495 research outputs found

    Public Opinion on Peace as a Reflection of Social Differentiation and Politicisation of Identity in Sri Lanka

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    This article provides a critical analysis of the public opinion on peace in Sri Lanka, with consideration to two determinants: social differentiation and politicisation of identities. Specifically, it aims at developing arguments about the correlations between public opinion, social position, and political mobilisation. Inspired by Bourdieu\u27s concepts of habitus, social space, and political field, this article develops an empirical analysis of the links between ethnic identity and public opinion on peace, and between social differentiation and opinions within the Sinhalese majority community in Sri Lanka. This article argues that ethnic polarisation and politicisation were the foremost determinants of public opinion during the peace process in 2002-2009

    Basement provenance revealed by U-Pb detrital zircon ages: A tale of African and European heritage in Tuscany, Italy

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    A new data set of ca. 500 LA-ICP-MS U-Pb detrital zircon ages for six metasedimentary units from the Tuscan basement (Apuan Alps, Monti Pisani, Monticiano-Roccastrada), along with a precise SHRIMP U-Pb crystallization age of a metavolcanic unit (Apuan Alps) have been collected to determine their depositional ages and provenance. These results have been integrated with the recently published ca. 900 U-Pb detrital zircon ages from Elba Island to draw a complete picture of the Paleozoic journey of the Tuscan basement. A major change in the sources supplying sediments to the Tuscan basins is shown to occur during this journey. Detrital zircon ages of early Cambrian to middle Ordovician metasediments mirror those of coeval northern Africa sediments: most samples were sourced in western Africa, while one sample is derived material from central northern Africa. The Tuscan block was therefore located at the peri-Gondwana margin, close to central northern Africa. The prominent mid-Ordovician magmatic arc activity (ca. 460. Ma) at the northern Gondwana margin and its detritus, characterise the zircon age distribution of Ordovician and Silurian volcano-sedimentary rocks, that were therefore generated at the northernmost Gondwana margin during subduction and subsequent initial Paleotethys rifting. The Carboniferous-Permian metasediments are dominated by populations of Ordovician and Variscan-age zircons, with a minor occurrence of Neoarchean and Paleoproterozoic zircons that is best explained by recycling of European Neoproterozoic-Cambrian metasediments. In summary, the main sources supplying the Tuscan basins were located in northern Africa throughout Cambrian-Ordovician times, shifting to the volcanic arc active at the northern Gondwana margin during the middle Ordovician. During Variscan and post-Variscan times, detrital zircon sources were mostly located in European terrains, witnessing the shift of Tuscany from Africa to Europe

    An Easy-To-Use Simulation Program Demonstrates Variations in Bacterial Cell Cycle Parameters Depending on Medium and Temperature

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    Many studies are performed on chromosome replication and segregation in Escherichia coli and other bacteria capable of complex replication with C phases spanning several generations. For such investigations an understanding of the replication patterns, including copy numbers of origins and replication forks, is crucial for correct interpretation of the results

    Nanoscopic and Photonic Ultrastructural Characterization of Two Distinct Insulin Amyloid States

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    Two different conformational isoforms or amyloid strains of insulin with different cytotoxic capacity have been described previously. Herein these filamentous and fibrillar amyloid states of insulin were investigated using biophysical and spectroscopic techniques in combination with luminescent conjugated oligothiophenes (LCO). This new class of fluorescent probes has a well defined molecular structure with a distinct number of thiophene units that can adopt different dihedral angles depending on its binding site to an amyloid structure. Based on data from surface charge, hydrophobicity, fluorescence spectroscopy and imaging, along with atomic force microscopy (AFM), we deduce the ultrastructure and fluorescent properties of LCO stained insulin fibrils and filaments. Combined total internal reflection fluorescence microscopy (TIRFM) and AFM revealed rigid linear fibrous assemblies of fibrils whereas filaments showed a short curvilinear morphology which assemble into cloudy deposits. All studied LCOs bound to the filaments afforded more blue-shifted excitation and emission spectra in contrast to those corresponding to the fibril indicating a different LCO binding site, which was also supported by less efficient hydrophobic probe binding. Taken together, the multi-tool approach used here indicates the power of ultrastructure identification applying AFM together with LCO fluorescence interrogation, including TIRFM, to resolve structural differences between amyloid states
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