Optical and Near-IR Imaging of the Dark Globule CB 52

The internal structure of the dark globule CB 52 is investigated by means of broadband imaging in the optical and near-IR spectral range. By exploiting the extinction of the stellar light within this object, we derive observational parameters suitable to infer the internal structure of this cloud. Extinction maps were obtained at different wavelengths by using both stellar counts and two-color diagrams. While in the optical region the extinction is better evaluated at the cloud boundaries, the internal regions are more conveniently probed in the near-IR, so a combined map was derived. The total-to-selective extinction ratio RV was also observed to increase toward the inner regions, and a plot versus the extinction AV suggests that grain growth processes are active in this cloud. The statistical fluctuation of the AV, estimated in the line of sight of the background stars, is investigated by comparing the observed stellar colors with those of the unreddened stars. The dispersion σAV, derived from optical observations, is found to be almost independent of the mean extinction, AV, while by using near-IR data we find a more complex behavior: the σAV versus AV relation increases until AV ~ 6 and then decreases for larger extinctions. This is discussed in the framework of a simple model, suggesting that a clumpy and clustered structure can explain the observations in the inner regions, while outside the cloud the mass distribution remains more homogeneous

The BLAST Survey of the Vela Molecular Cloud: Dynamical Properties of the Dense Cores in Vela-D

The Vela-D region, according to the nomenclature given by Murphy & May (1991), of the star forming complex known as the Vela Molecular Ridge (VMR), has been recently analyzed in details by Olmi et al. (2009), who studied the physical properties of 141 pre- and proto-stellar cold dust cores, detected by the ``Balloon-borne Large-Aperture Submillimeter Telescope'' (BLAST) during a much larger (55 sq. degree) Galactic Plane survey encompassing the whole VMR. This survey's primary goal was to identify the coldest, dense dust cores possibly associated with the earliest phases of star formation. In this work, the dynamical state of the Vela-D cores is analyzed. Comparison to dynamical masses of a sub-sample of the Vela-D cores estimated from the 13CO survey of Elia et al. (2007), is complicated by the fact that the 13CO linewidths are likely to trace the lower density intercore material, in addition to the dense gas associated with the compact cores observed by BLAST. In fact, the total internal pressure of these cores, if estimated using the 13CO linewidths, appears to be higher than the cloud ambient pressure. If this were the case, then self-gravity and surface pressure would be insufficient to bind these cores and an additional source of external confinement (e.g., magnetic field pressure) would be required. However, if one attempts to scale down the 13CO linewidths, according to the observations of high-density tracers in a small sample of sources, then most proto-stellar cores would result effectively gravitationally bound.Comment: This paper has 12 pages and 6 figures. Accepted for publication by the Astrophysical Journal on July 19, 201

Exoplanet Searches in the Habitable Zone with Gravitational Microlensing

There are different methods for finding exoplanets such as radial spectral shifts, astrometrical measurements, transits, timing, etc. Gravitational microlensing (including pixel-lensing) is among the most promising techniques with the potential of detecting Earth-like planets at distances about a few astronomical units from their host stars. Here we emphasize the importance of polarization measurements which can help to resolve degeneracies in theoretical models. In particular, the polarization angle could give additional information about the relative position of the lens with respect to the sourc

The Structure of the Small Dark Cloud CB 107

This paper presents the near-IR imaging observations of CB 107, a small dark globule projected against a rich stellar background. By means of accurate photometry, the near-IR two-color diagram J - H versus H - K was obtained for the stellar background. This information was used to estimate the color excesses of the detected stars so that, given the reddening curve, it was possible to derive the extinction map of the cloud. The structural properties of the dark globule were investigated by plotting the extinction dispersion σ, obtained in a given spatial box, as a function of the mean extinction AV. This relationship has shown quite a definite linear behavior, with the slope increasing with the box size. The results of the present analysis, compared with those obtained by other authors on larger dark clouds, suggest that for a given spatial scale the slope of the σ versus AV relation is greater in CB 107 than in larger clouds. The so-called Δ-variance method was also used to investigate the structure of the dark globule by evaluating the drift behavior of its extinction map. In this way, we have found that the power spectrum of the extinction map is characterized by a power law with exponent β ~ 2.7. This value is lower than expected, for the same range of spatial scales, on the basis of previous work on large molecular clouds

Effects of low-grade gas composition on the energy/exergy performance of a polygeneration system (CH2HP) based on biomass gasification and ICE

Bio-hydrogen from sustainable biomass (i.e. agro-industrial residues) gasification can play a relevant role in the hydrogen economy, providing constant hydrogen from renewable sources. Nowadays, most hydrogen production systems integrate one or more water-gas shift (WGS) units to maximize the hydrogen yield that, however, needs additional syngas treatments, investment and operational costs. Besides, different electricity inputs are needed along the process to power the compression of raw syngas, shifted syngas, and pure hydrogen to the desired pressure. This common process integration with WGS generates a kind of off-gas from the hydrogen separation unit whose composition may or may not be suitable for power production, depending on the operating conditions of the gasification unit. In this regard, this work proposes a different approach in which no WGS reactors are involved and the off-gas is used to generate heat and power to provide the energy input needed by the system. In particular, the authors tested the bio-syngas and the corresponding off-gas in a 4-cylinders, spark ignition natural gas internal combustion engine operated in cogeneration mode with the aim to analyse the effect of removing the hydrogen from the original bio-syngas on mechanical/electric and thermal power, on fuel efficiency and CO2 specific emission

Exoplanet searches in the habitable zone with gravitational microlensing

There are different methods for finding exoplanets such as radial spectral shifts, astrometrical measurements, transits, timing, etc. Gravitational microlensing (including pixel-lensing) is among the most promising techniques with the potential of detecting Earth-like planets at distances about a few astronomical units from their host stars. Here we emphasize the importance of polarization measurements which can help to resolve degeneracies in theoretical models. In particular, the polarization angle could give additional information about the relative position of the lens with respect to the sourc

What Is New in the Treatment of Smoldering Multiple Myeloma?

Smoldering multiple myeloma (SMM), an asymptomatic plasma cell neoplasm, is currently diagnosed according to the updated IMWG criteria, which reflect an intermediate tumor mass between monoclonal gammopathy of undetermined significance (MGUS) and active MM. However, SMM is a heterogeneous entity and individual case may go from an “MGUS-like” behavior to “early MM” with rapid transformation into symptomatic disease. This wide range of clinical outcomes poses challenges for prognostication and management of individual patients. However, initial studies showed a benefit in terms of progression or even survival for early treatment of high-risk SMM patients. While outside of clinical trials the conventional approach to SMM generally remains that of close observation, these studies raised the question of whether early treatment should be offered in high-risk patients, prompting evaluation of several different therapeutic approaches with different goals. While delay of progression to MM with a non-toxic treatment is clearly achievable by early treatment, a convincing survival benefit still needs to be proven by independent studies. Furthermore, if SMM is to be considered less biologically complex than MM, early treatment may offer the chance of cure that is currently not within reach of any active MM treatment. In this paper, we present updated results of completed or ongoing clinical trials in SMM treatment, highlighting areas of uncertainty and critical issues that will need to be addressed in the near future before the “watch and wait” paradigm in SMM is abandoned in favor of early treatmen

Comparative analysis between saliva and buccal swabs as source of DNA: lesson from HLA-B*57:01 testing

Aim: Our work aimed to designate the optimal DNA source for pharmacogenetic assays, such as the screening for HLA-B*57:01 allele. Materials & methods: A saliva and four buccal swab samples were taken from 104 patients. All the samples were stored at different time and temperature conditions and then genotyped for the HLA-B*57:01 allele by SSP-PCR and classical/capillary electrophoresis. Results: The genotyping analysis reported different performance rates depending on the storage conditions of the samples. Given our results, the buccal swab demonstrated to be more resistant and stable in time with respect to the saliva. Conclusion: Our investigation designates the buccal swab as the optimal DNA source for pharmacogenetic assays in terms of resistance, low infectivity, low-invasiveness and easy sampling, and safe transport in centralized medical centers providing specialized pharmacogenetic tests

<i>Herschel</i> observations of B1-bS and B1-bN: two first hydrostatic core candidates in the Perseus star-forming cloud

We report far-infrared Herschel observations obtained between 70 μm and 500 μm of two star-forming dusty condensations, [HKM99] B1-bS and [HKM99] B1-bN, in the B1 region of the Perseus star-forming cloud. In the western part of the Perseus cloud, B1-bS is the only source detected in all six PACS and SPIRE photometric bands, but it is not visible in the Spitzer map at 24 μm. B1-bN is clearly detected between 100 μm and 250 μm. We have fitted the spectral energy distributions of these sources to derive their physical properties, and find that a simple greybody model fails to reproduce the observed spectral energy distributions. At least a two-component model is required, consisting of a central source surrounded by a dusty envelope. The properties derived from the fit, however, suggest that the central source is not a Class 0 object. We then conclude that while B1-bS and B1-bN appear to be more evolved than a pre-stellar core, the best-fit models suggest that their central objects are younger than a Class 0 source. Hence, they may be good candidates to be examples of the first hydrostatic core phase. The projected distance between B1-bS and B1-bN is a few Jeans lengths. If their physical separation is close to this value, this pair would allow studying the mutual interactions between two forming stars at a very early stage of their evolution