Ford, A Village in the West Highlands of Scotland: A Case Study of Repopulation and Social Change in a Small Community

The Highlands of Scotland, like the southern Appalachians of the United States, have long been a problem area in Great Britain, troubled with a fading economy and loss of population. Most books about the region, however, are popular volumes that romanticize a bygone way of life. This study of Ford, a village of some 160 people in western Argyllshire, thus fills a gap in the literature and provides a look at the present realities of Scottish life. Although the Highlands are by no means a homogeneous region, Ford in its size and makeup is perhaps a representative rural settlement. John Stephenson, who conducted extensive interviews in the village during 1981, focuses his study on the theme of survival, on whether this particular village shows signs of enduring as a community of people bound together by common interests and situations. Though necessarily tentative, his conclusions are optimistic. Ford has shown a recent increase in population, consisting almost entirely of newcomers, and though its residents have now a more varied background, they seem to have a sense of place, of belonging to the village. This book will provide new insights not only for those interested in life in the Highlands but also for all those interested in small communities in other parts of the world. John B. Stephenson is professor of sociology and director of the Appalachian Center at the University of Kentucky. Captures the essence of social life in small communities operating on the margins of economic and social survival. —Contemporary Sociology This convincing portrait of the concerns of a group of contemporary Scots raises and even answers questions relevant in many other rural areas. —Choicehttps://uknowledge.uky.edu/upk_european_history/1029/thumbnail.jp

Appalachia in the Sixties: Decade of Reawakening

In The Southern Appalachian Region: A Survey, published by the University Press of Kentucky in 1962, Rupert Vance suggested a decennial review of the region\u27s progress. No systematic study comparable to that made at the beginning of the decade is available to answer the question of how far Appalachia has come since then, but David S. Walls and John B. Stephenson have assembled a broad range of firsthand reports which together convey the story of Appalachia in the sixties. These observations of journalists, field workers, local residents, and social scientists have been gathered from a variety of sources ranging from national magazines to county weeklies. Focusing mainly on the coalfields of West Virginia, eastern Kentucky, southwestern Virginia, and north-central Tennessee, the editors first present selections that reflect the rediscovery” of the region as a problem area in the early sixties and describe the federal programs designed to rehabilitate it and their results. Other sections focus on the politics of the coal industry, the extent and impact of the continued migration from the region, and the persistence of human suffering and environmental devastation. A final section moves into the 1970s with proposals for the future. Although they conclude that there is little ground for claiming success in solving the region\u27s problems, the editors find signs of hope in the scattered movements toward grass-roots organization described by some of the contributors, and in the new tendency to define solutions in terms of reconstruction rather than amelioration. David S. Walls, professor emeritus of sociology at Sonoma State University, served on the staff of the Appalachian Volunteers, doing community-organizing work in central Appalachia. He is the author of The Activist\u27s Almanac: The Concerned Citizen\u27s Guide to the Leading Advocacy Organizations in America. John B. Stephenson, a native of the Appalachian mountains, was the first director of the Appalachian Center at the University of Kentucky and served as the president of Berea College from 1984 to 1994. He was the author of numerous books including Shiloh: A Mountain Community.https://uknowledge.uky.edu/upk_appalachian_studies/1005/thumbnail.jp

Activated lymphocyte recruitment into the tumor microenvironment following preoperative sipuleucel-T for localized prostate cancer.

BackgroundSipuleucel-T is a US Food and Drug Administration-approved immunotherapy for asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). Its mechanism of action is not fully understood. This prospective trial evaluated the direct immune effects of systemically administered sipuleucel-T on prostatic cancer tissue in the preoperative setting.MethodsPatients with untreated localized prostate cancer were treated on an open-label Phase II study of sipuleucel-T prior to planned radical prostatectomy (RP). Immune infiltrates in RP specimens (posttreatment) and in paired pretreatment biopsies were evaluated by immunohistochemistry (IHC). Correlations between circulating immune response and IHC were assessed using Spearman rank order.ResultsOf the 42 enrolled patients, 37 were evaluable. Adverse events were primarily transient, mild-to-moderate and infusion related. Patients developed T cell proliferation and interferon-γ responses detectable in the blood following treatment. Furthermore, a greater-than-three-fold increase in infiltrating CD3(+), CD4(+) FOXP3(-), and CD8(+) T cells was observed in the RP tissues compared with the pretreatment biopsy (binomial proportions: all P < .001). This level of T cell infiltration was observed at the tumor interface, and was not seen in a control group consisting of 12 concurrent patients who did not receive any neoadjuvant treatment prior to RP. The majority of infiltrating T cells were PD-1(+) and Ki-67(+), consistent with activated T cells. Importantly, the magnitude of the circulating immune response did not directly correlate with T cell infiltration within the prostate based upon Spearman's rank order correlation.ConclusionsThis study is the first to demonstrate a local immune effect from the administration of sipuleucel-T. Neoadjuvant sipuleucel-T elicits both a systemic antigen-specific T cell response and the recruitment of activated effector T cells into the prostate tumor microenvironment

Evidence for reactive synaptogenesis in the ventrolateral thalamus and red nucleus of the rat: changes in high affinity glutamate uptake and numbers of corticofugal fiber terminals

High affinity glutamate uptake into corticofugal fiber terminals was measured in the ventrolateral thalamus and red nucleus at varying time intervals after lesions were made by kainic acid in the contralateral interpositus nucleus of the cerebellum in rats. Under similar conditions the density of cortical fiber terminals was estimated using the Fink-Heimer impregnation technique. 1. Glutamate uptake steadily increased in the ventrolateral thalamus up to 60 days after lesions in the contralateral cerebellum. 2. Similar changes were noted in the red nucleus. 3. The changes were dependent on the integrity of corticofugal fibers to the thalamus and red nucleus. 4. No changes in uptake of gammaaminobutyric acid were noted. 5. Saturation curves for glutamate uptake suggested a change in the maximal number of transport sites. 6. Fink-Heimer degeneration studies showed an increase in cortical terminals in the ipsilateral ventrolateral thalamus and in both rostral and caudal regions of the red nucleus following lesions in the contralateral interpositus nucleus. The data are consistent with an increase in the number of cortical fiber terminals in reaction to loss of cerebellar input to the ventrolateral thalamus and red nucleus. This study correlates anatomical and biochemical evidence for collateral sprouting in a model based on electrophysiologic data in the red nucleus and extends the model to include the thalamus.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46558/1/221_2004_Article_BF00247028.pd

Indication, from Pioneer 10/11, Galileo, and Ulysses Data, of an Apparent Anomalous, Weak, Long-Range Acceleration

Radio metric data from the Pioneer 10/11, Galileo, and Ulysses spacecraft indicate an apparent anomalous, constant, acceleration acting on the spacecraft with a magnitude $\sim 8.5\times 10^{-8}$ cm/s$^2$, directed towards the Sun. Two independent codes and physical strategies have been used to analyze the data. A number of potential causes have been ruled out. We discuss future kinematic tests and possible origins of the signal.Comment: Revtex, 4 pages and 1 figure. Minor changes for publicatio

An Australian longitudinal pilot study examining health determinants of cardiac outcomes 12 months post percutaneous coronary intervention

Background Percutaneous coronary intervention (PCI) is a very common revascularisation procedure for coronary artery disease (CAD). The purpose of this study was to evaluate cardiac outcomes, health related quality of life (HRQoL), resilience and adherence behaviours in patients who have undergone a PCI at two time points (6 and 12 months) following their procedure. Methods A longitudinal pilot study was conducted to observe the cardiac outcomes across a cohort of patients who had undergone a percutaneous coronary intervention (PCI). Participants who had undergone PCI 6 months prior were invited. Those participants who met the inclusion criteria and provided consent then completed a telephone survey (time point 1). These participants were then contacted 6 months later (i.e. 12 months post-intervention, time point 2) and the measures were repeated. Results All patients (n = 51) were recorded as being alive at time point 1. The multiple model indicated that controlling for other factors, gender was significantly associated with a linear combination of outcome measures (p = 0.004). The effect was moderate in magnitude (partial-η2 = 0.303), where males performed significantly better than females 6 months after the PCI procedure physically and with mood. Follow-up univariate ANOVAs indicated that gender differences were grounded in the scale measuring depression (PHQ9) (p = 0.005) and the physical component score of the short form measuring HRQoL (SF12-PCS) (p = 0.003). Thirteen patients were lost to follow-up between time points 1 and 2. One patient was confirmed to have passed away. The pattern of correlations between outcome measures at time point 2 revealed statistically significant negative correlation between the PHQ instrument and the resilience scale (CD-RISC) (r = -0.611; p < 0.001); and the physical component score of the SF-12 instrument (r = -0.437; p = 0.054). Conclusions Men were performing better than women in the 6 months post-PCI, particularly in the areas of mood (depression) and physical health. This pilot results indicate gender-sensitive practices are recommended particularly up to 6 months post-PCI. Any gender differences observed at 6 month appear to disappear at 12 months post-PCI. Further research into the management of mood particularly for women post-PCI is warranted. A more detailed inquiry related to access/attendance to secondary prevention is also warranted

Influence of dietary fat source and feeding duration on finishing pig growth performance, carcass composition, and fat quality

Citation: Stephenson, E. W., Vaughn, M. A., Burnett, D. D., Paulk, C. B., Tokach, M. D., Dritz, S. S., . . . Gonzalez, J. M. (2016). Influence of dietary fat source and feeding duration on finishing pig growth performance, carcass composition, and fat quality. Journal of Animal Science, 94(7), 2851-2866. doi:10.2527/jas2015-9521A total of 160 finishing pigs (PIC 327 × 1050; initially 45.6 kg) were used in an 84-d experiment to evaluate the effects of dietary fat source and feeding duration on growth performance, carcass characteristics, and carcass fat quality. There were 2 pigs per pen with 8 pens per treatment. The 10 dietary treatments were a corn–soybean meal control diet with no added fat and a 3 × 3 factorial with main effects of fat source (4% tallow, 4% soybean oil, or a blend of 2% tallow and 2% soybean oil) and feeding duration (d 0 to 42, 42 to 84, or 0 to 84). The control corn– soybean meal diet was fed in place of added fat diets when needed for duration treatment purposes. On d 0, 1 pig was identified in each pen and fat biopsy samples of the back, belly, and jowl were collected on d 0, 41, and 81 for fatty acid analysis. At the conclusion of the study, all pigs were harvested, carcass characteristics were determined, and back, belly, and jowl fat samples were collected for analysis. Overall (d 0 to 84), there were no differences among pigs fed the different fat sources for growth and carcass characteristics; however, pigs fed diets with added fat for the entire study had improved (P = 0.036) G:F compared with pigs fed the control diet without added fat. Pigs fed supplemental fat throughout the entire study also had improved (P < 0.05) ADG and G:F as well as heavier d-84 BW (P = 0.006) compared with pigs fed additional fat during only 1 period. Adding fat for the entire study increased (P = 0.032) backfat and tended to reduce (P = 0.079) the fat free lean index compared with pigs fed the control diet without added fat. Added fat also increased (P < 0.05) the iodine value (IV) when compared with pigs fed the control diet. Increasing the feeding duration of soybean oil lowered MUFA and increased PUFA concentrations for all fat depots, whereas these values remained relatively unchanged by the addition of tallow (duration × fat source interactions, P < 0.05). Our study failed to show any feeding period × fat source interactions (P < 0.05) in fatty acid composition or IV for jowl fat, whereas this interaction occurred for belly fat and backfat, which would indicate a longer turnover rate for jowl fat. In conclusion, feeding additional fat improved ADG and G:F; however, feeding soybean oil for an increased duration, either alone or in combination with tallow, negatively affected the fatty acid composition and IV of different fat depots. © 2016 American Society of Animal Science. All rights reserved

Metal Abundances and Kinematics of Bright Metal-Poor Giants Selected from the LSE Survey: Implications for the Metal-Weak Thick Disk

We report medium-resolution (1-2 A) spectroscopy and broadband (UBV) photometry for a sample of 39 bright stars (the majority of which are likely to be giants) selected as metal-deficient candidates from an objective-prism survey concentrating on Galactic latitudes below |b| = 30 deg, the LSE survey of Drilling & Bergeron. Although the primary purpose of the LSE survey was to select OB stars (hence the concentration on low latitudes), the small number of bright metal-deficient giant candidates noted during this survey provide interesting information on the metal-weak thick disk (MWTD) population. The kinematics of the LSE giants indicate the presence of a rapidly rotating population, even at quite low metallicity. We consider the distribution of orbital eccentricity of the LSE giants as a function of [Fe/H], and conclude that the local fraction (i.e., within 1 kpc from the Sun) of metal-poor stars that might be associated with the MWTD is on the order of 30%-40% at abundances below [Fe/H] = -1.0. Contrary to recent analyses of previous (much larger) samples of non-kinematically selected metal-poor stars, we find that this relatively high fraction of local metal-poor stars associated with the MWTD may extend to metallicities below [Fe/H] = -1.6, much lower than had been considered before. We identify a subsample of 11 LSE stars that are very likely to be members of the MWTD, based on their derived kinematics; the lowest metallicity among these stars is [Fe/H] = -2.35. Implications of these results for the origin of the MWTD and for the formation of the Galaxy are considered. (abridged)Comment: 41 pages, 9 tables, 6 figures, accepted for publication in The Astronomical Journa

Conceptual learning : the priority for higher education

The common sense notion of learning as the all-pervasive acquisition of new behaviour and knowledge, made vivid by experience, is an incomplete characterisation, because it assumes that the learning of behaviour and the learning of knowledge are indistinguishable, and that acquisition constitutes learning without reference to transfer. A psychological level of analysis is used to argue that conceptual learning should have priority in higher education

The importance of sea ice area biases in 21st century multimodel projections of Antarctic temperature and precipitation

Climate models exhibit large biases in sea ice area (SIA) in their historical simulations. This study explores the impacts of these biases on multimodel uncertainty in Coupled Model Intercomparison Project phase 5 (CMIP5) ensemble projections of 21st century change in Antarctic surface temperature, net precipitation, and SIA. The analysis is based on time slice climatologies in the Representative Concentration Pathway 8.5 future scenario (2070–2099) and historical (1970–1999) simulations across 37 different CMIP5 models. Projected changes in net precipitation, temperature, and SIA are found to be strongly associated with simulated historical mean SIA (e.g., cross-model correlations of r = 0.77, 0.71, and −0.85, respectively). Furthermore, historical SIA bias is found to have a large impact on the simulated ratio between net precipitation response and temperature response. This ratio is smaller in models with smaller-than-observed SIA. These strong emergent relationships on SIA bias could, if found to be physically robust, be exploited to give more precise climate projections for Antarctica