
- Publication venue
- Nature Communications
- Publication date
- 01/01/2020
- Field of study
Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro CarĂ Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
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- Arnold John
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- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
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- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Review of home paediatric parenteral nutrition in the UK
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- Publication venue
- Publication date
- 28/06/2001
- Field of study
Home parenteral nutrition (HPN) is an expensive technological development which has given life to children with chronic intestinal failure. However, HPN is a complex therapy which carries life-threatening risks. The British Artificial Nutrition Survey (BANS), launched in 1996, monitors and audits HPN in the UK. It is the largest ongoing survey in the world, reviewing patients receiving enteral and parenteral nutrition. Data collated from health professionals between June 1996 and September 1999 identified 81 children who were registered. The commonest diagnosis for starting HPN was short-bowel syndrome, with 41% of the children being under the age of 1 year. Readmission rates of children to hospital were reported as less than 2%, suggesting that most of the burden of care is placed on families. Questionnaire data received from families (response rate 38%) identified that sleep disturbance was common. Families also experience a deterioration in their family life. This relates to poor social life activities and overall quality of life after the child had started HPN. Further qualitative research data are required to review the ongoing psychosocial issues for families
Scaling Performance via Self-Tuning Approximation for Graphics Engines
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- 'Association for Computing Machinery (ACM)'
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- Field of study
Assessment of Three Methods to Reduce the Influence of Mathematical Coupling on Oxygen Consumption and Delivery Relationships
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- Publication venue
- 'American College of Chest Physicians'
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- Field of study
Pathologic Dependence of Oxygen Consumption on Oxygen Delivery in Acute Respiratory Failure Secondary to AIDS-Related Pneumocystis carinii Pneumonia
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- 'American College of Chest Physicians'
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- Field of study
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