Investigation of the Damping of Liquids in Right-Circular Cylindrical Tanks, Including the Effects of a Time-Variant Liquid Depth

An experimental investigation was conducted to determine the effects of several basic variables upon the damping of the fundamental antisymmetric mode of liquids in right-circular cylindrical tanks without baffles. The variables examined include liquid depth, efflux rate, liquid amplitude, kinematic viscosity, and tank size. The data are presented in dimensionless form and compared with available theory. For the range of variables examined, variations of efflux rate and liquid amplitude were found to have no significant effects on the liquid damping. The following theoretical relationship was found to be adequate for the prediction of the variation of damping with liquid depth, kinematic viscosity, and tank size: [for equation see full text] where v is the kinematic viscosity, R is the cylinder radius, g is the acceleration due to gravity, and h is the liquid depth. However, the constant K was experimentally found in this investigation to have the value 5.23, which is 50 percent higher than the theoretically predicted value

The Adaptive Nature of Impulsivity

An old joke circulates among animal behavior instructors. One can, the joke goes, divide the topics of animal behavior into four Fs: fighting, fleeing, feeding, and reproduction. This somewhat tired joke carries considerable truth. Animals behaving in nature surely must make decisions about conflicts, predator avoidance, feeding, and mating. Male crickets, for example, are notoriously combative. Studies have shown, however, that they escalate fights in some situations and retreat to fight another day in others (Beaugrand, 1997; Parker, 1974; Parker & Rubenstein, 1981). Squirrels, like many small animals, respond to the presence or absence of protective cover; for example, they will carry large food items into the safety of the bushes to consume them but eat small items immediately (Lima, Valone, & Caraco, 1985). Female widow birds prefer males with long tails, and evolutionary theorists have argued that tail length correlates with male quality (Andersson, 1982, 1994). So a female confronted with a short-tailed male faces a dilemma: mate now or keep looking. Notice that in all of these choice situations, time complicates the animal’s problem: Risk injury by fighting now or retreat to fight later; stay exposed to possible predation or invest time in moving to a safer place; settle for the short-tailed male or keep looking. Each of these situations, and indeed virtually any naturally occurring choice situation one can imagine, is an intertemporal choice problem. We define these as choice situations in which an animal’s alternatives vary in the time at which the animal realizes consequences and in the quality of those consequences once the animal secures them. Although intertemporal choice applies to many domains (and all four Fs), we need to focus on a specific situation to make scientific headway, and for virtually all behavioral ecologists interested in intertemporal choice that focal situation is foraging. We can observe animal foraging choices easily (e.g., animals eat more often than they reproduce), and we can manipulate the time and magnitude of foraging options much more easily than we can manipulate mate quality or predation risk. Moreover, we have a large base of theoretical and empirical results that help us frame the intertemporal choice problem in the context of animal foraging behavior. Foraging is not only a convenient topic but also a fundamentally important one; actively seeking food is a basic part of animal existence that deserves our attention. In the first part of this chapter, we focus on adaptive aspects of intertemporal choice in animal foraging behavior, and especially on the problem of impulsivity, which we see as a central problem in intertemporal choice. In the second part of this chapter, we take a broader perspective, including domains other than food and extending beyond impulsivity to a more encompassing view of intertemporal choice. Within this general view, we explore the adaptive nature of impulsivity

Discounting and Reciprocity in an Iterated Prisoner’s Dilemma

The Iterated Prisoner’s Dilemma (IPD) is a central paradigm in the study of animal cooperation. According to the IPD framework, repeated play (repetition) and reciprocity combine to maintain a cooperative equilibrium. However, experimental studies with animals suggest that cooperative behavior in IPDs is unstable, and some have suggested that strong preferences for immediate benefits (that is, temporal discounting) might explain the fragility of cooperative equilibria. We studied the effects of discounting and strategic reciprocity on cooperation in captive blue jays. Our results demonstrate an interaction between discounting and reciprocity. Blue jays show high stable levels of cooperation in treatments with reduced discounting when their opponent reciprocates, but their levels of cooperation decline in all other treatment combinations. This suggests that stable cooperation requires both reduced discounting and reciprocity, and it offers an explanation of earlier failures to find cooperation in controlled payoff games

Superconductivity in Co-doped LaFeAsO

Here we report the synthesis and basic characterization of LaFe1-xCoxAsO for several values of x. The parent phase LaFeAsO orders antiferromagnetically (TN ~ 145 K). Replacing Fe with Co is expected to both electron dope the system and introduce disorder in the FeAs layer. For x = 0.05 antiferromagnetic order is destroyed and superconductivity is observed at Tconset = 11.2 K. For x = 0.11 superconductivity is observed at Tc(onset) = 14.3 K, and for x = 0.15 Tc = 6.0 K. Superconductivity is not observed for x = 0.2 and 0.5, but for x = 1, the material appears to be ferromagnetic (Tc ~ 56 K) as judged by magnetization measurements. We conclude that Co is an effective dopant to induce superconductivity. Somewhat surprisingly, the system appears to tolerate considerable disorder in the FeAs planes.Comment: 19 pages, 9 figure

Structure-dependent Inhibition of the ETS-Family Transcription Factor PU.1 by Novel Heterocyclic Diamidines

ETS transcription factors mediate a wide array of cellular functions and are attractive targets for pharmacological control of gene regulation. We report the inhibition of the ETS-family member PU.1 with a panel of novel heterocyclic diamidines. These diamidines are derivatives of furamidine (DB75) in which the central furan has been replaced with selenophene and/or one or both of the bridging phenyl has been replaced with benzimidazole. Like all ETS proteins, PU.1 binds sequence specifically to 10-bp sites by inserting a recognition helix into the major groove of a 50-GGAA-30 consensus, accompanied by contacts with the flanking minor groove. We showed that diamidines target the minor groove of AT-rich sequences on one or both sides of the consensus and disrupt PU.1 binding. Although all of the diamidines bind to one or both of the expected sequences within the binding site, considerable heterogeneity exists in terms of stoichiometry, site–site interactions and induced DNA conformation. We also showed that these compounds accumulate in live cell nuclei and inhibit PU.1-dependent gene transactivation. This study demonstrates that heterocyclic diamidines are capable of inhibiting PU.1 by targeting the flanking sequences and supports future efforts to develop agents for inhibiting specific members of the ETS family

Meridional Survey of the Central Pacific Reveals Iodide Accumulation in Equatorial Surface Waters and Benthic Sources in the Abyssal Plain

The distributions of iodate and iodide were measured along the GEOTRACES GP15 meridional transect at 152°W from the shelf of Alaska to Papeete, Tahiti. The transect included oxygenated waters near the shelf of Alaska, the full water column in the central basin in the North Pacific Basin, the upper water column spanning across seasonally mixed regimes in the north, oligotrophic regimes in the central gyre, and the equatorial upwelling. Iodide concentrations are highest in the permanently stratified tropical mixed layers, which reflect accumulation due to light-dependent biological processes, and decline rapidly below the euphotic zone. Vertical mixing coefficients (Kz), derived from complementary 7Be data, enabled iodide oxidation rates to be estimated at two stations. Iodide half-lives of 3–4 years show the importance of seasonal mixing processes in explaining north-south differences in the transect, and also contribute to the decrease in iodide concentrations with depth below the mixed layer. These estimated half-lives are consistent with a recent global iodine model. No evidence was found for significant inputs of iodine from the Alaskan continental margin, but there is a significant enrichment of iodide in bottom waters overlying deep sea sediments from the interior of the basin

Dynamical inference from a kinematic snapshot: The force law in the Solar System

If a dynamical system is long-lived and non-resonant (that is, if there is a set of tracers that have evolved independently through many orbital times), and if the system is observed at any non-special time, it is possible to infer the dynamical properties of the system (such as the gravitational force or acceleration law) from a snapshot of the positions and velocities of the tracer population at a single moment in time. In this paper we describe a general inference technique that solves this problem while allowing (1) the unknown distribution function of the tracer population to be simultaneously inferred and marginalized over, and (2) prior information about the gravitational field and distribution function to be taken into account. As an example, we consider the simplest problem of this kind: We infer the force law in the Solar System using only an instantaneous kinematic snapshot (valid at 2009 April 1.0) for the eight major planets. We consider purely radial acceleration laws of the form a_r = -A [r/r_0]^{-\alpha}, where r is the distance from the Sun. Using a probabilistic inference technique, we infer 1.989 < \alpha < 2.052 (95 percent interval), largely independent of any assumptions about the distribution of energies and eccentricities in the system beyond the assumption that the system is phase-mixed. Generalizations of the methods used here will permit, among other things, inference of Milky Way dynamics from Gaia-like observations

Di-cationic arylimidamides Act Against Neospora caninum tachyzoites by Interference in Membrane Structure and Nucleolar Integrity and are Active Against Challenge Infection in Mice

Neospora caninum is considered to be the main cause of bovine abortion in Europe and the USA, leading to considerable financial impact. Losses are caused directly by abortions or indirectly through breeding of calves with impaired viability. Due to the lack of effective chemotherapy against bovine neosporosis, there is a need to develop new anti-protozoal compounds, which would either eliminate the parasite or avoid its transmission. In order to identify compounds of interest, the in vitro activities of 41 di-cationic pentamidine derivatives were studied employing a transgenic N. caninum clone expressing beta-galactosidase as a reporter gene. The arylimidamide DB745, previously shown to be highly active against Leishmania donovani in vitro and in vivo, appeared as the most promising compound, with an IC50 of 80 nM in 3-day growth assays and severely affecting both host cell invasion as well as intracellular proliferation. TEM of intracellular tachyzoites identified distinct alterations related to the nucleolus and the nuclear and cellular membrane. Long-term growth assays showed that DB745 acted parasiticidal upon the Nc-Liv isolate, but not against the Nc-1 isolate of N. caninum. In vivo studies in N. caninum (Nc-1 isolate) infected mice showed that daily intraperitoneal application of DB745 for a period of 14 days resulted in a decreased number of clinically affected animals, and lower cerebral parasite burdens in DB745-treated mice compared to non-treated mice. These results illustrate the potential of dicationic arylimidamides for the treatment of N. caninum infections