Inflorescence Architecture and Floral Morphology of Aratitiyopea lopezii (Xyridaceae)

Aratitiyopea lopezii is a robust perennial species of Xyridaceae from seasonally saturated, mid- to high-elevation, sandstone and granite sites in northern South America. The species lacks the scapose inflorescence characteristic of Xyridaceae and, having the gestalt of a rhizomatous bromeliad, it is seemingly aberrant in the family. However, closer examination confirms features consistent with the family and the previously noted morphological similarities to Orectanthe. Details of inflorescence structure and floral morphology are presented and compared to other genera of Xyridaceae

Alpha Interferon-Induced Antiretroviral Activities: Restriction of Viral Nucleic Acid Synthesis and Progeny Virion Production in Human Immunodeficiency Virus Type 1-Infected Monocytes

Alpha interferon (IFN-a) restricts multiple steps of the human immunodeficiency virus type 1 (HIV-i) life cycle. A well-described effect of IFN-a is in the modulation of viral nucleic acid synthesis. We demonstrate that IFN-α influences HIV-1 DNA synthesis principally by reducing the production of late products of reverse transcription. The magnitude of IFN-α-induced downregulation of HIV-1 DNA and/or progeny virion production was dependent on the IFN-α concentration, the duration of cytokine administration, the multiplicity of infection, the viral strain, and the cycles of viral infection. Interestingly, reductions in viral DNAs could not fully account for the observed IFN-a-induced abrogation of progeny virion production. These data, by our investigation of both single-cycle and spreading viral infections, support a predominant but not exclusive effect of IFN-α on viral DNA synthesis

The Influence of Trail Design on the Impacts of Walkers, Mountain Bikers and Multi-use Trail Users: An Environmentally Responsible Approach

Trail design and building guidelines are essential tools for influencing the behaviour—and therefore the environmental impact—of users of walking, mountain biking and multi-use recreation trails. Yet, these tools are often not explicitly considered in research that monitors their environmental impact. This is the first study to investigate the role of trail design in shaping how walkers and mountain bikers utilise mountain biking, walking and multi-use trails. The research differentiates trail feature types to examine how they shape user behaviour and, therefore, environmental impact. This observational study uses time-series photographic imagery to examine behaviour and impacts over 12 months. Impacts at each site were examined using current trail building design guidelines. The findings show that shortcuts were commonly employed to avoid long sections on walker-only trails, and to cut across meandering tracks on the multi-use trails in the mountain bike park. Trail spread occurs when walkers use the edges of the trail to avoid rough or uneven surfaces such as stairs and tree roots. Depressions in the trail before technical mountain biking features such as berms and drops were also apparent. Further observations include toilet paper and litter on the walking trails. The research furthermore indicates the unintended environmental impacts when trail users did not adhere to specific trail features or did not use the trails as intended. Unique trail design principles are required where walkers and mountain bikers use the same trails, and this paper provides recommendations for improving trail design

The social mobility challenges faced by young muslims

Young Muslims face the 'broken promise of social mobility': compared to other groups, their improved success in education at all levels does not translate into good labour market outcomes. Despite their educational gains, Muslims experience the greatest economic disadvantages of any group in UK society. They are more likely than non-Muslims to experience neighbourhood deprivation, housing, educational and health disadvantage, and unemployment. This qualitative report explores the attitudes and reasons behind this situation. It offers an account of young Muslims’ perceptions of growing up and seeking work in the UK. The report is designed to contribute to a better understanding of the causes of low social mobility for young Muslims. Drawing on the perceptions of young Muslims (through focus groups and interviews) and of key stakeholders (through a three-stage Delphi survey) the research sought evidence on: • The barriers young Muslims see to social mobility in the UK – in particular, why educational gains are not translating into employment gains for young Muslims. • How these perceptions differ depending on gender, ethnicity, socio-economic background and different forms of educational participation

Buckle up safely: a cluster randomised trial to evaluate the effectiveness of a pre-school based program to increase appropriate use of child restraints

BACKGROUND: Road traffic crashes for car occupants are a leading cause of death and serious injury in children from high and middle income countries globally. Correct use of appropriate child restraints can significantly reduce death and serious injury but there is a need for well powered trials to examine effectiveness of programs to increase optimal child restraint practices. The aim of this trial is to examine the effectiveness of a comprehensive intervention to increase the use of appropriate child restraints, and decrease incorrect use of child restraints in pre-school aged children traveling in cars. METHODS AND DESIGN: A cluster randomised controlled trial will be conducted, involving 28 pre-school or childcare centres in low income areas of Sydney, Australia, over one calendar year. The intervention is an educational program involving an in-service for centre staff, distribution of educational materials to parents, a parent workshop demonstrating restraint use, subsidised restraints for parents in need, and vouchers for a free restraint checking service. Blinded assessors will observe restraint use at all centres at the end of the calendar year. Data will be analysed on an intention-to-treat basis; the primary analysis will compare the proportion of each of the two outcome measures (use of appropriate restraints, and incorrect use of restraints) at each centre between intervention and control groups. Detailed process evaluation will be conducted, including examination of implementation and utilisation of various elements of the program by both centres and families. DISCUSSION: This assessor blinded cluster randomised trial is powered to provide credible evidence about the efficacy of an education and distribution program in a pre-school setting to increase appropriate use, and decrease incorrect use of child restraints. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry ACTRN12609000612213

Automated classification of neonatal sleep states using EEG

Objective: To develop a method for automated neonatal sleep state classification based on EEG that can be applied over a wide range of age. Methods: We collected 231 EEG recordings from 67 infants between 24 and 45 weeks of postmenstrual age. Ten minute epochs of 8 channel polysomnography (N = 323) from active and quiet sleep were used as a training dataset. We extracted a set of 57 EEG features from the time, frequency, and spatial domains. A greedy algorithm was used to define a reduced feature set to be used in a support vector machine classifier. Results: Performance tests showed that our algorithm was able to classify quiet and active sleep epochs with 85% accuracy, 83% sensitivity, and 87% specificity. The performance was not substantially lowered by reducing the epoch length or EEG channel number. The classifier output was used to construct a novel trend, the sleep state probability index, that improves the visualisation of brain state fluctuations. Conclusions: A robust EEG-based sleep state classifier was developed. It performs consistently well across a large span of postmenstrual ages. Significance: This method enables the visualisation of sleep state in preterm infants which can assist clinical management in the neonatal intensive care unit. (C) 2017 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.Peer reviewe

Predicting the growth of the amphibian chytrid fungus in varying temperature environments

Environmental temperature is a crucial abiotic factor that influences the success of ectothermic organisms, including hosts and pathogens in disease systems. One example is the amphibian chytrid fungus, Batrachochytrium dendrobatidis (Bd), which has led to widespread amphibian population declines. Understanding its thermal ecology is essential to effectively predict outbreaks. Studies that examine the impact of temperature on hosts and pathogens often do so in controlled constant temperatures. Although varying temperature experiments are becoming increasingly common, it is unrealistic to test every temperature scenario. Thus, reliable methods that use constant temperature data to predict performance in varying temperatures are needed. In this study, we tested whether we could accurately predict Bd growth in three varying temperature regimes, using a Bayesian hierarchical model fit with constant temperature Bd growth data. We fit the Bayesian hierarchical model five times, each time changing the thermal performance curve (TPC) used to constrain the logistic growth rate to determine how TPCs influence the predictions. We then validated the model predictions using Bd growth data collected from the three tested varying temperature regimes. Although all TPCs overpredicted Bd growth in the varying temperature regimes, some functional forms performed better than others. Varying temperature impacts on disease systems are still not well understood and improving our understanding and methodologies to predict these effects could provide insights into disease systems and help conservation efforts

Regionalizing Government in Maine: Opportunities for the Future

In keeping with his promise to make government work better for the people of Maine, Governor Angus King commissioned the Task Force on Regional Options for Better Government. The Governor charged the task force with recommending some alternative regional arrangements for the delivery of government services currently provided by state or local government. The task force evaluated three services in which regionalism offered some advantages: economic development; demand response transportation; and municipal management information systems

Neurocognitive, genetic and environmental risk factors of learning disorders in children

Our research has already uncovered a range of behavioural and neural factors that can differentiate between children whose development is impaired and those whose development is progressing typically. Intriguingly, our recent findings have also suggested that multiple learning disorders are often present in children with general cognitive difficulties like autism spectrum disorder and ADHD. However, a common feature of research in this area is that of a ‘distinct syndrome’ approach, only studying childhood disabilities separately.https://ir.lib.uwo.ca/brainscanprojectsummaries/1013/thumbnail.jp