Colour changes in pulses fumigated with different metal phosphide formulations: Poster

Many phosphine-emitting products are used globally to control insect pests in dried vegetables, grains and pulses. However, variation in phosphide formulations is associated with colour change in many pulses. This study evaluated the effect of fumigation using Mg3P2 containing ammonium carbamate; AlP containing no ammonium carbamate and pure ammonium carbamate on colour of diferrent pulses. Different pulses showed different reactions towards fumigation with phosphine. A distinctly darker discolouration was observed in broad beans and lentils when fumigated with ammonium carbamate containing Mg3P2 and pure ammonium carbamate, whereas there were no apparent colour changes in white kidney beans, soybeans and green peas. The use of ammonium carbamate-free AlP resulted in no changes in any of the pulses. Therefore, formulation type of the phosphine product plays a major role in the visible colour change of the pulses.Many phosphine-emitting products are used globally to control insect pests in dried vegetables, grains and pulses. However, variation in phosphide formulations is associated with colour change in many pulses. This study evaluated the effect of fumigation using Mg3P2 containing ammonium carbamate; AlP containing no ammonium carbamate and pure ammonium carbamate on colour of diferrent pulses. Different pulses showed different reactions towards fumigation with phosphine. A distinctly darker discolouration was observed in broad beans and lentils when fumigated with ammonium carbamate containing Mg3P2 and pure ammonium carbamate, whereas there were no apparent colour changes in white kidney beans, soybeans and green peas. The use of ammonium carbamate-free AlP resulted in no changes in any of the pulses. Therefore, formulation type of the phosphine product plays a major role in the visible colour change of the pulses

Inborn Errors of Energy Metabolism Associated with Myopathies

Inherited neuromuscular disorders affect approximately one in 3,500 children. Structural muscular defects are most common; however functional impairment of skeletal and cardiac muscle in both children and adults may be caused by inborn errors of energy metabolism as well. Patients suffering from metabolic myopathies due to compromised energy metabolism may present with exercise intolerance, muscle pain, reversible or progressive muscle weakness, and myoglobinuria. In this review, the physiology of energy metabolism in muscle is described, followed by the presentation of distinct disorders affecting skeletal and cardiac muscle: glycogen storage diseases types III, V, VII, fatty acid oxidation defects, and respiratory chain defects (i.e., mitochondriopathies). The diagnostic work-up and therapeutic options in these disorders are discussed

Vereinbarkeit von Familie und Beruf für Väter : qualitative Untersuchung von Vätern in IT-Berufen

Diese Masterarbeit befasst sich mit der Vereinbarkeit von Familie und Beruf für Väter - exemplarisch anhand von Vätern in IT-Berufen. Konkret wird die Fragestellung beantwortet: Wie erleben Väter in IT Berufen die Vereinbarkeit von Familie und Beruf? Ziel der Masterarbeit ist es, eine Bestandsaufnahme aus der Sicht der Väter hinsichtlich der Fragestellung zu erhalten, zu erfahren welche Herausforderungen, Spannungsfelder und Wünsche entstehen und wie sie damit umgehen. Dabei werden auch die individuellen Karrierewege und beruflichen Anforderungen berücksichtigt. Zur Beantwortung der Forschungsfrage wird ein qualitatives Forschungsverfahren angewandt. Dazu werden Einzelfallanalysen mittels problemzentrierter Leitfaden-Interviews mit Vätern aus IT-Berufen durchgeführt. Die Auswertung der Interviews erfolgt durch die qualitative Inhaltsanalyse nach Mayring

Editorial

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First case of ivermectin-induced severe hepatitis

Loiasis, caused by the filarial parasite Loa loa, is endemic in West and Central Africa. Ivermectin has been shown to be an effective treatment of loiasis. We report the case of a 20-year-old woman originally from Cameroon who was infected by the L. loa parasite and developed severe hepatitis, identified 1 month after a single dose of ivermectin. Liver biopsy showed intralobular inflammatory infiltrates, confluent necrosis and apoptosis, compatible with drug-induced liver disease. To our knowledge, this is the first case of ivermectin-induced severe liver disease published in the literatur

Record of Albertus C. Van Raalte\u27s Two Years at the Gymnasium

A record of Albertus C. Van Raalte\u27s two years of studies at the Gymnasium in this city.https://digitalcommons.hope.edu/vrp_1820s/1000/thumbnail.jp

An unexpected inhibition of antiviral signaling by virus-encoded tumor suppressor p53 in pancreatic cancer cells

AbstractVirus-encoded tumor suppressor p53 transgene expression has been successfully used in vesicular stomatitis virus (VSV) and other oncolytic viruses (OVs) to enhance their anticancer activities. However, p53 is also known to inhibit virus replication via enhanced type I interferon (IFN) antiviral responses. To examine whether p53 transgenes enhance antiviral signaling in human pancreatic ductal adenocarcinoma (PDAC) cells, we engineered novel VSV recombinants encoding human p53 or the previously described chimeric p53-CC, which contains the coiled-coil (CC) domain from breakpoint cluster region (BCR) protein and evades the dominant-negative activities of endogenously expressed mutant p53. Contrary to an expected enhancement of antiviral signaling by p53, our global analysis of gene expression in PDAC cells showed that both p53 and p53-CC dramatically inhibited type I IFN responses. Our data suggest that this occurs through p53-mediated inhibition of the NF-κB pathway. Importantly, VSV-encoded p53 or p53-CC did not inhibit antiviral signaling in non-malignant human pancreatic ductal cells, which retained their resistance to all tested VSV recombinants. To the best of our knowledge, this is the first report of p53-mediated inhibition of antiviral signaling, and it suggests that OV-encoded p53 can simultaneously produce anticancer activities while assisting, rather than inhibiting, virus replication in cancer cells