Implicit Gender Bias, Engagement, and Protective Factors in STEM Faculty

The present study assessed implicit gender bias and job engagement among STEM faculty at a mid-size liberal arts university. Forty-nine faculty in each of the departments of natural and social sciences were assessed for implicit gender bias and job engagement. We found that men had greater implicit gender bias than women in the natural sciences. In addition, women in natural science departments felt marginally less engaged than women in social science departments. Women’s disengagement was positively associated with imposter phenomenon and perceived lack of control in departmental decisions. However, women who actively participated in a women’s organization or had an advocate had more positive psychological outcomes. These findings suggest that although women STEM faculty, particularly in the natural sciences, experience challenges, support provided by women’s organizations or advocates may be an important strategy to reduce the effects of these challenges

Contextualizing Kindergarten Readiness Data: A Qualitative Research Study of Forest Park Neighborhood in Spartanburg, South Carolina

This project was undertaken as a result of conversations initiated by members of the Spartanburg Academic Movement (SAM) about the desirability of qualitative data to contextualize quantitative data generated by the use of a validated national instrument in Spartanburg County Schools. SAM is a nonprofit and community movement that facilitates the discussion of shared information and intentional, collaborative, and strategic work by cross-sector partnerships in order to foster high levels of academic attainment for all children in Spartanburg County. As part of data-gathering efforts by SAM, the Early Development Instrument (EDI) was implemented to gather data about kindergarten readiness first in Spartanburg School District 7, then in 2017, across all seven Spartanburg County school districts. The EDI is a validated, population-based measure of early child development in five key domains (physical health, emotional maturity, social competence, language and cognitive skills, and communications skills and general knowledge).1 Kindergarten teachers respond to the questions on the EDI for each child in a kindergarten clas

Mathematicians’ Central Role in Educating the STEM Workforce

In the recent report Engage to Excel,1 President Obama’s Council of Advisors on Science and Technology (PCAST) identifies mathematics as a bottleneck in undergraduate Science, Technology, Engineering, and Mathematics (STEM) education. Among PCAST’s recommendations are ones calling for the development and teaching of college-level mathematics courses “by faculty from mathematics-intensive disciplines other than mathematics” and for “a new pathway for producing K–12 mathematics teachers…in programs in mathematics-intensive fields other than mathematics.”2 While we are in sharp disagreement with these specific recommendations, we do share PCAST’s concern for the state of STEM education. We encourage the mathematics community to focus constructively on the broad view the report sketches. We appeal to the community to amplify its communications with other STEM disciplines, to publicize its teaching innovations, and to redouble its efforts to meet the challenges discussed by PCAST

Identification and cardiotropic actions of sulfakinin peptides in the American lobster Homarus americanus

In arthropods, a group of peptides possessing a -Y(SO3H)GHM/ LRFamide carboxy-terminal motif have been collectively termed the sulfakinins. Sulfakinin isoforms have been identified from numerous insect species. In contrast, members of this peptide family have thus far been isolated from just two crustaceans, the penaeid shrimp Penaeus monodon and Litopenaeus vannamei. Here, we report the identification of a cDNA encoding prepro-sulfakinin from the American lobster Homarus americanus. Two sulfakinin-like sequences were identified within the open-reading frame of the cDNA. Based on modifications predicted by peptide modeling programs, and on homology to the known isoforms of sulfakinin, particularly those from shrimp, the mature H. americanus sulfakinins were hypothesized to be pEFDEY(SO3H)GHMRFamide (Hoa-SK I) and GGGEY(SO3H)DDY(SO3H)GHLRFamide (Hoa-SK II). Hoa-SK I is identical to one of the previously identified shrimp sulfakinins, while Hoa-SK II is a novel isoform. Exogenous application of either synthetic Hoa-SK I or Hoa-SK II to the isolated lobster heart increased both the frequency and amplitude of spontaneous heart contractions. In preparations in which spontaneous contractions were irregular, both peptides increased the regularity of the heartbeat. Our study provides the first molecular characterization of a sulfakinin-encoding cDNA from a crustacean, as well as the first demonstration of bioactivity for native sulfakinins in this group of arthropods

Efficacy and mechanism of sub-sensory sacral (optimised) neuromodulation in adults with faecal incontinence:Study protocol for a randomised controlled trial

Background: Faecal incontinence (FI) is a substantial health problem with a prevalence of approximately 8% in community-dwelling populations. Sacral neuromodulation (SNM) is considered the first-line surgical treatment option in adults with FI in whom conservative therapies have failed. The clinical efficacy of SNM has never been rigorously determined in a trial setting and the underlying mechanism of action remains unclear. Methods/design: The design encompasses a multicentre, randomised, double-blind crossover trial and cohort follow-up study. Ninety participants will be randomised to one of two groups (SNM/SHAM or SHAM/SNM) in an allocation ratio of 1:1. The main inclusion criteria will be adults aged 18-75 years meeting Rome III and ICI definitions of FI, who have failed non-surgical treatments to the UK standard, who have a minimum of eight FI episodes in a 4-week screening period, and who are clinically suitable for SNM. The primary objective is to estimate the clinical efficacy of sub-sensory SNM vs. SHAM at 32 weeks based on the primary outcome of frequency of FI episodes using a 4-week paper diary, using mixed Poisson regression analysis on the intention-to-treat principle. The study is powered (0.9) to detect a 30% reduction in frequency of FI episodes between sub-sensory SNM and SHAM stimulation over a 32-week crossover period. Secondary objectives include: measurement of established and new clinical outcomes after 1 year of therapy using new (2017 published) optimised therapy (with standardised SNM-lead placement); validation of new electronic outcome measures (events) and a device to record them, and identification of potential biological effects of SNM on underlying anorectal afferent neuronal pathophysiology (hypothesis: SNM leads to increased frequency of perceived transient anal sphincter relaxations; improved conscious sensation of defaecatory urge and cortical/subcortical changes in afferent responses to anorectal electrical stimulation (main techniques: high-resolution anorectal manometry and magnetoencephalography). Discussion: This trial will determine clinical effect size for sub-sensory chronic electrical stimulation of the sacral innervation. It will provide experimental evidence of modifiable afferent neurophysiology that may aid future patient selection as well as a basic understanding of the pathophysiology of FI

Genome based cell population heterogeneity promotes tumorigenicity: the evolutionary mechanism of cancer.

Cancer progression represents an evolutionary process where overall genome level changes reflect system instability and serve as a driving force for evolving new systems. To illustrate this principle it must be demonstrated that karyotypic heterogeneity (population diversity) directly contributes to tumorigenicity. Five well characterized in vitro tumor progression models representing various types of cancers were selected for such an analysis. The tumorigenicity of each model has been linked to different molecular pathways, and there is no common molecular mechanism shared among them. According to our hypothesis that genome level heterogeneity is a key to cancer evolution, we expect to reveal that the common link of tumorigenicity between these diverse models is elevated genome diversity. Spectral karyotyping (SKY) was used to compare the degree of karyotypic heterogeneity displayed in various sublines of these five models. The cell population diversity was determined by scoring type and frequencies of clonal and non-clonal chromosome aberrations (CCAs and NCCAs). The tumorigenicity of these models has been separately analyzed. As expected, the highest level of NCCAs was detected coupled with the strongest tumorigenicity among all models analyzed. The karyotypic heterogeneity of both benign hyperplastic lesions and premalignant dysplastic tissues were further analyzed to support this conclusion. This common link between elevated NCCAs and increased tumorigenicity suggests an evolutionary causative relationship between system instability, population diversity, and cancer evolution. This study reconciles the difference between evolutionary and molecular mechanisms of cancer and suggests that NCCAs can serve as a biomarker to monitor the probability of cancer progression

Clinical Research and Development of Tuberculosis Diagnostics: Moving From Silos to Synergy

The development, evaluation, and implementation of new and improved diagnostics have been identified as critical needs by human immunodeficiency virus (HIV) and tuberculosis researchers and clinicians alike. These needs exist in international and domestic settings and in adult and pediatric populations. Experts in tuberculosis and HIV care, researchers, healthcare providers, public health experts, and industry representatives, as well as representatives of pertinent US federal agencies (Centers for Disease Control and Prevention, Food and Drug Administration, National Institutes of Health, United States Agency for International Development) assembled at a workshop proposed by the Diagnostics Working Group of the Federal Tuberculosis Taskforce to review the state of tuberculosis diagnostics development in adult and pediatric populations

Wildfire Risk as a Socioecological Pathology

Wildfire risk in temperate forests has become a nearly intractable problem that can be characterized as a socioecological “pathology”: that is, a set of complex and problematic interactions among social and ecological systems across multiple spatial and temporal scales. Assessments of wildfire risk could benefit from recognizing and accounting for these interactions in terms of socioecological systems, also known as coupled natural and human systems (CNHS). We characterize the primary social and ecological dimensions of the wildfire risk pathology, paying particular attention to the governance system around wildfire risk, and suggest strategies to mitigate the pathology through innovative planning approaches, analytical tools, and policies. We caution that even with a clear understanding of the problem and possible solutions, the system by which human actors govern fire-prone forests may evolve incrementally in imperfect ways and can be expected to resist change even as we learn better ways to manage CNHS

Pemodelan Turbin Cross-flow Untuk Diaplikasikan Pada Sumber Air Dengan Tinggi Jatuh Dan Debit Kecil

Telah dilakukan suatu upaya memodifikasi dan rekayasa turbin jenis cross-flow. Rekayasa dilakukan dengan merubah jumlah sudut dan hubungannya dengan jumlah putaran, daya turbin, dan efisiensi turbin. Rekayasa juga dilakukan terhadap bentuk saluran yang digunakan yaitu saluran terbuka berbentuk persegi, setengah lingkaran dan trapesium. Penelitian ini dilakukan dengan mengambil beberapa input yang disesuaikan dengan kebanyakan yang ada di lapangan. Input yang diambil adalah kecepatan alir, tinggi jatuh, kemiringan saluran, lebar penampang saluran, jari-jari saluran, diameter luar turbin, dan lebar turbin. Sementara itu besaran yang dibuat variabel adalah jumlah sudu pada turbin cross-flow. Penampang sebagai saluran air dipakai persegi, setengah lingkaran, dan trapesium dan ketiganya dibuat terbuka. Hasil penelitian menunjukkan bahwa dengan asumsi lebar penampang 4 m, tinggi jatuh 2 m, jari-jari 2 m, kemiringan 1/√3, kecepatan aliran 2 m/s, diameter luar turbin 0,75 m, dan lebar turbin 4,3 m, maka turbin dengan jumlah sudu 12 memiliki jumlah putaran, daya turbin, dan efisiensi turbin yang paling besar. Bilamana jumlah sudu diperbanyak, maka jumlah putaran, daya turbin, dan efisiensi turbin semakin kecil. Sementara itu penelitian untuk menentukan jenis penampang saluran didapatkan bahwa jenis saluran dengan penampang trapesium dihasilkan jumlah putaran, daya turbin, dan efisiensi turbin yang paling besar disusul jenis persegi dan setengah lingkaran