Impulse

Features: [Page] 2 Expo\u27s physics wizard captures attention of high schoolers: The Wonders of Science never get old for Professor Larry Browning.[Page] 4 Science and Engineering Fair: The campus attracts nearly 500budding scientists every year[Page] 6 Key donation, cooperation create observatory at Oak Lake: Two remotely controlled telescopes will be in operation the fall.Faculty: [Page] 8 A Storry worth telling: Co-workers and former students remember late dean Junis Storry.[Page] 10 Math Professor Ken Yocom isn\u27t about to retire: Long-time department head has taken a new position. [Page] 12 Dennis Loban is remembered for quality and precise work[Page] 13 George Duffey may be retired, but he is not finished writing [Page] 15 Howard Nielsen sharpens the skills of a MATHCOUNTS team[Page] 16 Mike Ropp can now measure the speed of wind at more places[Page] 19 Derek Hengeveld and Mike Twedt are draft a new energy codeStudents: [Page] 20 Jordan Williams wins the Barry Goldwater Scholarship[Page] 22 For the second time in six years, SDSU claims the Ridgway[Page] 23 Civil engineering club again claims community service honors[Page] 24 Seven students spend spring break in Manchester, EnglandAlumni: [Page] 26 Hassoun, Micko, Morgan named Distinguished Engineers[Page] 28 From Briggs to Morgan, a list of all Distingui bed Engineers[Page] 30 Seven engineering grads used in SDSU television campaign[Page] 47 Col. Beth Kaspar salutes her alma materContributors: [Page] 30-35 Dean\u27s Club[Page] 36-46 Donorshttps://openprairie.sdstate.edu/coe_impulse/1015/thumbnail.jp

Impulse

Features: [Page] 2 Enterprise Institute moves from idea to $2.3-million building: Three agencies operating out of three-story Enterprise Center.[Page] 6 ACE & YEA camps put high schoolers on career path: The Aerospace Career and Education camp and the Youth Engineering Adventure camp both bring high schoolers lo camp for a week in the summer. Many of them are coming back when it\u27s time to enroll as a collegian. Corporate sponsorship may help camp numbers grow.College:[Page] 9 Four Programs reaccredited: The Electrical, Mechanical. Civil Engineering, and Agricultural and Biosystems Engineering programs all have been reaccredited for six years.[Page] 10 New Doctorates: Classes begin in !he fall for degrees in statistics and geospatial scienceFaculty[Page] 12 Dennis Helder wins top award: USGS honors department head with its top honor to non-employees[Page] 14 Hassan Ghazi: retiring mechanical engineering professor marked twenty years at SDSU[Page] 15 Nadim Wehbe: The College doesn\u27t stop teaching engineers after they\u27ve been employed[Page] 16 Delvin De Boer: A class for water plant operators has one a national education award[Page] 18 Dennis Helder, Sung Shin: Korean manufacturers may decide to move facilities to South Dakota[Page] 20 Orie Leisure: After thirty-nine years, physics professor Leisure is ready for some leisure.[Page] 22 Structures test: First tests performed in Jerry Lohr Structure LabStudents: [Page] 23 New map: EROS replaces black-and-white map in Crothers[Page] 24 Robiotics: Freshman ME major returns to high school to help[Page] 26 Swedish Engineers: Three Swedes adjust to life in South Dakota Alumni:[Page] 28 Joe Vogel: Creates first scholarship for software engineering programContributors: [Page 30-32] Dean\u27s Clubhttps://openprairie.sdstate.edu/coe_impulse/1014/thumbnail.jp

Impulse

Features: [Page] 2 South Dakota no longer is merely a launching pad: An industrialization of the economy has made the state a land of opportunity for engineers while still having a small town feel.[Page] 4 While you were away: Brookings and SDSU aren\u27t the places many alums remember them to be.[Page] 6 What will lead future growth in the region?: University and community leaders are proposing a 134-acre research park adjacent to the SDSU campus.[Page] 8 GIS Center of Excellence: Scientists have been hired for the inaugural year of operation for the Geographic Information Science Center of Excellence.Students: [Page] 10 Right brain meets left brain: Graphic design majors create the Engineering Expo logo[Page] 11 Making a game of it: Creativity was the key in a new computer programming contest[Page] 12 Senior design links students, sponsors[Page] 16 What a job: Joe Schenkel gains an eight-week internship at NASA[Page] 18 Record-setting Phonathon: Putting fun into fundraising[Page] 19 Extreme makeover: Storage room becomes a tech lab[Page] 20 Jennifer Shin: IBM internship fast-forwards her careerFaculty[Page] 22 Bob Lacher: Retiring after thirty-five-year career in math[Page] 24 Chuck Tiltrum: Student favorite leaving CE DepartmentCollege[Page] 26 NASA impressed: Kevin Dalsted presents award to Hillcrest[Page] 28 Water center: New name, defined focus for Water ResearchAlumni[Page] 30 Distinguished Engineers: Gaspar, Christianson, Walker, OeKraai[Page] 33 Roderick Anderson: Forty-one years of giving back to SDSU[Page] 46 Tom Liebsch: EE grad leads team in designing fastest computerContributors[Page] 30-35 Dean\u27s Club[Page] 36-45 Donorshttps://openprairie.sdstate.edu/coe_impulse/1013/thumbnail.jp

Developing smart people in smart cities through education: The role of personality

Since 2017, Indonesia has implemented a pilot project for the Smart City Movement. Even though focused on digital technology usage, smart cities also need people with skills in the digital economy. As one of the foundational skills in the digital economy, Human Skills are vitally important and in greater demand in smart cities. This becomes a challenge as well as an opportunity for higher education. The present study relates Human Skills to graduate attributes as developed by BINUS University, called BINUS Graduate Attributes (BGA) and identifies the role of personality as an access point for developing those skills. Using questionnaires distributed through BINUS Maya and the Lumina Spark online system, we collected 2,014 participants from various majors at the undergraduate level. Out of the 24 personality qualities measured in the Lumina Spark model, Adaptable and Cautious are qualities that do not significantly correlate with those skills. Through regression analysis, it was shown that several qualities have a role in predicting each skill. The result of this study can be used for educators to modify learning methods and environments that enhance the possibility for students to develop each of these Human Skills by utilizing their personalities

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist

Challenges and opportunities for conducting a vaccine trial during the COVID-19 pandemic in the United Kingdom

The COVID-19 pandemic has resulted in unprecedented challenges for healthcare systems worldwide. It has also stimulated research in a wide range of areas including rapid diagnostics, novel therapeutics, use of technology to track patients and vaccine development. Here, we describe our experience of rapidly setting up and delivering a novel COVID-19 vaccine trial, using clinical and research staff and facilities in three National Health Service Trusts in Cambridgeshire, United Kingdom. We encountered and overcame a number of challenges including differences in organisational structures, research facilities available, staff experience and skills, information technology and communications infrastructure, and research training and assessment procedures. We overcame these by setting up a project team that included key members from all three organisations that met at least daily by teleconference. This group together worked to identify the best practices and procedures and to harmonise and cascade these to the wider trial team. This enabled us to set up the trial within 25 days and to recruit and vaccinate the participants within a further 23 days. The lessons learned from our experiences could be used to inform the conduct of clinical trials during a future infectious disease pandemic or public health emergency

Improving Nursing Home Care through Feedback On PerfoRMance Data (INFORM): Protocol for a cluster-randomized trial

Background Audit and feedback is effective in improving the quality of care. However, methods and results of international studies are heterogeneous, and studies have been criticized for a lack of systematic use of theory. In TREC (Translating Research in Elder Care), a longitudinal health services research program, we collect comprehensive data from care providers and residents in Canadian nursing homes to improve quality of care and life of residents, and quality of worklife of caregivers. The study aims are to a) systematically feed back TREC research data to nursing home care units, and b) compare the effectiveness of three different theory-based feedback strategies in improving performance within care units. Methods INFORM (Improving Nursing Home Care through Feedback On PerfoRMance Data) is a 3.5-year pragmatic, three-arm, parallel, cluster-randomized trial. We will randomize 67 Western Canadian nursing homes with 203 care units to the three study arms, a standard feedback strategy and two assisted and goal-directed feedback strategies. Interventions will target care unit managerial teams. They are based on theory and evidence related to audit and feedback, goal setting, complex adaptive systems, and empirical work on feeding back research results. The primary outcome is the increased number of formal interactions (e.g., resident rounds or family conferences) involving care aides – non-registered caregivers providing up to 80% of direct care. Secondary outcomes are a) other modifiable features of care unit context (improved feedback, social capital, slack time) b) care aides’ quality of worklife (improved psychological empowerment, job satisfaction), c) more use of best practices, and d) resident outcomes based on the Resident Assessment Instrument – Minimum Data Set 2.0. Outcomes will be assessed at baseline, immediately after the 12-month intervention period, and 18 months post intervention. Discussion INFORM is the first study to systematically assess the effectiveness of different strategies to feed back research data to nursing home care units in order to improve their performance. Results of this study will enable development of a practical, sustainable, effective, and cost-effective feedback strategy for routine use by managers, policy makers and researchers. The results may also be generalizable to care settings other than nursing homes. Trial registration ClinicalTrials.gov Identifier: NCT02695836 . Date of registration: 24 February 201

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely