The Drawing Book. A survey of drawing: the primary means of expression

‘The Drawing Book’ was conceived and edited by Kovats. Other invited authors included Kate Macfarlane and Katherine Stout (The Drawing Room, London), and Charles Darwent (art historian and writer). The publication sought to survey drawing as the primary means of expression. The book explored whether it was possible to employ a renaissance model, the commonplace book, which is primarily a text-based model, visually. Drawings were gathered together to explore certain themes that then form a visual narrative rather than a text-based one. The book was also an exploration of the subjective nature of visual memory, a journey into the imagination of an individual, in itself a model of the form of drawing, as a personal and subjective cosmology of drawing. The vast collection of drawings span the history of art and design, including the rich dynamic state of contemporary drawing today. This book examines the relationship between drawing and thinking, and looks at what drawings do, as well as how they look. It is organized into thematic chapters based on the form of a commonplace book. The selected drawings trace the continuous line flowing through detailing how artists, scientists, architects, designers, philosophers understand our world and our experience in it. Originally printed as a hardback copy (January 2006), the book has subsequently been reprinted in paperback (June 2007). The book has been reviewed in Blueprint (Andrew Ross, No. 242, May 2006) and Varoom Magazine - The Journal of Illustration and Made Images (Ian Massey, Issue 2, November 2006)

Physiological and bioinformatic studies on polarity development in Ceratopteris richardii spores

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13-Historic Period Sites Recorded for the Kalamazoo River Basin, 1977-1981

During the five year Kalamazoo Basin Survey project (1976-1980), survey teams, under the direction of Dr. William M. Cremin of the Department of Anthropology, Western Michigan University, investigated by means of surface reconnaissance nine survey transects placed across the Kalamazoo River in Allegan, Kalamazoo, Calhoun and Jackson Counties, Michigan. Surveyor coverage in the nine transects aggregated 135 km 2 , or 18% of the land area delimited by their boundaries, and resulted in the recording of 328 prehistoric sites. In addition, interviews with area landowners and collectors ~aving knowledge of local prehistory and the whereabouts of archaeological sites resulted in the discovery of 24 sites located outside of the survey transects (Cremin 1981). Last year the WMU archaeological field school, under the direction of Dr. Cremin, traveled to western Jackson County to conduct limited test excavations at several sites located by KBS surveyors during the previous year and to expand upon the results of that program of research by undertaking some additional site location survey along the South Branch Kalamazoo River both within and outside of the boundaries established for KBS Transect l980C. On this occasion, surveyors evaluated about 2.1 km2 and recorded 24 more prehistoric sites occurring in western Jackson and eastern Calhoun Counties (Cremin and Clark 1981). In total, WMU\u27s program of systematic site location survey in this universe between 1976 and 1981 has resulted in the recovery of data representing 376 prehistoric sites in the four counties investigated. However, the various annual reports and the recently published overview of the Kalamazoo Basin Survey project do not reference a potentially important data set consisting of 47 sites that postdate Euro-American settlement of southern Lower Michigan and reflect in part the activities of both Euro-American and Native American residents of the Kalamazoo River Basin during the 19th and 20th centuries

14-An Archaeological Survey along Portage River and Dorrance Creek above Indian Lake in Pavilion Township, Kalamazoo County, Michigan

For three weeks during the 1982 field season, the Western Michigan University archaeological field school was located near Indian Lake in Pavilion Township, T3S RlOW, Kalamazoo County, Michigan (Map 1). As part of the research program, systematic site location survey was planned for this area;one which had not received any prior archaeological attention. With the cooperation of area landowners and the assistance of several local artifact collectors, more than 20 parcels of cultivated land aggregating 3.9 km2 were evaluated by means of surface re~onnaissance or walk-over survey. There follows a report of survey activity, together with descriptions of the archaeological sites recorded

The Effects of Promethazine on Human Performance, Mood States, and Motion Sickness Tolerance

Intramuscular (IM) injections of promethazine in 25 mg or 50 mg dosages are commonly used to treat space motion sickness in astronauts. The present study examined the effects of IM injections of promethazine on neuropsy-chological performance, mood states, and motion sickness tolerance in humans. Twelve men, mean age 36 plus or minus 3.1 participated in one training (no injections) and three treatment conditions: a 25 mg injection of promethazine, a 50 mg injection of promethazine, and a placebo injection of sterile saline. Each condition, spaced at 7 day intervals, required an 8-10 hr session in which subjects were given four repetitions of 12 performance tasks, and one rotating chair motion sickness test. On the training day subjects were trained on each task to establish stability and proficiency. On treatment days, the order in which the drug or placebo was assigned to subjects was counter-balanced and a double-blind technique was used. Statistically significant decrements in performance were observed on 10 of 12 tasks when subjects were given 25 mg or 50 mg of promethazine as compared to the placebo. Performance decrements were associated with mean blood alcohol dose equivalency levels of 0.085% for 25 mg and 0. 1 37% for 50 mg dosages. The mood scale results showed significant changes in individual subjective experiences with maximum deterioration in the arousal state and fatigue level. When compared to placebo significant increases in motion sickness tolerance were found for both dosages of promethazine. These data suggest that effective dosages of promethazine currently used to counteract motion sickness in astronauts may significantly impair task components of their operational performance

CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype.

Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer-related deaths in the United States, whereas colorectal cancer is the third most common cancer. The RNA-binding protein HuR (ELAVL1) supports a pro-oncogenic network in gastrointestinal (GI) cancer cells through enhanced HuR expression. Using a publically available database, HuR expression levels were determined to be increased in primary PDA and colorectal cancer tumor cohorts as compared with normal pancreas and colon tissues, respectively. CRISPR/Cas9 technology was successfully used to delete the HuR gene in both PDA (MIA PaCa-2 and Hs 766T) and colorectal cancer (HCT116) cell lines. HuR deficiency has a mild phenotype

Gas emissions, minerals, and tars associated with three coal fires, Powder River Basin, USA.

Ground-based surveys of three coal fires and airborne surveys of two of the fires were conducted near Sheridan, Wyoming. The fires occur in natural outcrops and in abandoned mines, all containing Paleocene-age subbituminous coals. Diffuse (carbon dioxide (CO(2)) only) and vent (CO(2), carbon monoxide (CO), methane, hydrogen sulfide (H(2)S), and elemental mercury) emission estimates were made for each of the fires. Additionally, gas samples were collected for volatile organic compound (VOC) analysis and showed a large range in variation between vents. The fires produce locally dangerous levels of CO, CO(2), H(2)S, and benzene, among other gases. At one fire in an abandoned coal mine, trends in gas and tar composition followed a change in topography. Total CO(2) fluxes for the fires from airborne, ground-based, and rate of fire advancement estimates ranged from 0.9 to 780mg/s/m(2) and are comparable to other coal fires worldwide. Samples of tar and coal-fire minerals collected from the mouth of vents provided insight into the behavior and formation of the coal fires

Review and Hypothesis. New insights into the reaction mechanism of transhydrogenase: Swivelling the dIII component may gate the proton channel

AbstractThe membrane protein transhydrogenase in animal mitochondria and bacteria couples reduction of NADP+ by NADH to proton translocation. Recent X-ray data on Thermus thermophilus transhydrogenase indicate a significant difference in the orientations of the two dIII components of the enzyme dimer (Leung et al., 2015). The character of the orientation change, and a review of information on the kinetics and thermodynamics of transhydrogenase, indicate that dIII swivelling might assist in the control of proton gating by the redox state of bound NADP+/NADPH during enzyme turnover

Reducing Legionella Colonization of Water Systems with Monochloramine

Monochloramine reduced colonization in building hot water systems