Bilateral Vestibular Hypofunction in Neurosarcoidosis: A Case Report

We describe the case of a 59-year-old woman who presented with progressive bilateral vestibular hypofunction and who was found to have bilateral granulomatous mass lesions of the mesial temporal lobe. Initially, her condition stabilized neurologically with corticosteroids, but a diagnosis of neurosarcoidosis was delayed because of the unusual presentation and persistently normal chest imaging results and serum angiotensin-converting enzyme (ACE) levels. Approximately 1 year after her initial presentation, the patient died of complications of a myocardial infarction and pulmonary embolism. Sarcoidosis should be considered in the differential diagnosis of idiopathic bilateral vestibular hypofunction even if the chest imaging and serum ACE levels are normal, particularly when there is evidence of a multisystem process

Using a decline in serum hCG between days 0-4 to predict ectopic pregnancy treatment success after single-dose methotrexate:a retrospective cohort study

<p>Abstract</p> <p>Background</p> <p>The current measure of treatment efficacy of single-dose methotrexate for ectopic pregnancy, is a fall in serum hCG of ≥15% between days 4–7 of treatment, which has a positive predictive value of 93% for treatment success. Two small studies have proposed a fall in serum hCG between days 0–4 after treatment confers similar, earlier prognostic information, with positive predictive values of 100% and 88% for treatment success. We sought to validate this in a large, independent cohort because of the potentially significant clinical implications.</p> <p>Methods</p> <p>We conducted a retrospective study of women (n=206) treated with single-dose methotrexate for ectopic pregnancy (pre-treatment serum hCG levels ≤3000 IU/L) at Scottish hospitals between 2006–2011. Women were divided into two cohorts based on whether their serum hCG levels rose or fell between days 0–4 after methotrexate. Treatment outcomes of women in each cohort were compared, and the test performance characteristics calculated. This methodology was repeated for the current measure (≥15% fall in serum hCG between days 4–7 of treatment) and an alternate early measure (<20% fall in serum hCG between days 0–4 of treatment), and all three measures were compared for their ability to predict medical treatment success.</p> <p>Results</p> <p>In our cohort, the positive predictive value of the current clinical measure was 89% (95% CI 84-94%) (121/136). A falling serum hCG between days 0–4 predicted treatment success in 85% (95% CI 79-92%) of cases (94/110) and a <20% fall in serum hCG between days 0–4 predicted treatment success in 94% (95% CI 88-100%) of cases (59/63). There was no significant difference in the ability of these tests to predict medical treatment success.</p> <p>Conclusions</p> <p>We have verified that a decline in serum hCG between days 0–4 after methotrexate treatment for ectopic pregnancies, with pre-treatment serum hCG levels ≤3000 IU/L, provides an early indication of likelihood of treatment success, and performs just as well as the existing measure, which only provides prognostic information on day 7.</p

A deep campaign to characterize the synchronous radio/X-ray mode switching of PSR B0943+10

We report on simultaneous X-ray and radio observations of the mode-switching pulsar PSR B0943+10 obtained with the XMM-Newton satellite and the LOFAR, LWA and Arecibo radio telescopes in November 2014. We confirm the synchronous X-ray/radio switching between a radio-bright (B) and a radio-quiet (Q) mode, in which the X-ray flux is a factor ~2.4 higher than in the B-mode. We discovered X-ray pulsations, with pulsed fraction of 38+/-5% (0.5-2 keV), during the B-mode, and confirm their presence in Q-mode, where the pulsed fraction increases with energy from ~20% up to ~65% at 2 keV. We found marginal evidence for an increase in the X-ray pulsed fraction during B-mode on a timescale of hours. The Q-mode X-ray spectrum requires a fit with a two-component model (either a power-law plus blackbody or the sum of two blackbodies), while the B-mode spectrum is well fit by a single blackbody (a single power-law is rejected). With a maximum likelihood analysis, we found that in Q-mode the pulsed emission has a thermal blackbody spectrum with temperature ~3.4x10^6 K and the unpulsed emission is a power-law with photon index ~2.5, while during B-mode both the pulsed and unpulsed emission can be fit by either a blackbody or a power law with similar values of temperature and photon index. A Chandra image shows no evidence for diffuse X-ray emission. These results support a scenario in which both unpulsed non-thermal emission, likely of magnetospheric origin, and pulsed thermal emission from a small polar cap (~1500 m^2) with a strong non-dipolar magnetic field (~10^{14} G), are present during both radio modes and vary in intensity in a correlated way. This is broadly consistent with the predictions of the partially screened gap model and does not necessarily imply global magnetospheric rearrangements to explain the mode switching.Comment: To be published on The Astrophysical Journa

Discovery and Follow-up of Rotating Radio Transients with the Green Bank and LOFAR Telescopes

We have discovered 21 Rotating Radio Transients (RRATs) in data from the Green Bank Telescope (GBT) 350-MHz Drift-scan and the Green Bank North Celestial Cap pulsar surveys using a new candidate sifting algorithm. RRATs are pulsars with sporadic emission that are detected through their bright single pulses rather than Fourier domain searches. We have developed {\tt RRATtrap}, a single-pulse sifting algorithm that can be integrated into pulsar survey data analysis pipelines in order to find RRATs and Fast Radio Bursts. We have conducted follow-up observations of our newly discovered sources at several radio frequencies using the GBT and Low Frequency Array (LOFAR), yielding improved positions and measurements of their periods, dispersion measures, and burst rates, as well as phase-coherent timing solutions for four of them. The new RRATs have dispersion measures (DMs) ranging from 15 to 97 pc cm$^{-3}$, periods of 240 ms to 3.4 s, and estimated burst rates of 20 to 400 pulses hr$^{-1}$ at 350 MHz. We use this new sample of RRATs to perform statistical comparisons between RRATs and canonical pulsars in order to shed light on the relationship between the two populations. We find that the DM and spatial distributions of the RRATs agree with those of the pulsars found in the same survey. We find evidence that slower pulsars (i.e. $P>200$ ms) are preferentially more likely to emit bright single pulses than are faster pulsars ($P<200$ ms), although this conclusion is tentative. Our results are consistent with the proposed link between RRATs, transient pulsars, and canonical pulsars as sources in various parts of the pulse activity spectrum.Comment: 18 pages, 13 figures, 5 tables, published in Ap

A millisecond pulsar in a stellar triple system

Gravitationally bound three-body systems have been studied for hundreds of years and are common in our Galaxy. They show complex orbital interactions, which can constrain the compositions, masses, and interior structures of the bodies and test theories of gravity, if sufficiently precise measurements are available. A triple system containing a radio pulsar could provide such measurements, but the only previously known such system, B1620-26 (with a millisecond pulsar, a white dwarf, and a planetary-mass object in an orbit of several decades), shows only weak interactions. Here we report precision timing and multi-wavelength observations of PSR J0337+1715, a millisecond pulsar in a hierarchical triple system with two other stars. Strong gravitational interactions are apparent and provide the masses of the pulsar (1.4378(13) Msun, where Msun is the solar mass and the parentheses contain the uncertainty in the final decimal places) and the two white dwarf companions (0.19751(15) Msun and 0.4101(3) Msun), as well as the inclinations of the orbits (both approximately 39.2 degrees). The unexpectedly coplanar and nearly circular orbits indicate a complex and exotic evolutionary past that differs from those of known stellar systems. The gravitational field of the outer white dwarf strongly accelerates the inner binary containing the neutron star, and the system will thus provide an ideal laboratory in which to test the strong equivalence principle of general relativity.Comment: 17 pages, 3 figures, 1 table. Published online by Nature on 5 Jan 2014. Extremely minor differences with published version may exis

The PALFA Survey: Going to great depths to find radio pulsars

The on-going PALFA survey is searching the Galactic plane (|b| < 5 deg., 32 < l < 77 deg. and 168 < l < 214 deg.) for radio pulsars at 1.4 GHz using ALFA, the 7-beam receiver installed at the Arecibo Observatory. By the end of August 2012, the PALFA survey has discovered 100 pulsars, including 17 millisecond pulsars (P < 30 ms). Many of these discoveries are among the pulsars with the largest DM/P ratios, proving that the PALFA survey is capable of probing the Galactic plane for millisecond pulsars to a much greater depth than any previous survey. This is due to the survey's high sensitivity, relatively high observing frequency, and its high time and frequency resolution. Recently the rate of discoveries has increased, due to a new more sensitive spectrometer, two updated complementary search pipelines, the development of online collaborative tools, and access to new computing resources. Looking forward, focus has shifted to the application of artificial intelligence systems to identify pulsar-like candidates, and the development of an improved full-resolution pipeline incorporating more sophisticated radio interference rejection. The new pipeline will be used in a complete second analysis of data already taken, and will be applied to future survey observations. An overview of recent developments, and highlights of exciting discoveries will be presented.Comment: Proceedings of IAUS 291 "Neutron Stars and Pulsars: Challenges and Opportunities after 80 years", J. van Leeuwen (ed.); 6 pages, 4 figure

A Multi-telescope Campaign on FRB 121102: Implications for the FRB Population

We present results of the coordinated observing campaign that made the first subarcsecond localization of a Fast Radio Burst, FRB 121102. During this campaign, we made the first simultaneous detection of an FRB burst by multiple telescopes: the VLA at 3 GHz and the Arecibo Observatory at 1.4 GHz. Of the nine bursts detected by the Very Large Array at 3 GHz, four had simultaneous observing coverage at other observatories. We use multi-observatory constraints and modeling of bursts seen only at 3 GHz to confirm earlier results showing that burst spectra are not well modeled by a power law. We find that burst spectra are characterized by a ~500 MHz envelope and apparent radio energy as high as $10^{40}$ erg. We measure significant changes in the apparent dispersion between bursts that can be attributed to frequency-dependent profiles or some other intrinsic burst structure that adds a systematic error to the estimate of DM by up to 1%. We use FRB 121102 as a prototype of the FRB class to estimate a volumetric birth rate of FRB sources $R_{FRB} \approx 5x10^{-5}/N_r$ Mpc$^{-3}$ yr$^{-1}$, where $N_r$ is the number of bursts per source over its lifetime. This rate is broadly consistent with models of FRBs from young pulsars or magnetars born in superluminous supernovae or long gamma-ray bursts, if the typical FRB repeats on the order of thousands of times during its lifetime.Comment: 17 pages, 7 figures. Submitted to AAS Journal

An Experimental and Analytical Evaluation of Wall And Window Retrofit Configurations: Supporting the Residential Retrofit Best Practices Guide

A Retrofit Best Practices Guide was developed to encourage homeowners to consider energy conservation issues whenever they modify their siding or windows. In support of this guide, an experimental program was implemented to measure the performance of a number of possible wall siding and window retrofit configurations. Both thermal and air-leakage measurements were made for a 2.4 x 2.4 m (8 x 8 ft) wall section with and without a 0.9 x 1.2 m (3 x 4 ft) window. The windows tested were previously well-characterized at a dedicated window test facility. A computer model was also used to provide information for the Best Practices Guide. The experimental data for walls and windows were used in conjunction with this model to estimate the total annual energy savings for several typical houses in a number of different locations

The Green Bank Northern Celestial Cap Pulsar Survey - I: Survey Description, Data Analysis, and Initial Results

We describe an ongoing search for pulsars and dispersed pulses of radio emission, such as those from rotating radio transients (RRATs) and fast radio bursts (FRBs), at 350 MHz using the Green Bank Telescope. With the Green Bank Ultimate Pulsar Processing Instrument, we record 100 MHz of bandwidth divided into 4,096 channels every 81.92 $\mu s$. This survey will cover the entire sky visible to the Green Bank Telescope ($\delta > -40^\circ$, or 82% of the sky) and outside of the Galactic Plane will be sensitive enough to detect slow pulsars and low dispersion measure ($<$30 $\mathrm{pc\,cm^{-3}}$) millisecond pulsars (MSPs) with a 0.08 duty cycle down to 1.1 mJy. For pulsars with a spectral index of $-$1.6, we will be 2.5 times more sensitive than previous and ongoing surveys over much of our survey region. Here we describe the survey, the data analysis pipeline, initial discovery parameters for 62 pulsars, and timing solutions for 5 new pulsars. PSR J0214$+$5222 is an MSP in a long-period (512 days) orbit and has an optical counterpart identified in archival data. PSR J0636$+$5129 is an MSP in a very short-period (96 minutes) orbit with a very low mass companion (8 $M_\mathrm{J}$). PSR J0645$+$5158 is an isolated MSP with a timing residual RMS of 500 ns and has been added to pulsar timing array experiments. PSR J1434$+$7257 is an isolated, intermediate-period pulsar that has been partially recycled. PSR J1816$+$4510 is an eclipsing MSP in a short-period orbit (8.7 hours) and may have recently completed its spin-up phase.Comment: 18 pages, 10 figures, 5 tables, accepted by Ap

KNOWN PULSARS IDENTIFIED in the GMRT 150 MHz ALL-SKY SURVEY

We have used the 150 MHz radio continuum survey (TGSS ADR) from the Giant Metrewave Radio Telescope (GMRT) to search for phase-averaged emission toward all well-localized radio pulsars north of -53° decl. We detect emission toward 200 pulsars with high confidence (=5s) and another 88 pulsars at fainter levels. We show that most of our identifications are likely from pulsars, except for a small number where the measured flux density is confused by an associated supernova or pulsar-wind nebula, or a globular cluster. We investigate the radio properties of the 150 MHz sample and find an unusually high number of gamma-ray binary millisecond pulsars with very steep spectral indices. We also note a discrepancy in the measured flux densities between GMRT and LOFAR pulsar samples, suggesting that the flux density scale for the LOFAR pulsar sample may be in error by approximately a factor of two. We carry out a separate search of 30 well-localized gamma-ray, radio-quiet pulsars in an effort to detect a widening of the radio beam into the line of sight at lower frequencies. No steep-spectrum emission was detected either toward individual pulsars or in a weighted stack of all 30 images