Marshall University Music Department Presents the Marshall University Percussion Ensemble, Steven Hall, conductor, Levi Billiter, assistant conductor

https://mds.marshall.edu/music_perf/1448/thumbnail.jp

Marshall University Music Department Presents the Marshall University Percussion Ensemble, Steven Hall, conductor, Levi Billiter, assistant conductor, featuring, Lana Mendonca & The In Dance Performance Group

https://mds.marshall.edu/music_perf/1480/thumbnail.jp

Coagulation abnormalities in critically ill patients

Many critically ill patients develop hemostatic abnormalities, ranging from isolated thrombocytopenia or prolonged global clotting tests to complex defects, such as disseminated intravascular coagulation. There are many causes for a deranged coagulation in critically ill patients and each of these underlying disorders may require specific therapeutic or supportive management. In recent years, new insights into the pathogenesis and clinical management of many coagulation defects in critically ill patients have been accumulated and this knowledge is helpful in determining the optimal diagnostic and therapeutic strategy

Effects of Acute Cold Exposure on Plasma Biomarkers Associated with Cardiovascular Disease Risk

Background and Aims: The underlying cause of the majority of the cases of CVD is atherosclerosis, which is a condition initiated and progressed by chronic inflammation and hyperlipidemia. We are interested in evaluating the efficacy of cold-exposure to increase shivering- and non-shivering thermogenesis energy expenditure (RMR) as a non-pharmaceutical weight loss tool analogous to low intensity exercise. Naturally, we are concurrently evaluating the possible effects of cold exposure on risk factors associated with CVD risk. Inflammatory cytokines and lipid mediators are used as biomarkers for CVD risk. This proposed study aims to measure cardiovascular inflammatory and lipid biomarkers to expand our knowledge of cold exposure and CVD risk. The two biomarkers collected during this study were Interleukin-1 Beta (IL-β) and Chemokine Ligand 2 (CCL2). The hypothesis was that there would be no change in biomarker values before and after cold exposure. Methods: Twenty subjects were recruited and subjected to a 30-min cold exposure test while a metabolic cart collected metabolic data via indirect calorimetry. Venous plasma collected at: pre cold exposure, immediately after cold exposure, and 2 hours post cold exposure was centrifuged for subsequent biomarkers analysis. Results: RMR increases dramatically during acute cold exposure during shivering and remains increased 5 minutes after the cessation of shivering. Five minutes post-cold exposure, RMR rapidly decreases to pre-cold exposure RMR and is maintained for up to 120 minutes. There was no change in CCL2 values when comparing the three stages. IL-β values increased between blood draws immediately after cold exposure and 2 hours post cold exposure, however this increase was not statistically significant. Conclusions: With these pilot results, we conclude that cold exposure has no effect on biomarkers for CVD risk. However, this study was limited by 1) accuracy of analysis techniques, 2) cold exposure protocol, 3) analysis of only two representative biomarkers. Further biomarker analysis is underway for a more comprehensive picture of the purported cold exposure effects

CubeSat System Reference Model (CSRM) as an OMG Specification

This paper describes the transformation of the CubeSat Reference Model™ (CSRM™) into an Object Management Group® (OMG®) specification, as effected by the International Committee on System Engineering (INCOSE) Space System Working Group (SSWG) from 2016 to 2022. The CSRM is a logical model of engineering artifacts used by a CubeSat mission team to build its mission-specific logical and physical models according to its individual engineering methodology. It is based on Model-Based System Engineering (MBSE) principles, is OMG System Modeling Language (SysML) compliant, is hosted on a graphical modeling tool, and is intended to foster completeness and economies of scale associated with reusability. The OMG, an international standards organization, has a mature, worldwide, and open process for identifying the need for a specification, as well as for soliciting, developing, approving, and distributing a specification. In 2018, the OMG initiated a process to provide the CSRM as an OMG specification. This resulted in the normative CSRM Profile Specification document, the normative CSRM Profile XMI file for import into a graphical modeling tool, and the non-normative CSRM Profile Model. Supplementing these files are the non-normative CSRM Model file and the non-normative CSRM HTML file which allows for exploration and evaluation of the CSRM without the need to acquire a graphical modeling tool and provides sufficient guidance for establishing a mission specific CSRM

Environmental Influences on HIV Medication Adherence: The Role of Neighborhood Disorder

Objectives. We hypothesized that highly disordered neighborhoods would expose residents to environmental pressures, leading to reduced antiretroviral (ARV) medication adherence. Methods: Using targeted sampling, we enrolled 503 socioeconomically disadvantaged HIV-positive substance users in urban South Florida between 2010 and 2012. Participants completed a 1-time standardized interview that took approximately 1 hour. We tested a multiple mediation model to examine the direct and indirect effects of neighborhood disorder on diversion-related nonadherence to ARVs; risky social networks and housing instability were examined as mediators of the disordered neighborhood environment. Results: The total indirect effect in the model was statistically significant (P = .001), and the proportion of the total effect mediated was 53%. The model indicated substantial influence of neighborhood disorder on nonadherence to ARVs, operating through recent homelessness and diverter network size. Conclusions: Long-term improvements in diversion-related ARV adherence will require initiatives to reduce demand for illicit ARV medications, as well as measures to reduce patient vulnerability to diversion, including increased resources for accessible housing, intensive treatment, and support services

Benzodiazepine Dependence Among Multidrug Users in the Club Scene

Background: Benzodiazepines (BZs) are among the most frequently prescribed drugs with the potential for abuse. Young adults ages 18–29 report the highest rates of BZ misuse in the United States. The majority of club drug users are also in this age group, and BZ misuse is prevalent in the nightclub scene. BZ dependence, however, is not well documented. This paper examines BZ dependence and its correlates among multidrug users in South Florida\u27s nightclub scene. Methods: Data were drawn from structured interviews with men and women (N = 521) who reported regular attendance at large dance clubs and recent use of both club drugs and BZs. Results: Prevalences of BZ-related problems were 7.9% for BZ dependence, 22.6% BZ abuse, and 25% BZ abuse and/or dependence. In bivariate logistic regression models, heavy cocaine use (OR 2.27; 95% CI 1.18, 4.38), severe mental distress (OR 2.63; 95% CI 1.33, 5.21), and childhood victimization history (OR 2.43; 95% CI 1.10, 5.38) were associated with BZ dependence. Heavy cocaine use (OR 2.14; 95% CI 1.10, 4.18) and severe mental distress (OR 2.16; 95% CI 1.07, 4.37) survived as predictors in the multivariate model. Discussion: BZ misuse is widespread among multidrug users in the club scene, who also exhibit high levels of other health and social problems. BZ dependence appears to be more prevalent in this sample than in other populations described in the literature. Recommendations for intervention and additional research are described

Health and Social Problems associated with Prescription Opioid Misuse among a Diverse Sample of Substance-Using MSM

This study examines associations between prescription opioid misuse and demographics, substance use, sexual behavior, and related health and social problems. Baseline data were collected between 2008 and 2010 from 515 high risk men who have sex with men, ages 18–55, in the Miami-Ft. Lauderdale metropolitan area who reported heavy substance use and HIV risk in the past 90 days. Prescription opioid misuse was associated with other substance use, drug injection, substance dependence, and history of arrest. Implications, limitations, and directions for future study are discussed