229 research outputs found
Include medical ethics in the Research Excellence Framework
The Research Excellence Framework of the Higher Education
Funding Council for England is taking place in 2013, its three
key elements being outputs (65% of the profile), impact (20%),
and âquality of the research environmentâ (15%). Impact will
be assessed using case studies that âmay include any social,
economic or cultural impact or benefit beyond academia that
has taken place during the assessment period.â1
Medical ethics in the UK still does not have its own cognate
assessment panelâfor example, bioethics or applied
ethicsâunlike in, for example, Australia. Several researchers
in medical ethics have reported to the Institute of Medical Ethics
that during the internal preliminary stage of the Research
Excellence Framework several medical schools have decided
to include only research that entails empirical data gathering.
Thus, conceptual papers and ethical analysis will be excluded.
The arbitrary exclusion of reasoned discussion of medical ethics
issues as a proper subject for medical research unless it is based
on empirical data gathering is conceptually mistaken. âEmpirical
ethicsâ is, of course, a legitimate component of medical ethics
research, but to act as though it is the only legitimate component
suggests, at best, a partial understanding of the nature of ethics
in general and medical ethics in particular. It also mistakenly
places medicine firmly on only one side of the
science/humanities âtwo culturesâ divide instead of in its rightful
place bridging the divide.
Given the emphasis by the General Medical Council on medical
ethics in properly preparing âtomorrowâs doctors,â we urge
medical schools to find a way of using the upcoming Research
Excellence Framework to highlight the expertise residing in
their ethicist colleagues. We are confident that appropriate
assessment will reveal work of high quality that can be shown
to have social and cultural impact and benefit beyond academia,
as required by the framework
Eminent scientists reject the supernatural: A survey of the Fellows of the Royal Society
Fellows of the Royal Society of London were invited to participate in a survey of attitudes toward religion. They were asked about their beliefs in a personal God, the existence of a supernatural entity, consciousness surviving death, and whether religion and science occupy non-overlapping magisteria (NOMA). Overwhelmingly the majority of Fellows affirmed strong opposition to the belief in a personal god, to the existence of a supernatural entity and to survival of death. On 'NOMA', the majority of Fellows indicated neither a strong disagreement nor strong agreement. We also found that while (surprisingly) childhood religious upbringing and age were not significantly related to current attitudes toward religion, scientific discipline played a small but significant influence: biological scientists are even less likely to be religious than physical scientists and were more likely to perceive conflict between science and religion
Recruitment to publicly funded trials - are surgical trials really different?
Good recruitment is integral to the conduct of a high-quality randomised controlled trial. It has been suggested that recruitment is particularly difficult for evaluations of surgical interventions, a field in which there is a dearth of evidence from randomised comparisons. While there is anecdotal speculation to support the inference that recruitment to surgical trials is more challenging than for medical trials we are unaware of any formal assessment of this. In this paper, we compare recruitment to surgical and medical trials using a cohort of publicly funded trials. Data: Overall recruitment to trials was assessed using of a cohort of publicly funded trials (n = 114). Comparisons were made by using the Recruitment Index, a simple measure of recruitment activity for multicentre randomised controlled trials. Recruitment at the centre level was also investigated through three example surgical trials. Results: The Recruitment Index was found to be higher, though not statistically significantly, in the surgical group (n = 18, median = 38.0 IQR (10.7, 77.4)) versus (n = 81, median = 34.8 IQR (11.7, 98.0)) days per recruit for the medical group (median difference 1.7 (â 19.2, 25.1); p = 0.828). For the trials where the comparison was between a surgical and a medical intervention, the Recruitment Index was substantially higher (n = 6, 68.3 (23.5, 294.8)) versus (n = 93, 34.6 (11.7, 90.0); median difference 25.9 (â 35.5, 221.8); p = 0.291) for the other trials. Conclusions: There was no clear evidence that surgical trials differ from medical trials in terms of recruitment activity. There was, however, support for the inference that medical versus surgical trials are more difficult to recruit to. Formal exploration of the recruitment data through a modelling approach may go some way to tease out where important differences exist.The first author was supported by a Medical Research Council UK Fellowship.Peer reviewedAuthor versio
The challenges faced in the design, conduct and analysis of surgical randomised controlled trials
Randomised evaluations of surgical interventions are rare; some interventions have been widely
adopted without rigorous evaluation. Unlike other medical areas, the randomised controlled trial
(RCT) design has not become the default study design for the evaluation of surgical interventions.
Surgical trials are difficult to successfully undertake and pose particular practical and methodological challenges. However, RCTs have played a role in the assessment of surgical innovations and there is scope and need for greater use. This article will consider the design, conduct and analysis of an RCT of a surgical intervention. The issues will be reviewed under three
headings: the timing of the evaluation, defining the research question and trial design issues.
Recommendations on the conduct of future surgical RCTs are made. Collaboration between
research and surgical communities is needed to address the distinct issues raised by the assessmentof surgical interventions and enable the conduct of appropriate and well-designed trials.The Health Services Research Unit is funded by the Scottish Government Health DirectoratesPeer reviewedPublisher PD
Ferumoxytol-enhanced magnetic resonance imaging in acute myocarditis
Objectives Ultrasmall superparamagnetic particles of iron oxide (USPIO)-enhanced MRI can detect tissue-resident macrophage activity and identify cellular inflammation within tissues. We hypothesised that USPIO-enhanced MRI would provide a non-invasive imaging technique that would improve the diagnosis and management of patients with acute myocarditis. Methods Ten volunteers and 14 patients with suspected acute myocarditis underwent T2, T2* and late gadolinium enhancement (LGE) 3T MRI, with further T2* imaging at 24âhours after USPIO (ferumoxytol, 4âmg/kg) infusion, at baseline and 3 months. Myocardial oedema and USPIO enhancement were determined within areas of LGE as well as throughout the myocardium. Results Myocarditis was confirmed in nine of the 14 suspected cases of myocarditis. There was greater myocardial oedema in regions of LGE in patients with myocarditis when compared with healthy volunteer myocardium (T2 value, 57.1±5.3 vs 46.7±1.6âms, p0.05). Imaging after 3 months in patients with myocarditis revealed a reduction in volume of LGE, a reduction in oedema measures within regions displaying LGE and improvement in ejection fraction (mean â19.7âmL, 95%âCI (â0.5 to â40.0)), â5.8âms (â0.9 to â10.7) and +6% (0.5% to 11.5%), respectively, p<0.05 for all). Conclusion In patients with acute myocarditis, USPIO-enhanced MRI does not provide additional clinically relevant information to LGE and T2 mapping MRI. This suggests that tissue-resident macrophages do not provide a substantial contribution to the myocardial inflammation in this condition. Clinical trial registration NCT02319278; Results
Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos
Background
The aetiology of recurrent miscarriage (RM) remains largely unexplained. Women with RM have a shorter time to pregnancy interval than normally fertile women, which may be due to more frequent implantation of non-viable embryos. We hypothesized that human endometrial stromal cells (H-EnSCs) of women with RM discriminate less effectively between high-and low-quality human embryos and migrate more readily towards trophoblast spheroids than H-EnSCs of normally fertile women.
Methodology/Principal Findings
Monolayers of decidualized H-EnSCs were generated from endometrial biopsies of 6 women with RM and 6 fertile controls. Cell-free migration zones were created and the effect of the presence of a high-quality (day 5 blastocyst, n = 13), a low-quality (day 5 blastocyst with three pronuclei or underdeveloped embryo, n = 12) or AC-1M88 trophoblast cell line spheroid on H-ESC migratory activity was analyzed after 18 hours. In the absence of a spheroid or embryo, migration of H-EnSCs from fertile or RM women was similar. In the presence of a low-quality embryo in the zone, the migration of H-EnSCs of control women was inhibited compared to the basal migration in the absence of an embryo (P<0.05) and compared to the migration in the presence of high-quality embryo (p<0.01). Interestingly, the migratory response H-EnSCs of women with RM did not differ between high- and low-quality embryos. Furthermore, in the presence of a spheroid their migration was enhanced compared to the H-EnSCs of controls (p<0.001).
Conclusions
H-EnSCs of fertile women discriminate between high- and low-quality embryos whereas H-EnSCs of women with RM fail to do so. H-EnSCs of RM women have a higher migratory response to trophoblast spheroids. Future studies will focus on the mechanisms by which low-quality embryos inhibit the migration of H-EnSCs and how this is deregulated in women with RM
Ultra-small superparamagnetic particles of iron oxide in magnetic resonance imaging of cardiovascular disease
Associations of mood symptoms with ante- and postnatal weight change in obese pregnancy are not mediated by cortisol
Ultrasmall superparamagnetic particles of iron oxide-enhanced magnetic resonance imaging in the assessment of cellular inflammation after myocardial infarction
Hiding Relations
The present vogue of âmanaging for development resultsâ is an expression of a historically dominant mode of thought in international aid â âsubstantialismâ â which sees the world primarily in terms of âentitiesâ such as âpovertyâ, âbasic needsâ, ârightsâ, âwomenâ, or âresultsâ. Another important mode of thought, ârelationalismâ â in association more generally with ideas of process and complexity â appears to be absent in the thinking of aid institutions. Drawing on my own experiences of working with the UK Department for International Development (DFID), I illustrate how despite formally subscribing to the institutionâs substantialist view of the world, some staff are âcloset relationistsâ, behaving according to one mode of thought while officially framing their action in terms of the other, more orthodox mode. In so doing, they may be unwittingly keeping international aid sufficiently viable - by the apparent proof of the efficacy of results-based management - to enable the institution as a whole to maintain its substantialist imaginary
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