Giant and reversible inverse barocaloric effects near room temperature in ferromagnetic MnCoGeB0.03

Hydrostatic pressure represents an inexpensive and practical method of driving caloric effects in brittle magnetocaloric materials, which display first-order magnetostructural phase transitions whose large latent heats are traditionally accessed using applied magnetic fields. Here, moderate changes of hydrostatic pressure are used to drive giant and reversible inverse barocaloric effects near room temperature in the notoriously brittle magnetocaloric material MnCoGeB0.03. The barocaloric effects compare favorably with those observed in barocaloric materials that are magnetic. The inevitable fragmentation provides a large surface for heat exchange with pressure-transmitting media, permitting good access to barocaloric effects in cooling devices.Peer ReviewedPostprint (author's final draft

X-ray Observations of a [C II]-bright, z=6.59 Quasar/Companion System

We present deep Chandra observations of PSO J231.6576$-$20.8335, a quasar at redshift z=6.59 with a nearby (${\sim}8$ proper kpc) companion galaxy. ALMA observed both the quasar and companion to be bright in [C II], and the system has significant extended Ly$\alpha$ emission around the quasar, suggesting that a galaxy merger is ongoing. Unlike previous studies of two similar systems, and despite observing the system with Chandra for 140 ks, we do not detect the companion in X-rays. The quasar itself is detected, but only $13.3^{+4.8}_{-3.7}$ net counts are observed. From a basic spectral analysis, the X-ray spectrum of the quasar is soft (hardness ratio of $\mathcal{HR} = -0.60_{-0.27}^{+0.17}$, power-law index of $\Gamma=2.6^{+1.0}_{-0.9}$), which results in a rest-frame X-ray luminosity comparable to other bright quasars ($L_{2-10} = 1.09^{+2.20}_{-0.70}\times 10^{45}\ \textrm{erg}\ \textrm{s}^{-1}$) despite the faint observed X-ray flux. We highlight two possible interpretations of this result: the quasar has a steep value of$\Gamma$-- potentially related to observed ongoing Eddington accretion -- thereby pushing much of the emission out of our observed band, or the quasar has a more normal spectrum ($\Gamma{\sim}2$) but is therefore less X-ray luminous ($L_{2-10} \sim 0.6 \times 10^{45}\ \textrm{ erg}\ \textrm{ s}^{-1}$).Comment: 11 pages, 4 figures. Accepted for publication in Ap

Persistence of functional memory B cells recognizing SARS-CoV-2 variants despite loss of specific IgG

Although some COVID-19 patients maintain SARS-CoV-2-specific serum immunoglobulin G (IgG) for more than 6 months postinfection, others eventually lose IgG levels. We assessed the persistence of SARS-CoV-2-specific B cells in 17 patients, 5 of whom had lost specific IgGs after 5–8 months. Differentiation of blood-derived B cells in vitro revealed persistent SARS-CoV-2-specific IgG B cells in all patients, whereas IgA B cells were maintained in 11. Antibodies derived from cultured B cells blocked binding of viral receptor-binding domain (RBD) to the cellular receptor ACE-2, had neutralizing activity to authentic virus, and recognized the RBD of the variant of concern Alpha similarly to the wild type, whereas reactivity to Beta and Gamma were decreased. Thus, differentiation of memory B cells could be more sensitive for detecting previous infection than measuring serum antibodies. Understanding the persistence of SARS-CoV-2-specific B cells even in the absence of specific serum IgG will help to promote long-term immunity

The Role of Policy Makers and Institutions in the Energy Sector: The Case of Energy Infrastructure Governance in Nigeria

This paper focuses on investigating the linkages and consequences of the policy decision process in the governance of energy infrastructure in Nigeria. It attempts to gain a better understanding of the role of policy makers and institutions in the provision of energy infrastructure in Nigeria. Using a combination of semi-structured interviews and documentary evidences from published literature, this study reveals three essential areas where the policy-making processes (and therefore policy makers) intervene in the provision of energy infrastructure. These are: (1) granting access to historical data; (2) regulations; and (3) permitting/issuance of licenses. This study also reveals three major unintended consequences of the policy decision processes and institutions in the governance of energy infrastructure provisions in Nigeria, which are: (1) government financing corruption in the energy sector; (2) economic delusion; and (3) uncontrolled growth in energy demand driven more by export and not local internal demand

In-depth profiling of COVID-19 risk factors and preventive measures in healthcare workers

PURPOSE To determine risk factors for coronavirus disease 2019 (COVID-19) in healthcare workers (HCWs), characterize symptoms, and evaluate preventive measures against SARS-CoV-2 spread in hospitals. METHODS In a cross-sectional study conducted between May 27 and August 12, 2020, after the first wave of the COVID-19 pandemic, we obtained serological, epidemiological, occupational as well as COVID-19-related data at a~quaternary care, multicenter hospital~in Munich, Germany. RESULTS 7554 HCWs participated, 2.2% of whom tested positive for anti-SARS-CoV-2 antibodies. Multivariate analysis revealed increased COVID-19 risk for nurses (3.1% seropositivity, 95% CI 2.5-3.9%, p = 0.012), staff working on COVID-19 units (4.6% seropositivity, 95% CI 3.2-6.5%, p = 0.032), males (2.4% seropositivity, 95% CI 1.8-3.2%, p = 0.019), and HCWs reporting high-risk exposures to infected patients (5.5% seropositivity, 95% CI 4.0-7.5%, p = 0.0022) or outside of work (12.0% seropositivity, 95% CI 8.0-17.4%, p < 0.0001). Smoking was a protective factor (1.1% seropositivity, 95% CI 0.7-1.8% p = 0.00018) and the symptom taste disorder was strongly associated with COVID-19 (29.8% seropositivity, 95% CI 24.3-35.8%, p < 0.0001). An unbiased decision tree identified subgroups with different risk profiles. Working from home as a preventive measure did not protect against SARS-CoV-2 infection. A PCR-testing strategy focused on symptoms and high-risk exposures detected all larger COVID-19 outbreaks. CONCLUSION Awareness of the identified COVID-19 risk factors and successful surveillance strategies are key to protecting HCWs against SARS-CoV-2, especially in settings with limited vaccination capacities or reduced vaccine efficacy

Adrenal tropism of SARS-CoV-2 and adrenal findings in a post-mortem case series of patients with severe fatal COVID-19

Progressive respiratory failure and hyperinflammatory response is the primary cause of death in the coronavirus disease 2019 (COVID-19) pandemic. Despite mounting evidence of disruption of the hypothalamus-pituitary-adrenal axis in COVID-19, relatively little is known about the tropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to adrenal glands and associated changes. Here we demonstrate adrenal viral tropism and replication in COVID-19 patients. Adrenal glands showed inflammation accompanied by inflammatory cell death. Histopathologic analysis revealed widespread microthrombosis and severe adrenal injury. In addition, activation of the glycerophospholipid metabolism and reduction of cortisone intensities were characteristic for COVID-19 specimens. In conclusion, our autopsy series suggests that SARS-CoV-2 facilitates the induction of adrenalitis. Given the central role of adrenal glands in immunoregulation and taking into account the significant adrenal injury observed, monitoring of developing adrenal insufficiency might be essential in acute SARS-CoV-2 infection and during recovery.</p