Extragenic Suppression analysis of TS mutations using Sec61p

During synthesis, secretory and membrane proteins are cotranslationally translocated into the lumen of the endoplasmic reticulum through an aqueous gated channel. Proper folding, degradation, and transport of many polypeptides depend on a diverse set of helper proteins termed chaperone. I hypothesize that
Sec 61p is a membrane chaperone, which actively directs membrane protein folding.
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The Fusion of Fashion and Rap Music

This project reviewed the relevant literature on the link between Hip-Hip and fashion, determined the frequency of brands being mentioned in the discographies of the artists chosen, and explained why it is important to know which brands are being mentioned by the artists chosen. The media we consume all means something, and this project determined what the Hip-hop music medium tells us about the fashion industry, and what brands artists choose to wear and endorse

My Girl From Tennessee

https://digitalcommons.library.umaine.edu/mmb-vp/4983/thumbnail.jp

Atomic data for neutron-capture elements I. Photoionization and recombination properties of low-charge selenium ions

We present multi-configuration Breit-Pauli AUTOSTRUCTURE calculations of distorted-wave photoionization (PI) cross sections, and total and partial final-state resolved radiative recombination (RR) and dielectronic recombination (DR) rate coefficients for the first six ions of the trans-iron element Se. These calculations were motivated by the recent detection of Se emission lines in a large number of planetary nebulae. Se is a potentially useful tracer of neutron-capture nucleosynthesis, but accurate determinations of its abundance in photoionized nebulae have been hindered by the lack of atomic data governing its ionization balance. Our calculations were carried out in intermediate coupling with semi-relativistic radial wavefunctions. PI and recombination data were determined for levels within the ground configuration of each ion, and experimental PI cross-section measurements were used to benchmark our results. For DR, we allowed dn=0 core excitations, which are important at photoionized plasma temperatures. DR is the dominant recombination process for each of these Se ions at temperatures representative of photoionized nebulae (~10^4 K). To estimate the uncertainties of these data, we compared results from three different configuration-interaction expansions for each ion, and tested the sensitivity of the results to the radial scaling factors in the structure calculations. We find that the internal uncertainties are typically 30-50% for the direct PI cross sections and ~10% for the computed RR rate coefficients, while those for low-temperature DR can be considerably larger (from 15-30% up to two orders of magnitude) due to the unknown energies of near-threshold autoionization resonances. The results are suitable for incorporation into photoionization codes used to numerically simulate astrophysical nebulae, and will enable robust determinations of nebular Se abundances.Comment: 17 pages, 8 figures, accepted for publication in Astronomy and Astrophysic

Timing of Quantal Release from the Retinal Bipolar Terminal Is Regulated by a Feedback Circuit

AbstractIn isolation, a presynaptic terminal generally releases quanta according to Poisson statistics, but in a circuit its release statistics might be shaped by synaptic interactions. We monitored quantal glutamate release from retinal bipolar cell terminals (which receive GABA-ergic feedback from amacrine cells) by recording spontaneous EPSCs (sEPSCs) in their postsynaptic amacrine and ganglion cells. In about one-third of these cells, sEPSCs were temporally correlated, arriving in brief bursts (10–55 ms) more often than expected from a Poisson process. Correlations were suppressed by antagonizing the GABAC receptor (expressed on bipolar terminals), and correlations were induced by raising extracellular calcium or osmolarity. Simulations of the feedback circuit produced “bursty” release when the bipolar cell escaped intermittently from inhibition. Correlations of similar duration were present in the light-evoked sEPSCs and spike trains of sluggish-type ganglion cells. These correlations were suppressed by antagonizing GABAC receptors, indicating that glutamate bursts from bipolar terminals induce spike bursts in ganglion cells