Meta-evaluation of the impacts and legacy of the London 2012 Olympic Games and Paralympic Games : Developing methods paper

This report brings together the interim findings from the Developing Meta-Evaluation Methods study, which is being undertaken in conjunction with the Meta-Evaluation of the Impacts and Legacy of the London 2012 Olympic Games and Paralympic Games. The work on methods is funded by the Economic and Social Research Council (ESRC). The aim of this paper is to review the existing evidence on conducting meta-evaluation, and provide guidance appropriate to the Meta Evaluation of the Games as well as other meta-evaluation studies

Persistence of scrapie infectivity within a farm environment after cleaning and decontamination

Scrapie of sheep/goats and Chronic Wasting Disease (CWD) of deer/elk are contagious prion diseases where environmental reservoirs are directly implicated in the transmission of disease. In this study the effectiveness of recommended scrapie farm decontamination regimes was evaluated by a sheep bioassay using buildings naturally contaminated with scrapie. Pens within a farm building were treated with either 20,000ppm free chorine solution for one hour, or were treated to same but were followed with painting and full re-galvanisation or replacement of metalwork within the pen. Scrapie susceptible lambs of the PRNP genotype VRQ/VRQ were reared within these pens and their scrapie status was monitored by RAMALT. All animals became infected over an 18-month period, even in the pen that had been subject to the most stringent decontamination process. This data suggests that recommended current guidelines for the decontamination of farm buildings following outbreaks of scrapie do little to reduce the titre of infectious scrapie material and that environmental re-contamination could also be an issue associated with these premises

Post-exercise Supplementation of Sodium Bicarbonate Improves Acid Base Balance Recovery and Subsequent High-Intensity Boxing Specific Performance

The aim of this study was to assess the effects of post-exercise sodium bicarbonate (NaHCO3) ingestion (0.3 g.kg−1 body mass) on the recovery of acid-base balance (pH, HCO−3, and the SID) and subsequent exercise performance in elite boxers. Seven elite male professional boxers performed an initial bout of exhaustive exercise comprising of a boxing specific high-intensity interval running (HIIR) protocol, followed by a high-intensity run to volitional exhaustion (TLIM1). A 75 min passive recovery then ensued, whereby after 10 min recovery, participants ingested either 0.3 g.kg−1 body mass NaHCO3, or 0.1 g.kg−1 body mass sodium chloride (PLA). Solutions were taste matched and administered double-blind. Participants then completed a boxing specific punch combination protocol, followed by a second high-intensity run to volitional exhaustion (TLIM2). Both initial bouts of TLIM1 were well matched between PLA and NaHCO3 (ICC; r = 0.94, p = 0.002). The change in performance from TLIM1 to TLIM2 was greater following NaHCO3 compared to PLA (+164 ± 90 vs. +73 ± 78 sec; p = 0.02, CI = 45.1, 428.8, g = 1.0). Following ingestion of NaHCO3, pH was greater prior to TLIM2 by 0.11 ± 0.02 units (1.4%) (p < 0.001, CI = 0.09, 0.13, g = 3.4), whilst HCO−3 was greater by 8.8 ± 1.5 mmol.l−1 (26.3%) compared to PLA (p < 0.001, CI = 7.3, 10.2, g = 5.1). The current study suggests that these significant increases in acid base balance during post-exercise recovery facilitated the improvement in the subsequent bout of exercise. Future research should continue to explore the role of NaHCO3 supplementation as a recovery aid in boxing and other combat sports

Circulation of prions within dust on a scrapie affected farm

Prion diseases are fatal neurological disorders that affect humans and animals. Scrapie of sheep/goats and Chronic Wasting Disease (CWD) of deer/elk are contagious prion diseases where environmental reservoirs have a direct link to the transmission of disease. Using protein misfolding cyclic amplification we demonstrate that scrapie PrPSc can be detected within circulating dusts that are present on a farm that is naturally contaminated with sheep scrapie. The presence of infectious scrapie within airborne dusts may represent a possible route of infection and illustrates the difficulties that may be associated with the effective decontamination of such scrapie affected premises

Objects in contact with classical scrapie sheep act as a reservoir for scrapie transmission

Classical scrapie is an environmentally transmissible prion disease of sheep and goats. Prions can persist and remain potentially infectious in the environment for many years and thus pose a risk of infecting animals after re-stocking. In vitro studies using serial protein misfolding cyclic amplification (sPMCA) have suggested that objects on a scrapie- affected sheep farm could contribute to disease transmission. This in vivo study aimed to determine the role of field furniture (water troughs, feeding troughs, fencing, and other objects that sheep may rub against) used by a scrapie-infected sheep flock as a vector for disease transmission to scrapie-free lambs with the prion protein genotype VRQ/VRQ, which is associated with high susceptibility to classical scrapie. When the field furniture was placed in clean accommodation, sheep became infected when exposed to either a water trough (four out of five) or to objects used for rubbing (four out of seven). This field furniture had been used by the scrapie-infected flock 8 weeks earlier and had previously been shown to harbor scrapie prions by sPMCA. Sheep also became infected (20 out of 23) through exposure to contaminated field furniture placed within pasture not used by scrapie-infected sheep for 40 months, even though swabs from this furniture tested negative by PMCA. This infection rate decreased (1 out of 12) on the same paddock after replacement with clean field furniture. Twelve grazing sheep exposed to field furniture not in contact with scrapie-infected sheep for 18 months remained scrapie free. The findings of this study highlight the role of field furniture used by scrapie-infected sheep to act as a reservoir for disease re-introduction although infectivity declines considerably if the field furniture has not been in contact with scrapie-infected sheep for several months. PMCA may not be as sensitive as VRQ/VRQ sheep to test for environmental contamination

Small-scale fisheries, food security, and the SSF Guidelines: value chain challenges in two community-managed fisheries in western Madagascar

Madagascar, among the world’s poorest countries, depends heavily on small-scale fisheries for food security and income. Many of its fisheries have transitioned from subsistence- to market-oriented in recent decades, driven by the emergence of new export markets. In this chapter we consider the Voluntary Guidelines for Securing Sustainable Small-scale Fisheries in the Context of Food Security and Poverty Eradication (‘SSF Guidelines’) in light of experiences from two small-scale fisheries in Madagascar: for octopus (Octopus cyanea) and mud crab (Scylla serrata). We focus on articles related to value chains, post-harvest and trade. The dispersed nature of the fisheries means fishers rely on private sector collectors to access markets. Post-harvest actors hold disproportionate negotiating power, with benefits from management initiatives accruing mainly to actors high in the value chain rather than the fishers who implement them. To address these imbalances and increase the contribution of these fisheries to poverty reduction and food security, it is critical to empower fishers and improve their representation in management processes. Data deficiencies must also be tackled, to enhance transparency and provide an evidence base for decision-making

Between neoliberalism and nationalist populism: What role for the ‘European Social Model’ and social quality in post-Brexit Europe?

This article investigates the idea of ‘the social’ in Europe after the UK's EU Referendum vote, with reference to the ‘European social model’. It is argued that the key drivers of the vote outcome did not feature in the referendum campaign but are features of longer running and deeper fractures in both British and wider European society. Especially, the lack of response to societal problems, the downplaying of individual participation, and a crisis in democracy created by an increasingly neoliberal direction within an EU concerned with austerity and social control, contrary to the values of the ‘European social model’ (Walker, 2005). In the absence of action for better ‘social quality’, this overall neoliberal direction has also weakened the progressive and integrative potential of social policy. The result is the regressive nationalist populist backlash against neoliberal technocracy. Instead, we argue that answers to contemporary European challenges must focus on improving social quality and democracy