2,386 research outputs found
Global communication part 1: the use of apparel CAD technology
Trends needed for improved communication systems, through the development of future computer-aided design technology (CAD) applications, is a theme that has received attention due to its perceived benefits in improving global supply chain efficiencies. This article discusses the developments of both 2D and 3D computer-aided design capabilities, found within global fashion supply chain relationships and environments. Major characteristics identified within the data suggest that CAD/CAM technology appears to be improving; however, evidence also suggest a plateau effect, which is accrediting forced profits towards information technology manufactures, and arguably compromising the industry's competitive advantage. Nevertheless, 2D CAD increases communication speed; whereas 3D human interaction technology is seen to be evolving slowly and questionably with limited success. The article discusses the findings and also presents the issues regarding human interaction; technology education; and individual communication enhancements using technology processes. These are still prevalent topics for the future developments of global strategy and cultural communication amalgamation
Relations between teachers' goal orientations, their instructional practices and student motivation
Relations between teachersâ goal orientations, their instructional practices as expressed in perceived class- room goal structures and studentsâ goal orientations were analyzed, focusing also on potential moderators. Results of a questionnaire study with 46 Mathematics teachers and their 930 students supported the as-sumption that teachersâ goal orientations affect their instructional practices and studentsâ goal orientations. These effects were, in part, moderated by teacher beliefs (implicit theories, self-efficacy beliefs). Overall, the results provided strong support for the notion that the mechanisms underlying these effects are based on the functionality of certain instructional practices for the attainment of teachersâ goals
Deciphering the physiological response of Escherichia coli under high ATP demand
One longâstanding question in microbiology is how microbes buffer perturbations in energy metabolism. In this study, we systematically analyzed the impact of different levels of ATP demand in Escherichia coli under various conditions (aerobic and anaerobic, with and without cell growth). One key finding is that, under all conditions tested, the glucose uptake increases with rising ATP demand, but only to a critical level beyond which it drops markedly, even below wildâtype levels. Focusing on anaerobic growth and using metabolomics and proteomics data in combination with a kinetic model, we show that this biphasic behavior is induced by the dual dependency of the phosphofructokinase on ATP (substrate) and ADP (allosteric activator). This mechanism buffers increased ATP demands by a higher glycolytic flux but, as shown herein, it collapses under very low ATP concentrations. Model analysis also revealed two major rateâcontrolling steps in the glycolysis under high ATP demand, which could be confirmed experimentally. Our results provide new insights on fundamental mechanisms of bacterial energy metabolism and guide the rational engineering of highly productive cell factories
Analytical studies on commercial artistsâ colour charts from Das Deutsche Farbenbuch (1925)âidentification of synthetic and natural organic colourants by Raman microscopy, surface-enhanced Raman spectroscopy and metal underlayer ATR-FTIR spectroscopy
Historical colour charts provide a rich and often well-dated reference materials source for studying the chemical composition of all kinds of commercial brands of artists' paints. This article presents the results of an extensive analytical study of more than 80 paint hues from 11 colour charts that are included in the German standard book Das Deutsche Farbenbuch by H. Trillich (1925, Part II). Our research focused on the identification of synthetic organic pigments, whose quickly increasing significance for artists' paints in the early twentieth century is impossible to evaluate by documentary source research alone. A stepwise procedure combining different non- or minimally invasive vibrational spectroscopy techniques-Normal Raman and Surface-Enhanced Raman spectroscopy as well as Metal Underlayer Attenuated Total Reflection Fourier-transform Infrared Spectroscopy-allowed the identification of 18 different organic colourants in artists' watercolours, tempera and oil colours from six German manufacturers. In addition, micro-X-Ray Fluorescence spectroscopy was applied to determine the elemental pattern of substrates, fillers, and admixed inorganic pigments. In addition to a few traditional natural organic colourants (dark and rose madder lake, cochineal lake), most of the identified compounds comprised synthetic organic pigments or synthetic dyes from various chemical classes (indigo, anthraquinone, monoazo, ss-naphthol, xanthene, triarylcarbonium, nitroso, and azine compounds). Some of these have not or only rarely been reported in artists' paints so far. Since the identified organic colourants have mainly poor to fair (only sometimes good) fastness to light according to modern standards and partially also to solvents typically used in conservation treatments, it is evident that works of art from this period should be treated keeping in mind the possible presence of such colourants, when planning both interventive treatments and preventive measures
Mean-risk models using two risk measures: A multi-objective approach
This paper proposes a model for portfolio optimisation, in which distributions are characterised and compared on the basis of three statistics: the expected value, the variance and the CVaR at a specified confidence level. The problem is multi-objective and transformed into a single objective problem in which variance is minimised while constraints are imposed on the expected value and CVaR. In the case of discrete random variables, the problem is a quadratic program. The mean-variance (mean-CVaR) efficient solutions that are not dominated with respect to CVaR (variance) are particular efficient solutions of the proposed model. In addition, the model has efficient solutions that are discarded by both mean-variance and mean-CVaR models, although they may improve the return distribution. The model is tested on real data drawn from the FTSE 100 index. An analysis of the return distribution of the chosen portfolios is presented
Parasite Dynamics in Untreated Horses Through One Calendar Year
Background: Horses are host to a plethora of parasites. Knowledge of the seasonality of parasite egg shedding and transmission is important for constructing parasite control programs. However, studies describing these patterns are sparse, and have largely been conducted only in the United Kingdom. This study evaluated strongylid egg shedding patterns and transmission dynamics of Strongylus vulgaris in naturally infected and untreated mares and foals through one calendar year in Kentucky, USA. The study also investigated the existence of a peri-parturient rise (PPR) in strongylid egg counts in foaling mares and collected information about Strongyloides westeri and Parascaris spp. in the foals. Methods: This study was conducted from January to December 2018. A herd of 18 mares, one stallion, and 14 foals born in 2018 were followed throughout the year. Sera and feces were collected biweekly from all horses, and worm burdens enumerated in 13 foals at necropsy. An S. vulgaris ELISA antibody test was run on all serum samples. Fecal egg counts were determined for all horses, and coproculture and qPCR assay were employed to test for the presence of S. vulgaris in the mature horses. Data were analyzed using the proc glimmix procedure in the SAS 9.4 software program. Results: We found a general lack of seasonality in strongylid egg shedding throughout the year among the mature horses, and no PPR was demonstrated. Shedding of S. vulgaris eggs displayed a higher abundance during the spring, but fndings were variable and not statistically signifcant. Anti-S. vulgaris antibody concentrations did not display signifcant fuctuations in the mature horses, but evidence of passive transfer of antibodies to the foals was demonstrated, and foals assumed their own production of antibodies starting at approximately 20 weeks of age. Overall, colts shed higher numbers of strongylid, ascarid, and S. westeri eggs than fllies. Conclusions: This study demonstrated a lack of seasonality in strongylid egg shedding for the study population, which is in stark contrast to previous studies conducted elsewhere. This strongly suggests that more studies should be done investigating these patterns under diferent climatic condition
A comparison of nanoparticullate CpG immunotherapy with and without allergens in spontaneously equine asthma-affected horses, an animal model
Introduction: New therapeutic strategies to modulate the immune response of
human and equine allergic asthma are still under extensive investigation.
Immunomodulating agents stimulating T-regulatory cells offer new treatment
options beyond conventional symptomatic treatment or specific immunotherapy
for human and equine allergic airway diseases, with the goal of a homoeostatic
T-helper cell balance. The aim of this study was to evaluate the effects of a
nebulized gelatin nanoparticle-CpG formulation (CpG-GNP) with and without
specific allergens for the treatment of spontaneous allergic equine asthma as
a model for human asthma. Methods: Twenty equine asthma-affected horses were
treated either with CpG-GNP alone or CpG-GNP with allergens. Two specific
allergens were selected for each horse based on history and an in-vitro test.
Each horse received seven administrations of the respective nebulized
composition and was examined before treatment, immediately after and 6 weeks
after the treatment course. Results: Clinical parameters such as breathing
rate, indirect interpleural measurement, arterial blood gases, amount of
tracheal mucus and percentage of neutrophils and cytokines in tracheal washes
and serum samples were evaluated. Treatment with CpG-GNP alone as well as in
combinations with relevant allergens resulted in clinical improvement of nasal
discharge, breathing rate, amount of secretion and viscosity, neutrophil
percentage and partial oxygen pressure directly after and 6 weeks after
treatment. There were no significant differences between the two treatments in
clinical parameters or local cytokine profiles in the tracheal wash fluid
(IL-10, IFN-g, and IL-17). IL-4 concentrations decreased significantly in both
groups. Conclusion: Nonspecific CpG-GNP-based immunotherapy shows potential as
a treatment for equine and possibly also human allergic asthma
Comparative investigations on digestion in grazing (Ceratotherium simum) and browsing (Diceros bicornis) rhinoceroses
Rhinoceroses represent the largest extant herbivores with extensive dietary specialization for plant groups like browse (black rhino Diceros bicornis) or grass (white rhino Ceratotherium simum). However, it is not clear to what extent such diet selection patterns are reflected in adaptations of digestive physiology of the respective feeding types. In this study, feeding trials with four black and five white rhinos were conducted in four zoos. The animals had ad libitum access to the same batch of grass hay (second cut; neutral detergent fiber (NDF) 63% dry matter (DM), crude protein 10.2% DM). Total intake, fecal N content, in vitro digestibility of NDF residues of feces, fecal particle size and mean retention time (MRT) of particles (Cr-mordanted fiber; 1â2 mm) and fluid (Co-EDTA) were quantified. The average daily DM intake was 70±12 g/kg BW0.75 for white and 73±10 g/kg BW0.75 for black rhinos. In the in vitro fermentation test fecal NDF residues of black rhinos resulted in higher gas productions at fermentation times of 12 to 24 h, indicating that white rhinos have a superior capacity to digest NDF. Average MRT for fluids and particles was 28±4 h and 43±5 h in white and 34±4 h and 39±4 h in black rhinos. The selectivity factor (SF=MRTparticle /MRTfluid) was higher for white (1.5±0.2) than for black rhinos (1.2±0.1) (p=0.016). In a comparison of 12 ruminant and 3 rhino species, SF was correlated to percentage of grass in diet (R=0.75). Mean fecal particle size was higher in white (9.1±1.94 mm) than in black rhinos (6.1±0.79 mm) (p=0.016). The results demonstrate differences between white and black rhinos in terms of retention times and fiber digestibility. The more selective retention of particles by the white rhino corresponds with the higher digestion of fiber measured indirectly. Furthermore there is indication for a general pattern of high SF in grazing ruminants and rhinos. The difference in fecal particle size between both rhino species might be due to the considerable difference in body weight
Parasite Dynamics in Untreated Horses through One Calendar Year
BACKGROUND: Horses are host to a plethora of parasites. Knowledge of the seasonality of parasite egg shedding and transmission is important for constructing parasite control programs. However, studies describing these patterns are sparse, and have largely been conducted only in the United Kingdom. This study evaluated strongylid egg shedding patterns and transmission dynamics of Strongylus vulgaris in naturally infected and untreated mares and foals through one calendar year in Kentucky, USA. The study also investigated the existence of a peri-parturient rise (PPR) in strongylid egg counts in foaling mares and collected information about Strongyloides westeri and Parascaris spp. in the foals.
METHODS: This study was conducted from January to December 2018. A herd of 18 mares, one stallion, and 14 foals born in 2018 were followed throughout the year. Sera and feces were collected biweekly from all horses, and worm burdens enumerated in 13 foals at necropsy. An S. vulgaris ELISA antibody test was run on all serum samples. Fecal egg counts were determined for all horses, and coproculture and qPCR assay were employed to test for the presence of S. vulgaris in the mature horses. Data were analyzed using the proc glimmix procedure in the SAS 9.4 software program.
RESULTS: We found a general lack of seasonality in strongylid egg shedding throughout the year among the mature horses, and no PPR was demonstrated. Shedding of S. vulgaris eggs displayed a higher abundance during the spring, but findings were variable and not statistically significant. Anti-S. vulgaris antibody concentrations did not display significant fluctuations in the mature horses, but evidence of passive transfer of antibodies to the foals was demonstrated, and foals assumed their own production of antibodies starting at approximately 20 weeks of age. Overall, colts shed higher numbers of strongylid, ascarid, and S. westeri eggs than fillies.
CONCLUSIONS: This study demonstrated a lack of seasonality in strongylid egg shedding for the study population, which is in stark contrast to previous studies conducted elsewhere. This strongly suggests that more studies should be done investigating these patterns under different climatic conditions
Statistics of Partial Minima
Motivated by multi-objective optimization, we study extrema of a set of N
points independently distributed inside the d-dimensional hypercube. A point in
this set is k-dominated by another point when at least k of its coordinates are
larger, and is a k-minimum if it is not k-dominated by any other point. We
obtain statistical properties of these partial minima using exact probabilistic
methods and heuristic scaling techniques. The average number of partial minima,
A, decays algebraically with the total number of points, A ~ N^{-(d-k)/k}, when
1<=k<d. Interestingly, there are k-1 distinct scaling laws characterizing the
largest coordinates as the distribution P(y_j) of the jth largest coordinate,
y_j, decays algebraically, P(y_j) ~ (y_j)^{-alpha_j-1}, with
alpha_j=j(d-k)/(k-j) for 1<=j<=k-1. The average number of partial minima grows
logarithmically, A ~ [1/(d-1)!](ln N)^{d-1}, when k=d. The full distribution of
the number of minima is obtained in closed form in two-dimensions.Comment: 6 pages, 1 figur
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