New Zealand Retirement Income: Policy as an ‘Eco-system’

The New Zealand retirement income system involves a range of policy areas and initiatives beyond New Zealand Superannuation and KiwiSaver. These interact with each other, and with wider social and economic trends. The potential for prolonging working lives, self-funding/decumulation and trends in homeownership need to be considered alongside the sustainability of current policy settings. A unified policy approach is required to ensure the adequacy of retirement incomes for older people and also intergenerational equity

Health seeking behaviours among electronic waste workers in Ghana

Abstract Background Electronic waste workers are prone to various illnesses and injuries from numerous hazards thus the need for them to seek health care. The aim of this study was to describe health-seeking behavior, and social and other factors affecting this behavior, among electronic waste workers at Agbogbloshie, Accra, Ghana. Methods In-depth interviews were conducted and analyzed qualitatively from a grounded theory perspective. Results Workers experienced various kinds of ailments. These included physical injuries, chest and respiratory tract associated symptoms, malaria, headaches, body pains and stomach discomfort. They reported seeking health care from multiple sources, and the main determinants of health seeking behaviour were severity of illness, perceived benefit of treatment, accessibility of service, quality of service, ease of communication with service provider and cost of health care. Conclusion Multiple sources of health care were used by the e-waste workers. As cost was a major barrier to accessing formal health care, most of the workers did not subscribe to health insurance. Since enrollment in health insurance is low amongst the workers, education campaigns on the need to register with the National Health Insurance Scheme would facilitate access to formal health care and could result in improved health outcomes among e-waste workers.http://deepblue.lib.umich.edu/bitstream/2027.42/115463/1/12889_2015_Article_2376.pd

A general role for TANGO1, encoded by MIA3, in secretory pathway organization and function

Complex machinery is required to drive secretory cargo export from the endoplasmic reticulum (ER), which is an essential process in eukaryotic cells. In vertebrates, the MIA3 gene encodes two major forms of transport and Golgi organization protein 1 (TANGO1S and TANGO1L), which have previously been implicated in selective trafficking of procollagen. Using genome engineering of human cells, light microscopy, secretion assays, genomics and proteomics, we show that disruption of the longer form, TANGO1L, results in relatively minor defects in secretory pathway organization and function, including having limited impacts on procollagen secretion. In contrast, loss of both long and short forms results in major defects in cell organization and secretion. These include a failure to maintain the localization of ERGIC53 (also known as LMAN1) and SURF4 to the ER–Golgi intermediate compartment and dramatic changes to the ultrastructure of the ER–Golgi interface. Disruption of TANGO1 causes significant changes in early secretory pathway gene and protein expression, and impairs secretion not only of large proteins, but of all types of secretory cargo, including small soluble proteins. Our data support a general role for MIA3/TANGO1 in maintaining secretory pathway structure and function in vertebrate cells

Contrasting responses of DMS and DMSP to ocean acidification in Arctic waters

Increasing atmospheric CO2 is decreasing ocean pH most rapidly in colder regions such as the Arctic. As a component of the EPOCA pelagic mesocosm experiment off Spitzbergen in 2010, we examined the consequences of decreased pH and increased pCO2 on the concentrations of dimethylsulphide (DMS). DMS is an important reactant and contributor to aerosol formation and growth in the Arctic troposphere. In the nine mesocosms with initial pH 8.3 to 7.5, equivalent to pCO2 of 180 to 1420 μatm, highly significant but inverse responses to acidity (hydrogen ion concentration [H+]) occurred following nutrient addition. Compared to ambient [H+], average concentrations of DMS during the most representative phase of the 30 d experiment were reduced by approximately 60% at the highest [H+] and by 35% at [H+] equivalent to 750 μatm pCO2, as predicted for 2100. In contrast, concentrations of dimethylsulphoniopropionate (DMSP), the precursor of DMS, were elevated by approximately 50% at the highest [H+] and by 30% at [H+] corresponding to 750 μatm pCO2. Measurements of the specific rate of synthesis of DMSP by phytoplankton indicate increased production at high [H+], in parallel to rates of inorganic carbon fixation. The elevated DMSP production at high [H+] was largely a consequence of increased dinoflagellate biomass and in particular, the increased abundance of the species Heterocapsa rotundata. We discuss both phytoplankton and bacterial processes that may explain the reduced ratios of DMS:DMSPt at higher [H+]. The experimental design of eight treatment levels provides comparatively robust empirical relationships of DMS and DMSP concentration, DMSP production and dinoflagellate biomass versus [H+] in Arctic waters

ADHD in adults with recurrent depression

BACKGROUND: Depression is highly heterogeneous in its clinical presentation. Those with attention deficit/hyperactivity disorder (ADHD) may be at risk of a more chronic and impairing depression compared to those with depression alone according to studies of young people. However, no studies to date have examined ADHD in recurrently depressed adults in mid-life. METHOD: In a sample of women in mid-life (n=148) taken from a UK based prospective cohort of adults with a history of recurrent depression, we investigated the prevalence of ADHD and the association of ADHD with clinical features of depression. RESULTS: 12.8% of the recurrently depressed women had elevated ADHD symptoms and 3.4% met DSM-5 diagnostic criteria for ADHD. None of the women reported having a diagnosis of ADHD from a medical professional. ADHD symptoms were associated with earlier age of depression onset, higher depression associated impairment, a greater recurrence of depressive episodes and increased persistence of subthreshold depression symptoms over the study period, higher levels of irritability and increased risk of self-harm or suicide attempt. ADHD symptoms were associated with increased risk of hospitalisation and receiving non-first-line antidepressant medication. LIMITATIONS: ADHD was measured using a questionnaire measure. We focussed on mothers in a longitudinal study of recurrent depression, so the findings may not apply to males or other groups. CONCLUSIONS: Higher ADHD symptoms appear to index a worse clinical presentation for depression. Clinical implications include that in women with early onset, impairing and recurrent depression, the possibility of underlying ADHD masked by depression needs to be considered

Deviation from STEM Peers and Employers in Employability Focuses: the Case of Maths, Stats, Physics and Astronomy Students

STEM employability is a non-homogenous phenomenon with mixed outcomes for graduates from different disciplines. A myriad of factors may contribute to the diverse employability. Here we examine the heterogeneity of career and employability development focuses among different STEM student cohorts in the curricular context. We utilised a structured framework of Career Information Literacy (CIL) to map career and employability focuses of STEM students and employers. This paper presents findings from the Mathematics, Statistics, Physics and Astronomy cohort. Data was collected from final year capstone unit students at a STEM faculty in an Australian university (N=517, response rate 44%). Of which, Maths, Stats, Physics and Astronomy (MSPA) students were analysed as a cohort (N=80, response rate 73%). Concurrent data collection took place with STEM employers and industry stakeholders who engaged this faculty in recruitment and employability activities (N=62, response rate 78%). Upon comparing student cohorts’ focuses on career and employability development with their peers and employers, we found MSPA students differ from both their STEM peers and employers. Most other STEM student cohorts differ from employers, but not their peers. The implications point to a different career development need of this cohort to fully realise the benefits of their STEM education

Following the children of depressed parents from childhood to adult life: A focus on mood and anxiety disorders

BACKGROUND: Parental depression increases risk for anxiety and depression in offspring. The transition from adolescence to adulthood is a common risk period for onset of such disorders. However, relatively few studies have considered development of these disorders from childhood to adulthood including multiple assessments during this transition period. METHOD: Offspring of depressed parents aged 9–17 years at baseline were followed prospectively for 13 years (n = 337). Average length of follow-up was 16 months between the first and second waves, 13 months between the second and third, and 8 years between the third and fourth. Current (3-month) psychopathology was assessed at each wave using diagnostic interviews. We derived estimates of 3-month prevalence, age at first diagnosis, course and comorbidity of disorders. Social functioning in adult life was assessed at the final wave and we assessed how prior and current disorder impacted adult functioning. RESULTS: A quarter of young people met criteria for a mood disorder and a third for anxiety disorder at least once. Mood and anxiety disorder prevalence increased from 4.5% and 15.8% respectively in childhood (9–11 years) to 22.3% and 20.9% respectively by age 23–28. Increased prevalence across the transition from adolescence to adulthood was particularly marked in males, while prevalence increased earlier in adolescence in females. Age at first diagnosis varied widely (mood disorder mean = 16.5 years (range 9–26); anxiety disorder mean = 14.5 years (range 9–28)). Over half (52%) reported functional impairment in early adulthood, 31% harmful alcohol use, and 10% self-harm or a suicide attempt. Both previous and current mood or anxiety disorder were associated with functional impairment in early adulthood. CONCLUSIONS: There is a prolonged risk period for mood and anxiety disorders in this group, with prevalence peaking in early adulthood. This highlights the need for prolonged vigilance and effective targeted interventions in the offspring of depressed parents

The IeDEA Harmonist Data Toolkit: A Data Quality and Data Sharing Solution for a Global HIV Research Consortium.

We describe the design, implementation, and impact of a data harmonization, data quality checking, and dynamic report generation application in an international observational HIV research network. The IeDEA Harmonist Data Toolkit is a web-based application written in the open source programming language R, employs the R/Shiny and RMarkdown packages, and leverages the REDCap data collection platform for data model definition and user authentication. The Toolkit performs data quality checks on uploaded datasets, checks for conformance with the network's common data model, displays the results both interactively and in downloadable reports, and stores approved datasets in secure cloud storage for retrieval by the requesting investigator. Including stakeholders and users in the design process was key to the successful adoption of the application. A survey of regional data managers as well as initial usage metrics indicate that the Toolkit saves time and results in improved data quality, with a 61% mean reduction in number of error records in a dataset. The generalized application design allows the Toolkit to be easily adapted to other research networks