A possible experimental determination of ms/m^m_s/{\hat m} from Kμ4K_{\mu 4} decays

$K\pi$ scattering and $K_{\mu 4}$ decays are studied at leading order of improved chiral perturbation theory. It is shown that high precision $K_{\mu 4}$ experiments at, e.g., DA$\Phi$NE should allow for a direct measurement of the quark mass ratio $m_s$/${\hat m}$.Comment: 9 pages, preprint IPNO-TH 93-17, 2 figures not included, available upon request, plain Latex, April 199

Integration of leadership training into a problem/case-based learning program for first- and second-year medical students.

Purpose: The evolution of health care systems in response to societal and financial pressures has changed care delivery models, which presents new challenges for physicians. Leadership training is increasingly being recognized as an essential component of medical education training to prepare physicians to meet these needs. Unfortunately, most medical schools do not include leadership training. It has been suggested that a longitudinal and integrated approach to leadership training should be sought. We hypothesized that integration of leadership training into our hybrid problem-based learning (PBL)/case-based learning (CBL) program, Patient-Centered Explorations in Active Reasoning, Learning and Synthesis (PEARLS), would be an effective way for medical students to develop leadership skills without the addition of curricular time. Methods: We designed a unique leadership program in PEARLS in which 98 medical students participated during each of their six courses throughout the first 2 years of school. A program director and trained faculty facilitators educated students and coached them on leadership development throughout this time. Students were assessed by their facilitator at the end of every course on development of leadership skills related to teamwork, meaningful self-assessment, process improvement, and thinking outside the box. Results: Students consistently improved their performance from the first to the final course in all four leadership parameters evaluated. The skills that demonstrated the greatest change were those pertaining to thinking outside the box and process improvement. Conclusion: Incorporation of a longitudinal and integrated approach to leadership training into an existing PBL/CBL program is an effective way for medical students to improve their leadership skills without the addition of curricular time. These results offer a new, time-efficient option for leadership development in schools with existing PBL/CBL programs

Light quarks masses and condensates in QCD

We review some theoretical and phenomenological aspects of the scenario in which the spontaneous breaking of chiral symmetry is not triggered by a formation of a large condensate . Emphasis is put on the resulting pattern of light quark masses, on the constraints arising from QCD sum rules and on forthcoming experimental tests.Comment: 23 pages, 12 Postscript figures, LaTeX, uses svcon2e.sty, to be published in the Proceedings of the Workshop on Chiral Dynamics 1997, Mainz, Germany, Sept. 1-5, 199

The Low Energy π π\pi\,\pi Amplitude to One and Two Loops

The low-energy $\pi\pi$ amplitude is computed explicitly to two-loop accuracy in the chiral expansion. It depends only on six independent (combinations of) low-energy constants which are not fixed by chiral symmetry. Four of these constants are determined {\it via} sum rules which are evaluated using $\pi\pi$ scattering data at higher energies. Dependence of the low-energy phase shifts and of the threshold parameters on the remaining two constants (called $\alpha$ and $\beta$) are discussed and compared to the existing data from $K_{l4}$ experiments. Using generalised $\chi$PT, the constants $\alpha$ and $\beta$ are related to fundamental QCD parameters such as the quark condensate $\langle 0|\bar{q}q|0\rangle$ and the quark mass ratio $m_s/\widehat{m}$. It is shown that forthcoming accurate low-energy $\pi\pi$ data can be used to provide, for the first time, experimental evidence in favour of or against the existence of a large quark-antiquark condensate in the QCD vacuum.Comment: 61 pages, LaTeX, 10 figures in separate tarred, compressed and uuencoded Postscript fil

Amelioration of Proteolipid Protein 139–151-Induced Encephalomyelitis in SJL Mice by Modified Amino Acid Copolymers and Their Mechanisms

Copolymer 1 [Cop1, glatiramer acetate, Copaxone, poly(Y,E,A,K)n] is widely used in the treatment of relapsing/remitting multiple sclerosis in which it reduces the frequency of relapses by ≈30%. In the present study, copolymers with modified amino acid compositions (based on the binding motif of myelin basic protein 85–99 to HLA-DR2) have been developed with the aim of suppressing multiple sclerosis more effectively. The enhanced efficacy of these copolymers in experimental autoimmune encephalomyelitis (EAE) induced in SJL/J mice with proteolipid protein 139–151 was demonstrated by using three protocols: (i) simultaneous administration of autoantigen and copolymer (termed prevention), (ii) pretreatment with copolymers (vaccination), or (iii) administration of copolymers after disease onset (treatment). Strikingly, in the treatment protocol administration of soluble VWAK and FYAK after onset of disease led to stasis of its progression and suppression of histopathological evidence of EAE. The mechanisms by which these effects are achieved have been examined in several types of assays: binding of copolymers to I-As in competition with proteolipid protein 139–151 (blocking), cytokine production by T cells (T helper 2 polarization), and transfer of protection by CD3+ splenocytes or, notably, by copolymer-specific T cell lines (induction of regulatory T cells). The generation of these copolymerspecific regulatory T cells that secrete IL-4 and IL-10 and are independent of the immunizing autoantigen is very prominent among the multiple mechanisms that account for the observed suppressive effect of copolymers in EAE

Conductivity in quasi two-dimensional systems

The conductivity in quasi two-dimensional systems is calculated using the quantum kinetic equation. Linearizing the Lenard-Balescu collision integral with the extension to include external field dependences allows one to calculate the conductivity with diagrams beyond the GW approximation including maximally crossed lines. Consequently the weak localization correction as an interference effect appears here from the field dependence of the collision integral (the latter dependence sometimes called intra-collisional field effect). It is shown that this weak localization correction has the same origin as the Debye-Onsager relaxation effect in plasma physics. The approximation is applied to a system of quasi two-dimensional electrons in hetero-junctions which interact with charged and neutral impurities and the low temperature correction to the conductivity is calculated analytically. It turns out that the dynamical screening due to charged impurities leads to a linear temperature dependence, while the scattering from neutral impurities leads to the usual Fermi-liquid behavior. By considering an appropriate mass action law to determine the ratio of charged to neutral impurities we can describe the experimental metal-insulator transition at low temperatures as a Mott-Hubbard transition.Comment: 7 pages 7 pages appendix 11 figure

The staggered domain wall fermion method

A different lattice fermion method is introduced. Staggered domain wall fermions are defined in 2n+1 dimensions and describe 2^n flavors of light lattice fermions with exact U(1) x U(1) chiral symmetry in 2n dimensions. As the size of the extra dimension becomes large, 2^n chiral flavors with the same chiral charge are expected to be localized on each boundary and the full SU(2^n) x SU(2^n) flavor chiral symmetry is expected to be recovered. SDWF give a different perspective into the inherent flavor mixing of lattice fermions and by design present an advantage for numerical simulations of lattice QCD thermodynamics. The chiral and topological index properties of the SDWF Dirac operator are investigated. And, there is a surprise ending...Comment: revtex4, 7 figures, minor revisions, 2 references adde

High levels of anti-tuberculin (IgG) antibodies correlate with the blocking of T-cell proliferation in individuals with high exposure to Mycobacterium tuberculosis

SummaryObjectivesTo determine the effect of anti-tuberculin antibodies in the T-cell proliferation in response to tuberculin and Candida antigens in individuals with different levels of tuberculosis (TB) risk.MethodsSixteen high-risk TB individuals, 30 with an intermediate TB risk (group A), and 45 with a low TB risk (group B), as well as 49 control individuals, were studied. Tuberculin skin test (TST) results were analyzed and serum levels of antibodies (IgG and IgM) against purified protein derivative (PPD) were measured by ELISA. Tuberculin and Candida antigens were used to stimulate T-cell proliferation in the presence of human AB serum or autologous serum.ResultsHigh levels of anti-tuberculin IgG antibodies were found to be significantly associated with the blocking of T-cell proliferation responses in cultures stimulated with tuberculin but not with Candida antigens in the presence of autologous serum. This phenomenon was particularly frequent in high-risk individuals with high levels of anti-tuberculin IgG antibodies in the autologous serum when compared to the other risk groups, which exhibited lower levels of anti-tuberculin antibodies.ConclusionsAlthough cellular immunity plays a central role in the protection against TB, humoral immunity is critical in the control of Mycobacterium tuberculosis infection in high-risk individuals with latent TB infection

Developmental Bias in Cleavage-Stage Mouse Blastomeres

The cleavage stage mouse embryo is composed of superficially equivalent blastomeres that will generate both the embryonic inner cell mass (ICM) and the supportive trophectoderm (TE). However, it remains unsettled whether the contribution of each blastomere to these two lineages can be accounted for by chance. Addressing the question of blastomere cell fate may be of practical importance, as preimplantation genetic diagnosis (PGD) requires removal of blastomeres from the early human embryo. To determine if blastomere allocation to the two earliest lineages is random, we developed and utilized a recombination-mediated, non-invasive combinatorial fluorescent labeling method for embryonic lineage tracing