REALISTIC DETECTABILITY OF CLOSE INTERSTELLAR COMETS

During the planet formation process, billions of comets are created and ejected into interstellar space. The detection and characterization of such interstellar comets (ICs) (also known as extra-solar planetesimals or extra-solar comets) would give us in situ information about the efficiency and properties of planet formation throughout the galaxy. However, no ICs have ever been detected, despite the fact that their hyperbolic orbits would make them readily identifiable as unrelated to the solar system. Moro-Martin et al. have made a detailed and reasonable estimate of the properties of the IC population. We extend their estimates of detectability with a numerical model that allows us to consider "close" ICs, e.g., those that come within the orbit of Jupiter. We include several constraints on a "detectable" object that allow for realistic estimates of the frequency of detections expected from the Large Synoptic Survey Telescope (LSST) and other surveys. The influence of several of the assumed model parameters on the frequency of detections is explored in detail. Based on the expectation from Moro-Martin et al., we expect that LSST will detect 0.001-10 ICs during its nominal 10 year lifetime, with most of the uncertainty from the unknown number density of small (nuclei of similar to 0.1-1 km) ICs. Both asteroid and comet cases are considered, where the latter includes various empirical prescriptions of brightening. Using simulated LSST-like astrometric data, we study the problem of orbit determination for these bodies, finding that LSST could identify their orbits as hyperbolic and determine an ephemeris sufficiently accurate for follow-up in about 4-7 days. We give the hyperbolic orbital parameters of the most detectable ICs. Taking the results into consideration, we give recommendations to future searches for ICs.Peer reviewe

The Orbit, Mass, and Albedo of Transneptunian Binary 1999 RZ253

We have observed 1999 RZ253 with the Hubble Space Telescope at seven separate epochs and have fit an orbit to the observed relative positions of this binary. Two orbital solutions have been identified that differ primarily in the inclination of the orbit plane. The best fit corresponds to an orbital period, P=46.263 +0.006/-0.074 days, semimajor axis a=4,660 +/-170 km and orbital eccentricity e=0.460 +/-0.013 corresponding to a system mass m=3.7 +/-0.4 x10^18 kg. For a density of rho = 1000 kg m^-3 the albedo at 477 nm is p = 0.12 +/-0.01, significantly higher than has been commonly assumed for objects in the Kuiper Belt. Multicolor, multiepoch photometry shows this pair to have colors typical for the Kuiper belt with a spectral gradient of 0.35 per 100 nm in the range between 475 and 775 nm. Photometric variations at the four epochs we observed were as large as 12 +/-3% but the sampling is insufficient to confirm the existence of a lightcurve

Evidence of Orbital Motion in the Binary Brown Dwarf Kelu-1AB

We have resolved Kelu-1 into a binary system with a separation of ~290 mas using the Laser Guide Star Adaptive Optics system on the Keck II telescope. We have also re-analyzed a 1998 HST observation of Kelu-1 and find that the observed PSF is best fit by a binary object separated by 45 mas. Observations on multiple epochs confirm the two objects share a common proper motion and clearly demonstrate the first evidence of orbital motion. Kelu-1B is fainter than Kelu-1A by 0.39+/-0.01 magnitudes in the K' filter and 0.50+/-0.01 magnitudes in the H filter. We derive spectral types of L2+/-1 and L3.5+/-1 for Kelu-1A and B, respectively. The separation of flux into the two components rectifies Kelu-1's over-luminosity problem that has been known for quite some time. Given the available data we are able to constrain the inclination of the system to >81 degrees and the orbital period to >~40 years.Comment: 15 pages, 3 figures, Accepted to PASP. Changes include: title, author list, new data, more analysis, and new journa

Impact of age and race on outcomes of a program to prevent excess weight gain and disordered eating in adolescent girls

Interpersonal psychotherapy (IPT) prevents weight gain and reduces loss-of-control (LOC)-eating in adults. However, IPT was not superior to health-education (HE) for preventing excess weight gain and reducing LOC-eating over 1-year in adolescent girls at risk for excess weight gain and eating disorders. Limited data suggest that older and non-White youth may be especially responsive to IPT. In secondary analyses, we examined if age or race moderated weight and LOC-eating outcomes. The 113 participants (12–17 years; 56.6% White) from the original trial were re-contacted 3 years later for assessment. At baseline and follow-up visits through 3 years, we assessed BMI, adiposity by dual energy X-ray absorptiometry, and LOC-eating presence. In linear mixed models, baseline age moderated 3-year BMI outcome; older girls in IPT had the lowest 3-year BMI gain compared to younger girls in IPT and all girls in HE, p = 0.04. A similar pattern was observed for adiposity. Race moderated 3-year LOC-eating; non-White girls in IPT were most likely to abstain from LOC-eating at 3 years compared to all other girls, p = 0.04. This hypothesis-generating analysis suggests future studies should determine if IPT is especially efficacious at reducing LOC-eating in older, non-White adolescents

L-Band Photometry of L and T Dwarfs

We present K- and L-band photometry obtained with the Keck I telescope for a representative sample of L and T dwarfs. These observations were motivated in part by the dominant role water and methane play in shaping the flux near 2 and 3 microns and by the potential use of these bands as indicators of spectral class in the infrared. In addition, these observations aid the determination of the bolometric luminosity of L and T dwarfs. Here we report the K, L' and Ls magnitudes of our objects and the trends observed in the (K-L') and (K-Ls) colors as a function of L- and T-dwarf spectral class. We compare these colors with theoretical models, derive a relationship between effective temperature and L-spectral class, and compare our temperature estimates with others.Comment: Paper to be published in ApJL, 15 pages, 3 figure

Evidence for Two Populations of Classical Transneptunian Objects: The Strong Inclination Dependence of Classical Binaries

We have searched 101 Classical transneptunian objects for companions with the Hubble Space Telescope. Of these, at least 21 are binary. The heliocentric inclinations of the objects we observed range from 0.6-34 degrees. We find a very strong anticorrelation of binaries with inclination. Of the 58 targets that have inclinations of less than 5.5 degrees, 17 are binary, a binary fraction of 29 +7/-6%. All 17 are similar-brightness systems. On the contrary, only 4 of the 42 objects with inclinations greater than 5.5 degrees have satellites and only 1 of these is a similar-brightness binary. This striking dichotomy appears to agree with other indications that the low eccentricity, non-resonant Classical transneptunian objects include two overlapping populations with significantly different physical properties and dynamical histories.Comment: 32 pages, 4 figures, 2 tables in press for Icarus volume 194 Note added in proof and reference updates in this corrected versio

Evaluation of Arylimidamides DB1955 and DB1960 as Candidates against Visceral Leishmaniasis and Chagas' Disease: In Vivo Efficacy, Acute Toxicity, Pharmacokinetics, and Toxicology Studies

Arylimidamides (AIAs) have shown outstanding in vitro potency against intracellular kinetoplastid parasites, and the AIA 2,5-bis[2-(2-propoxy)-4-(2-pyridylimino)aminophenyl]furan dihydrochloride (DB766) displayed good in vivo efficacy in rodent models of visceral leishmaniasis (VL) and Chagas' disease. In an attempt to further increase the solubility and in vivo antikinetoplastid potential of DB766, the mesylate salt of this compound and that of the closely related AIA 2,5-bis[2-(2-cyclopentyloxy)-4-(2-pyridylimino)aminophenyl]furan hydrochloride (DB1852) were prepared. These two mesylate salts, designated DB1960 and DB1955, respectively, exhibited dose-dependent activity in the murine model of VL, with DB1960 inhibiting liver parasitemia by 51% at an oral dose of 100 mg/kg/day × 5 and DB1955 reducing liver parasitemia by 57% when given by the same dosing regimen. In a murine Trypanosoma cruzi infection model, DB1960 decreased the peak parasitemia levels that occurred at 8 days postinfection by 46% when given orally at 100 mg/kg/day × 5, while DB1955 had no effect on peak parasitemia levels when administered by the same dosing regimen. Distribution studies revealed that these compounds accumulated to micromolar levels in the liver, spleen, and kidneys but to a lesser extent in the heart, brain, and plasma. A 5-day repeat-dose toxicology study with DB1960 and DB1955 was also conducted with female BALB/c mice, with the compounds administered orally at 100, 200, and 500 mg/kg/day. In the high-dose groups, DB1960 caused changes in serum chemistry, with statistically significant increases in serum blood urea nitrogen, lactate dehydrogenase, aspartate aminotransferase, and alanine aminotransferase levels, and a 21% decrease in body weight was observed in this group. These changes were consistent with microscopic findings in the livers and kidneys of the treated animals. The incidences of observed clinical signs (hunched posture, tachypnea, tremors, and ruffled fur) were more frequent in DB1960-treated groups than in those treated with DB1955. However, histopathological examination of tissue samples indicated that both compounds had adverse effects at all dose levels.This work was supported by a grant from the Bill and Melinda Gates Foundation, contract N01-AI-60011 with SRI International from the National Institute of Allergy and Infectious Diseases, FIOCRUZ, and by Fundação Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ) PPSUS, APQ1, and Pensa-Rio (16/2009-E-26/110-313/2010), Conselho Nacional Desenvolvimento científico e Tecnológico (CNPq), PDTIS/FIOCRUZ, and PROEP. We thank the other members of the Consortium for Parasitic Drug Development for helpful discussions

KELT-16b: A Highly Irradiated, Ultra-short Period Hot Jupiter Nearing Tidal Disruption

We announce the discovery of KELT-16b, a highly irradiated, ultra-short period hot Jupiter transiting the relatively bright (V = 11.7) star TYC 2688-1839-1/KELT-16. A global analysis of the system shows KELT-16 to be an F7V star with K and . The planet is a relatively high-mass inflated gas giant with density g cm-3, surface gravity , and K. The best-fitting linear ephemeris is and day. KELT-16b joins WASP-18b, -19b, -43b, -103b, and HATS-18b as the only giant transiting planets with P \u3c 1 day. Its ultra-short period and high irradiation make it a benchmark target for atmospheric studies by the Hubble Space Telescope, Spitzer, and eventually the James Webb Space Telescope. For example, as a hotter, higher-mass analog of WASP-43b, KELT-16b may feature an atmospheric temperature-pressure inversion and day-to-night temperature swing extreme enough for TiO to rain out at the terminator. KELT-16b could also join WASP-43b in extending tests of the observed mass-metallicity relation of the solar system gas giants to higher masses. KELT-16b currently orbits at a mere ∼1.7 Roche radii from its host star, and could be tidally disrupted in as little as a few ×105 years (for a stellar tidal quality factor of ). Finally, the likely existence of a widely separated bound stellar companion in the KELT-16 system makes it possible that Kozai-Lidov (KL) oscillations played a role in driving KELT-16b inward to its current precarious orbit

Combined Treatment of Heterocyclic Analogues and Benznidazole upon Trypanosoma cruzi In Vivo

Chagas disease caused by Trypanosoma cruzi is an important cause of mortality and morbidity in Latin America but no vaccines or safe chemotherapeutic agents are available. Combined therapy is envisioned as an ideal approach since it may enhance efficacy by acting upon different cellular targets, may reduce toxicity and minimize the risk of drug resistance. Therefore, we investigated the activity of benznidazole (Bz) in combination with the diamidine prodrug DB289 and in combination with the arylimidamide DB766 upon T. cruzi infection in vivo. The oral treatment of T.cruzi-infected mice with DB289 and Benznidazole (Bz) alone reduced the number of circulating parasites compared with untreated mice by about 70% and 90%, respectively. However, the combination of these two compounds decreased the parasitemia by 99% and protected against animal mortality by 100%, but without providing a parasitological cure. When Bz (p.o) was combined with DB766 (via ip route), at least a 99.5% decrease in parasitemia levels was observed. DB766+Bz also provided 100% protection against mice mortality while Bz alone provided about 87% protection. This combined therapy also reduced the tissular lesions induced by T. cruzi infection: Bz alone reduced GPT and CK plasma levels by about 12% and 78% compared to untreated mice group, the combination of Bz with DB766 resulted in a reduction of GPT and CK plasma levels of 56% and 91%. Cure assessment through hemocultive and PCR approaches showed that Bz did not provide a parasitological cure, however, DB766 alone or associated with Bz cured ≥13% of surviving animals