23,090 research outputs found
Embedding ethics and ethical practice within and across the curriculum: emerging findings from a TQEF-funded project
Mass distributions in a variational model
The time-dependent Hartree-Fock approach may be derived from a variational
principle and a Slater Determinant wavefunction Ansatz. It gives a good
description of nuclear processes in which one-body collisions dominate and has
been applied with success to giant resonances and collisions around the
barrier. It is inherently unable to give a good description of two-body
observables. A variational principle, due to Balian and Veneroni has been
proposed which can be geared to good reproduction of two-body observables.
Keeping the Slater Determinant Ansatz, and restricting the two-body observables
to be the squares of one-body observables, the procedure can be implemented as
a modification of the time-dependent Hartree-Fock procedure. Applications,
using the Skyrme effective interaction, are presented for the mass
distributions of fragments following de-excitation of the giant dipole
resonance in S-32. An illustration of the method's use in collisions is given.Comment: 5 pages, proceedings of XXXII Symposium on Nuclear Physics, Cocoyoc,
Mexic
Hypervelocity impact microfoil perforations in the LEO space environment (LDEF, MAP AO-023 experiment)
The Microabrasion Foil Experiment comprises arrays of frames, each supporting two layers of closely spaced metallic foils and a back-stop plate. The arrays, deploying aluminum and brass foil ranging from 1.5 to some 30 microns were exposed for 5.78 years on NASA's LDEF at a mean altitude of 458 km. They were deployed on the North, South, East, West, and Space pointing faces; results presented comprise the perforation rates for each location as a function of foil thickness. Initial results refer primarily to aluminum of 5 microns thickness or greater. This penetration distribution, comprising 2,342 perforations in total, shows significantly differing characteristics for each detector face. The anisotropy confirms, incorporating the dynamics of particulate orbital mechanics, the dominance of incorporating extraterrestrial particulates penetrating thicknesses greater than 20 microns in Al foil, yielding fluxes compatible with hyperbolic geocentric velocities. For thinner foils, a disproportionate increase in flux of particles on the East, North, and South faces shows the presence of orbital particulates which exceed the extraterrestrial component perforation rate at 5 micron foil thickness by a factor of approx. 4
Economic evaluation of the routine use of echocardiography versus natriuretic peptide and ECG-targeted echocardiography in the diagnosis of heart failure
Objectives: To investigate the most efficient use of echocardiography and natriuretic peptide testing in the diagnosis of heart failure.
Design: An economic model comparing two strategies: (A) provide echocardiography and electrocardiogram (ECG) for all individuals who present to a GP with symptoms that may be due to heart failure; (B) carry out B-type natriuretic peptide (BNP) blood test and ECG on all such individuals and provide echocardiography only where an abnormality is detected in one of more of these tests.
Setting: Primary care in the UK NHS.
Subjects: Individuals who present to a GP with new symptoms of heart failure.
Main outcome measures: Cost per life year gained.
Results: Baseline cost per life year gained by strategy A compared with strategy B is £3,987.
Conclusions: Immediate echocardiography is the most cost-effective option. Where echocardiography is a scarce resource, efficient use can be obtained by using BNP and ECG tests to identify patients most likely to have heart failure
Gemini/GMOS Transmission Spectral Survey: Complete Optical Transmission Spectrum of the hot Jupiter WASP-4b
We present the complete optical transmission spectrum of the hot Jupiter
WASP-4b from 440-940 nm at R ~ 400-1500 obtained with the Gemini Multi-Object
Spectrometers (GMOS); this is the first result from a comparative
exoplanetology survey program of close-in gas giants conducted with GMOS.
WASP-4b has an equilibrium temperature of 1700 K and is favorable to study in
transmission due to a large scale height (370 km). We derive the transmission
spectrum of WASP-4b using 4 transits observed with the MOS technique. We
demonstrate repeatable results across multiple epochs with GMOS, and derive a
combined transmission spectrum at a precision about twice above photon noise,
which is roughly equal to to one atmospheric scale height. The transmission
spectrum is well fitted with a uniform opacity as a function of wavelength. The
uniform opacity and absence of a Rayleigh slope from molecular hydrogen suggest
that the atmosphere is dominated by clouds with condensate grain size of ~1 um.
This result is consistent with previous observations of hot Jupiters since
clouds have been seen in planets with similar equilibrium temperatures to
WASP-4b. We describe a custom pipeline that we have written to reduce GMOS
time-series data of exoplanet transits, and present a thorough analysis of the
dominant noise sources in GMOS, which primarily consist of wavelength- and
time- dependent displacements of the spectra on the detector, mainly due to a
lack of atmospheric dispersion correction.Comment: 23 pages, 12 figures, accepted for publication in AJ, 2017 July
Crucial Dependence of ``Precarious'' and ``Autonomous'' phi^4s Upon the Normal-ordering Mass
Using the Gaussian wave-functional approach with the normal-ordering
renormalization prescription, we show that for the (3+1)-dimensional massive
lambda phi^4 theory, ``precarious'' and ``autonomous'' phi^4s can exist if and
only if the normal-ordering mass is equal to the classical masses at the
symmetrc and asymmetric vacua, respectively.Comment: 6 pages, no figures, Revtex file, accepted for publication in Mod.
Phys. Lett.
The Non-Trivial Effective Potential of the `Trivial' lambda Phi^4 Theory: A Lattice Test
The strong evidence for the `triviality' of (lambda Phi^4)_4 theory is not
incompatible with spontaneous symmetry breaking. Indeed, for a `trivial' theory
the effective potential should be given exactly by the classical potential plus
the free-field zero-point energy of the shifted field; i.e., by the one-loop
effective potential. When this is renormalized in a simple, but nonperturbative
way, one finds, self-consistently, that the shifted field does become
non-interacting in the continuum limit. For a classically scale-invariant (CSI)
lambda Phi^4 theory one finds m_h^2 = 8 pi^2 v^2, predicting a 2.2 TeV Higgs
boson. Here we extend our earlier work in three ways: (i) we discuss the
analogy with the hard-sphere Bose gas; (ii) we extend the analysis from the CSI
case to the general case; and (iii) we propose a test of the predicted shape of
the effective potential that could be tested in a lattice simulation.Comment: 22 pages, LaTeX, DE-FG05-92ER40717-
NEOWISE observations of comet C/2013 A1 (Siding Spring) as it approaches Mars
The Near-Earth Object Wide-field Infrared Survey Explorer (NEOWISE) mission
observed comet C/2013 A1 (Siding Spring) three times at 3.4 {\mu}m and 4.6
{\mu}m as the comet approached Mars in 2014. The comet is an extremely
interesting target since its close approach to Mars in late 2014 will be
observed by various spacecraft in-situ. The observations were taken in 2014
Jan., Jul. and Sep. when the comet was at heliocentric distances of 3.82 AU,
1.88 AU, and 1.48 AU. The level of activity increased significantly between the
Jan. and Jul. visits but then decreased by the time of the observations in
Sep., approximately 4 weeks prior to its close approach to Mars. In this work
we calculate Af\r{ho} values, and CO/CO2 production rates.Comment: 9 pages, 3 figures, accepted by Astrophysical Journal Letter
Influence of convective transport on tropospheric ozone and its precursors in a chemistry-climate model
The impact of convection on tropospheric O<sub>3</sub> and its precursors has been examined in a coupled chemistry-climate model. There are two ways that convection affects O<sub>3</sub>. First, convection affects O<sub>3</sub> by vertical mixing of O<sub>3</sub> itself. Convection lifts lower tropospheric air to regions where the O<sub>3</sub> lifetime is longer, whilst mass-balance subsidence mixes O<sub>3</sub>-rich upper tropospheric (UT) air downwards to regions where the O<sub>3</sub> lifetime is shorter. This tends to decrease UT O<sub>3</sub> and the overall tropospheric column of O<sub>3</sub>. Secondly, convection affects O<sub>3</sub> by vertical mixing of O<sub>3</sub> precursors. This affects O<sub>3</sub> chemical production and destruction. Convection transports isoprene and its degradation products to the UT where they interact with lightning NO<sub>x</sub> to produce PAN, at the expense of NO<sub>x</sub>. In our model, we find that convection reduces UT NO<sub>x</sub> through this mechanism; convective down-mixing also flattens our imposed profile of lightning emissions, further reducing UT NO<sub>x</sub>. Over tropical land, which has large lightning NO<sub>x</sub> emissions in the UT, we find convective lofting of NO<sub>x</sub> from surface sources appears relatively unimportant. Despite UT NO<sub>x</sub> decreases, UT O<sub>3</sub> production increases as a result of UT HO<sub>x</sub> increases driven by isoprene oxidation chemistry. However, UT O<sub>3</sub> tends to decrease, as the effect of convective overturning of O<sub>3</sub> itself dominates over changes in O<sub>3</sub> chemistry. Convective transport also reduces UT O<sub>3</sub> in the mid-latitudes resulting in a 13% decrease in the global tropospheric O<sub>3</sub> burden. These results contrast with an earlier study that uses a model of similar chemical complexity. Differences in convection schemes as well as chemistry schemes – in particular isoprene-driven changes are the most likely causes of such discrepancies. Further modelling studies are needed to constrain this uncertainty range
The clinical effectiveness and cost-effectiveness of inhaler devices used in the routine management of chronic asthma in older children: a systematic review and economic evaluation
Background:
This review examines the clinical effectiveness and
cost-effectiveness of hand-held inhalers to deliver
medication for the routine management of chronic
asthma in children aged between 5 and 15 years.
Asthma is a common disease of the airways, with a
prevalence of treated asthma in 5–15-year-olds of
around 12% and an actual prevalence in the community
as high as 23%. Treatment for the condition
is predominantly by inhalation of medication. There
are three main types of inhaler device, pressurised
metered dose, breath actuated, and dry powder, with
the option of the attachment of a spacer to the first
two devices under some prescribed circumstances.
Two recent reviews have examined the clinical and
cost-effectiveness evidence on inhaler devices, but
one was for children aged under 5 years and the
comparison in the second was made between pressurised
metered dose inhalers and other types only.
Objectives:
This review examines the clinical effectiveness and
cost-effectiveness of manual pressurised metered
dose inhalers, breath-actuated metered dose
inhalers, and breath-actuated dry powder inhalers,
with and without spacers as appropriate, to deliver
medication for the routine management of chronic
asthma in children aged between 5 and 15 years.
Methods:
Two previous HTA reviews have compared the
effectiveness of inhaler devices, one focusing on
asthma in children aged under 5 years and the
other on asthma and chronic obstructive airways
disease in all age groups. For the current review, a
literature search was carried out to identify all
evidence relating to the use of inhalers in older
children with chronic asthma. A search of in-vitro
studies undertaken for one of the previous reviews
was also updated.
The data sources used were: 15 electronic bibliographic
databases; the reference lists of one of the
previous HTA reports and other relevant articles;
health services research-related internet resources;
and all sponsor submissions.
Studies were selected according to strict inclusion
and exclusion criteria, and relevant information
concerning effectiveness and patient compliance
and preference was extracted directly on to an
extraction/evidence table. Quality assurance
was monitored.
Economic evaluation was undertaken by reviewing
existing cost-effective evidence. Further economic
modelling was carried out, and tables constructed
to determine device cost-minimisation and
incremental quality-adjusted life-year (QALY)
thresholds between devices.
Results:
Number and quality of studies, and
direction of evidence:
Fourteen randomised controlled studies were
identified relating to the clinical effectiveness of
inhaler devices for delivering β2-agonists. A further
five were on devices delivering corticosteroids and
one concerned the delivery of cromoglicate.
Overall, there were no differences in clinical
efficacy between inhaler devices, but a pressurised
metered dose inhaler with a spacer would appear
to be more effective than one without. These
findings endorse those of a previous HTA review
but extend them to other inhaler devices.
Seven randomised controlled trials examined the
impact on clinical effectiveness of using a nonchlorofluorocarbon
(CFC) propellant in place of
a CFC propellant in metered dose inhalers, both
pressurised and breath activated, although only one
study considered the latter type. No differences were
found between inhalers containing either propellant.
A further 30 studies of varying quality, from 12 randomised
controlled trials to non-controlled studies,
were identified that concerned the impact of use
by, and preference for, inhaler type, and treatment
adherence in children. Differences between the
studies, and limitations in comparative data between
various inhaler device types, make it difficult to draw
any firm conclusions from this evidence.
Summary of benefits:
No obvious benefits for one inhaler device type
over another for use in children aged 5–15 years
were identified.
Costs and cost per quality-adjusted
life-year:
Two approaches have been taken: cost-minimisation
and QALY threshold. In the QALY threshold
approach, additional QALYs that each device must
produce compared with a cheaper device to achieve
an acceptable cost per QALY were calculated. Using
the cheapest and most expensive devices for delivering
200 μg of beclometasone per day, assuming no
cost offset for any device, and a threshold of £5000,
the largest QALY needed was 0.00807. With such
a small QALY increase, no intervention can be
categorically rejected as not cost-effective.
Conclusions:
Generalisability of findings:
On the available evidence there are no obvious
benefits for one inhaler device over another
when used by children aged 5–15 years with
chronic asthma. However, the evidence, in the
majority of cases, was compiled on children
with mild to moderate asthma and restricted
to a limited number of drugs. Therefore the
findings may not be generalisable to those at
the more severe end of the spectrum of the
disease or to inhaler devices delivering some
of the drugs used in the management of asthma.
Need for further research:
Many of the previous studies are likely to
have been underpowered. Further clinical
trials with a robust methodology, sufficient
power and qualitative components are needed
to demonstrate any differences in clinical
resource use and patients’ asthma symptoms.
Further studies should also include the
behavioural aspects of patients towards their
medication and its delivery mechanisms.
It is acknowledged that sufficient power may
prove impractical owing to the large numbers
of patients required
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