Improving Access to Addiction Recovery Care in Central Appalachia Through Organizational Collaboration

Fahe, a Network of 50+ members throughout Appalachia based in Berea KY, has brought together a coalition to finance, build, and manage several addiction recovery care centers across Kentucky and West Virginia, increase access to employment, and deploy vouchers for supportive services

Synthesis of unsymmetrical pendant-armed and phosphonic acid-pendant-armed cross-bridged tetraazamacrocycles

The synthesis of a variety of cross-bridged tetraazamacrocycles bearing phosphonate pendant arms and their corresponding phosphonic acid derivatives as well as their Cu(II) complexes are presented. The half-life of decomplexation of Cu(II)·51 in 5M HCl at 90°C was found to be 3.8 hours. Ligand 51 showed faster complexation kinetics relative to known cross-bridged tetraazamacrocycles bearing ionizable pendant arms. The biodistribution of 64Cu(II)·51 was studied in male rats and indicated an improved blood and liver clearance and higher bone retention of 64Cu(II)·51 relative to 64Cu(II)·10.*. The formation of a single pendant-armed cross-bridged cyclam is presented through an unusual single alkylation of cross-bridged cyclam. Several experiments were implemented to probe the origin of the selectivity of the reaction including computational studies, 1D 1H NMR and 2D NMR experiments. Monoamide ligand 64 was used as a springboard for the formation of several unsymmetrical pendant-armed cross-bridged cyclams.*. Attempts were made toward the synthesis of two potential bifunctional chelators for radiopharmaceuticals, each bearing only one phosphonic acid pendant arm and one free carboxylate for conjugation to somatostatin analogues.*

Downsizing a human inflammatory protein to a small molecule with equal potency and functionality

A significant challenge in chemistry is to rationally reproduce the functional potency of a protein in a small molecule, which is cheaper to manufacture, non-immunogenic, and also both stable and bioavailable. Synthetic peptides corresponding to small bioactive protein surfaces do not form stable structures in water and do not exhibit the functional potencies of proteins. Here we describe a novel approach to growing small molecules with protein-like potencies from a functionally important amino acid of a protein. A 77-residue human inflammatory protein (complement C3a) important in innate immunity is rationally transformed to equipotent small molecules, using peptide surrogates that incorporate a turn-inducing heterocycle with correctly positioned hydrogen-bond-accepting atoms. Small molecule agonists (molecular weigh

Legal risk concerning trading in own stocks on the stock market

Manuell avslutsregistrering innebär att flertalet aktieägare utestängs från bolagets återköp, genom att de inte har anlitat samma börsmedlem som det återköpande bolaget. Blockaffärer krymper kretsen potentiella motparter ytterligare; för att vara part vid ett sådant avslut krävs anlitande av samma börsmedlem som bolaget anlitar och ett aktieinnehav överstigande 250 handelsposter. Likhetsprincipen i ABL kan därmed sägas ha frångåtts, eftersom aktieägare som anlitar annan börsmedlem än vad bolaget gör inte kan få sina aktier återköpta av bolaget genom manuell avslutsregistrering. Avslut i egna aktier som förgåtts av förmedling bör ses som en enskild överenskommelse med aktieägare om förvärv av dennes aktier och är därmed otillåtet. Återköp och återförsäljning av egna aktier innebär en sammanblandning av den primära och sekundära marknaden för aktier. Ett återköp eller återförsäljning av egna aktier riskerar att medföra otillbörlig nackdel för bolagets motpart, beroende på förändringar i antalet utestående aktier vilket direkt påverkar utestående aktiers marknadsvärde. Risken uppkommer på grund av att information om återköp eller återförsäljning av egna aktier inte offentliggörs förrän transaktionerna har ägt rum. Risken att allmänhetens förtroende kan skadas av återköp och återförsäljning av egna aktier ökar med den högsta tillåtna handelsvolymen per börsdag, eftersom osäkerheten kring storleken på variabeln"utestående aktier"ökar. Handel i egna aktier enligt 25 % -regeln bör enligt min mening inte ge upphov till någon större osäkerhet hos allmänheten, vad gäller variabeln "utestående aktier". Någon risk för otillbörlig nackdel för aktieägare eller annan torde inte heller föreligga om handel i egna aktier sker enligt 25 % -regeln. Handel enligt 25 % -regeln eliminerar dock i de flesta fall återköp- och återförsäljningsinstrumentets användbarhet för att snabbt reglera bolagets kapitalstruktur

The mathematical foundations of classical ballet

This treatise sets out to show how both the mathematical aspect of ballet (and music to a very limited extent) and the associated psychological aspects of both the dancer and the stage space in which he or she operates contribute together to create an entire gestalt that becomes visible on and within the bodies of the dancers as they move through time and space. The recognition of both intention in the role of speaking a language with meaning, along with the existence of energy projection in music, dance and drama, make apparent the existence of this extension of the mental realm into the physical one. Although some people accord the spoken language a privileged status which causes a gap between artists and analytical philosophers, I have attempted, in this work, to show a way in which language may be considered as a concept applying to all languages, including those used in the arts. In this manner, hopefully, this gap between the two sets of theoretical concerns may be shown to be no longer applicable, and a manner of bridging the theoretical split can be forged upon the theory suggested by this treatise